β-Sitosterol blocks the LEF-1-mediated Wnt/β-catenin pathway to inhibit proliferation of human colon cancer cells

CONCLUSION: According to our results, LEF-1 down-regulation can effectively block Wnt/β-catenin pathway, inhibit CC cell growth and migration. Collectively, β-sitosterol can be used to treat CC, which can provide anti-tumor activity by targeting LEF-1.PMID:36603684 | DOI:10.1016/j.cellsig.2022.110585

Source: Cellular Signalling - January 5, 2023 Category: Cytology Authors: Shengliang Gu Fahui Liu Xueheng Xie Meng Ding Fan Wang Xiaoyan Xing Tianbao Xiao Xiaobo Sun Source Type: research