Anticandidal activity of the extract and compounds isolated from Cyperus conglomertus Rottb
Publication date: Available online 12 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): Ghaferah H. Al-Hazmi, Amani S. Awaad, Monerah R. Alothman, Saleh I. AlqasoumiAbstractThe phytochemical screening of Cyperus conglomeratus showed that carbohydrates and/or glycosides, flavonoids, tannins, sterols and/or triterpenes, and proteins and/or amino acids are present. The fatty acid profile comprised major; palmitic, oleic, heptadecanoic, linoleic and minor; arachidonic, lignoceric, stearic, and myristic acid. Two compounds; namely, α-amyrin and β-sitosterol were isolated by the fractionation of unsaponifiable ...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The role of SAMHD1 expression and its relation to HIV-2 (Vpx) gene production
Publication date: Available online 12 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): Talal M. BakirAbstractSAMHD1 (sterile alpha motif and HD domain 1) is a protein that is found in myeloid cells, which restricts HIV1 replication. It depletes the de-oxy-nucleoside tri-phosphate (dNTPs) pool needed for a viral cDNA synthesis leading to inhibition of viral replication inside the cells. However, it does not restrict HIV2 replication in myeloid cells due to the presence of viral Vpx protein. Vpx is a virion-associated protein which augments viral infectivity and it only exists in HIV2 and it has been recently shown i...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Reduction of Animal Sacrifice in Biomedical Science & Research through Alternative Design of Animal Experiments
Publication date: Available online 12 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): Jagdish Rai, Kuldeep KaushikAbstractVarious upcoming techniques can be used in replacement of experiments requiring animal sacrifice or products of animal sacrifice. In many instances these techniques provide more reproducibility and control of parameter, compared to experiments involving animal or animal products. Use of these techniques can avoid the question of the animal sacrifice during experiment and subsequently permission of ethical approval. In silico simulation, informatics, 3D cell culture models, organ-on-chips are so...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Self-medication practice in pregnant women from central Mexico
The objective of this study was to evaluate the prevalence and the factors associated with self-medication among Mexican women living in the central region of Mexico. This is a descriptive interview-study of 1798 pregnant women or women who were pregnant no more than 3 years ago, when the interview was carried out. Data analysis was carried out with chi-square analysis and odds ratio. The prevalence of self-medication (allopathic drugs, medicinal plants, and other products, including vitamins, food supplements, among others) was 21.9%. The factors associated (p 
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Resveratrol-loaded PLGA nanoparticles mediated programmed cell death in prostate cancer cells
In this study polymeric nanoparticles encapsulating resveratrol (RLPLGA) were designed and their cytotoxic and mode of apoptotic cells death against prostate cancer cell line (LNCaP) was determined. Nanoparticles were prepared by solvent displacement method and characterized for particle size, TEM, entrapment efficiency, DSC and drug release study. RLPLGA exhibited a significant decrease in cell viability with 50% and 90% inhibitory concentration (IC50 and IC90) of 15.6 ± 1.49 and 41.1 ± 2.19 μM respectively against the LNCaP cells. This effect was mediated by apoptosis as confirmed by cell cycle...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Novel in-situ gel for intravesical administration of ketorolac
The objective of the present study was to optimize an in-situ gel formulation of poloxamer and chitosan for intravesical delivery of ketorolac tromethamine. The gelling temperature of the prepared combinations ranged from 20.67 to 25.8 °C. In-vitro release of KT was sustained for up to 7 h using a poloxamer concentration ranging from 17% to 19% and a chitosan concentration ranging from 1% to 2%. Design-Expert® 10 was used to select the optimized formulation (poloxamer/chitosan 17/1.589% w/w) which significantly (p 
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluating the preceptor–preceptee relationship among Pharm D students at the King Saud University School of Pharmacy
