MAGraine: Magnesium compared to conventional therapy for treatment of migraines
Due to the healthcare burden associated with migraines, prompt and effective treatment is vital to improve patient outcomes and ED workflow. This was a prospective, randomized, double-blind trial. Adults who presented to the ED with a diagnosis of migraine from August of 2019 to March of 2020 were included. Pregnant patients, or with renal impairment were excluded. Patients were randomized to receive intravenous magnesium, prochlorperazine, or metoclopramide. The primary outcome was change in pain from baseline on a numeric rating scale (NRS) evaluated at 30  min after initiation of infusion of study drug. (Source: The A...
Source: The American Journal of Emergency Medicine - September 14, 2020 Category: Emergency Medicine Authors: Manar Kandil, Sabrin Jaber, Dharati Desai, Stephany Nunez Cruz, Nadine Lomotan, Uzma Ahmad, Michael Cirone, Jaxson Burkins, Marc McDowell Source Type: research

In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review
In this study, we performed an extensive literature search to find and summarize all papers on the chosen phenothiazines and their potential in treating different types of cancerin vitro for further animal/clinical trials. Fluphenazine, perphenazine and prochlorperazine possess anticancer activity towards different types of human cancer. The antitumor activity is mainly mediated by an effect of the drugs on the cell cycle, proliferation or apoptosis. Possible molecular targets of phenothiazine derivatives are the drug's efflux pumps (ABCB1 and P ‐glycoprotein) and two parallel pathways (AKT and Wnt) regulated by the D2 r...
Source: Journal of Applied Toxicology - August 27, 2020 Category: Toxicology Authors: Micha ł Otręba, Leon Kośmider Tags: REVIEW ARTICLE Source Type: research

Intravenous Migraine Treatment in Children and Adolescents
AbstractPurpose of ReviewPediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents. Outpatient management is not always effective, and intravenous migraine management may be necessary for headache treatment in the pediatric emergency department. Most current treatment is based on retrospective evidence and there is a lack of well-designed randomized double-blinded controlled pediatric studies. Intravenous drug treatment agents including intravenous fluids, prochlorperazine, diphenhydramine, metoclopramide, dexamethasone, magnesium, valproate and propofol, and dihydroergotamine...
Source: Current Pain and Headache Reports - July 8, 2020 Category: Neurology Source Type: research

Ketamine for Migraine in the Emergency Department
Ketamine is utilized often in the emergency department (ED) for rapid sequence intubation, procedural sedation, and acute pain management. The treatment of migraine headache in the ED varies widely and is dependent on several factors including migraine cause, previous successful abortive methods, and provider preference. Several medications are currently employed to treat acute migraine including nonsteroidal anti-inflammatory drugs, triptans, antihistamines, prochlorperazine, and corticosteroids, among others. Interest in ketamine as an abortive agent to treat migraine has increased as evidenced by recent studies evaluati...
Source: Advanced Emergency Nursing Journal - April 1, 2020 Category: Emergency Medicine Tags: APPLIED PHARMACOLOGY Source Type: research

Case Series: Rapid Induction Onto Long Acting Buprenorphine Injection for High Potency Synthetic Opioid Users.
CONCLUSION: All five participants were retained at least 1-month postinduction. SCIENTIFIC SIGNIFICANCE: It may be feasible to provide BXR treatment to HPSO-positive heroin users rapidly to achieve clinical stabilization. (Am J Addict 2020;00:00-00). PMID: 32167629 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - March 13, 2020 Category: Addiction Authors: Mariani JJ, Mahony A, Iqbal MN, Luo SX, Naqvi NH, Levin FR Tags: Am J Addict Source Type: research

The Real-World Safety and Effectiveness of Prochlorperazine in Indian Patients with Dizziness.
Authors: Haldipur D, Krishnamurthy N, A B Abstract Background: Considering the prevailing concerns about extrapyramidal symptoms (EPS) associated with oral prochlorperazine, this study was conducted to assess the safety of oral prochlorperazine (in recommended dose/duration) in the management of acute dizziness. Effectiveness was also assessed in the Indian real-world setting. Methods: A prospective, multicentric, single-arm observational study was conducted across 20 centers in India. Data from 500 patients were analyzed. Patients presenting with a complaint of dizziness, receiving prochlorperazine (Stemetil&r...
Source: Journal of the Association of Physicians of India - February 6, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Acute dystonic reactions in children treated for headache with prochlorperazine or metoclopramide
The incidences of dystonic reactions to metoclopramide and prochlorperazine have not been well characterized in children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 3, 2020 Category: Neurology Authors: Laura Kirkpatrick, Yoshimi Sogawa, Catalina Cleves Tags: Short Communication Source Type: research

