Paradoxical worsening of parkinsonism upon neuroleptic withdrawal: More common than we think?

Drug-induced parkinsonism is well understood to be caused by chronic exposure to dopamine-blocking agents. These include typical and so-called “atypical” antipsychotics, anti-nausea medications such as metoclopramide and prochlorperazine, and others. Drug-induced parkinsonism usually improves or completely resolves after removal of the causative agent, though these effects might rarely be irreversible. In these cases the term tardive p arkinsonism has been used, though the existence of this as a distinct clinical entity is controversial.

Source: Parkinsonism and Related Disorders - March 20, 2018 Category: Neurology Authors: Ada Florescu, David Whitney, Danish Bhatti, John M. Bertoni, Diego Torres-Russotto Tags: Correspondence Source Type: research