Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy.
CONCLUSIONS: Cannabis-based medications may be useful for treating refractory chemotherapy-induced nausea and vomiting. However, methodological limitations of the trials limit our conclusions and further research reflecting current chemotherapy regimens and newer anti-emetic drugs is likely to modify these conclusions.
PMID: 26561338 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 12, 2015 Category: Journals (General) Authors: Smith LA, Azariah F, Lavender VT, Stoner NS, Bettiol S Tags: Cochrane Database Syst Rev Source Type: research
Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting.
CONCLUSIONS: There is low-quality evidence supporting the use of PC6 acupoint stimulation over sham. Compared to the last update in 2009, no further sham comparison trials are needed. We found that there is moderate-quality evidence showing no difference between PC6 acupoint stimulation and antiemetic drugs to prevent PONV. Further PC6 acupoint stimulation versus antiemetic trials are futile in showing a significant difference, which is a new finding in this update. There is inconclusive evidence supporting the use of a combined strategy of PC6 acupoint stimulation and antiemetic drug over drug prophylaxis, and further hig...
Source: Cochrane Database of Systematic Reviews - November 2, 2015 Category: Journals (General) Authors: Lee A, Chan SK, Fan LT Tags: Cochrane Database Syst Rev Source Type: research
Drugs for the treatment of nausea and vomiting in adults in the emergency department setting.
CONCLUSIONS: In an ED population, there is no definite evidence to support the superiority of any one drug over any other drug, or the superiority of any drug over placebo. Participants receiving placebo often reported clinically significant improvement in nausea, implying general supportive treatment such as intravenous fluids may be sufficient for the majority of people. If a drug is considered necessary, choice of drug may be dictated by other considerations such as a person's preference, adverse-effect profile and cost. The review was limited by the paucity of clinical trials in this setting. Future research should inc...
Source: Cochrane Database of Systematic Reviews - September 28, 2015 Category: Journals (General) Authors: Furyk JS, Meek RA, Egerton-Warburton D Tags: Cochrane Database Syst Rev Source Type: research
Antipsychotic Drug Use and the Risk of Seizures: Follow-up Study with a Nested Case–Control Analysis
Conclusions
Current use of medium-to-high potency first-generation antipsychotic drugs was associated with a 2.5-fold increased risk of seizures compared with non-use of antipsychotic drugs in patients with affective disorders. In these patients, current use of all other antipsychotic drug subclasses was not associated with seizures. In patients with dementia, current and past use of all antipsychotic drug subclasses, except amisulpride, aripiprazole, risperidone, or sulpiride, was associated with an increased risk of seizures. (Source: CNS Drugs)
Source: CNS Drugs - August 4, 2015 Category: Neurology Source Type: research
Sensitive detection of piperazinyl phenothiazine drugs by field‐amplified sample stacking in capillary electrophoresis with dispersive liquid‐liquid microextraction
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - August 1, 2015 Category: Biochemistry Authors: Yi‐Yi Tu, Ming‐Mu Hsieh, Sarah Y. Chang Tags: Research Paper Source Type: research
Induction aND ANTAGONISM OF PICA INDUCED bY TERIPARATIDE IN RATS.
In this study, we investigated the characteristics of teriparatide-induced pica and the abilities of anti-emetic drugs to inhibit teriparatide-induced pica. Male and female adolescent (4-week-old), young (8-week-old), and adult (30-week-old) naive rats, and ovariectomized (OVX: 17-week-old) and sham-operated (17-week-old) rats subcutaneously received teriparatide (0.4mg/kg, n=4), and their kaolin and food intakes were monitored for 24h after the injection. Among the tested rats, we found that OVX rats, rather than male, female, and sham-operated rats, showed marked teriparatide-induced pica (0mg/kg: 0.17±0.07g, 0.4mg/kg: ...
Source: European Journal of Pharmacology - July 16, 2015 Category: Drugs & Pharmacology Authors: Yamamoto K, Kato N, Isogai Y, Kuroda T, Ishida T, Yamatodani A Tags: Eur J Pharmacol Source Type: research
Incidence of nausea and vomiting induced by oxycodone administered with prochlorperazine in Japanese cancer patients.
CONCLUSIONS: The incidence of nausea induced by oxycodone with prochlorperazine was 18.1% in opioid-naïve Japanese inpatients. Female sex may be a risk factor for oxycodone-induced nausea. These results suggest that a clinical study would require 314 participants (157 in each group) to decrease the incidence from 18% to 8% (10% decrease) with a new preventive treatment (alpha error=0.05, beta error=0.2).