ConclusionPharm D students were somewhat satisfied with their preceptors’ teaching behaviors in communication skills, practice, and teaching skills as well as feedback and evaluation to students. To enhance the quality of experiential education, preceptors should be trained to develop programs that direct and energize advancement. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Mosquito and tick repellency of two Anthemis essential oils from Saudi Arabia
Publication date: Available online 27 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): Hasan Soliman Yusufoglu, Nurhayat Tabanca, Ulrich R. Bernier, Andrew Y. Li, Mohammed Ayman Salkini, Saleh Ibrahim Alqasoumi, Betul DemirciAbstractThe essential oils (EOs) of Anthemis melampodina (Am) and Anthemis scrobicularis (As) (Asteraceae) were extracted from the aerial parts of the plants by hydrodistillation, and their chemical compositions were analyzed using GC-FID and GC-MS. Fifty-six components representing 85.5% of the oil composition of Anthemis melampdina were identified, and the major components were α-pinene...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and antibacterial activity of novel heterocycle, coumacine, and two of its derivatives
Publication date: Available online 27 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): Yasser Fakri MustafaAbstractHeterocyclic nucleus plays a fundamental role in the medicinal chemistry and serves as a key template for the development of various therapeutic agents including broad spectrum antibacterial drugs. In an effort to develop new antibacterial agents, a bicyclic twelve-membered heterocyclic nucleus derived from coumarin was prepared by an uncomplicated method. The rate of ring closure for this nucleus, which was given the name coumacine, in addition to two of its derivatives was monitored spectroscopically...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis, biological evaluation and in silico molecular docking of novel 1-hydroxy-naphthyl substituted heterocycles
Publication date: Available online 27 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): El-Sayed I. El-Desoky, Eman M. Keshk, Aya A. El-Sawi, Mohamed A. Abozeid, Laila A. Abouzeid, Abdel-Rahman H. Abdel-RahmanAbstractThe versatile precursor 2-acetyl-4-allyl-1-hydroxy naphthalene was synthesized efficiently via Claisen rearrangement 2-acetyl-1-allyloxynaphthalene. The Claisen-Schmidt condensation of latter precursor afforded the corresponding chalcones which were exploited to synthesize a series of potential heterocycles such as pyrazoline, isoxazoline, benzocoumarin and benzoflavone. The synthesized products showed ...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of teratogenicity and genotoxicity induced by kramecyne (KACY)
Publication date: Available online 29 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): J.M. Cristóbal-Luna, N. Paniagua-Castro, G.N. Escalona-Cardoso, M.S. Pérez-Gutiérrez, I. Álvarez-González, E. Madrigal-Bujaidar, G. Chamorro-CevallosAbstractKramecyne (KACY), a polymer isolated from Krameria cytisoides Cav, has anti-inflammatory, anti-nociceptive, anti-arthritic and anti-ulcerogenic properties. As a part of standard preclinical safety tests, the present study sought to determine potential developmental toxicity (in female rats) and genotoxicity (in male mice) of KACY. Pregnant f...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Use of herbal extract from Artemisia herba-alba (Shih) in pharmaceutical preparations for dental hygiene
Publication date: Available online 30 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): Amanullah Mohammed, Sadatullah Syed, M.Yaseen Syed, Azhar Dawasaz AliAbstractAntibiotic resistance in bacterial species is opening new avenues to search for alternative modes of antimicrobial treatment, medicinal plant extracts being one among them. The aim of this study was to access the possibility of medicinal plant extract from Shih in the manufacture of pharmaceutical preparations for oral hygiene specifically for the prevention and treatment of dental caries due to Streptococcus mutans. Antimicrobial effects of crude organi...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Investigation of antioxidant compounds in commercial pomegranate molasses products using matrix-solid phase dispersion extraction coupled with HPLC
Publication date: Available online 30 March 2018Source: Saudi Pharmaceutical JournalAuthor(s): Y.T. Kamal, Prawez Alam, Saleh Ibrahim Alqasoumi, Ahmed Ibrahim Foudah, Mohammed Hamed Alqarni, Hasan Soliman YusufogluAbstractPomegranate is a well known fruit for its unique flavor, taste and health benefits. The medicinal properties of this fruits directly associated with the phenolic content present, with great anti-oxidant potential. The research is intended to develop matrix solid phase dispersion method (MSPD) and HPLC quantification of four major anti-oxidant marker constituents (vitamin C, gallic acid, rutin & ellagi...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Nanostructured liquid crystalline formulation as a remarkable new drug delivery system of anti-epileptic drugs for treating children patients
