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Total 1289 results found since Jan 2013.
Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
Neoplasia. 2022 Nov;33:100837. doi: 10.1016/j.neo.2022.100837. Epub 2022 Sep 24.ABSTRACTKRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regulator of the unfolded protein response (UPR). Following up on our recent discoveries that GRP78 haploinsufficiency suppresses both KRASG12D-driven pancreatic and lung tumorigenesis, we seek to determine the underlying mechanisms. Here, we rep...
Source: Neoplasia - September 26, 2022 Category: Cancer & Oncology Authors: Dat P Ha Bo Huang Han Wang Daisy Flores Rangel Richard Van Krieken Ze Liu Soma Samanta Nouri Neamati Amy S Lee Source Type: research
Correction: Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer
Pichler M, Rodriguez-Aguayo C, Nam SY, et al. Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut 2020;69:1818–31. In figure 6A a wrong panel was included in the bottom row. The correct figure 6 is below. The figure legend remains the same. In the section: siRNA therapeutics targeting FLANC leads to decreased proliferation and metastasis in vivo the paragraph should read as: ‘Regarding tumour growth related parameters, we observed a lower number of mice with bioluminescence signals in the whole mouse (figure 6A), as well as in the isolated livers (figure 6B), i...
Source: Gut - September 10, 2022 Category: Gastroenterology Tags: Miscellaneous Source Type: research
Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells
Biochem Biophys Res Commun. 2022 Aug 31;628:110-115. doi: 10.1016/j.bbrc.2022.08.082. Online ahead of print.ABSTRACTColorectal cancer is a significant cause of morbidity and represents a serious public health issue in many countries. The development of a breakthrough preventive method for colorectal cancer is urgently needed. Aspirin has recently been attracting attention as a cancer preventive drug, and its inhibitory effects on the development of various cancers have been reported in several large prospective studies. However, the underlying molecular mechanisms have not yet been elucidated in detail. In the present stud...
Source: Biochemical and Biophysical Research communications - September 9, 2022 Category: Biochemistry Authors: Ayaka Imai Mano Horinaka Yuichi Aono Yosuke Iizumi Hideki Takakura Hisako Ono Shusuke Yasuda Keiko Taniguchi Emi Nishimoto Hideki Ishikawa Michihiro Mutoh Toshiyuki Sakai Source Type: research
Correction: Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer
Pichler M, Rodriguez-Aguayo C, Nam SY, et al. Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut 2020;69:1818–31. In figure 6A a wrong panel was included in the bottom row. The correct figure 6 is below. The figure legend remains the same. In the section: siRNA therapeutics targeting FLANC leads to decreased proliferation and metastasis in vivo the paragraph should read as: ‘Regarding tumour growth related parameters, we observed a lower number of mice with bioluminescence signals in the whole mouse (figure 6A), as well as in the isolated livers (figure 6B), i...
Source: Gut - September 7, 2022 Category: Gastroenterology Tags: Miscellaneous Source Type: research
GSE201069 The alterations of gene expression profiling induced by LINC00857 knockdown in HCT116 cells
This study reveals a novel role of LINC00857 in downstream gene regulation and provides a new explanation of LINC00857 ’ s function in colorectal cancer.
Source: GEO: Gene Expression Omnibus - August 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells
Biochem Biophys Res Commun. 2022 Jul 19;623:133-139. doi: 10.1016/j.bbrc.2022.07.055. Online ahead of print.ABSTRACTE type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC2 by poly(ADP-ribose) polymerase 14 (PARP14) may be required to induce the expression of EP4 receptors. The suppression of PARP14 activity by siRNA and/or its inhibitors reduced the mRNA expression of EP4 receptors. Thus, the expression of their proteins to approx...
Source: Biochemical and Biophysical Research communications - August 1, 2022 Category: Biochemistry Authors: Masato Mashimo Asuka Shimizu Aimi Mori Ayaka Hamaguchi Keijo Fukushima Naofumi Seira Takeshi Fujii Hiromichi Fujino Source Type: research
CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro
In this study, we loaded colorectal cancer (CRC) cell lysate on DCs and inhibited the expression of CTLA-4 by small interfering RNA (siRNA) in them to investigate the DCs’ functional and phenotypical features, and T-cell mediated responses following DC/T cell co-culture. Our results demonstrated that blockade of CTLA-4 could promote stimulatory properties of DCs. In addition, CTLA-4 silenced CRC cell lysate-loaded DCs compared to the DCs without CTLA-4 silencing resulted in augmented T cell proliferation and cytokine production, i.e., IFN-γ and IL-4. Taken together, our findings suggest CTLA-4 silenced CRC cell lysate-l...
Source: Frontiers in Immunology - August 1, 2022 Category: Allergy & Immunology Source Type: research
GSE208785 Differentially expressed genes after siRNA transfection in human cancer cell line
Contributors : R Yasudome ; N SekiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by siRNAs transfection in human colon cancer cell line, HCT116 was subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - July 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Aptamer-conjugated nanoliposomes containing COL1A1 siRNA sensitize CRC cells to conventional chemotherapeutic drugs
In this study, As1411 aptamer-conjugated liposomes were used for targeted siRNA delivery against the COL1A1 gene in colorectal cancer (CRC) cells. Cationic liposomes were synthesized and siRNA loading and conjugation of aptamer were confirmed by gel shift assay and spectrophotometry method. Release of siRNA from liposomes was assessed using dialysis method. Binding and uptake of aptamer-conjugated liposomes to and into cancer cells was assessed by fluorescence microscopy and flowcytometry. Gene expression was evaluated using qRT-PCR. Cell viability, chemosensitivity and apoptosis were determined by MTT assay and Annexin/PI...
Source: Colloids and Surfaces - July 29, 2022 Category: Biotechnology Authors: Hamed Manoochehri Akram Jalali Hamid Tanzadehpanah Amir Taherkhani Rezvan Najafi Source Type: research
Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221103318. doi: 10.1177/15330338221103318.ABSTRACTColorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small interfering RNAs (siRNAs) are expected to be remarkable tools capable of regulating gene expression by participating in a process called RNA interference (RNAi). RNAi is a biological process among eukaryotes wherein specific messe...
Source: Technology in Cancer Research and Treatment - July 28, 2022 Category: Cancer & Oncology Authors: Junlin Xie Shubin Wang Source Type: research
Calycosin suppresses colorectal cancer progression by targeting ER β, upregulating PTEN, and inhibiting PI3K/Akt signal pathway
In this study, we analyzed the effect of calycosin on the viability and apoptosis of human CRC HCT116 and SW480 cells via MTT assay, flow cytometry assay, and caspase-3/7 activity assay. The protein expressions of estrogen receptor β (ERβ), PTEN, and PI3K/Akt signal pathways were determined by Western blot analysis. And then, the alterations of biological behavior in CRC cells transfected with ERβ siRNA were analyzed. Mouse xenograft models were further performed to detect the antitumor effect in vivo. The results show that calycosin reduces CRC cell viability, induces cell apoptosis, and suppresses xenograft tumor grow...
Source: Cell Biology International - July 17, 2022 Category: Cytology Authors: Lin Zhu Sha Liu Yi-Fan Liao Yan-Mei Sheng Ji-Chun He Zheng-Xue Cai Qiong Man Yi-Ying Wu Source Type: research
