Harms from haloperidol for symptom management in palliative care; a post hoc pooled analysis of three randomized controlled studies and two consecutive cohort studies
Symptom control for people with cancer improves quality of life. Haloperidol is a key drug in palliative care and is frequently used for the treatment of delirium, nausea and vomiting.[1] Haloperidol, a butyrophenone, is a more potent D2 receptor antagonist than other antiemetics such as prochlorperazine, olanzapine or chlorpromazine. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - May 19, 2019 Category: Palliative Care Authors: Hiromichi Matsuoka, Meera Agar, Zac Vandersman, Phillip Good, Belinda Fazekas, Linda Brown, Hardy Janet, Jennifer Weil, D.C. Currow Source Type: research
Harms From Haloperidol for Symptom Management in Palliative Care —a Post Hoc Pooled Analysis of Three Randomized Controlled Studies and Two Consecutive Cohort Studies
Symptom control for people with cancer improves quality of life. Haloperidol is a key drug in palliative care and is frequently used for the treatment of delirium, nausea, and vomiting.1 Haloperidol, a butyrophenone, is a more potent D2 receptor antagonist than other antiemetics, such as prochlorperazine, olanzapine, or chlorpromazine. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - May 19, 2019 Category: Palliative Care Authors: Hiromichi Matsuoka, Meera Agar, Zac Vandersman, Philip Good, Belinda Fazekas, Linda Brown, Hardy Janet, Jennifer Weil, David Christopher Currow Tags: Letter Source Type: research
The Efficacy and Safety of Prochlorperazine in Patients With Acute Migraine: A Systematic Review and Meta-Analysis.
CONCLUSIONS: For adult patients with acute migraine, PCP could effectively abort the acute attack and reduce the request for rescue analgesia in the ED. However, compared with placebo, PCP could increase the risk of adverse events.
PMID: 30990883 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 15, 2019 Category: Neurology Authors: Golikhatir I, Cheraghmakani H, Bozorgi F, Jahanian F, Sazgar M, Montazer SH Tags: Headache Source Type: research
Safety and effectiveness of intravenous prochlorperazine for intractable vomiting in children with gastroenteritis
Prochlorperazine (PCZ) was first introduced as an anti-psychotic in the 1950s, and subsequently found to be effective to control vomiting. It is a weak dopamine receptor blocker and depresses the chemoreceptor trigger zone (1). Although pediatric studies are limited, research suggests the medication is effective to prevent vomiting, the need for intravenous fluids, and hospital admission. The majority of recent literature has focused on the use of PCZ for the treatment of migraine headaches in young people [2-4]. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - April 11, 2019 Category: Emergency Medicine Authors: Lindsey Ouellette, Bryan Judge, Angela Zamarripa, Patrick McFadden, Jeffrey Jones Source Type: research
Real-world insights on the management of migraine patients: an Italian nationwide study.
CONCLUSION: Results from this study suggested an unmet need in the management of migraine: too many patients did not receive MPTs, with this potentially due to several reasons requiring further investigations. Furthermore, even among patients receiving MPTs, disease control level with now available drugs seemed to be sub-optimal.
PMID: 30924392 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research
Optimization of Individual Pharmacotherapy Based on Multiple Evaluations of Patient Data.
Abstract
To date, limited drug information is available for the individual optimization of pharmacotherapy. The author attempted multiple evaluations of patient data on factors related to the pharmacokinetics, drug efficacy, and adverse reactions observed in clinical settings. Through the clinical studies, drug information on the individual optimization of pharmacotherapy needed by health professionals including physicians and pharmacists was identified. Major findings were: 1) Cachectic cancer patients had high plasma concentrations of oxycodone via the reduction of CYP3A activity. The metabolic reduction...
Source: Biological and Pharmaceutical Bulletin - February 6, 2019 Category: Drugs & Pharmacology Authors: Naito T Tags: Biol Pharm Bull Source Type: research
Intravenous Fluid for the Treatment of Emergency Department Patients With Migraine Headache: A Randomized Controlled Trial
ConclusionThis pilot study showed no statistically significant treatment effect from fluid administration, but does not exclude the possibility of a clinically important treatment effect. The study protocol and approach to blinding are both feasible and effective. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - October 27, 2018 Category: Emergency Medicine Source Type: research
What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?
CONCLUSIONS: This review identified eight Cochrane systematic reviews that provided evidence of unknown to moderate quality regarding the use of cannabinoids as a therapeutic intervention. Further studies are still imperative for solid conclusions to be reached regarding practical recommendations.
PMID: 30365598 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - October 22, 2018 Category: General Medicine Authors: Latorraca COC, Pacheco RL, Martimbianco ALC, Pachito DV, Riera R Tags: Sao Paulo Med J Source Type: research
Multiple perianal ulcers due to suppositories.
