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Total 1289 results found since Jan 2013.
Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer
This study was designed to investigate the potential key genes of ADP-ribosylation factor-like 15 (ARL15) regulating glycolysis and lipogenesis in colon cancer. Hematoxylin-eosin (HE) staining and immunohistochemistry were used to observe the expression of ARL15 in 10 normal colon tissues and 10 colon cancer tissues. Immunofluorescence staining was used to observe the expression position of ARL15 in normal human colorectal mucosa cells (FHC) and colon cancer cells (HCT116 and SW620) with a confocal microscope. The ARL15 plasmid and small interfering RNA (siRNA) were constructed. After transfection, the expression levels of...
Source: Journal of Physiology and Pharmacology - October 27, 2022 Category: Drugs & Pharmacology Authors: F Du H-J Zhang W Shao Y-Y Tu K-J Yang L-S Piao Source Type: research
Retraction Note: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA
Mol Cell Biochem. 2022 Oct 17. doi: 10.1007/s11010-022-04567-1. Online ahead of print.NO ABSTRACTPMID:36251172 | DOI:10.1007/s11010-022-04567-1
Source: Molecular and Cellular Biochemistry - October 17, 2022 Category: Biochemistry Authors: Jingchun Wang Weifeng Ding Baolan Sun Rongrong Jing Hua Huang Gongsheng Shi Huimin Wang Source Type: research
CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway
ConclusionTaken together, this study suggests that inflammatory factors may increase CYP24A1 expressionvia NF- κB pathway activation, which in turn stimulates Wnt signaling.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research
Precision medicine-guided co-delivery of ASPN siRNA and oxaliplatin by nanoparticles to overcome chemoresistance of colorectal cancer
This study uncovered the critical role of ASPN in causing OXA resistance in CRC patients and suggests a promising nanoformulation that may be more effective than current standard-of-care medications.PMID:36228517 | DOI:10.1016/j.biomaterials.2022.121827
Source: Biomaterials - October 13, 2022 Category: Materials Science Authors: Cheng-Zhi Huang Yue Zhou Qi-Song Tong Qi-Jia Duan Qing Zhang Jin-Zhi Du Xue-Qing Yao Source Type: research
Targeting K-Ras Mutations Show Promise Towards Ending Ras's "Undruggable" Era
Protein Pept Lett. 2022 Oct 3. doi: 10.2174/0929866529666221003124202. Online ahead of print.ABSTRACTIt has almost been 40 years since the Ras proteins were discovered as the first human oncogenes. They remain among the most important genes for regulating mammalian cell growth and are involved in more than a quarter of human cancers. Out of 167 members of the Ras superfamily, K-Ras mutations are the most abundant in human cancers. Particularly, the K-Ras G12C mutations are known to be involved in pancreatic, colon and lung cancers as well as leukemias. Though progress has been made, approaches that target Ras proteins for ...
Source: Protein and Peptide Letters - October 6, 2022 Category: Biochemistry Authors: Paul D Adams D Jamali Muhoza Source Type: research
