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Total 1289 results found since Jan 2013.
LAP+CD4+T cells regulate the anti-tumor role of CIK cells in colorectal cancer through IL-10 and TGF- β
Am J Transl Res. 2022 Jun 15;14(6):3716-3728. eCollection 2022.ABSTRACTThe rate of colorectal cancer (CRC) is increasing. Adoptive immune cell therapy (ACT) is a research hotspot in CRC treatment, and the common adoptive cells are cytokine-induced killer cells (CIK). The problem of ACT is that some regulatory T cells (Treg) will affect the efficacy. Latent associated polypeptide (LAP)+CD4+T is a new Treg, and its immunosuppressive effect is much higher than that of traditional Tregs. This research mainly explored the influence of LAP+CD4+T cells on anti-tumor lethality of CIK cells, so as to fill this gap. The LAP+CD4+T CI...
Source: American Journal of Translational Research - July 15, 2022 Category: Research Authors: Wu Zhong Chuanfa Fang Hongquan Liu Lei Zhang Xiaofei Zhang Junqiao Zhong Xianping He Leichang Zhang Source Type: research
ASAP Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and < italic toggle="yes" > Pcsk9 < /italic > siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c06001
Source: ACS Applied Materials and Interfaces - July 11, 2022 Category: Materials Science Authors: Wenjing Guo, Huabin Gao, Hui Li, Songhan Ge, Fenfen Zhang, Liyuan Wang, Huijuan Shi, and Anjia Han Source Type: research
Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells
ConclusionDHA can effectively promote ferroptosis-mediated tumor killing by increasing intracellular lipid peroxidation. Both ALOX5 dependent and independent pathways are involved in DHA-FIN induced ferroptosis. And during this process, free DHA plays an important role.
Source: European Journal of Nutrition - July 9, 2022 Category: Nutrition Source Type: research
ASAP Nanodrugs Incorporating LDHA siRNA Inhibit M2-like Polarization of TAMs and Amplify Autophagy to Assist Oxaliplatin Chemotherapy against Colorectal Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c05841
Source: ACS Applied Materials and Interfaces - July 7, 2022 Category: Materials Science Authors: Lijun Hu, Sicong Huang, Gengjia Chen, Bo Li, Tan Li, Minzhao Lin, Yongquan Huang, Zecong Xiao, Xintao Shuai, and Zhongzhen Su Source Type: research
Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research
