Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques
Publication date: Available online 14 November 2018Source: Saudi Pharmaceutical JournalAuthor(s): Sultan M. Alshehri, Faiyaz Shakeel, Mohamed A. Ibrahim, Ehab M. Elzayat, Mohammad Altamimi, Kazi Mohsin, Osaid T. Almeanazel, Musaed Alkholief, Abdullah Alshetaili, Bader Alsulays, Fars K. Alanazi, Ibrahim A. AlsarraAbstractApigenin (APG) is a poorly soluble bioactive compound/nutraceutical which shows poor bioavailability upon oral administration. Hence, the objective of this research work was to develop APG solid dispersions (SDs) using different techniques with the expectation to obtain improvement in its in vitro dissoluti...
Source: Saudi Pharmaceutical Journal - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Psychotropic Drug-Prescribing Correlates of Disorganized Speech in Asians with Schizophrenia: The REAP-AP Study
Publication date: Available online 13 November 2018Source: Saudi Pharmaceutical JournalAuthor(s): Yong Chon Park, Min-Soo Lee, Tian-Mei Si, Helen F.K. Chiu, Shigenobu Kanba, Mian-Yoon Chong, Adarsh Tripathi, Pichet Udomratn, Kok Yoon Chee, Andi J. Tanra, Golam Rabbani, Afzal Javed, Samudra Kathiarachchi, Win Aung Myint, Tran Van Cuong, Kang Sim, Shu-yu Yang, Norman Sartorius, Chay-Hoon Tan, Naotaka ShinfukuAbstractBackgroundAlthough disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large sample...
Source: Saudi Pharmaceutical Journal - November 14, 2018 Category: Drugs & Pharmacology Source Type: research

Assessment of the risk of QT-interval prolongation associated with potential drug-drug interactions in patients admitted to Intensive Care Units
ConclusionsIn patients exposed to drugs associated with prolonged QTc in the 24 hours prior to ICU admission, pharmacodynamic DDIQT are associated with increased risk of QTc prolongation. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 11, 2018 Category: Drugs & Pharmacology Source Type: research

Practices, Awareness and Attitudes toward Self-Medication of Analgesics Among Health Sciences Students in Riyadh, Saudi Arabia
Publication date: Available online 10 November 2018Source: Saudi Pharmaceutical JournalAuthor(s): Mohammed Al Essa, Abdulmajeed Alshehri, Mohammed Alzahrani, Rami Bustami, Shazia Adnan, Atheer Alkeraidees, Amjad Mudshil, Jawaher Gramish (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 11, 2018 Category: Drugs & Pharmacology Source Type: research

Are dietary supplements containing plant-derived ingredients safe microbiologically?
Publication date: Available online 10 November 2018Source: Saudi Pharmaceutical JournalAuthor(s): Jolanta Dlugaszewska, Magdalena Ratajczak, Dorota Kamińska, Marzena GajeckaAbstractDietary supplements, particularly those containing ingredients of natural origin, may contain microbiological contaminants, both bacterial and fungal.The present study evaluated the microbiological purity of selected dietary supplements containing plant-based ingredients before their release to the market, as well as raw materials of plant origin which are used in the production of such supplements. A total of 122 samples of supplements and 30 ...
Source: Saudi Pharmaceutical Journal - November 11, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Hydroxylated Solvents on the Active Constituents of Salvadora persica root “Siwak”
In conclusion extraction of S. persica with hydroxylated solvents will alter the structure of the active compound benzyl isothiocyanate and leads to loss of antimicrobial activity. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Attitude and Knowledge of Saudi community pharmacists towards Use of Proton Pump Inhibitors
ConclusionCommunity pharmacists in Saudi Arabia usually recommend and prescribe PPIs to their patients. Most of them have some knowledge on PPIs indications and side effects. Managing OTC PPI use in the community pharmacy setting is necessary to promote both patient and medication safety. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: November 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 7Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - October 31, 2018 Category: Drugs & Pharmacology Source Type: research