A week-long outpatient induction onto XR-naltrexone in patients with opioid use disorder.
Conclusion: The results support the feasibility of a week-long outpatient induction onto XR-naltrexone with ascending doses of naltrexone and standing doses of adjunctive medications. By circumventing the need for a protracted period of abstinence and mitigating the severity of withdrawal symptoms experienced during naltrexone titration, this strategy has the potential to increase patient acceptability and access to relapse prevention treatment with XR-naltrexone. PMID: 31860366 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - December 20, 2019 Category: Addiction Authors: Sibai M, Mishlen K, Nunes EV, Levin FR, Mariani JJ, Bisaga A Tags: Am J Drug Alcohol Abuse Source Type: research

A Brief Look at Urgent Care Visits for Migraine: The Care Received and Ideas to Guide Migraine Care in this Proliferating Medical Setting.
CONCLUSIONS: The majority of patients in our study who sought medical treatment for migraine in these 2 urgent care centers were not established patients within the urgent care centers' healthcare system. While 93.6% (73/78) of patients were experiencing current pain upon presentation to the urgent care centers, only 12.3% (9/73) received administration of the medications with the highest level of evidence by the American Headache Society (Level B) for acute migraine treatment in an ED. In addition, the majority of patients with a migraine history presenting to the urgent care setting were not given triptans or anti-emetic...
Source: Headache - December 4, 2019 Category: Neurology Authors: Minen MT, Zhou K, Miller L Tags: Headache Source Type: research

Forskrivning av antipsykotika til hjemmeboende eldre 2006 –18.
Forskrivning av antipsykotika til hjemmeboende eldre 2006–18. Tidsskr Nor Laegeforen. 2019 Nov 05;139(16): Authors: Tveito M, Handal M, Engedal K, Smith RL, Høiseth G, Skurtveit S Abstract BACKGROUND: It is generally agreed that prescribing of antipsychotic drugs to older patients should be reduced, but figures for the prescribing of these drugs to older patients living at home in Norway are not available. The study aimed to investigate developments in prescribing of antipsychotic drugs among older patients living at home from 2006 to 2018, and whether there were differences in prescribin...
Source: Tidsskrift for den Norske Laegeforening - November 5, 2019 Category: General Medicine Authors: Tveito M, Handal M, Engedal K, Smith RL, Høiseth G, Skurtveit S Tags: Tidsskr Nor Laegeforen Source Type: research

Prochlorperazine for treatment of acute migraines in adults.
Abstract Migraine headache results in over 1 million emergency department visits per year in the United States.1-3 Several treatments have been offered to treat the headache.4-6 Prochlorperazine has been tested in randomized trials and, despite adverse effects such as dystonic reactions several societies recommend its use.4,6. PMID: 31592565 [PubMed - as supplied by publisher] (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - October 8, 2019 Category: Emergency Medicine Authors: Long B, Koyfman A, Gottlieb M Tags: Acad Emerg Med Source Type: research

Transdermal Delivery of Antipsychotics: Rationale and Current Status
AbstractThe aim of this article is to provide the rationale for the development of transdermal formulations of antipsychotics by highlighting their main advantages, starting with an overview of the antipsychotic formulations that are currently available on the market. Progress regarding transdermal antipsychotic formulations was investigated by performing a search of papers, patents and clinical trials published in the last 10  years. Available data on antipsychotic transdermal formulations are reported and discussed, focusing on the characteristics of the dosage forms and their ability to promote drug absorption. Des...
Source: CNS Drugs - September 6, 2019 Category: Neurology Source Type: research

Ondansetron for Acute Migraine in the Pediatric Emergency Department
Migraines are a common illness presenting to pediatric emergency departments (PED). Significant research has been devoted towards establishing treatment regimens for treating migraines. Much of this research involves antidopaminergic antiemetics such as prochlorperazine and metoclopramide. Despite a comparably more favorable side effect profile, no research has been directed towards examining ondansetron, a selective type three 5-hydroxytryptamine receptor antagonist, in the treatment of migraines. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 5, 2019 Category: Neurology Authors: Afsaneh Talai, Benjamin Heilbrunn Tags: Research Paper Source Type: research

