Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury
Journal of Neurotrauma , Vol. 0, No. 0. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - September 19, 2017 Category: Neurology Authors: Sylvie Liabeuf Laetitia Stuhl-Gourmand Florian Gacki ère Renzo Mancuso Irene Sanchez Brualla Philippe Marino Fr édéric Brocard Laurent Vinay Source Type: research
Prochlorperazine Found Superior to Hydropmorphone for Migraine in the Emergency Department
No abstract available (Source: Neurology Today)
Source: Neurology Today - July 6, 2017 Category: Neurology Tags: Features Source Type: research
The “Silver Star” Initiative: Proactively Protecting Our Older Adult Population
Topic Significance& Study Purpose/Background/Rationale: BMT recipients aged 65 years or older comprise 30% of patients at this large academic health system. BMT protocols commonly use medications at standardized doses often bringing about the need for aggressive symptom management. Lorazepam, prochlorperazine, promethazine and diphenhydramine are frequently used to treat the nausea, vomiting and diarrhea which often follow BMT conditioning regimens. Literature indicates that geriatric individuals are at a greater risk for medication-related adverse events as described per BEERS and STOP/START criteria. (Source: Biology of ...
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Jeanne Verrecchio Source Type: research
Mild, aqueous α-arylation of ketones: towards new diversification tools for halogenated metabolites and drug molecules.
Abstract
The palladium-catalyzed aqueous α-arylation of ketones was developed and tested for a large variety of reaction partners. These mild conditions enabled the coupling of aryl/ alkyl-ketones with N-protected halotryptophans, heterocyclic haloarenes, and challenging base-sensitive compounds. The synthetic potential of this new methodology for the diversification of complex bioactive molecules was exemplified by derivatising prochlorperazine. The methodology is mild, aqueous and flexible, representing a means of functionalizing a wide range of halo-aromatics and therefore has the potential to be exten...
Source: Chemistry - February 13, 2017 Category: Chemistry Authors: Marelli E, Renault Y, Sharma SV, Nolan SP, Goss RJ Tags: Chemistry Source Type: research
Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. Meyering, Stefan H; Stringer, Ryan W; Hysell, Matthew K
Abstract
Introduction: Headaches represent over 3 million Emergency Department visits per year comprising 2.4 percent of all ED visits. Headaches are thought to be one of the three most common complaints of patient presentations to EDs across the country. There are many proposed methods and clinical guidelines of treating acute headache presentations however data on intravenous acetaminophen usage in these settings are lacking.
Objectives: The study attempts to determine the efficacy of IV Acetaminophen as an adjunct to a standard therapy for the treatment of patients who present to the emerge...
Source: Western Journal of Emergency Medicine - January 1, 2017 Category: Emergency Medicine Source Type: research
Shortage of psychotropic medications in community pharmacies in Saudi Arabia: Causes and solutions
Conclusions The findings of this study should expedite the reform process in both the Ministry of Health and the Saudi Food and Drug Authority (SFDA) to publish and enforce an essential list of medications for retail community pharmacies, which should include the most commonly prescribed psychotropic medications. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 12, 2016 Category: Drugs & Pharmacology Source Type: research
Inhaled Drug Therapy Development for the Treatment of Migraine.
Authors: Chua AL, Silberstein S
Abstract
INTRODUCTION: Currently, migraine abortive therapies are available in oral, intranasal, injectable, transdermal, suppository and intravenous routes. These formulations each come with their own set of challenges, such as poor bioavailability, intolerable side effects or inconvenient administration. The inhalation of substances, both medicinally and recreationally, is a commonly used method of drug administration but has been underutilized in the treatment of neurologic disorders such as migraine. Three drugs have been studied as potential inhalable treatments for acu...