Identifying treatment related problems and associated factors among hospitalized post-stroke patients through medication management review: a multi-center study
ConclusionLack of drug efficacy, inappropriate drug adherence and patient knowledge were the major TRPs identified via delivering the MMR service to post-stroke patients. The identified TRPs highlights the importance of the MMR service, and supports planning future strategies aimed at decreasing the incidence of strokes. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Utilizing Mixer Torque Rheometer in the Prediction of Optimal Wet Massing Parameters for Pellet Formulation by Extrusion/Spheronization
In conclusion, wet granulations can be controlled by monitoring the composition of the binder solution and pellet composition. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Exploring healthcare professionals’ perceptions of medication errors in an adult oncology department in Saudi Arabia: A qualitative study
ConclusionThere were numerous causes for medication errors in the adult oncology department. This means substantive improvement in medication safety is likely to require multiple, inter-relating, complex interventions. More research should be conducted to examine context-specific interventions that may have the potential to improve medication safety in this and similar departments. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - October 17, 2018 Category: Drugs & Pharmacology Source Type: research

Cassia grandis Lf nanodispersion is a hypoglycemic product with a potent α-glucosidase and pancreatic lipase inhibitor effect
This study aimed to evaluate the hypoglycemic effect, antioxidant, α-glucosidase and lipase inhibitory activity, and the cytotoxicity of the Cassia grandis nanodispersion (CgND).MethodsThe hypoglycemic effect was evaluated in alloxan-induced diabetic mice. The particle size, polydispersion index, ζ-potential, and conductivity, as well as the drug-loaded content, were monitored in shelf-live, along a year. The delivery profile was evaluated in simulated intestinal fluids at pH 6.5 and 7.4. The antioxidant effect was evaluated as DPPH and ABTS inhibition. The murine α-glucosidase inhibitory activity and the ...
Source: Saudi Pharmaceutical Journal - October 17, 2018 Category: Drugs & Pharmacology Source Type: research

Vitamin D status in relation to age, bone mineral density of the spine and femur in obese Saudi females- a hospital-based study
In this study; 120 obese Saudi females with no diagnosed chronic diseases attending the Outpatient clinic at king Abdul-Aziz University hospital in Riyadh. Saudi Arabia, recruited randomly in period of 12 months. In this study, Serum levels of total Vitamin D were considered to be severe deficient if it was lower than 25 ng/mL, mild to moderate deficient if it was between 25 and 60 ng/mL and optimum level if it was 61-200 ng/mL. The results showed that; sun exposure was significantly affect and corelate with serum level of Vitamin D in the subjects. In addition, daily consumption of Vitamin D supplement was significantly a...
Source: Saudi Pharmaceutical Journal - October 17, 2018 Category: Drugs & Pharmacology Source Type: research