PMID: 25959201 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Yamada T, Kanazawa Y, Aoki Y, Uchida E Tags: J Nippon Med Sch Source Type: research
Acute Migraine Treatment in Adults.
This study aims to review current medical office-based acute migraine therapy in adults and provides readers with an organized approach to this important facet of migraine treatment. A general literature review includes a review of several recent published guidelines. Acetaminophen, 4 nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, acetylsalicylic acid [ASA], naproxen sodium, and diclofenac potassium), and 7 triptans (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan) have good evidence for efficacy and form the core of acute migraine treatment. NSAID-triptan combinati...
Source: Headache - April 15, 2015 Category: Neurology Authors: Becker WJ Tags: Headache Source Type: research
Acute Migraine Treatment in Adults
This study aims to review current medical office‐based acute migraine therapy in adults and provides readers with an organized approach to this important facet of migraine treatment. A general literature review includes a review of several recent published guidelines. Acetaminophen, 4 nonsteroidal anti‐inflammatory drugs (NSAIDs) (ibuprofen, acetylsalicylic acid [ASA], naproxen sodium, and diclofenac potassium), and 7 triptans (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan) have good evidence for efficacy and form the core of acute migraine treatment. NSAID–triptan com...
Source: Headache: The Journal of Head and Face Pain - April 15, 2015 Category: Neurology Authors: Werner J. Becker Tags: Review Article Source Type: research
Antipsychotic Drugs and the Risk of Ventricular Arrhythmia and/or Sudden Cardiac Death: A Nation-wide Case-Crossover Study [Epidemiology]
Conclusion
Use of antipsychotic drugs is associated with an increased risk of VA and/or SCD. Careful evaluations of the risks and benefits of antipsychotic treatment are highly recommended. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 23, 2015 Category: Cardiology Authors: Wu, C.-S., Tsai, Y.-T., Tsai, H.-J. Tags: Epidemiology Source Type: research
A Comparison of Acute Treatment Regimens for Migraine in the Emergency Department
Migraine headaches are a common presenting complaint in emergency departments. Abortive treatment in this setting is not well studied, leading to considerable variation in treatment. The relationship between acute medications and emergency department revisits has not been studied.
Eighty-five percent of children with migraine are successfully discharged from the emergency department; only 1 in 18 children require a return visit. Prochlorperazine is associated with less revisits than metoclopramide, and diphenhydramine use is associated with increased risk of return visits. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - February 2, 2015 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research
A Comparison of Acute Treatment Regimens for Migraine in the Emergency Department
CONCLUSIONS:
The majority of children with migraines are successfully discharged from the ED and only 1 in 18 required a revisit within 3 days. Prochlorperazine appears to be superior to metoclopramide in preventing a revisit, and diphenhydramine use is associated with increased rates of return. (Source: PEDIATRICS)
Source: PEDIATRICS - February 2, 2015 Category: Pediatrics Authors: Bachur, R. G., Monuteaux, M. C., Neuman, M. I. Tags: Correction Article Source Type: research
The Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles related to acute ...
Source: Headache: The Journal of Head and Face Pain - January 20, 2015 Category: Neurology Authors: Michael J. Marmura, Stephen D. Silberstein, Todd J. Schwedt Tags: American Headache Society Evidence Assessment Source Type: research
Repurposing of Prochlorperazine for Use Against Dengue Virus Infection
In this study, we found that prochlorperazine (PCZ), a dopamine D2 receptor (D2R) antagonist approved to treat nausea, vomiting, and headache in humans has potent in vitro and in vivo antiviral activity against DENV infection. PCZ can block DENV infection by targeting viral binding and viral entry through D2R- and clathrin-associated mechanisms, respectively. Administration of PCZ immediately or 6 hours after DENV infection in a Stat1-deficient mouse model completely protected against or delayed lethality. Overall, PCZ showed a previously unknown antiviral effect against DENV infection, and D2R may play a role in the DENV ...
Source: The Journal of Infectious Diseases - January 6, 2015 Category: Infectious Diseases Authors: Simanjuntak, Y., Liang, J.-J., Lee, Y.-L., Lin, Y.-L. Tags: VIRUSES Source Type: research
The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.
Abstract
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify ...
Source: Headache - January 1, 2015 Category: Neurology Authors: Marmura MJ, Silberstein SD, Schwedt TJ Tags: Headache Source Type: research
