Novel, fast, and reliable electrochemical dsDNA biosensor based on O-terminated pristine nanocrystalline boron-doped diamond electrode for DNA interaction studies
We present a novel application of a nanocrystalline boron-doped diamond electrode (B-NCDE) for the construction of an electrochemical DNA biosensor based on double-stranded DNA (dsDNA) for various bioanalytical applications. Surface characterization of the transducer surface (prior and after the fabrication of negatively charged O-terminated surface - O-B-NCDE) was performed by scanning electron microscopy (SEM), Raman spectroscopy, and linear sweep voltammetry (LSV) that was further used for the voltammetric determination, scan rate dependence investigation, and repeatability examination of dsDNA electrochemical oxidation...
Source: Bioelectrochemistry - April 4, 2024 Category: Biochemistry Authors: Michal August ín Rene Pfeifer Ondrej Szab ó Ji ří Barek Marian Vojs Alexander Kromka Vlastimil Vysko čil Source Type: research
Novel, fast, and reliable electrochemical dsDNA biosensor based on O-terminated pristine nanocrystalline boron-doped diamond electrode for DNA interaction studies
We present a novel application of a nanocrystalline boron-doped diamond electrode (B-NCDE) for the construction of an electrochemical DNA biosensor based on double-stranded DNA (dsDNA) for various bioanalytical applications. Surface characterization of the transducer surface (prior and after the fabrication of negatively charged O-terminated surface - O-B-NCDE) was performed by scanning electron microscopy (SEM), Raman spectroscopy, and linear sweep voltammetry (LSV) that was further used for the voltammetric determination, scan rate dependence investigation, and repeatability examination of dsDNA electrochemical oxidation...
Source: Bioelectrochemistry - April 4, 2024 Category: Biochemistry Authors: Michal August ín Rene Pfeifer Ondrej Szab ó Ji ří Barek Marian Vojs Alexander Kromka Vlastimil Vysko čil Source Type: research
Discovering common pathogenetic processes between COVID-19 and tuberculosis by bioinformatics and system biology approach
ConclusionThis research provides novel strategies and valuable references for the treatment of tuberculosis and COVID-19. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - December 15, 2023 Category: Microbiology Source Type: research
Immuno-PET and Targeted {alpha}-Therapy Using Anti-Glypican-1 Antibody Labeled with 89Zr or 211At: A Theranostic Approach for Pancreatic Ductal Adenocarcinoma
Conclusion: [89Zr]GPC1 mAb PET showed high tumoral uptake in the early phase after administration, and targeted α-therapy using [211At]GPC1 mAb showed tumor growth suppression. GPC1 is a promising target for future applications for the precise diagnosis of pancreatic ductal adenocarcinoma and GPC1-targeted theranostics. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - December 1, 2023 Category: Nuclear Medicine Authors: Watabe, T., Kabayama, K., Naka, S., Yamamoto, R., Kaneda, K., Serada, S., Ooe, K., Toyoshima, A., Wang, Y., Haba, H., Kurimoto, K., Kobayashi, T., Shimosegawa, E., Tomiyama, N., Fukase, K., Naka, T. Tags: Basic Science Investigations Source Type: research
Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs. This review explores the impact of phenothiazines, primarily used as antipsychotic agents, on key mechanisms driving tumor growth and metastasis. The cationic and amphiphilic nature of phenothiazines allows interaction with the lipid bilayer of cellular membranes, resulting in alterations in lipid composition, modulation of calcium channels, fluidity, thinning, and integrity of the plasma membrane. This...
Source: Frontiers in Oncology - November 23, 2023 Category: Cancer & Oncology Source Type: research
Review of Dopamine Antagonists for Nausea and Vomiting in Palliative Care Patients
J Pain Palliat Care Pharmacother. 2023 Oct 16:1-7. doi: 10.1080/15360288.2023.2268065. Online ahead of print.ABSTRACTSymptoms of nausea and vomiting are common in palliative care and hospice patients. One of the many classes of medications used for the treatment of nausea and vomiting is dopamine receptor antagonists which are particularly helpful for treating nausea mediated by the chemoreceptor trigger zone (CTZ) and impaired gastrointestinal function. While dopamine antagonists can be very effective treatments for nausea they should be used with caution as they carry the risk of QTc prolongation, have a FDA black box wa...