Cost of prochlorperazine rose 700% after drug companies colluded, alleges watchdog
(Source: BMJ News)
Source: BMJ News - May 29, 2019 Category: General Medicine Source Type: research

Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex
Publication date: Available online 27 May 2019Source: Journal of Pharmacological SciencesAuthor(s): Keisuke Obara, Saki Horiguchi, Toma Shimada, Takumi Ikarashi, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio TanakaAbstractAntipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat dementia. We investigated the inhibitory effects of 26 antipsychotics on [N-Methyl-3H]scopolamine specific binding in mouse cerebral cortex. At 1...
Source: Journal of Pharmacological Sciences - May 29, 2019 Category: Drugs & Pharmacology Source Type: research

Harms from haloperidol for symptom management in palliative care; a post hoc pooled analysis of three randomized controlled studies and two consecutive cohort studies
Symptom control for people with cancer improves quality of life. Haloperidol is a key drug in palliative care and is frequently used for the treatment of delirium, nausea and vomiting.[1] Haloperidol, a butyrophenone, is a more potent D2 receptor antagonist than other antiemetics such as prochlorperazine, olanzapine or chlorpromazine. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - May 20, 2019 Category: Palliative Care Authors: Hiromichi Matsuoka, Meera Agar, Zac Vandersman, Phillip Good, Belinda Fazekas, Linda Brown, Hardy Janet, Jennifer Weil, D.C. Currow Source Type: research

Harms From Haloperidol for Symptom Management in Palliative Care —a Post Hoc Pooled Analysis of Three Randomized Controlled Studies and Two Consecutive Cohort Studies
Symptom control for people with cancer improves quality of life. Haloperidol is a key drug in palliative care and is frequently used for the treatment of delirium, nausea, and vomiting.1 Haloperidol, a butyrophenone, is a more potent D2 receptor antagonist than other antiemetics, such as prochlorperazine, olanzapine, or chlorpromazine. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - May 20, 2019 Category: Palliative Care Authors: Hiromichi Matsuoka, Meera Agar, Zac Vandersman, Philip Good, Belinda Fazekas, Linda Brown, Hardy Janet, Jennifer Weil, David Christopher Currow Tags: Letter Source Type: research

The Efficacy and Safety of Prochlorperazine in Patients With Acute Migraine: A Systematic Review and Meta-Analysis.
CONCLUSIONS: For adult patients with acute migraine, PCP could effectively abort the acute attack and reduce the request for rescue analgesia in the ED. However, compared with placebo, PCP could increase the risk of adverse events. PMID: 30990883 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 16, 2019 Category: Neurology Authors: Golikhatir I, Cheraghmakani H, Bozorgi F, Jahanian F, Sazgar M, Montazer SH Tags: Headache Source Type: research

Safety and effectiveness of intravenous prochlorperazine for intractable vomiting in children with gastroenteritis
Prochlorperazine (PCZ) was first introduced as an anti-psychotic in the 1950s, and subsequently found to be effective to control vomiting. It is a weak dopamine receptor blocker and depresses the chemoreceptor trigger zone (1). Although pediatric studies are limited, research suggests the medication is effective to prevent vomiting, the need for intravenous fluids, and hospital admission. The majority of recent literature has focused on the use of PCZ for the treatment of migraine headaches in young people [2-4]. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - April 12, 2019 Category: Emergency Medicine Authors: Lindsey Ouellette, Bryan Judge, Angela Zamarripa, Patrick McFadden, Jeffrey Jones Source Type: research