Knowledge and attitude towards dentist-industry relationship and their association with own behavior among dentists working in Saudi Arabia
Publication date: Available online 18 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Abdulaziz M. Albaker, Fahad D. AlosaimiAbstractObjectivesTo examine the knowledge and attitude towards dentist-industry relationship including accepting gifts, influence on decisions, and accuracy of given information among dentists working in Saudi Arabia. In addition, to examine the association of such knowledge and attitude of dentists' behavior with industry, including sorts of interaction and accepting industrial gifts.MethodsA cross-sectional study was conducted among dental practitioners working in the private and gove...
Source: Saudi Pharmaceutical Journal - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Ocular Administration of Acetazolamide Microsponges In situ Gel Formulations
Publication date: Available online 24 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Manar M. Obiedallah, A.M. Abdel-Mageed, Tahani H. ElfahamAbstractIn the present work, the antiglaucoma drug, acetazolamide, was formulated as microsponges in situ gel for ocular drug delivery aiming an improved therapeutic efficacy and reduction in the systemic side effects of oral acetazolamide. The microsponges were prepared by the quasi emulsion solvent diffusion method and were incorporated into 25% pluronic F-127 in situ gel. Ethyl cellulose polymer in different proportions with drug was used to prepare the microsponges....
Source: Saudi Pharmaceutical Journal - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Comparative evaluation of cytotoxic, antimicrobial and antioxidant activities of the crude extracts of three Plectranthus species grown in Saudi Arabia
Publication date: Available online 25 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Ramzi A. Mothana, Jamal M. Khaled, Ali A. El-Gamal, Omar M. Noman, Ashok Kumar, Mohamed F. Alajmi, Adnan J. Al-Rehaily, Mansour S. Al-SaidAbstractNatural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate t...
Source: Saudi Pharmaceutical Journal - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Influence of chitosan coating on the oral bioavailability of gold nanoparticles in rats
This study evaluated the oral bioavailability of gold nanoparticles coated with chitosan (C-AuNPs), a natural mucoadhesive polymer. We employed traditional method of evaluating bioavailability that involve estimation of maximum concentrations and area under the curve of 3 nm chitosan coated gold nanoparticles (C-AuNPs) in the rat plasma following intravenous and oral administrations (0.8 mg and 8 mg /kg body weight respectively). The oral bioavailability of C-AuNPs was found to be 2.46 % (approximately 25 folds higher than polyethylene glycol (PEG) coated gold nanoparticles, reported earlier). These findings suggest that c...
Source: Saudi Pharmaceutical Journal - September 22, 2018 Category: Drugs & Pharmacology Source Type: research

The Knowledge and Attitude towards Dentist-Industry Relationship and their Association with own Behavior among Dentists Working in Saudi Arabia
Publication date: Available online 18 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Abdulaziz M. Albaker, Fahad Dakheel AlosaimiAbstractObjectivesTo examine the knowledge and attitude towards dentist-industry relationship including accepting gifts, influence on decisions, and accuracy of given information among dentists working in Saudi Arabia. In addition, to examine the association of such knowledge and attitude of dentists' behavior with industry, including sorts of interaction and accepting industrial gifts.MethodsA cross-sectional study was conducted among dental practitioners working in the private and...
Source: Saudi Pharmaceutical Journal - September 19, 2018 Category: Drugs & Pharmacology Source Type: research

Pregnant women’s use and attitude toward herbal, vitamin, and mineral supplements in an academic tertiary care center, Riyadh, Saudi Arabia
ConclusionThe prevalence of using herbal medicine is considerably high among pregnant women in Saudi Arabia. Unfortunately, the majority of the users relied on informal sources to use herbal medicine during pregnancy. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - September 18, 2018 Category: Drugs & Pharmacology Source Type: research

“Pregnant women’s use and attitude toward herbal, vitamin, and mineral supplements in an academic tertiary care center, Riyadh, Saudi Arabia”
ConclusionThe prevalence of using herbal medicine is considerably high among pregnant women in Saudi Arabia. Unfortunately, the majority of the users relied on informal sources to use herbal medicine during pregnancy. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Quantification of the Constituents of the Traditional Korea Medicine, Samryeongbaekchul-San, and Assessment of its Antiadipogenic Effect
Publication date: Available online 11 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Chang-Seob Seo, Sae-Rom Yoo, Soo-Jin Jeong, Hyekyung HaAbstractSamryeongbaekchul-san (SBS) is a traditional herbal formula, which is used for the treatment of dyspepsia, chronic gastritis, and anorexia in Korea. To evaluate the quality of SBS decoction by quantifying its main constituents simultaneously using high-performance liquid chromatography coupled with photodiode array (HPLC–PDA) detection, and secondly to determine the antiadipogenic effect of SBS decoction. The main constituents in a 10-μL injection volume ...
Source: Saudi Pharmaceutical Journal - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study
Publication date: Available online 11 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Abdulrahman A. Almehizia, Hatem H. Abuelizz, Hanan A.A. Taie, Anouar ElHassane, Mohamed Marzouk, Rashad Al-SalahiAbstractPreviously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1-16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1-16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines sh...
Source: Saudi Pharmaceutical Journal - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical Composition and Biological Activity of the Essential Oil from the Root of Jatropha pelargoniifolia Courb. Native to Saudi Arabia
Publication date: Available online 11 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Hanan Aati, Ali El-Gamal, Oliver KayserAbstractThe chemical composition of the essential oil from Jatropha pelargoniifolia roots was determined via GC-FID. There were 80 compounds, representing 99.99% of the total oil constituents. Among these, 77.31% were sesquiterpenes, 14.62% were fatty acids, 7.21% were other components (i.e., phenolics, hydrocarbons, etc.), and 0.85% were monoterpenes. The major compounds in the oil were γ-eudesmol (35.31%), 5-guaien-11-ol (14.43%), epi-cedrol (8.19%), oleic acid (5.23%), bulnesol ...
Source: Saudi Pharmaceutical Journal - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

