SUMO1 modification stabilizes TET3 protein and increases colorectal cancer radiotherapy sensitivity

CONCLUSIONS: we elucidated the sensitizing role of TET3 protein in the radiation of CRC cells, depending on SUMO1 modification of TET3 at the lysine sites (K479, K758, K1012, K1188, K1397, K1623), in turn stabilizing TET3 expression in the nucleus and subsequently increasing the sensitivity of colorectal cancer to radiotherapy. Together, this study highlights the potentially critical role of TET3 SUMOylation in radiation regulation, which may contribute to an enhanced understanding of the relationship between DNA demethylation and radiotherapy.PMID:37244630 | DOI:10.1016/j.ijrobp.2023.05.037

Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Fengting Liu Ya Ma Hao Sun Hui Cai Xin Liang Chang Xu Liqing Du Yan Wang Qiang Liu Source Type: research