ConclusionsCubosomal-gel could be considered an innovative dosage-form for Cl through the transdermal route. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antibacterial prophylaxis in pediatric patients with leukemia
ConclusionAntibacterial prophylaxis mainly with coverage against Gram-positive bacteria is recommended in pediatric patients with AML. For ALL patients, prophylaxis may be considered for patients who are undergoing intensive chemotherapy phases and are at high risk for infections with ciprofloxacin being the most commonly used agent. In general more studies are needed to determine the role of antibacterial prophylaxis in pediatric patients with leukemia. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Vitamin B12 protects against DNA damage induced by hydrochlorothiazide
In this study, we aimed to investigate the harmful effects of hydrochlorothiazide on DNA by measuring the spontaneous frequency of sister chromatid exchanges (SCEs) in cultured human lymphocytes. We also aimed to investigate the possible protection of that damage by vitamin B12. The results showed that hydrochlorothiazide (5 µg/mL) significantly increased the frequency of sister chromatid exchanges (P 
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

New derivatives of hydrogenated pyrido[4,3-b]indoles as potential neuroprotectors: Synthesis, biological testing and solubility in pharmaceutically relevant solvents
Publication date: Available online 6 April 2018Source: Saudi Pharmaceutical JournalAuthor(s): Svetlana Blokhina, Angelica Sharapova, Marina Ol'khovich, Anatoly Ustinov, German PerlovichAbstractThe derivatives of hydrogenated pyrido[4,3-b]indoles as potential neuroprotectors have been synthesized. The different substituents were introduced into position 8 of the carboline fragment of the molecule: methyl-, methoxy-, fluorine- and chlorine-. Biological tests have shown that all the studied compounds can modulate glutamate-dependent uptake of calcium ions in rats’ cerebral cortex synaptosomes. The shake-flask method was...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

An exploration of parents’ knowledge, attitudes and practices towards the use of antibiotics in childhood upper respiratory tract infections in a tertiary Jordanian Hospital
ConclusionThe results demonstrated the need for educational interventions to increase the awareness of parents about antibiotics to reduce inappropriate use and its consequences. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

A Survey on Traditional Plants Used in Al Khobah Village
Publication date: Available online 11 April 2018Source: Saudi Pharmaceutical JournalAuthor(s): Maged S. Abdel-Kader, Ali M.A. Hazazi, Osman A. Elmakki, Saleh I. AlqasoumiAbstractThe use of traditional medicine for treatment of various diseases is a common practise in most of the developing countries including the Kingdom of Saudi Arabia especially in rural areas. In this survey, Al Khobah village was selected to study the status of Traditional Medicine. Al Khobah village is located on the Southern boarders of the kingdom and characterized by diverse topography and moderate weather. The plants with medicinal uses were colle...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Sodium polystyrene sulfonate induced intestinal necrosis; a case report
ConclusionSPS is commonly used to decrease potassium levels. SPS has been reported to be associated with several gastrointestinal complications. FDA issued warning against the use of SPS in patients at risk for complications. Here we report a case with SPS induced colonic necrosis in the absence of risk factors reported in the literature. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Rivaroxaban prescribing in a Saudi tertiary care teaching hospital
ConclusionsThe introduction of oral rivaroxaban represents a paradigm shift in anticoagulation management. Future longer, larger multi-center research is needed to identify the most effective interventions to enhance rivaroxaban knowledge translation and reduce the likelihood of inappropriate rivaroxaban prescribing and associated economic and side effects sequelae. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Patterns of antibiotic use and administration in hospitalized patients in Jordan.