Adherence to oral glucose lowering drugs, quality of life, treatment satisfaction and illness perception: A cross-sectional study in patients with type 2 diabetes
ConclusionPerceived effectiveness and patient’s quality of life seem to be important parameters enhancing adherence. Based on this study, planning interventions to enhance treatment adherence and improve the quality of life is crucial for all diabetic patients. Additional efforts are suggested to be made by concerned authorities to set up awareness campaigns to increase alertness on the importance of adherence to medications in diabetics. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - September 8, 2018 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: September 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 6Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - September 7, 2018 Category: Drugs & Pharmacology Source Type: research

Patterns of antibiotic use and administration in hospitalized patients in Jordan
ConclusionThis study shows a shortage in the implementation of guidelines which are important to decrease antibiotic resistance and improving clinical outcomes. The clinical Pharmacist needs to be more involved in antibiotics prescription with the aim of improving effectiveness and decreasing potential antimicrobial resistance in hospital settings. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - September 7, 2018 Category: Drugs & Pharmacology Source Type: research

Knowledge and Attitude Towards Antibiotic Use Within Consumers in Alkharj, Saudi Arabia
ConclusionThe participants who have good knowledge towards antibiotics use showed positive attitude towards antibiotics use. Some specific groups should to be targeted for educational intervention in terms of appropriate antibiotic use, such as those who have received a low level of education and are in receipt of a low monthly income. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - September 6, 2018 Category: Drugs & Pharmacology Source Type: research

Transdermal Patches Loaded with L-Cysteine HCL as a Strategy for Protection from Mobile Phone Emitting Electromagnetic Radiation Hazards
Publication date: Available online 5 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Samia M. Omar, Mohamed Nasr, Diana A. RaflaAbstractMobile phone usage has been increased in the last few years emitting electromagnetic radiation (EMR), which disturbs normal cellular processes via oxidative stress. L-cysteine, a glutathione precursor, prevents oxidative damage. Transdermal patches (TDPs) loaded with L-cysteine hydrochloride (L-CyS-HCL) were fabricated by dispersion of L-CyS-HCL 5% w/w and different concentrations of sorbitol as a plasticizer in room-temperature vulcanizable synthetic silicone matrices (RTV-Si...
Source: Saudi Pharmaceutical Journal - September 5, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro dissolution and bioavailability study of furosemide nanosuspension prepared using design of experiment (DoE)
ConclusionsFurosemide nanosuspensions prepared using antisolvent precipitation method enhanced the dissolution rate and oral bioavailability compared to raw furosemide powder. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - September 4, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation, characterization, and antibacterial activity of diclofenac-loaded chitosan nanoparticles
Publication date: Available online 29 August 2018Source: Saudi Pharmaceutical JournalAuthor(s): Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Eram El Tahir, Bushra T. AlQuadeib, Ibrahim A. Alsarra, Jouri S. Alanazi, Hosam Gharib AbdelhadyAbstractEmerging antibiotic resistance necessitates the development of new therapeutic approaches. Many studies have reported the antimicrobial activity of diclofenac sodium (DIC) and chitosan nanoparticles (CNPs). Hence, this study aimed to prepare non-antibiotic DIC-loaded CNPs (DIC.CNPs) and characterize their in vitro antibacterial activity. DIC.CNPs were prepared from low and high m...
Source: Saudi Pharmaceutical Journal - August 29, 2018 Category: Drugs & Pharmacology Source Type: research