Source: Journal of Pain and Palliative Care Pharmacotherapy - October 16, 2023 Category: Palliative Care Authors: Grace Jenkins Source Type: research
A case of carcinoid syndrome probably exacerbated by hemodialysis in which prochlorperazine maleate was effective
We report the case of a patient with liver metastasis of neuroendocrine carcinoma who suffered from acute abdominal pain and diarrhea triggered by hemodialysis. Various differential diagnoses were considered, but we concluded these symptoms to be probably caused by exacerbation of carcinoid syndrome, as the serum 5HIAA level was markedly elevated, and a drug with anti-serotonin activity was effective. Prochlorperazine maleate, which has anti-serotonin activity, was effective for these symptoms, and the patient was able to continue maintenance hemodialysis, which contributed to his quality of life and prognosis. We speculat...
Source: CEN Case Reports - August 22, 2023 Category: Urology & Nephrology Source Type: research
Headache in the Emergency Department: A Multicenter Observational Study from Singapore
Conclusions: Primary headaches constituted most ED headache diagnoses. ED imaging of selected patients yielded a relatively high pick-up rate for significant intracranial abnormalities. Opioid use for symptomatic relief of headaches in the ED was found to be high, underscoring the need for improvement in headache analgesia relief practices in the ED.PMID:37512151 | PMC:PMC10384407 | DOI:10.3390/medicina59071340 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Win Sen Kuan Ranjeev Kumar Ying Wei Yau Wei Ming Ng Dennis Wen Jie Chia Ee Yang Ng Kanwar Sudhir Lather Mui Teng Chua Source Type: research
Headache in the Emergency Department: A Multicenter Observational Study from Singapore
Conclusions: Primary headaches constituted most ED headache diagnoses. ED imaging of selected patients yielded a relatively high pick-up rate for significant intracranial abnormalities. Opioid use for symptomatic relief of headaches in the ED was found to be high, underscoring the need for improvement in headache analgesia relief practices in the ED.PMID:37512151 | PMC:PMC10384407 | DOI:10.3390/medicina59071340 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Win Sen Kuan Ranjeev Kumar Ying Wei Yau Wei Ming Ng Dennis Wen Jie Chia Ee Yang Ng Kanwar Sudhir Lather Mui Teng Chua Source Type: research
Headache in the Emergency Department: A Multicenter Observational Study from Singapore
Conclusions: Primary headaches constituted most ED headache diagnoses. ED imaging of selected patients yielded a relatively high pick-up rate for significant intracranial abnormalities. Opioid use for symptomatic relief of headaches in the ED was found to be high, underscoring the need for improvement in headache analgesia relief practices in the ED.PMID:37512151 | PMC:PMC10384407 | DOI:10.3390/medicina59071340 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Win Sen Kuan Ranjeev Kumar Ying Wei Yau Wei Ming Ng Dennis Wen Jie Chia Ee Yang Ng Kanwar Sudhir Lather Mui Teng Chua Source Type: research
Headache in the Emergency Department: A Multicenter Observational Study from Singapore
Conclusions: Primary headaches constituted most ED headache diagnoses. ED imaging of selected patients yielded a relatively high pick-up rate for significant intracranial abnormalities. Opioid use for symptomatic relief of headaches in the ED was found to be high, underscoring the need for improvement in headache analgesia relief practices in the ED.PMID:37512151 | PMC:PMC10384407 | DOI:10.3390/medicina59071340 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Win Sen Kuan Ranjeev Kumar Ying Wei Yau Wei Ming Ng Dennis Wen Jie Chia Ee Yang Ng Kanwar Sudhir Lather Mui Teng Chua Source Type: research
Headache in the Emergency Department: A Multicenter Observational Study from Singapore
Conclusions: Primary headaches constituted most ED headache diagnoses. ED imaging of selected patients yielded a relatively high pick-up rate for significant intracranial abnormalities. Opioid use for symptomatic relief of headaches in the ED was found to be high, underscoring the need for improvement in headache analgesia relief practices in the ED.PMID:37512151 | PMC:PMC10384407 | DOI:10.3390/medicina59071340 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Win Sen Kuan Ranjeev Kumar Ying Wei Yau Wei Ming Ng Dennis Wen Jie Chia Ee Yang Ng Kanwar Sudhir Lather Mui Teng Chua Source Type: research
Headache in the Emergency Department: A Multicenter Observational Study from Singapore
Conclusions: Primary headaches constituted most ED headache diagnoses. ED imaging of selected patients yielded a relatively high pick-up rate for significant intracranial abnormalities. Opioid use for symptomatic relief of headaches in the ED was found to be high, underscoring the need for improvement in headache analgesia relief practices in the ED.PMID:37512151 | PMC:PMC10384407 | DOI:10.3390/medicina59071340 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Win Sen Kuan Ranjeev Kumar Ying Wei Yau Wei Ming Ng Dennis Wen Jie Chia Ee Yang Ng Kanwar Sudhir Lather Mui Teng Chua Source Type: research