Publication date: Available online 18 April 2018Source: Saudi Pharmaceutical JournalAuthor(s): Anan S. Jarab, Tareq L. Mukattash, Buthaina Nusairat, Mohammad Shawaqfeh, Rana Abu Farha (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

A comprehensive review on Brigatinib – A wonder drug for targeted cancer therapy in non-small cell lung cancer
This article is intended to provide readers with an overview of chemistry, pharmacokinetic, pharmacodynamic and safety profile of brigatinib, which addresses an unmet medical need. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Development of differentiated pharmaceutical packaging for greater autonomy and quality of life for physically and visually impaired patients
Publication date: Available online 25 April 2018Source: Saudi Pharmaceutical JournalAuthor(s): Beatriz Gamberini Cernic, Ana Carolina Kogawa, Hérida Regina Nunes SalgadoAbstract20–45% of the world population present special needs, permanent or provisional. This index is higher than that presented by the WHO, which determines that 10% of a country's population has some kind of disabled, in times of peace. This work proposes, focused on Assistive Technology, to seek solutions to daily problems encountered during the distribution of toothpaste for the toothbrushing of persons with visual impairment or with reduce...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Physical and chemical screening of honey samples available in the Saudi market: An important aspect in the authentication process and quality assessment
Publication date: Available online 25 April 2018Source: Saudi Pharmaceutical JournalAuthor(s): Haya I. Aljohar, Hadir M. Maher, Jawza Albaqami, Maha Al-Mehaizie, Rawan Orfali, Razan Orfali, Sarah AlrubiaAbstractHoney is becoming accepted as a reputable and effective therapeutic agent by practitioners of conventional medicine and by the general public. It has many biological activities and has been effectively used in the treatment of many diseases, e.g. gastrointestinal diseases, skin diseases, cancer, heart diseases, and neurological degeneration. Honey is an excellent source of energy containing mainly carbohydrates and ...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Knowledge, attitudes & practices of healthcare professionals in hospitals towards the reporting of adverse drug reactions in Saudi Arabia: A multi-centre cross sectional study
Publication date: Available online 26 April 2018Source: Saudi Pharmaceutical JournalAuthor(s): Thamir M. AlShammari, Mohammed J. AlmoslemAbstractIntroductionAdverse drug reactions (ADRs) are a major global clinical problem, causing substantial mortality and morbidity especially in hospitals. Healthcare professionals (HCPs) knowledges’, attitude and practices are crucial points to evaluate the hospital safety environment. Objective of the study was to investigate the knowledge, attitudes, and practices of HCPs regarding the ADRs reporting system.MethodsA cross-sectional survey was conducted between January and Februar...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Investigate the effect of solvents on wet granulation of microcrystalline cellulose using hydroxypropyl methylcellulose as a binder and evaluation of rheological and thermal characteristics of granules
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Dharti Tank, Kapish Karan, Bhavin Y. Gajera, Rutesh H. DaveAbstractWet granulation is the most commonly used technique in the pharmaceutical industry for delivering oral solid dosage forms. In wet granulation, the binder solvent is one of the critical factors affecting granule properties. In the current study, an attempt was made to investigate the effect of solvents (aqueous and hydro-alcoholic) on thermal and flow properties of Microcrystalline Cellulose (MCC) granules prepared using two different grades of Hydroxypropyl Methylce...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Newly developed controlled release subcutaneous formulation for tramadol hydrochloride
This study presents a drug delivery system of poly (Ɛ-caprolactone) (PCL) ribbons to optimize the pharmaceutical action of tramadol for the first time according to our knowledge. PCL ribbons were fabricated and loaded with tramadol HCl. Ribbons were prepared by slip casting technique and coated with dipping technique with β-cyclodextrin. The chemical integrity and surface morphology of the ribbons were confirmed using FTIR and SEM coupled with EDX. In addition, thermodynamic behavior of the fabricated ribbons was investigated using DSC/TGA. Tramadol loading into PCL ribbons, biodegradation of ribbons and tramadol rel...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Comparison between the dissolution profiles of nine meloxicam tablet brands commercially available in Buenos Aires, Argentina