Source: Expert Opinion on Pharmacotherapy - July 16, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
The Use of a Pediatric Migraine Practice Guideline in an Emergency Department Setting
Conclusions: Our MCPG was clinically safe and effective in treating children with acute migraine headaches. Our data add to the dearth of existing published literature on migraine treatment protocols in the ED setting. We recommend additional prospective and comparative studies to further evaluate the effectiveness of our protocol in this patient population. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - July 1, 2016 Category: Emergency Medicine Tags: Original Articles Source Type: research
Management of Adults With Acute Migraine in the Emergency Department: The American Headache Society Evidence Assessment of Parenteral Pharmacotherapies
ConclusionsThe search identified 68 unique randomized controlled trials utilizing 28 injectable medications. Of these, 19 were rated class 1 (low risk of bias), 21 were rated class 2 (higher risk of bias), and 28 were rated class 3 (highest risk of bias). Metoclopramide, prochlorperazine, and sumatriptan each had multiple class 1 studies supporting acute efficacy, as did dexamethasone for prevention of headache recurrence. All other medications had lower levels of evidence.
RecommendationsIntravenous metoclopramide and prochlorperazine, and subcutaneous sumatriptan should be offered to eligible adults who present to an ED ...
Source: Headache: The Journal of Head and Face Pain - June 13, 2016 Category: Neurology Authors: Serena L. Orr, Benjamin W. Friedman, Suzanne Christie, Mia T. Minen, Cynthia Bamford, Nancy E. Kelley, Deborah Tepper Tags: Review Article Source Type: research
Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics
Megan Brafford May,1 Ashley E Glode2 1Department of Pharmacy, Baptist Health Lexington, Lexington, KY, USA; 2Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Abstract: Chemotherapy-induced nausea and vomiting (CINV) is one of the most common symptoms feared by patients, but may be prevented or lessened with appropriate medications. Several antiemetic options exist to manage CINV. Corticosteroids, serotonin receptor antagonists, and neurokinin receptor antagonists are the classes most commonly used in the prevention o...
Source: Cancer Management and Research - May 11, 2016 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
The Safety of Prochlorperazine in Children: A Systematic Review and Meta-Analysis
Conclusions
The most common AEs reported with the pediatric use of prochlorperazine are EPS and sedation. Fatalities, life-threatening, and persistent AEs have also been reported. (Source: Drug Safety)
Source: Drug Safety - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review
ConclusionsOf the available evidence, ibuprofen, prochlorperazine, and certain triptan medications are the most effective and safe agents for acute management of migraine and other benign headache disorders in the pediatric population. Additional studies in this population are needed, and should take into consideration variables such as dosing, co‐administered medications, treatment duration, and length of treatment effect. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - January 21, 2016 Category: Neurology Authors: Irene R. Patniyot, Amy A. Gelfand Tags: Review Article Source Type: research
Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review.
CONCLUSIONS: Of the available evidence, ibuprofen, prochlorperazine, and certain triptan medications are the most effective and safe agents for acute management of migraine and other benign headache disorders in the pediatric population. Additional studies in this population are needed, and should take into consideration variables such as dosing, co-administered medications, treatment duration, and length of treatment effect.
PMID: 26790849 [PubMed - in process] (Source: Headache)
Source: Headache - January 1, 2016 Category: Neurology Authors: Patniyot IR, Gelfand AA Tags: Headache Source Type: research
Novel management of postoperative pain using only oral analgesics after LADG
Conclusion
Postoperative pain management using oral analgesics after LADG is feasible and safe, and is an ideal pain treatment associated with few adverse events while providing pain relief not inferior to epidural anesthesia. (Source: Surgery Today)
Source: Surgery Today - December 9, 2015 Category: Surgery Source Type: research
Prescribing practices in hospice patients with adult failure to thrive or debility.
CONCLUSION: Recognized clinical components of failure to thrive syndrome include cognitive impairment, malnutrition, and depression. The hospice organization provided 80% of antidepressants, but infrequently provided appetite stimulants and drugs treating dementia. The most commonly provided drugs were those used for symptoms associated with most end-stage diseases.
PMID: 24904199 [PubMed - as supplied by publisher] (Source: Progress in Palliative Care)
Source: Progress in Palliative Care - December 2, 2015 Category: Palliative Care Tags: Prog Palliat Care Source Type: research
