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Total 1289 results found since Jan 2013.

Unbiased differential proteomic profiling between cancer-associated fibroblasts and cancer cell lines
We describe for the first time that heat shock protein β-6 (HSPB6/HSP20) and cyclooxygenase 1 (PTGS1/COX1) are overexpressed in CAFs compared to cancer cells.PMID:37481068 | DOI:10.1016/j.jprot.2023.104973
Source: Journal of Proteomics - July 22, 2023 Category: Biochemistry Authors: Rachel Lau Lu Yu Theodoros I Roumeliotis Adam Stewart Lisa Pickard Ruth Riisanes Bora Gurel Johann S de Bono Jyoti S Choudhary Udai Banerji Source Type: research

Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Conclusion YTHDF1 impairs antitumour immunity via an m6A-p65-CXCL1/CXCR2 axis to promote CRC and serves as a therapeutic target in immune checkpoint blockade therapy.
Source: Gut - July 6, 2023 Category: Gastroenterology Authors: Bao, Y., Zhai, J., Chen, H., Wong, C. C., Liang, C., Ding, Y., Huang, D., Gou, H., Chen, D., Pan, Y., Kang, W., To, K. F., Yu, J. Tags: Open access, Gut Colon Source Type: research

Cancers, Vol. 15, Pages 3432: Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1
In this study, using chromatin immunoprecipitation (ChIP) assay and siRNA, we demonstrate that vitamin D/VDR regulates PD-L1 expression in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells. We have examined whether a VDR antagonist, MeTC7, can inhibit PD-L1. To ensure that MeTC7 inhibits VDR/PD-L1 without off-target effects, we examined competitive inhibition of VDR by MeTC7, utilizing ligand-dependent dimerization of VDR-RXR, RXR-RXR, and VDR-coactivators in a mammalian 2-hybrid (M2H) assay. MeTC7 inhibits VDR selectively, suppresses PD-L1 expression sparing PD-L2, and inhibits the cell viability, clon...
Source: Cancers - June 30, 2023 Category: Cancer & Oncology Authors: Negar Khazan Emily R. Quarato Niloy A. Singh Cameron W. A. Snyder Taylor Moore John P. Miller Masato Yasui Yuki Teramoto Takuro Goto Sabeeha Reshi Jennifer Hong Naixin Zhang Diya Pandey Priyanka Srivastava Alexandra Morell Hiroki Kawano Yuko Kawano Thomas Tags: Article Source Type: research

Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stromal Cells as an Efficient Nanocarrier to Deliver siRNA or Drug to Pancreatic Cancer Cells
In conclusion, the use of UC-MSC-derived EVs as a drug delivery system for siRNAs or drugs could be a promising approach for the targeted treatment of PDAC.PMID:37296864 | DOI:10.3390/cancers15112901
Source: Cancer Control - June 10, 2023 Category: Cancer & Oncology Authors: Florian Draguet Nathan Dubois Cyril Bouland Karlien Pieters Dominique Bron Nathalie Meuleman Basile Stamatopoulos Laurence Lagneaux Source Type: research

Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53
ConclusionThis study revealed the anticancer efficacy of HST against CRC via opposite modulation of wtp53 and mutp53R273H, indicating the potential of HST to be a CRC drug candidate targeting p53 signaling.
Source: Hormones and Cancer - May 31, 2023 Category: Cancer & Oncology Source Type: research

The Expression and Role of NADPH Oxidase 2 in Colon Cancer
CONCLUSION: NOX2 expression level has a close association with the prognosis of colon cancer patients and physiological functions of colon cancer cells. NOX2 may be a useful prognostic biomarker for colon cancer patients.PMID:37247898 | DOI:10.21873/anticanres.16427
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Koichi Takiguchi Hiroki Shimizu Katsutoshi Shoda Kensuke Shiraishi Shinji Furuya Naohiro Hosomura Hidenori Akaike Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Kunio Mochizuki Tetsuo Kondo Daisuke Ichikawa Source Type: research

SUMO1 modification stabilizes TET3 protein and increases colorectal cancer radiotherapy sensitivity
CONCLUSIONS: we elucidated the sensitizing role of TET3 protein in the radiation of CRC cells, depending on SUMO1 modification of TET3 at the lysine sites (K479, K758, K1012, K1188, K1397, K1623), in turn stabilizing TET3 expression in the nucleus and subsequently increasing the sensitivity of colorectal cancer to radiotherapy. Together, this study highlights the potentially critical role of TET3 SUMOylation in radiation regulation, which may contribute to an enhanced understanding of the relationship between DNA demethylation and radiotherapy.PMID:37244630 | DOI:10.1016/j.ijrobp.2023.05.037
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Fengting Liu Ya Ma Hao Sun Hui Cai Xin Liang Chang Xu Liqing Du Yan Wang Qiang Liu Source Type: research

Inhibition of ubiquitin specific peptidase 8 is effective against 5-fluorouracil resistance in colon cancer via suppressing EGFR and EGFR-mediated signaling pathways
CONCLUSIONS: Our work is the first to reveal the essential role of USP8 in colon cancer via EGFR oncogenic signalling pathways. Our findings provide a proof-of-concept that USP8 inhibitors are promising candidates to overcome 5-FU resistance in colon cancer.PMID:37222451 | DOI:10.14670/HH-18-629
Source: Histology and Histopathology - May 24, 2023 Category: Cytology Authors: Changlei Xi Zhilin Gong Hui Ye Longlei Cao Jie Yu Source Type: research

Cancers, Vol. 15, Pages 2901: Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stromal Cells as an Efficient Nanocarrier to Deliver siRNA or Drug to Pancreatic Cancer Cells
In conclusion, the use of UC-MSC-derived EVs as a drug delivery system for siRNAs or drugs could be a promising approach for the targeted treatment of PDAC.
Source: Cancers - May 24, 2023 Category: Cancer & Oncology Authors: Florian Draguet Nathan Dubois Cyril Bouland Karlien Pieters Dominique Bron Nathalie Meuleman Basile Stamatopoulos Laurence Lagneaux Tags: Article Source Type: research

Exosomes-delivered PD-L1 siRNA and CTLA-4 siRNA protect against growth and tumor immune escape in colorectal cancer
CONCLUSION: Exosomes containing PD-L1 siRNA and CTLA-4 siRNA suppressed CRC progression and enhanced tumor immune responses.PMID:37217085 | DOI:10.1016/j.ygeno.2023.110646
Source: Genomics - May 22, 2023 Category: Genetics & Stem Cells Authors: Jian Li Yuxiang Chen Mingmei Liao Shuyi Yu Binwen Yuan Zeming Jia Lin Zhou Yaping Tang Source Type: research