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Laura D. Simionato, Luciana Petrone, Mariela Baldut, Silvina L. Bonafede, Adriana Inés SegallAbstractIn this work, the dissolution profiles of nine meloxicam tablet brands marketed in Argentina have been evaluated. As meloxicam is a Class 2 Biopharmaceutical Classification System (BSC) drug, interchangeability between commercial products must be demonstrated through in vivo bioequivalence studies. However, in our country, such studies remain to be performed.Dissolution studies have been performed according to USP 38 and eval...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moieties
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Nazar Trotsko, Urszula Kosikowska, Agata Paneth, Monika Wujec, Anna MalmAbstractA series of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moiety (28–65) were synthesized by the reaction of (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid chlorides with 5-(hydroxybenzylidene) thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin derivatives. Obtained compounds (28–65) were tested on reference strains of Gram-positive bacteria and ones of the Gram-n...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Inverse docking based screening and identification of protein targets for Cassiarin alkaloids against Plasmodium falciparum
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Arvind Negi, Nitisha Bhandari, Bharti Rajesh Kumar Shyamlal, Sandeep ChaudharyAbstractVarious reports have shown Cassiarin alkaloids, selective in vitro activities against various strains of Plasmodium falciparum with low cytotoxicity, which indicates their possible candidature as antimalarial drug. However, poor recognition of their protein targets and molecular binding behaviour, certainly limits their exploration as antimalarial drug candidature. To address this, we utilises inverse screening, based on three different docking me...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

In – Vitro activity of Desmostachya bipinnata (L.) Stapf successive extracts against Helicobacter pylori clinical isolates
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Nermin H. Ibrahim, Amani S. Awaad, Rawan A. Alnafisah, Saleh I. Alqasoumi, Reham.M. El-Meligy, Amani Z. MahmoudAbstractHelicobacter pylori are well acknowledged as a major cause of gastrointestinal ailments and gastric cancers. Therefore, the present study aimed to investigate the potential in vitro activity of Desmostachya bipinnata against H. pylori, focusing on the determination of the most active extract responsible for the anti-helicobacter activity to produce new active drug from natural source.Desmostachya bipinnata total al...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Assessment of knowledge, attitude and practice of adverse drug reaction reporting among healthcare professionals in secondary and tertiary hospitals in the capital of Pakistan
This study was designed to assess the knowledge, attitude, practice and factors associated with ADR reporting by healthcare professionals (physicians and pharmacists) in secondary and tertiary hospitals of Islamabad. A pretested questionnaire comprising of 27 questions (knowledge 12, attitude 4, practice 9 and factors influencing ADR reporting 2) was administered to 384 physicians and pharmacists in public and private hospitals. Respondents were evaluated for their knowledge, attitude and practice related to ADR reporting. Additionally, the factors which encourage and discourage respondents to report ADRs were also determi...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

GC quantitative analysis of benzyl isothiocyanate in Salvadora persica roots extract and dental care herbal products
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Maged Saad Abdel-Kader, Elsadig Hassan Khamis, Ahmed Ibrahim Foudah, Mohammed Hamed AlqarniAbstractAn accurate, sensitive, precise and simple method was developed utilizing Gas Chromatography for the quantitative analysis of benzyl isothicyanate in Siwak extract and dental care herbal products claimed to contain Siwak. Rtx (30.0 m × 0.25 mm ID, 25 µm thickness) column was used and helium as carrier gas at a flow rate of 0.74 mL/min. The retention time of standard benzyl isothicyanate was 13.470 min under t...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Robert Skibiński, Jakub Trawiński, Łukasz Komsta, Diana MurzecAbstractForced degradation of toloxatone in solutions under basic, acidic, neutral, photo UV–VIS, photo UVC and oxidative stress conditions was investigated and structural elucidation of its degradation products was performed with the use of UHPLC system coupled ESI-Q-TOF mass spectrometer. Eight degradation products were found and their masses and formulas were obtained with high accuracy (0.09–3.79 ppm). The structure of unknown degradation products we...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical pharmacy in Kuwait: Services provided, perceptions and barriers
ConclusionAlthough clinical pharmacy is in its infancy in Kuwait, it is well perceived and requested by physicians. Major barriers must be addressed and in this context, having a national framework for pharmacy practice from Ministry of Health, supported by cutting edge education and a pro-active professional association would be key assets to evolve the practice in Kuwait. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