Development and validation of a new HPLC analytical method for the determination of diclofenac in tablets
Publication date: Available online 3 August 2018Source: Saudi Pharmaceutical JournalAuthor(s): Bushra tuwfeeq alquadeibAbstractA new selective and sensitive high-performance liquid chromatography (HPLC) method was developed for the quantification of diclofenac sodium (DS) in pharmaceutical dosage form using lidocaine as internal standard (IS). Chromatographic separation was achieved on a symmetry C18 column (4.6 mm × 150 mm, 3 μm spherical particles using 0.05M orthophosporic (pH 2.0) 35% and acetonitrile as 65%, as the mobile phase at a flow rate of 2.0 mL/min and monitored at 210 nm. The run time was 2 min.The m...
Source: Saudi Pharmaceutical Journal - August 4, 2018 Category: Drugs & Pharmacology Source Type: research

Prevalence of Torsades de Pointes Inducing Drugs Usage among Elderly Outpatients in North Jordan Hospitals
ConclusionHigh usage of TdP-inducing drugs among geriatric patients in North Jordan demonstrated the urgent need for increasing awareness of TdP’s risk induced by commonly prescribed medications. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 30, 2018 Category: Drugs & Pharmacology Source Type: research

Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation
Publication date: Available online 29 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Bilal Ahmad, Muneeb U Rehman, Insha Amin, Manzoor ur Rahman Mir, Sheikh Bilal Ahmad, Adil Farooq, Showkeen Muzamil, Ishraq Hussain, Mubashir Masoodi, Bilques FatimaAbstractDiabetes is considered as the most common metabolic disease affecting millions of people all around the world. Use of natural herbal medicines can be effective in treating diabetes. Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) a polyphenolic alkanone extracted from ginger has a broad spectrum of pharmacological properties and thus can be used as a promis...
Source: Saudi Pharmaceutical Journal - July 29, 2018 Category: Drugs & Pharmacology Source Type: research

Green Chromatographic Method for Analysis of Some Anti-Cough Drugs and Their Toxic Impurities with Comparison to Conventional Methods
Publication date: Available online 25 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Eglal A. Abdelaleem, Nada S. AbdelwahabAbstractToxic solvents are widely used in chemical laboratories, which are dangerous on health, safety of workers, and environment. Green chemistry established different principles to keep safety of environment, one of these goals is to replace toxic solvents by greener alternatives or by minimizing the used volumes.Paracetamol (PAR), Guaifenesin (GUF), Oxomemazine (OX), and Sodium benzoate (SB) combination is a widely used cough preparation. 4- aminophenol (4-AP) is PAR poisonous impurity an...
Source: Saudi Pharmaceutical Journal - July 26, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacists' interventions to reduce sedative/hypnotic use for insomnia in hospitalized patients
ConclusionThis study suggests that the use of sedative/hypnotics in the inpatient units (excluding the critical care unit), is somewhat prevalent, and many patients may be on more than one sedative/hypnotic, which could potentially cause cumulative harm. During the intervention phase, 25% of the total in-hospital orders for sedative/hypnotics were discontinued following recommendations made by a pharmacist, and significantly lower number of patients receiving duplicate sedative/hypnotics was noted. Further efforts should be implemented to avoid unnecessary sedative/hypnotic initiation in hospitalized patients, and to ensur...
Source: Saudi Pharmaceutical Journal - July 25, 2018 Category: Drugs & Pharmacology Source Type: research