Real-world insights on the management of migraine patients: an Italian nationwide study.
CONCLUSION: Results from this study suggested an unmet need in the management of migraine: too many patients did not receive MPTs, with this potentially due to several reasons requiring further investigations. Furthermore, even among patients receiving MPTs, disease control level with now available drugs seemed to be sub-optimal. PMID: 30924392 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Optimization of Individual Pharmacotherapy Based on Multiple Evaluations of Patient Data.
Abstract To date, limited drug information is available for the individual optimization of pharmacotherapy. The author attempted multiple evaluations of patient data on factors related to the pharmacokinetics, drug efficacy, and adverse reactions observed in clinical settings. Through the clinical studies, drug information on the individual optimization of pharmacotherapy needed by health professionals including physicians and pharmacists was identified. Major findings were: 1) Cachectic cancer patients had high plasma concentrations of oxycodone via the reduction of CYP3A activity. The metabolic reduction in cach...
Source: Biological and Pharmaceutical Bulletin - February 6, 2019 Category: Drugs & Pharmacology Authors: Naito T Tags: Biol Pharm Bull Source Type: research

Intravenous Fluid for the Treatment of Emergency Department Patients With Migraine Headache: A Randomized Controlled Trial
ConclusionThis pilot study showed no statistically significant treatment effect from fluid administration, but does not exclude the possibility of a clinically important treatment effect. The study protocol and approach to blinding are both feasible and effective. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - October 27, 2018 Category: Emergency Medicine Source Type: research

What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?
CONCLUSIONS: This review identified eight Cochrane systematic reviews that provided evidence of unknown to moderate quality regarding the use of cannabinoids as a therapeutic intervention. Further studies are still imperative for solid conclusions to be reached regarding practical recommendations. PMID: 30365598 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - October 22, 2018 Category: General Medicine Authors: Latorraca COC, Pacheco RL, Martimbianco ALC, Pachito DV, Riera R Tags: Sao Paulo Med J Source Type: research

Multiple perianal ulcers due to suppositories.
We report a case of long-standing inexplicable perianal ulcers. After exclusion of an inflammatory, infectious or neoplastic origin, a thorough personal history revealed that for many years the patient had been using analgesic suppositories containing indomethacin, caffeine, and prochlorperazine dimaleate, four to five times a week, for migraine. On stopping the suppositories, there was complete healing within 12 weeks. We hypothesize that vasoconstriction and vascular damage were the pathogenetic mechanisms behind the perianal ulcers. PMID: 30039854 [PubMed - as supplied by publisher] (Source: The Australasian J...
Source: The Australasian Journal of Dermatology - July 24, 2018 Category: Dermatology Authors: Savoia F, Sechi A, Tabanelli M, Zago S, Leuzzi M, Baraldi C, Patrizi A Tags: Australas J Dermatol Source Type: research

Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine
The Research to Practice Column is designed to improve translational research critique skills of nurse practitioners (NPs). In this issue, the article “Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine” is discussed in the context of a patient with an acute headache presenting to the emergency department (ED). The study was designed to assess the efficacy of intravenous prochlorperazine and diphenhydramine as compared with intravenous hydromorphone for patients with acute migraine in the ED. With the growing trend to avoid the use of opiates to curb potential addictio...
Source: Advanced Emergency Nursing Journal - July 1, 2018 Category: Emergency Medicine Tags: Research to Practice Source Type: research

Reversal of chloroquine resistance of Plasmodium vivax in Aotus monkeys.
The objective of this study was to assess if a combination of chloroquine (CQ) and prochlorperazine was able to reverse CQ resistance of the Plasmodium vivax AMRU-1 strain from Papua New Guinea in infected Aotus monkeys. For this purpose, in two independent experimental drug efficacy trials, a total of eighteen Aotus monkeys infected with blood obtained from donor animals, were randomly assigned into treatment and control groups and administered CQ at 10 mg/kg or prochlorperazine at 20 mg/kg orally for five consecutive days alone or in combination. Reversal of CQR was achieved in animals that received the drug combination,...
Source: Antimicrobial Agents and Chemotherapy - June 25, 2018 Category: Microbiology Authors: Obaldia N, Milhous WK, Kyle DE Tags: Antimicrob Agents Chemother Source Type: research

Predictors of First-Line Treatment Success in Children and Adolescents Visiting an Infusion Center for Acute Migraine.
Abstract OBJECTIVES: To characterize a population of pediatric patients visiting an infusion center for acute migraine and determine predictors of first-line treatment success in this population. BACKGROUND: Though migraine is common in the pediatric emergency department and specialized infusion centers, little is known about this patient population and whether or not clinical data can be used to predict treatment response. METHODS: This was an observational study involving a retrospective analysis of data from visits to the Cincinnati Children's Hospital infusion center for treatment of an acute migrain...
Source: Headache - June 21, 2018 Category: Neurology Authors: Orr SL, Kabbouche MA, Horn PS, O'Brien HL, Kacperski J, LeCates S, White S, Weberding J, Miller MN, Powers SW, Hershey AD Tags: Headache Source Type: research

