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Cancer: Colorectal Cancer
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Total 1289 results found since Jan 2013.
Short interfering RNA in colorectal cancer: is it wise to shoot the messenger?
This study focuses on many innovative siRNA therapies and methodologies for delivering siRNA therapeutics to the malignant site safely and effectively for the treatment of CRC. Treatment of CRC using siRNA-associated nanoparticles (NPs) may inhibit the activity of oncogenes and MDR-related genes by targeting a range of signaling mechanisms. This study summarizes several siRNAs targeting signaling molecules, as well as the therapeutic approaches that might be employed to treat CRC in the future.PMID:37011722 | DOI:10.1016/j.ejphar.2023.175699
Source: European Journal of Pharmacology - April 3, 2023 Category: Drugs & Pharmacology Authors: Kiruthiga Chandramohan Devasahayam Jaya Balan Kasi Pandima Devi Seyed Fazel Nabavi Sara Reshadat Maryam Khayatkashani Sepideh Mahmoodifar Rosanna Filosa Nilofar Amirkhalili Soroush Pishvaei Omolbanin Sargazi Aval Seyed Mohammad Nabavi Source Type: research
Silencing MARCH2 Inhibits the Invasion, Migration, and EMT Transformation of Human Colorectal Cancer SW480 Cells
Conclusions: The high expression of MARCH2 was unfavorable for patients' survival. Thus, MARCH2 might be an independent predictor for CRC patients, affecting the invasion and metastasis of CRC through EMT.PMID:36959742 | DOI:10.1177/15330338231164887
Source: Technology in Cancer Research and Treatment - March 24, 2023 Category: Cancer & Oncology Authors: Yun Liu Ran Longyan Qingxi Guo Xia Pu Shaohua Wang Xiabin Li Yin Tao Xingwang Sun Source Type: research
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Oncotarget. 2023 Mar 21;14:219-235. doi: 10.18632/oncotarget.28388.ABSTRACTGlypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to normal tissues. Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression...
Source: Oncotarget - March 21, 2023 Category: Cancer & Oncology Authors: Fang Cheng Victor Ch érouvrier Hansson Grigorios Georgolopoulos Katrin Mani Source Type: research
Suppression of small nucleolar RNA host gene 8 (SNHG8) inhibits the progression of colorectal cancer cells
In this study, we explored the role of SNHG8 in CRC cell lines by performing a series of functional experiments. Similar to the data reported in the Encyclopedia of RNA Interactome, our RT-qPCR results showed that SNHG8 expression was significantly upregulated in CRC cell lines (DLD-1, HT-29, HCT-116, and SW480) compared to the normal colon cell line (CCD-112CoN). We performed dicer-substrate siRNA transfection to knockdown the expression of SNHG8 in HCT-116 and SW480 cell lines which were expressing high levels of SNHG8. SNHG8 knockdown significantly reduced CRC cell growth and proliferation by inducing autophagy and apop...
Source: Cell Research - March 2, 2023 Category: Cytology Authors: Md Zahirul Islam Khan Helen Ka Wai Law Source Type: research
Surfactant like peptides for targeted gene delivery to cancer cells
Biochem Biophys Res Commun. 2023 Feb 13;652:35-45. doi: 10.1016/j.bbrc.2023.02.026. Online ahead of print.ABSTRACTSurfactant like peptides (SLPs) are a class of amphiphilic peptides widely used for drug delivery and tissue engineering. However, there are very few reports on their application for gene delivery. The current study was aimed at development of two new SLPs, named (IA)4K and (IG)4K, for selective delivery of antisense oligodeoxynucleotides (ODNs) and small interfering RNA (siRNA) to cancer cells. The peptides were synthesized by Fmoc solid phase synthesis. Their complexation with nucleic acids was studied by gel...
Source: Biochemical and Biophysical Research communications - February 22, 2023 Category: Biochemistry Authors: Roja Hadianamrei Mhd Anas Tomeh Jiqian Wang Stephen Brown Xiubo Zhao Source Type: research
Enhancing the Management of Metastatic Tumors by Robust Co-delivery of 5-fluorouracil/microRNA-10b inhibitor Using EGFR-targeted Nanovehicles
This article is protected by copyright. All rights reserved.PMID:36740892 | DOI:10.1002/adhm.202202989
Source: Adv Data - February 6, 2023 Category: Epidemiology Authors: Di Wang Liwei Wang Liming Zheng Jiaxin Chen Wei Zhang Wei Zhou Xiaobo Yang Lifeng Jiang Xiaoqiang Jin Xiaohua Yu Xin Liu Heng Chen Jianbin Xu Source Type: research
The Upregulation of GSTO2 is Associated with Colon Cancer Progression and a Poor Prognosis
J Oncol. 2023 Jan 11;2023:4931650. doi: 10.1155/2023/4931650. eCollection 2023.ABSTRACTColorectal cancer is the second-leading cause of cancer-related mortality in the United States. Glutathione S-transferase can affect the development of cancer. Glutathione S-transferase omega 2, a member of the GST family, plays an important role in many tumors. However, the role of Glutathione S-transferase omega 2 in the development of colon cancer remains unclear. Herein, our study aimed to investigate the exact role of Glutathione S-transferase omega 2 in colon cancer. We used RNA sequencing data from The Cancer Genome Atlas and the ...
Source: Journal of Oncology - January 23, 2023 Category: Cancer & Oncology Authors: Xingyu Peng Jinfeng Zhu Sicheng Liu Zitao Liu Chen Luo Xun Wu Zhonglin Yu Zhengming Zhu Source Type: research