Colon targeted beads loaded with pterostilbene: Formulation, Optimization, Characterization and In vivo evaluation
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Mudassir Ansari, Bhakti Sadarani, Anuradha MajumdarAbstractPterostilbene has a proven chemopreventive effect for colon carcinogenesis but suffers low bioavailability limitations. To overcome this problem, pterostilbene was formulated into an oral colon targeted beads by ionic gelation method using pectin and zinc acetate. Optimization was carried out by 23 factorial design whereby the optimized formulation comprised of 2% w/v of pectin concentration (X1), 2% w/v of zinc acetate concentration (X2) and 1:4 of pterostilbene:pectin ra...
Source: Saudi Pharmaceutical Journal - July 21, 2018 Category: Drugs & Pharmacology Source Type: research

Evolution Of Green Chemistry And Its Multidimensional Impacts: A Review
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Bianca Aparecida de Marco, Bárbara Saú Rechelo, Eliane Gandolpho Tótoli, Ana Carolina Kogawa, Hérida Regina Nunes SalgadoAbstractThe growing process of industrialization was a milestone for world economic evolution. Since the 1940s, social movements have revolutionized green chemistry and provided shifts in industrial positions and sustainable processes with advances in environmental impact and awareness of companies and population. Paul Anastas and John Warner, in the 1990s, postulated the 12 principle...
Source: Saudi Pharmaceutical Journal - July 21, 2018 Category: Drugs & Pharmacology Source Type: research

The impact of dapagliflozin on glucose excursions related to early proatherogenic derangement in the aortic wall
ConclusionDapagliflozin provides not only mere beneficial regulation of metabolic status with the depletion of glucose variability, but is also helpful in the prevention of early atherosclerosis related to the course of diabetes type 2. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 21, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of the role of CDKN2B gene in type 2 diabetes mellitus and hypertension in ethnic Saudi Arabs
ConclusionsOur finding does not support the notion of a critical role for the CDKN2B gene locus as a HTN or T2DM cardiovascular risk in ethnic Arabs. The study also demonstrates the importance of replication studies in ascertaining the role of a genomic sequence in disease. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Invalid Freeze-dried Platelet Gel Promotes Wound Healing
In conclusion, IF-PG might be a resourceful alternative for the wound care management, however further studies are required to validate its impact on various growth factors before proceeding to clinical studies. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Ginkgolide C reduced oleic acid-induced lipid accumulation in HepG2 cells
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Wen-Chung Huang, Ya-Ling Chen, Hui-Chia Liu, Shu-Ju Wu, Chian-Jiun LiouAbstractGinkgolide C, isolated from Ginkgo biloba, is a diterpene lactone that has multiple biological functions and can improve Alzheimer disease and platelet aggregation. Ginkgolide C also inhibits adipogenesis in 3T3-L1 adipocytes. The present study evaluated whether ginkgolide C reduced lipid accumulation and regulated the molecular mechanism of lipogenesis in oleic acid-induced HepG2 hepatocytes. HepG2 cells were treated with 0.5 mM oleic acid for 48 h to ...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Extracellular Directed Ag NPs Formation and Investigation of Their Antimicrobial and Cytotoxic Properties
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Berrak Dumlupinar Altinsoy, Gokce Şeker Karatoprak, Ismail OcsoyAbstractThe use of microbial cell culture a valuable tool for the biosynthesis of nanoparticles is considered a green technology as it is eco-friendly, inexpensive and simple. Here, the synthesis of nanosilver particle (AgNP) from the yeast, Saccharomyces cerevisiae, gram (+), Bacillus subtilis and gram (-), Escherichia coli was shown. In this field we are the first to study their the antimicrobial effects of the microorganisms mentioned above against pathogens and a...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

An approach to enhanced stability: Formulation and characterization of Solanum lycopersicum derived lycopene based topical emulgel
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Sohail Muhammad, Akhtar Naveed, Rouf Abdul, Gulfishan, Hajji Muhammad Shoaib Khan, Hira KhanAbstractFocus of the study was to design a novel and cost effective extraction technique for the lycopene from Lycopersicum esculentum L. fruit and to develop and characterize a stable emulgel formulation containing lycopene as an active ingredient as well as to design an analytical method to determine lycopene concentration in emulgel. Emulgel formulation was prepared and evaluated for its stability at different storage conditions, 8 oC, 2...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

