Efficacy of Prophylactic Treatment for Oxycodone‐Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo‐Controlled, Double‐Blind Trial
Conclusion.Routine use of prochlorperazine as a prophylactic antiemetic at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations.Implications for Practice.Prophylactic prochlorperazine seems to be ineffective in preventing opioid‐induced nausea and vomiting (OINV) and may cause adverse events such as somnolence. Routine use of prophylactic prochlorperazine at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetic...
Source: The Oncologist - March 9, 2018 Category: Cancer & Oncology Authors: Hiroaki Tsukuura, Masayuki Miyazaki, Tatsuya Morita, Mihoko Sugishita, Hiroshi Kato, Yuka Murasaki, Bishal Gyawali, Yoko Kubo, Masahiko Ando, Masashi Kondo, Kiyofumi Yamada, Yoshinori Hasegawa, Yuichi Ando Tags: Symptom Management and Supportive Care Source Type: research
Opioid-Induced "Likeability" and "Feeling Good" Are Not Associated With Return Visits to an ED Among Migraine Patients Administered IV Hydromorphone.
CONCLUSION: We did not detect an association between hydromorphone and medication likeability, feeling good, or return visits to the ED. Headache relief was associated with medication likeability and feeling good.
PMID: 29516486 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - March 8, 2018 Category: Neurology Authors: Friedman BW, Latev A, Campbell C, White D Tags: Headache Source Type: research
Relative Effectiveness of Dopamine Antagonists for Pediatric Migraine in the Emergency Department
Conclusions
This study suggests variable efficacy among 3 commonly used dopamine antagonists for pediatric migraine headache. Promethazine seems least effective and results in higher use of opioids compared with other available dopamine antagonists. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - March 1, 2018 Category: Emergency Medicine Tags: Original Articles Source Type: research
Randomized study of IV prochlorperazine plus diphenhydramine versus IV hydromorphone for migraine
Migraine headache is a common complaint among patients presenting to the Emergency Department (ED). Parenteral opioids are commonly used to treat migraines despite recommendations against their use from the American Headache Society and other expert opinions. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - March 1, 2018 Category: Emergency Medicine Authors: Benjamin Sholl Tags: Abstract Source Type: research
Opioid ‐Induced “Likeability” and “Feeling Good” Are Not Associated With Return Visits to an ED Among Migraine Patients Administered IV Hydromorphone
ConclusionWe did not detect an association between hydromorphone and medication likeability, feeling good, or return visits to the ED. Headache relief was associated with medication likeability and feeling good. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - March 1, 2018 Category: Neurology Authors: Benjamin W. Friedman, Alexander Latev, Caron Campbell, Deborah White Tags: Brief Communications Source Type: research
Randomized study of IV prochlorperazine plus diphenhydramine versus IV hydromorphone for migraine
Migraine headache is a common complaint among patients presenting to the Emergency Department (ED). Parenteral opioids are commonly used to treat migraines despite recommendations against their use from the American Headache Society and other expert opinions. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - March 1, 2018 Category: Emergency Medicine Authors: Benjamin Sholl Tags: Abstract Source Type: research
A Comparison of Headache Treatment in the Emergency Department: Prochlorperazine Versus Ketamine
Conclusion Prochlorperazine appears to be superior to ketamine for the treatment of benign headaches in the ED. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - February 17, 2018 Category: Emergency Medicine Source Type: research
Prochlorperazine Superior to Hydromorphone for Migraine
Intravenous (IV) hydromorphone, commonly used as first-line therapy to treat acute migraine in the emergency department (ED), is substantially less effective than IV prochlorperazine, according to atrial published inNeurology. (Source: JAMA)
Source: JAMA - December 26, 2017 Category: General Medicine Source Type: research
Stability of extemporaneously prepared preservative-free prochlorperazine nasal spray.
CONCLUSION: An extemporaneously prepared preservative-free nasal spray solution of prochlorperazine edisylate 5 mg/mL was physically, chemically, and microbiologically stable for 60 days when stored at room temperature in low-density polyethylene bottles.