A qualitative study exploring patients’ experiences regarding insulin pump use
ConclusionFrom the perspective of adults with type 2 diabetes, there are lots of benefits of using insulin pumps over other insulin delivery methods, mainly seen by the improvement of quality of life and patients’ adherence to doses. Policy-makers and healthcare professionals (HCPs) must be aware of such benefits and should support the wider implementation of this technology in the country by including patients with type 2 diabetes. Results of this study will help to inform healthcare provision and guideline modifications and to provide guidance for new patients using this therapy. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of the hepatoprotective effect of combination between hinokiflavone and Glycyrrhizin against CCl4 induced toxicity in rats
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Maged S. Abdel-Kader, Ashraf T. Abulhamd, Abubaker M. Hamad, Abdullah H. Alanazi, Rizwan Ali, Saleh I. AlqasoumiAbstractLiver diseases are one of the fatal syndromes due to the vital role of the liver. Most of the effective treatment of liver conditions are of natural origin. Silymarin (SI) is the standard drug used for treatment of impaired liver functions. Two natural compounds possessing promising liver protection and with different chemical structures namely; the bioflavonoid hinokiflavone (HF) isolated from Junipers phoenicea ...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Phytochemical contents and biological evaluation of Ruta chalepennsis L. growing in Saudi Arabia
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Shorok M. Alotaibi, Monerah S. Saleem, Jehan G. Al-humaidiAbstractPhytochemical screening of Ruta chalepensis L. exhibited the presence of different chemical groups. The dried aerial parts of the plant was total extracted by ethanol and successively using chloroform, ethyl acetate and Butanol, out of the successive extracts four compounds namely, scopletin, kaempferol, quercetin, quercetin 3-O-α-L-rhamno glucopyranosyl (Rutin) were isolated and biological evaluations. Total ethanol and successive extracts; chloroform, ethyl a...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmaceutical significance of Leuconostoc mesenteroides KS-TN11 isolated from Nile Tilapia, Oreochromis niloticus
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Bilal Ahmad Paray, Irfan A. Rather, Mohammad K. Al-Sadoon, Al-Shammari Fanar HamadAbstractAquatic animals are known for their myriad of beneficial bacteria with diverse biologically active compounds. The current study was aimed to isolate and characterize potentially beneficial lactic acid bacteria from Nile Tilapia and evaluate their pharmaceutical applications. The fish samples were dissected and stomach, intestine, and gills were collected and serially diluted for the isolation of lactic acid bacteria (LAB) on BCP agar media. Id...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Aggregation and conformational stability evaluation of myoglobin in the presence of ionic surfactant
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Mohammad A. AlsenaidyAbstractSodium lauroyl sarcosinate (SLS) is frequently used for the solubilization of inclusion bodies in vitro due to its structural similarity to lipid plasma membrane. There are many factors that could influence protein aggregation propensity, including overall protein surface charge and hydrophobicity. Here, the aggregation pathway of myoglobin protein was studied under different conditions (pH 3.5 and 7.4) in the presence of varying concentrations of SLS to evaluate the underlying forces dictating protein ...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Revisiting the systemic lipopolysaccharide mediated neuroinflammation: Appraising the effect of l-cysteine mediated hydrogen sulphide on it
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Abdulaziz S. Al-Saeedan, Varsha Gautam, Mohd Nazam Ansari, Manjari Singh, Rajnish K. Yadav, Jitendra K. Rawat, Uma Devi, Swetlana Gautam, Subhadeep Roy, Gaurav KaithwasAbstractThe present research was ventured to examine the effect of l-cysteine on neuro-inflammation persuaded by peripheral lipopolysaccharides (LPS, 125 μg/kg, i.p.) administration. No behavioral, biochemical, and inflammatory abnormality was perceived in the brain tissues of experimental animals after LPS administration. l-cysteine precipitated marginal sympto...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Self-emulsifying drug delivery system improves preventive effect of curcuminoids on chronic heart failure in rats
