Incidence of nausea and vomiting induced by oxycodone administered with prochlorperazine in Japanese cancer patients.

CONCLUSIONS: The incidence of nausea induced by oxycodone with prochlorperazine was 18.1% in opioid-naïve Japanese inpatients. Female sex may be a risk factor for oxycodone-induced nausea. These results suggest that a clinical study would require 314 participants (157 in each group) to decrease the incidence from 18% to 8% (10% decrease) with a new preventive treatment (alpha error=0.05, beta error=0.2). PMID: 25959201 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25959201?dopt=Abstract

Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Yamada T, Kanazawa Y, Aoki Y, Uchida E Tags: J Nippon Med Sch Source Type: research