Paradoxical worsening of parkinsonism upon neuroleptic withdrawal: More common than we think?
Drug-induced parkinsonism is well understood to be caused by chronic exposure to dopamine-blocking agents. These include typical and so-called “atypical” antipsychotics, anti-nausea medications such as metoclopramide and prochlorperazine, and others. Drug-induced parkinsonism usually improves or completely resolves after removal of the causative agent, though these effects might rarely be irreversible. In these cases the term tardive p arkinsonism has been used, though the existence of this as a distinct clinical entity is controversial. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 20, 2018 Category: Neurology Authors: Ada Florescu, David Whitney, Danish Bhatti, John Bertoni, Diego Torres-Russotto Tags: Correspondence Source Type: research

IV prochlorperazine + diphenhydramine improved migraine pain relief more than IV hydromorphone in the ED.
PMID: 29554666 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Chessman AW Tags: Ann Intern Med Source Type: research

Paradoxical worsening of parkinsonism upon neuroleptic withdrawal: More common than we think?
Drug-induced parkinsonism is well understood to be caused by chronic exposure to dopamine-blocking agents. These include typical and so-called “atypical” antipsychotics, anti-nausea medications such as metoclopramide and prochlorperazine, and others. Drug-induced parkinsonism usually improves or completely resolves after removal of the causative agent, though these effects might rarely be irreversible. In these cases the term tardive p arkinsonism has been used, though the existence of this as a distinct clinical entity is controversial. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 20, 2018 Category: Neurology Authors: Ada Florescu, David Whitney, Danish Bhatti, John M. Bertoni, Diego Torres-Russotto Tags: Correspondence Source Type: research

Efficacy of Prophylactic Treatment for Oxycodone‐Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo‐Controlled, Double‐Blind Trial
Conclusion.Routine use of prochlorperazine as a prophylactic antiemetic at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations.Implications for Practice.Prophylactic prochlorperazine seems to be ineffective in preventing opioid‐induced nausea and vomiting (OINV) and may cause adverse events such as somnolence. Routine use of prophylactic prochlorperazine at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetic...
Source: The Oncologist - March 9, 2018 Category: Cancer & Oncology Authors: Hiroaki Tsukuura, Masayuki Miyazaki, Tatsuya Morita, Mihoko Sugishita, Hiroshi Kato, Yuka Murasaki, Bishal Gyawali, Yoko Kubo, Masahiko Ando, Masashi Kondo, Kiyofumi Yamada, Yoshinori Hasegawa, Yuichi Ando Tags: Symptom Management and Supportive Care Source Type: research

Opioid-Induced "Likeability" and "Feeling Good" Are Not Associated With Return Visits to an ED Among Migraine Patients Administered IV Hydromorphone.
In this study, we quantify the extent to which nontherapeutic effects of opioids influence migraine outcomes. We hypothesized that "feeling good" and medication likeability would in fact be associated with receipt of opioids (rather than relief of migraine pain) and that receipt of opioids (rather than relief of migraine pain) would be associated with return visits to the ED. METHODS: During an ED-based clinical trial, migraine patients were randomized to receive hydromorphone 1 mg or prochlorperazine 10 mg + diphenhydramine 25 mg IV. Thirty minutes after medication administration, we asked, (1...
Source: Headache - March 8, 2018 Category: Neurology Authors: Friedman BW, Latev A, Campbell C, White D Tags: Headache Source Type: research

Relative Effectiveness of Dopamine Antagonists for Pediatric Migraine in the Emergency Department
Conclusions This study suggests variable efficacy among 3 commonly used dopamine antagonists for pediatric migraine headache. Promethazine seems least effective and results in higher use of opioids compared with other available dopamine antagonists. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - March 1, 2018 Category: Emergency Medicine Tags: Original Articles Source Type: research

Randomized study of IV prochlorperazine plus diphenhydramine versus IV hydromorphone for migraine
Migraine headache is a common complaint among patients presenting to the Emergency Department (ED). Parenteral opioids are commonly used to treat migraines despite recommendations against their use from the American Headache Society and other expert opinions. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - March 1, 2018 Category: Emergency Medicine Authors: Benjamin Sholl Tags: Abstract Source Type: research