We report a case of long-standing inexplicable perianal ulcers. After exclusion of an inflammatory, infectious or neoplastic origin, a thorough personal history revealed that for many years the patient had been using analgesic suppositories containing indomethacin, caffeine, and prochlorperazine dimaleate, four to five times a week, for migraine. On stopping the suppositories, there was complete healing within 12 weeks. We hypothesize that vasoconstriction and vascular damage were the pathogenetic mechanisms behind the perianal ulcers.
PMID: 30039854 [PubMed - as supplied by publisher] (Source: The Australasian Jo...
Source: The Australasian Journal of Dermatology - July 24, 2018 Category: Dermatology Authors: Savoia F, Sechi A, Tabanelli M, Zago S, Leuzzi M, Baraldi C, Patrizi A Tags: Australas J Dermatol Source Type: research
Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine
The Research to Practice Column is designed to improve translational research critique skills of nurse practitioners (NPs). In this issue, the article “Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine” is discussed in the context of a patient with an acute headache presenting to the emergency department (ED). The study was designed to assess the efficacy of intravenous prochlorperazine and diphenhydramine as compared with intravenous hydromorphone for patients with acute migraine in the ED. With the growing trend to avoid the use of opiates to curb potential addiction and in...
Source: Advanced Emergency Nursing Journal - July 1, 2018 Category: Emergency Medicine Tags: Research to Practice Source Type: research
Reversal of chloroquine resistance of Plasmodium vivax in Aotus monkeys.
The objective of this study was to assess if a combination of chloroquine (CQ) and prochlorperazine was able to reverse CQ resistance of the Plasmodium vivax AMRU-1 strain from Papua New Guinea in infected Aotus monkeys. For this purpose, in two independent experimental drug efficacy trials, a total of eighteen Aotus monkeys infected with blood obtained from donor animals, were randomly assigned into treatment and control groups and administered CQ at 10 mg/kg or prochlorperazine at 20 mg/kg orally for five consecutive days alone or in combination. Reversal of CQR was achieved in animals that received the drug combination,...
Source: Antimicrobial Agents and Chemotherapy - June 25, 2018 Category: Microbiology Authors: Obaldia N, Milhous WK, Kyle DE Tags: Antimicrob Agents Chemother Source Type: research
Predictors of First-Line Treatment Success in Children and Adolescents Visiting an Infusion Center for Acute Migraine.
CONCLUSIONS: Higher baseline headache frequency and presence of MOH may predict lower odds of treatment success after first-line intervention for pediatric migraine in the acute setting. These predictors may be useful in stratifying patients for treatment protocols and for planning future intervention studies.
PMID: 29926909 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 21, 2018 Category: Neurology Authors: Orr SL, Kabbouche MA, Horn PS, O'Brien HL, Kacperski J, LeCates S, White S, Weberding J, Miller MN, Powers SW, Hershey AD Tags: Headache Source Type: research
Paradoxical worsening of parkinsonism upon neuroleptic withdrawal: More common than we think?
Drug-induced parkinsonism is well understood to be caused by chronic exposure to dopamine-blocking agents. These include typical and so-called “atypical” antipsychotics, anti-nausea medications such as metoclopramide and prochlorperazine, and others. Drug-induced parkinsonism usually improves or completely resolves after removal of the causative agent, though these effects might rarely be irreversible. In these cases the term tardive p arkinsonism has been used, though the existence of this as a distinct clinical entity is controversial. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 20, 2018 Category: Neurology Authors: Ada Florescu, David Whitney, Danish Bhatti, John Bertoni, Diego Torres-Russotto Tags: Correspondence Source Type: research
IV prochlorperazine + diphenhydramine improved migraine pain relief more than IV hydromorphone in the ED.
PMID: 29554666 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Chessman AW Tags: Ann Intern Med Source Type: research
Paradoxical worsening of parkinsonism upon neuroleptic withdrawal: More common than we think?
Drug-induced parkinsonism is well understood to be caused by chronic exposure to dopamine-blocking agents. These include typical and so-called “atypical” antipsychotics, anti-nausea medications such as metoclopramide and prochlorperazine, and others. Drug-induced parkinsonism usually improves or completely resolves after removal of the causative agent, though these effects might rarely be irreversible. In these cases the term tardive p arkinsonism has been used, though the existence of this as a distinct clinical entity is controversial. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 20, 2018 Category: Neurology Authors: Ada Florescu, David Whitney, Danish Bhatti, John M. Bertoni, Diego Torres-Russotto Tags: Correspondence Source Type: research