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Yunbin Jiang, Junzhi Wang, Yunhong Wang, Xiumei Ke, Chuanhui Zhang, Rongping YangAbstractSeveral studies have reported the preventive or therapeutic effect of curcuminoids on chronic heart failure (CHF), but their application was limited due to low solubility and bioavailability. Our previous study indicates that self-emulsifying drug delivery system (SEDDS) improves the solubility and bioavailability of curcuminoids. Thus, the aim of this work was to investigate whether SEDDS could improve preventive effect of curcuminoids on CHF ...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The possible mechanisms of protocatechuic acid-induced central analgesia
Publication date: May 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 4Author(s): Rana Arslan, Sule Aydin, Dilara Nemutlu Samur, Nurcan BektasAbstractIt is aimed to investigate the central antinociceptive effect of protocatechuic acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C, α2-adrenergic and muscarinic receptors in protocatechuic acid-induced central analgesia in mice. Time-dependent antinociceptive effects of protocatechuic acid at the oral doses of 75, 150 and 300 mg/kg were tested in hot-plate (integrated supraspinal response) and tail-immersion (spinal reflex) tests in...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The relationship between blood eosinophil count and disease activity in ankylosing spondylitis patients treated with TNF-α inhibitors
Publication date: Available online 4 May 2018Source: Saudi Pharmaceutical JournalAuthor(s): Gokhan Sargin, Taskin Senturk, Irfan YavasogluAbstractAimAnti-tumor necrosis factor-alpha (Anti-TNF-α) therapy has achieved an important position, are widely used for ankylosing spondylitis (AS) patients. TNF-α inhibition improves clinical outcomes and has differential effects on haematopoiesis. Information about effects on eosinophils is limited. The aim of our study is to determine the relationship between blood eosinophil counts in AS patients treated with TNF-α inhibitors.MethodsSeventy-five patients diagnosed ...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Drug Shortages in Saudi Arabia: Root Causes and Recommendations
Publication date: Available online 12 May 2018Source: Saudi Pharmaceutical JournalAuthor(s): Yazed S. Alruthia, Monira Alwhaibi, Mashal F. Alotaibi, Shatha A. Asiri, Bushra M. Alghamdi, Ghadah S. Almuaythir, Wejdan R. Alsharif, Hala H. Alrasheed, Yahya A. Alswayeh, Abdulaziz J. Alotaibi, Mohammad Almeshal, Saleh N. Aldekhail, Abdulrahman Alhusaini, Sulaiman A. Alrashed, Ali M. Alrumaih, Mohammed A. Dahhas, Mohammed A. Alghamdi, Mohammad S. Aleheidib, Mohamed H. Alhaidari, Jameel A. AlharbiAbstractDrug shortages are a multifaceted problem that has been recurring in Saudi Arabia over the past decade with its significant nega...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of anti-ulcer and ulcerative colitis of Sonchus oleraceus L
Publication date: Available online 12 May 2018Source: Saudi Pharmaceutical JournalAuthor(s): Esraa A. Alothman, Amani S. Awaad, Amal A. Safhi, Shekhah S. Almoqren, Reham M. El-Meligy, Yara M. Zain, Fatmah A. Alasmary, Saleh I. AlqasoumiAbstractSonchus oleraceus L. was evaluated for its gastro antiulcerogenic and anti-ulcerative colitis activities Different extracts and fractions from Sonchus oleraceus aerial parts and roots were evaluated at different dose; total alcohol extracts of aerial parts SA and roots SR were evaluated doses 250 & 500 mg/kg, While Successive extracts (SAL, SRL, CSA, CSR, BSA & BSR) were ev...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anticancer effect of Cenchrus ciliaris L
Publication date: Available online 12 May 2018Source: Saudi Pharmaceutical JournalAuthor(s): Esraa A. Alothman, Amani S Awaad, Norah A. Al-Qurayn, Haya F. Al-Kanhal, Reham M. El-Meligy, Yara M. Zain, Fatmah A. Alasmary, Saleh I. AlqasoumiAbstractCenchrus ciliaris L total alcohol and successive extracts of both aerial and root parts were tested for their anticancer activities against lung (A-549), intestinal (CACO), colon (HCT-116), cervical (Hela), hepatocellular (HepG-2), and breast (MCF-7) (PC3) cell lines and compared with the standard drug vinblastine sulphate. The obtained results exhibited direct cytotoxic effect wit...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Development and validation of UPLC-PDA method for concurrent analysis of bergenin and menisdaurin in aerial parts of Flueggea virosa (Roxb. ex Willd.)
Publication date: Available online 22 May 2018Source: Saudi Pharmaceutical JournalAuthor(s): Afzal Hussain, Perwez Alam, Nasir Ali Siddiqui, Mohamed Fahad Alajmi, Md Tabish Rehman, Mohd Abul Kalam, Adnan Jathlan Al-RehailyAbstractBergenin and menisdaurin are biologically active components which are found in plant Flueggea virosa (Phyllanthaceae). Bergenin has pharmacological actions such as chemopreventive and antihepatotoxic while menisdaurin has an anti-viral activity which needs its evaluation by an analytical method (UPLC-PDA method) that can be applied to the quality control of pharmaceutical preparations. The develop...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research