A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
In conclusion, our research underscores the unique and synergistic potential of combining mechanotherapeutics and sonopermeation. Both approaches are undergoing clinical trials to enhance cancer therapy and have the potential to significantly improve nano-immunotherapy in sarcomas.PMID:38520790 | DOI:10.1016/j.neo.2024.100990 (Source: Neoplasia)
Source: Neoplasia - March 23, 2024 Category: Cancer & Oncology Authors: Fotios Mpekris Myrofora Panagi Antonia Charalambous Chrysovalantis Voutouri Christina Michael Antonia Papoui Triantafyllos Stylianopoulos Source Type: research

A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
In conclusion, our research underscores the unique and synergistic potential of combining mechanotherapeutics and sonopermeation. Both approaches are undergoing clinical trials to enhance cancer therapy and have the potential to significantly improve nano-immunotherapy in sarcomas.PMID:38520790 | DOI:10.1016/j.neo.2024.100990 (Source: Neoplasia)
Source: Neoplasia - March 23, 2024 Category: Cancer & Oncology Authors: Fotios Mpekris Myrofora Panagi Antonia Charalambous Chrysovalantis Voutouri Christina Michael Antonia Papoui Triantafyllos Stylianopoulos Source Type: research

A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
In conclusion, our research underscores the unique and synergistic potential of combining mechanotherapeutics and sonopermeation. Both approaches are undergoing clinical trials to enhance cancer therapy and have the potential to significantly improve nano-immunotherapy in sarcomas.PMID:38520790 | DOI:10.1016/j.neo.2024.100990 (Source: Neoplasia)
Source: Neoplasia - March 23, 2024 Category: Cancer & Oncology Authors: Fotios Mpekris Myrofora Panagi Antonia Charalambous Chrysovalantis Voutouri Christina Michael Antonia Papoui Triantafyllos Stylianopoulos Source Type: research

Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
CONCLUSION: This study sheds light on the alarming rise in CRC and EO-CRC across Gulf countries from 1990 to 2019, emphasizing Saudi Arabia's significant burden. It projects a concerning increase in CRC incidence and mortality by 2030, primarily in Saudi Arabia, and highlights the need for immediate public health interventions.PMID:38513469 | DOI:10.1016/j.neo.2024.100988 (Source: Neoplasia)
Source: Neoplasia - March 21, 2024 Category: Cancer & Oncology Authors: Majed Ramadan Hanin Ghamdi Doaa Aboalola Noha Alorainan Ragad Alsalmi Ahmed Afash Albaraa Hariri Atheer Alboloshi Alaa Samkari Rawiah Alsiary Source Type: research

Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
CONCLUSION: This study sheds light on the alarming rise in CRC and EO-CRC across Gulf countries from 1990 to 2019, emphasizing Saudi Arabia's significant burden. It projects a concerning increase in CRC incidence and mortality by 2030, primarily in Saudi Arabia, and highlights the need for immediate public health interventions.PMID:38513469 | DOI:10.1016/j.neo.2024.100988 (Source: Neoplasia)
Source: Neoplasia - March 21, 2024 Category: Cancer & Oncology Authors: Majed Ramadan Hanin Ghamdi Doaa Aboalola Noha Alorainan Ragad Alsalmi Ahmed Afash Albaraa Hariri Atheer Alboloshi Alaa Samkari Rawiah Alsiary Source Type: research

Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
CONCLUSION: This study sheds light on the alarming rise in CRC and EO-CRC across Gulf countries from 1990 to 2019, emphasizing Saudi Arabia's significant burden. It projects a concerning increase in CRC incidence and mortality by 2030, primarily in Saudi Arabia, and highlights the need for immediate public health interventions.PMID:38513469 | DOI:10.1016/j.neo.2024.100988 (Source: Neoplasia)
Source: Neoplasia - March 21, 2024 Category: Cancer & Oncology Authors: Majed Ramadan Hanin Ghamdi Doaa Aboalola Noha Alorainan Ragad Alsalmi Ahmed Afash Albaraa Hariri Atheer Alboloshi Alaa Samkari Rawiah Alsiary Source Type: research

Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways
Neoplasia. 2024 Mar 19;51:100991. doi: 10.1016/j.neo.2024.100991. Online ahead of print.ABSTRACTDihydroartemisinin (DHA) exerts an anti-tumor effect in multiple cancers, however, the molecular mechanism of DHA and whether DHA facilitates the anti-tumor efficacy of cisplatin in non-small cell lung cancer (NSCLC) are unclear. Here, we found that DHA potentiated the anti-tumor effects of cisplatin in NSCLC cells by stimulating reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress, C-Jun-amino-terminal kinase (JNK) and p38 MAPK signaling pathways both in vitro and in vivo. Of note, we demonstrated for the fi...
Source: Neoplasia - March 20, 2024 Category: Cancer & Oncology Authors: Lianli Ni Xinping Zhu Qi Zhao Yiwei Shen Lu Tao Ji Zhang Han Lin Weishan Zhuge Young-Chang Cho Ri Cui Wangyu Zhu Source Type: research

Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research

Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research

Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research

Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research

PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
Neoplasia. 2024 Mar 14;51:100987. doi: 10.1016/j.neo.2024.100987. Online ahead of print.ABSTRACTGene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the fusion induces HGSC cell migration by regulating ERK1/2 and increases resistance to platinum treatment. Platinum resistance was associated with rod and ring-like cellular structure formation. These structures contained, in addition to...
Source: Neoplasia - March 15, 2024 Category: Cancer & Oncology Authors: Heidi Rausio Alejandra Cervera Vanina D Heuser Gun West Jaana Oikkonen Elena Pianfetti Marta Lovino Elisa Ficarra Pekka Taimen Johanna Hynninen Rainer Lehtonen Sampsa Hautaniemi Olli Carp én Kaisa Huhtinen Source Type: research

PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
Neoplasia. 2024 Mar 14;51:100987. doi: 10.1016/j.neo.2024.100987. Online ahead of print.ABSTRACTGene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the fusion induces HGSC cell migration by regulating ERK1/2 and increases resistance to platinum treatment. Platinum resistance was associated with rod and ring-like cellular structure formation. These structures contained, in addition to...
Source: Neoplasia - March 15, 2024 Category: Cancer & Oncology Authors: Heidi Rausio Alejandra Cervera Vanina D Heuser Gun West Jaana Oikkonen Elena Pianfetti Marta Lovino Elisa Ficarra Pekka Taimen Johanna Hynninen Rainer Lehtonen Sampsa Hautaniemi Olli Carp én Kaisa Huhtinen Source Type: research

Advancing glioblastoma treatment by targeting metabolism
Neoplasia. 2024 Mar 12;51:100985. doi: 10.1016/j.neo.2024.100985. Online ahead of print.ABSTRACTAlterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic re...
Source: Neoplasia - March 13, 2024 Category: Cancer & Oncology Authors: Jinyi Zhao Xuemei Ma Peixian Gao Xueqi Han Pengxiang Zhao Fei Xie Mengyu Liu Source Type: research

Advancing glioblastoma treatment by targeting metabolism
Neoplasia. 2024 Mar 12;51:100985. doi: 10.1016/j.neo.2024.100985. Online ahead of print.ABSTRACTAlterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic re...
Source: Neoplasia - March 13, 2024 Category: Cancer & Oncology Authors: Jinyi Zhao Xuemei Ma Peixian Gao Xueqi Han Pengxiang Zhao Fei Xie Mengyu Liu Source Type: research