Opioid ‐Induced “Likeability” and “Feeling Good” Are Not Associated With Return Visits to an ED Among Migraine Patients Administered IV Hydromorphone
In this study, we quantify the extent to which nontherapeutic effects of opioids influence migraine outcomes. We hypothesized that “feeling good” and medication likeability would in fact be associated with receipt of opioids (rather than relief of migraine pain) and that receipt of opioids (rather than relief of migraine pain) would be associated with return visits to the ED. MethodsDuring an ED‐based clinical trial, migraine patients were randomized to receive hydromorphone 1 mg or prochlorperazine 10 mg + diphenhydramine 25 mg IV. Thirty minutes after medication administration, we asked, (1) H...
Source: Headache: The Journal of Head and Face Pain - March 1, 2018 Category: Neurology Authors: Benjamin W. Friedman, Alexander Latev, Caron Campbell, Deborah White Tags: Brief Communications Source Type: research

Randomized study of IV prochlorperazine plus diphenhydramine versus IV hydromorphone for migraine
Migraine headache is a common complaint among patients presenting to the Emergency Department (ED). Parenteral opioids are commonly used to treat migraines despite recommendations against their use from the American Headache Society and other expert opinions. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - March 1, 2018 Category: Emergency Medicine Authors: Benjamin Sholl Tags: Abstract Source Type: research

A Comparison of Headache Treatment in the Emergency Department: Prochlorperazine Versus  Ketamine
Conclusion Prochlorperazine appears to be superior to ketamine for the treatment of benign headaches in the ED. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - February 17, 2018 Category: Emergency Medicine Source Type: research

Prochlorperazine Superior to Hydromorphone for Migraine
Intravenous (IV) hydromorphone, commonly used as first-line therapy to treat acute migraine in the emergency department (ED), is substantially less effective than IV prochlorperazine, according to atrial published inNeurology. (Source: JAMA)
Source: JAMA - December 26, 2017 Category: General Medicine Source Type: research

Stability of extemporaneously prepared preservative-free prochlorperazine nasal spray.
CONCLUSION: An extemporaneously prepared preservative-free nasal spray solution of prochlorperazine edisylate 5 mg/mL was physically, chemically, and microbiologically stable for 60 days when stored at room temperature in low-density polyethylene bottles. PMID: 29273610 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 25, 2017 Category: Drugs & Pharmacology Authors: Yellepeddi VK Tags: Am J Health Syst Pharm Source Type: research

Medical Treatment Guidelines for Acute Migraine Attacks.
Authors: Hsu YC, Lin KC, Taiwan Headache Society TGSOTHS Abstract In 2015, the American Headache Society (AHS) amended the treatment guideline of acute migraine based on evidence-based medicine (EBM) that all triptans in any form of preparations, acetaminophen, and non-steroid anti-inflammation drugs-NSAID (aspirin, diclofenac, ibuprofen, naproxen), sumatriptan/naproxen, combined acetaminophen/aspirin/caffeine are considered effective (Level A). Previously effective drugs as prochlorperazine, and dihydroergotamine-DHE (excluded inhaled form) were downrated to probable effective (Level B). Taiwan Headache Society pu...
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews
Nausea and vomiting are common and distressing adverse events of chemotherapy. This review focuses on the findings and quality of systematic reviews (SRs) of cannabinoids for chemotherapy‐induced nausea and vomiting (CINV). Review of SRs, a systematic literature search, was conducted in several electronic databases and included SRs evaluating cannabinoids for CINV in cancer patients. Methodological quality and quality of reporting were evaluated by AMSTAR and PRISMA, respectively. Initial search retrieved 2,206 records, and 5 SRs were included. On the basis of findings of the sole SR judged as high methodological quality...
Source: Phytotherapy Research - November 23, 2017 Category: Biochemistry Authors: Victor Schussel, Lucas Kenzo, Andreia Santos, J úlia Bueno, Ellen Yoshimura, Carolina Oliveira Cruz Latorraca, Daniela Vianna Pachito, Rachel Riera Tags: REVIEW Source Type: research

Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine
Conclusions: IV hydromorphone is substantially less effective than IV prochlorperazine for the treatment of acute migraine in the ED and should not be used as first-line therapy. ClinicalTrials.gov identifier: NCT02389829. Classification of evidence: This study provides Class I evidence that for patients in the ED with migraine, IV prochlorperazine + diphenhydramine is superior to IV hydromorphone. (Source: Neurology)
Source: Neurology - November 13, 2017 Category: Neurology Authors: Friedman, B. W., Irizarry, E., Solorzano, C., Latev, A., Rosa, K., Zias, E., Vinson, D. R., Bijur, P. E., Gallagher, E. J. Tags: Migraine, Clinical trials Randomized controlled (CONSORT agreement), Class I ARTICLE Source Type: research

Development of Floating Delivery for Solid Self Micro-Emulsifying Drug Delivery System of Prochlorperazine Maleate.
Conclusion It can be concluded that SMEDD enhanced the solubility of drug and floating capsule gave site specific drug release of PCM with the advantages of reduced dosing frequency and better compliance. PMID: 29119940 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 11, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Perioperative Antiemetic Therapy for Fast-Track Laparoscopic Bariatric Surgery
ConclusionPONV is a common and peculiar problem in bariatric surgery patients. However, intraoperative multimodal antiemetic prophylaxis effectively minimizes PONV. Intraoperative multimodal antiemetic enhances fast-track bariatric surgical care, patient satisfaction, and perioperative outcomes. (Source: Obesity Surgery)
Source: Obesity Surgery - November 7, 2017 Category: Surgery Source Type: research

Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial.
CONCLUSION: Routine use of prochlorperazine as a prophylactic antiemetic at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations. IMPLICATIONS FOR PRACTICE: Prophylactic prochlorperazine seems to be ineffective in preventing opioid-induced nausea and vomiting (OINV) and may cause adverse events such as somnolence. Routine use of prophylactic prochlorperazine at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other anti...
Source: The Oncologist - October 16, 2017 Category: Cancer & Oncology Authors: Tsukuura H, Miyazaki M, Morita T, Sugishita M, Kato H, Murasaki Y, Gyawali B, Kubo Y, Ando M, Kondo M, Yamada K, Hasegawa Y, Ando Y Tags: Oncologist Source Type: research

Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury
Journal of Neurotrauma , Vol. 0, No. 0. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - September 19, 2017 Category: Neurology Authors: Sylvie Liabeuf Laetitia Stuhl-Gourmand Florian Gacki ère Renzo Mancuso Irene Sanchez Brualla Philippe Marino Fr édéric Brocard Laurent Vinay Source Type: research

Prochlorperazine Found Superior to Hydropmorphone for Migraine in the Emergency Department
No abstract available (Source: Neurology Today)
Source: Neurology Today - July 6, 2017 Category: Neurology Tags: Features Source Type: research

The “Silver Star” Initiative: Proactively Protecting Our Older Adult Population
Topic Significance& Study Purpose/Background/Rationale: BMT recipients aged 65 years or older comprise 30% of patients at this large academic health system. BMT protocols commonly use medications at standardized doses often bringing about the need for aggressive symptom management. Lorazepam, prochlorperazine, promethazine and diphenhydramine are frequently used to treat the nausea, vomiting and diarrhea which often follow BMT conditioning regimens. Literature indicates that geriatric individuals are at a greater risk for medication-related adverse events as described per BEERS and STOP/START criteria. (Source: Biology...
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Jeanne Verrecchio Source Type: research

Mild, aqueous α-arylation of ketones: towards new diversification tools for halogenated metabolites and drug molecules.
Mild, aqueous α-arylation of ketones: towards new diversification tools for halogenated metabolites and drug molecules. Chemistry. 2017 Feb 14;: Authors: Marelli E, Renault Y, Sharma SV, Nolan SP, Goss RJ Abstract The palladium-catalyzed aqueous α-arylation of ketones was developed and tested for a large variety of reaction partners. These mild conditions enabled the coupling of aryl/ alkyl-ketones with N-protected halotryptophans, heterocyclic haloarenes, and challenging base-sensitive compounds. The synthetic potential of this new methodology for the diversification of complex bioactive ...
Source: Chemistry - February 14, 2017 Category: Chemistry Authors: Marelli E, Renault Y, Sharma SV, Nolan SP, Goss RJ Tags: Chemistry Source Type: research