PMID: 29273610 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 25, 2017 Category: Drugs & Pharmacology Authors: Yellepeddi VK Tags: Am J Health Syst Pharm Source Type: research
Medical Treatment Guidelines for Acute Migraine Attacks.
Authors: Hsu YC, Lin KC, Taiwan Headache Society TGSOTHS
Abstract
In 2015, the American Headache Society (AHS) amended the treatment guideline of acute migraine based on evidence-based medicine (EBM) that all triptans in any form of preparations, acetaminophen, and non-steroid anti-inflammation drugs-NSAID (aspirin, diclofenac, ibuprofen, naproxen), sumatriptan/naproxen, combined acetaminophen/aspirin/caffeine are considered effective (Level A). Previously effective drugs as prochlorperazine, and dihydroergotamine-DHE (excluded inhaled form) were downrated to probable effective (Level B). Taiwan Headache S...
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews
Nausea and vomiting are common and distressing adverse events of chemotherapy. This review focuses on the findings and quality of systematic reviews (SRs) of cannabinoids for chemotherapy‐induced nausea and vomiting (CINV). Review of SRs, a systematic literature search, was conducted in several electronic databases and included SRs evaluating cannabinoids for CINV in cancer patients. Methodological quality and quality of reporting were evaluated by AMSTAR and PRISMA, respectively. Initial search retrieved 2,206 records, and 5 SRs were included. On the basis of findings of the sole SR judged as high methodological quality...
Source: Phytotherapy Research - November 23, 2017 Category: Biochemistry Authors: Victor Schussel, Lucas Kenzo, Andreia Santos, J úlia Bueno, Ellen Yoshimura, Carolina Oliveira Cruz Latorraca, Daniela Vianna Pachito, Rachel Riera Tags: REVIEW Source Type: research
Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine
Conclusions:
IV hydromorphone is substantially less effective than IV prochlorperazine for the treatment of acute migraine in the ED and should not be used as first-line therapy.
ClinicalTrials.gov identifier:
NCT02389829.
Classification of evidence:
This study provides Class I evidence that for patients in the ED with migraine, IV prochlorperazine + diphenhydramine is superior to IV hydromorphone. (Source: Neurology)
Source: Neurology - November 13, 2017 Category: Neurology Authors: Friedman, B. W., Irizarry, E., Solorzano, C., Latev, A., Rosa, K., Zias, E., Vinson, D. R., Bijur, P. E., Gallagher, E. J. Tags: Migraine, Clinical trials Randomized controlled (CONSORT agreement), Class I ARTICLE Source Type: research
Development of Floating Delivery for Solid Self Micro-Emulsifying Drug Delivery System of Prochlorperazine Maleate.
Conclusion It can be concluded that SMEDD enhanced the solubility of drug and floating capsule gave site specific drug release of PCM with the advantages of reduced dosing frequency and better compliance.
PMID: 29119940 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 11, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research
Perioperative Antiemetic Therapy for Fast-Track Laparoscopic Bariatric Surgery
ConclusionPONV is a common and peculiar problem in bariatric surgery patients. However, intraoperative multimodal antiemetic prophylaxis effectively minimizes PONV. Intraoperative multimodal antiemetic enhances fast-track bariatric surgical care, patient satisfaction, and perioperative outcomes. (Source: Obesity Surgery)
Source: Obesity Surgery - November 7, 2017 Category: Surgery Source Type: research
Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial.
CONCLUSION: Routine use of prochlorperazine as a prophylactic antiemetic at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations.
IMPLICATIONS FOR PRACTICE: Prophylactic prochlorperazine seems to be ineffective in preventing opioid-induced nausea and vomiting (OINV) and may cause adverse events such as somnolence. Routine use of prophylactic prochlorperazine at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other a...
Source: The Oncologist - October 16, 2017 Category: Cancer & Oncology Authors: Tsukuura H, Miyazaki M, Morita T, Sugishita M, Kato H, Murasaki Y, Gyawali B, Kubo Y, Ando M, Kondo M, Yamada K, Hasegawa Y, Ando Y Tags: Oncologist Source Type: research