“Pharmacists’ Interventions to Reduce Sedative/Hypnotic Use for Insomnia in Hospitalized Patients”
ConclusionThis study suggests that the use of sedative/hypnotics in the inpatient units (excluding the critical care unit), is somewhat prevalent, and many patients may be on more than one sedative/hypnotic, which could potentially cause cumulative harm. During the intervention phase, 25% of the total in-hospital orders for sedative/hypnotics were discontinued following recommendations made by a pharmacist, and significantly lower number of patients receiving duplicate sedative/hypnotics was noted. Further efforts should be implemented to avoid unnecessary sedative/hypnotic initiation in hospitalized patients, and to ensur...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Predicting the Content of Anthraquinone Bioactive in Rhei rhizome (Rheum officinale Baill.) with the Concentration Addition Model
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Zeyad Alehaideb, Kimberly C Chin, Mei Cun Yao, Francis CP Law (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Antimicrobial activities of novel bipyridine compounds produced by a new strain of Saccharothrix isolated from Saharan soil
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Abdelhadi Lahoum, Nasserdine Sabaou, Christian Bijani, Noureddine Bouras, Frédéric Pont, Selma P. Snini, Florence MathieuAbstractThe actinobacterium strain ABH26 closely related to Saccharothrix xinjiangensis, isolated from an Algerian Saharan soil sample, exhibited highly antagonist activity against Gram-positive bacteria, yeasts and filamentous fungi. Its ability to produce antimicrobial compounds was investigated using several solid culture media. The highest antimicrobial activity was obtained on Bennett medium. ...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of treatment with vitamin D plus calcium on oxidative stress in streptozotocin-induced diabetic rats
ConclusionOral supplementation with vitamin D and calcium may be a useful treatment for diabetic patients to reduce/prevent the pathological complications of diabetes. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Trigger tools are as effective as non-targeted chart review for adverse drug event detection in intensive care units
This study aimed to compare the use of trigger tools and non-targeted chart review as methods for the detection of adverse drug events in an intensive care unit considering the health system of a developing country.MethodsPatients were divided in groups that were submitted to different methods (trigger tool and non-targeted chart review) for adverse drug event detection. Medical records were retrospectively reviewed, and adverse drug events detected during the data collection were analyzed by a multidisciplinary team and classified according to their causality, predictability, severity and damage level.ResultsThe search fo...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Comparative extraction and simple isolation improvement techniques of active constituents’ momilactone A and B from rice husks of Oryza sativa by HPLC analysis and column chromatography
Publication date: Available online 20 July 2018Source: Saudi Pharmaceutical JournalAuthor(s): Ateeque Ahmad, Tran Dang Xuan, Truong Ngoc Minh, Nasir Ali Siddiqui, Nguyen Van QuanAbstractThis paper reports comparative extraction efficiencies and enhancement methods for natural herbicidal (growth inhibitors) compounds, momilactone A and B, respectively from the dried husks of Oryza sativa using different extraction techniques and different solvent systems. Four different extraction techniques viz. percolation, agitation with heat, sonication and soxhlet using five solvent systems as ethyl acetate, acetone, acetonitrile, meth...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Targeting of Somatostatin Receptors Expressed in Blood Cells Using Quantum Dots Coated with Vapreotide
This study highlights the active targeting of cancer cells by cells imaging with improving the therapeutic outcomes. VAP was conjugated to Qdots using amine-to-sulfhydryl crosslinker. The synthesized Qdots-VAP was characterized by determination of size, measuring the zeta-potential and UV fluorometer. The cellular uptake was studied using different cell lines. Finally, the Qdots-VAP was injected into a rat model. The results showed a size of 479.8 ± 15 and 604.88 ± 17 nm for unmodified Qdots and Qdots-VAP respectively, while the zeta potential of particles went from negative to positive charge which proved th...
Source: Saudi Pharmaceutical Journal - July 20, 2018 Category: Drugs & Pharmacology Source Type: research