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Total 1289 results found since Jan 2013.
β-Sitosterol blocks the LEF-1-mediated Wnt/β-catenin pathway to inhibit proliferation of human colon cancer cells
CONCLUSION: According to our results, LEF-1 down-regulation can effectively block Wnt/β-catenin pathway, inhibit CC cell growth and migration. Collectively, β-sitosterol can be used to treat CC, which can provide anti-tumor activity by targeting LEF-1.PMID:36603684 | DOI:10.1016/j.cellsig.2022.110585
Source: Cellular Signalling - January 5, 2023 Category: Cytology Authors: Shengliang Gu Fahui Liu Xueheng Xie Meng Ding Fan Wang Xiaoyan Xing Tianbao Xiao Xiaobo Sun Source Type: research
Inhibition of secretory leukocyte protease inhibitor (SLPI) promotes the PUMA-mediated apoptosis and chemosensitivity to cisplatin in colorectal cancer cells
ConclusionsTaken together, these findings demonstrated that suppression of SLPI might repress the growth of human colorectal cancer cells both in vitro and in vivo. These results suggested SLPI as a novel resistance factor to Cisplatin, and a combination of Cisplatin and SLPI inhibitor be beneficial for colorectal cancer therapy.
Source: Hormones and Cancer - January 3, 2023 Category: Cancer & Oncology Source Type: research
MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3
ConclusionsOur results uncover a newly identified MFAP2-CLK3 signaling axis, which is a potential therapeutic target for CRC metastasis.
Source: Cancer Medicine - December 30, 2022 Category: Cancer & Oncology Authors: Meng Xue,
Shuyi Mi,
Zizhen Zhang,
Hao Wang,
Wenwen Chen,
Wei Wei,
Guochun Lou Tags: RESEARCH ARTICLE Source Type: research
GSE86179 Knockdowns of total NFYA and a NFYA long 3 ’ UTR isoform followed by RNA-seq to determine isoform-specific effects on gene expression
Contributors : Thomas J Sweet ; Jeffrey M Bhasin ; Angela H TingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlternative cleavage and polyadenylation (APA) produces multiple isoforms of the Nuclear Transcription Factor Y Subunit Alpha (NFYA) gene with variable length 3? untranslated regions (UTRs). These isoforms have been detected in HCT116 colon cancer cells via polyA-seq and northern blots, as well as colon cancer tissue RNA-seq data. NFYA is a transcription factor that may regulate cell growth and proliferation in cancer and development. To determine if there may be transcripti...
Source: GEO: Gene Expression Omnibus - December 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Combination of Quercetin or/and siRNA-loaded DDAB-mPEG-PCL hybrid nanoparticles reverse resistance to Regorafenib in colon cancer cells
Colorectal cancer (CRC) is the second leading cause of cancer death. Although Regorafenib showed survival benefits in patients with CRC, reports imply the recurrence of malignant phenotype resulting from chemo...
Source: BMC Complementary and Alternative Medicine - December 27, 2022 Category: Complementary Medicine Authors: Shabnam Shahidi, Kobra Rostamizadeh, Mojtaba Fathi, Keivan Nedaei and Ali Ramazani Tags: Research Source Type: research
Molecules, Vol. 28, Pages 97: Alpha Ketoglutarate Downregulates the Neutral Endopeptidase and Enhances the Growth Inhibitory Activity of Thiorphan in Highly Aggressive Osteosarcoma Cells
sińska
Since natural substances are widely explored as epigenetic modulators of gene expression and epigenetic abnormalities are important causes of cancerogenesis, factors with pro-tumor activities subjected to epigenetic control, e.g., neutral endopeptidase (NEP, neprilysin), are promising anticancer targets for potential therapies acting via epigenetic regulation of gene expression. Alpha-ketoglutarate (AKG) is a naturally occurring co-substrate for enzymes involved in histone and DNA demethylation with suggested anti-cancer activity. Hence, we investigated a potential effect of AKG on the NEP expression in cells d...
Source: Molecules - December 22, 2022 Category: Chemistry Authors: Magdalena Mizerska-Kowalska Adrianna S ławińska-Brych Emilia Niedziela Viktor Brodovskiy Barbara Zdzisi ńska Tags: Article Source Type: research
ARID1A downregulation promotes cell proliferation and migration of colon cancer via VIM activation and CDH1 suppression
In this study, we investigated the ARID1A-VIM/CDH1 signalling axis's role in colon cancer proliferation and migration. The differentially expressed genes in cells that might be controlled by ARID1A were discovered by a database screening for ARID1A knockout. qPCR was used to analyse ARID1A and EMT markers expression levels in colon cancer. We utilized siRNA RID1A to explore the influence of ARID1A silencing on EMT in CRC cells. The function of ARID1A in the colon was investigated utilizing the wound healing, transwell and CCK-8 WST- assays. The molecular mechanism by which ARID1A regulates VIM and CDH1 was elucidated using...
Source: Molecular Medicine - November 24, 2022 Category: Molecular Biology Authors: Salem Baldi Qianshi Zhang Zhenyu Zhang Mohammed Safi Hassan Khamgan Han Wu Mengyan Zhang Yuanyuan Qian Yina Gao Abdullah Shopit Abdullah Al-Danakh Mohammed Alradhi Murad Al-Nusaif Yunfei Zuo Source Type: research
GSE191323 Characterization of normal fibroblast transcriptomes upon transient silencing of LTBP2 by RNAseq
Conclusions: Our study explored LTBP2 functions in normal fibroblasts. RNAseq data support its important role. After 48h, LTBP2 silencing induces changes in gene expression of numerous genes involved in fibroblast functions.
Source: GEO: Gene Expression Omnibus - November 22, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway
CONCLUSION: RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway, which may serve as a novel therapeutic target for cancers in which MAPK/ERK signaling is a dominant feature.PMID:36384455 | PMC:PMC9670436 | DOI:10.1186/s12860-022-00448-z
Source: Mol Biol Cell - November 17, 2022 Category: Molecular Biology Authors: Huahua Zhang Junli Liu Qingqing Dang Xueru Wang Jie Chen Xiaoyin Lin Na Yang Juan Du Haiyan Shi Yong Liu Jiming Han Source Type: research
Cancers, Vol. 14, Pages 5505: Gambogic Acid Induces Pyroptosis of Colorectal Cancer Cells through the GSDME-Dependent Pathway and Elicits an Antitumor Immune Response
This study provides novel insight into cancer chemoimmunotherapy.
Source: Cancers - November 9, 2022 Category: Cancer & Oncology Authors: Hanjie Xu Danya Zhang Rui Wei Ying Zhou Geyang Dai Jie Li Yue Sun Fei Li Ling Xi Tags: Article Source Type: research
Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer
This study was designed to investigate the potential key genes of ADP-ribosylation factor-like 15 (ARL15) regulating glycolysis and lipogenesis in colon cancer. Hematoxylin-eosin (HE) staining and immunohistochemistry were used to observe the expression of ARL15 in 10 normal colon tissues and 10 colon cancer tissues. Immunofluorescence staining was used to observe the expression position of ARL15 in normal human colorectal mucosa cells (FHC) and colon cancer cells (HCT116 and SW620) with a confocal microscope. The ARL15 plasmid and small interfering RNA (siRNA) were constructed. After transfection, the expression levels of...
Source: Journal of Physiology and Pharmacology - October 27, 2022 Category: Drugs & Pharmacology Authors: F Du H-J Zhang W Shao Y-Y Tu K-J Yang L-S Piao Source Type: research
