Effect of an Educational intervention on the number Potential Drug-Drug Interactions
ConclusionThe implementation of educational pharmacotherapy programs decreased the number of clinically significant drug interactions in the Cardiology Department of Emergency Hospitals. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

β-Sitosterol Derived Compound from Onion Husks non-polar Fraction Reduces Quorum Sensing Controlled Virulence and Biofilm Production
Publication date: Available online 4 April 2019Source: Saudi Pharmaceutical JournalAuthor(s): Hanan M. Al-Yousef, Ishfaq Ahmad SheikhAbstractQuorum sensing is an important regulatory factor of P. aeruginosa virulence induction such as BF, motility, formations of proteases, pyocyanin, and some toxins. The aim of the current study is to detect the effect of the pet.ether extract from onion husk and compound drive from it on quorum sensing and virulence formations of P. aeruginosa. Quorum sensing inhibiting effect of the pet.ether extract of onion husk and a compound drive from it, was evaluated by C. violaceum reporter using...
Source: Saudi Pharmaceutical Journal - April 6, 2019 Category: Drugs & Pharmacology Source Type: research

Liquisolid pellets: a pharmaceutical technology strategy to Improve the dissolution rate of ritonavir
In this study, formulations LP1 and LP2 were obtained (RTV 100 mg/unit dose) using microcrystalline cellulose (carrier), Kollidon® CL-SF (coating and disintegrating material) and high load (30 %, w/w) of Kolliphor® EL or PEG 400 (non-volatile solvent). LP1 and LP2 had narrow size distribution, good morphological properties, and excellent flowability. The partial conversion of RTV polymorph I to the less soluble form II occurred during the preparation of the liquid medications. LP1 (containing Kolliphor® EL) achieved 82.64 ± 2.17 % of drug dissolved in 30 min (Q30min), compared with 53.14 ± 0.6 % a...
Source: Saudi Pharmaceutical Journal - April 4, 2019 Category: Drugs & Pharmacology Source Type: research

Protective role of Roflumilast against cadmium-induced cardiotoxicity through inhibition of oxidative stress and NF-κB signaling in rats
Publication date: Available online 2 April 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mohd Nazam Ansari, Majid A. Ganaie, Najeeb-ur-Rehman, Khalid M. Alharthy, Tajdar H. Khan, Faisal Imam, Mushtaq A. Ansari, Naif O. Al-Harbi, Basit L. Jan, Ishfaq A. Sheikh, Abubaker M. HamadAbstractCadmium (Cd), a potent cardiotoxic environmental heavy metal, induces oxidative stress and membrane disturbances in cardiac myocytes. Phosphodiesterase (PDEs) retards the positive inotropic effects of β-adrenoceptor activation by decreasing levels of cAMP via degradation. Hence, PDE inhibitors sensitize the heart to catecholamine an...
Source: Saudi Pharmaceutical Journal - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Films based on the biopolymer poly(3-hydroxybutyrate) as platforms for the controlled release of dexamethasone
Publication date: Available online 2 April 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mercedes Villegas, Alicia Graciela Cid, Cintia Alejandra Briones, Analía Irma Romero, Florencia Alejandra Pistán, Elio Emilio Gonzo, Juan Carlos Gottifredi, José María BermúdezAbstractControlled drug delivery aims to achieve an effective drug concentration in the action site for a desired period of time, while minimizing side effects. In this contribution, biodegradable poly(3-hydroxybutyrate) films were evaluated as a reservoir platform for dexamethasone controlled release. These systems were mo...
Source: Saudi Pharmaceutical Journal - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Barriers Interfering with Establishment of Collaborative Drug Therapy Management (CDTM) Agreements Between Clinical Pharmacists and Physicians
ConclusionThere is a huge lack of knowledge and understanding about the role of clinical pharmacists and in CDTM concept. This lack of knowledge affected on having collaborations between clinical pharmacists and physicians in different settings. Educating health care providers and stakeholders about the role of clinical pharmacists in providing drug therapy management and encouraging the concept of CDTM among healthcare providers are the main solutions to enhance clinical pharmacist’s role in patient care. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies
Publication date: Available online 3 April 2019Source: Saudi Pharmaceutical JournalAuthor(s): Hamad M. Alkahtani, Mohammed M. Alanazi, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Ali Alhoshani, Fawaz E. Alanazi, Abdulrahman A. Almehizia, Ashraf N. Abdalla, Mashael G. Alanazi, Adel S. El-Azab, Alaa A.-M. Abdel-AzizAbstractA new series of 5,5-diphenylhydantoin derivatives containing benzylidene or isatin (4-19) was synthesized. Their anticancer activity against HeLa, a cervical cancer cell line, A549, a lung cancer cell line, and MDA-MB-231, a breast cancer cell line, was evaluated. Compounds 13, 16, 17 and 18 exhibited ...
Source: Saudi Pharmaceutical Journal - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Antidiabetic, antioxidant, molecular docking and HPTLC analysis of Miquelianin isolated from Euphorbia schimperi C. Presl
Publication date: Available online 19 March 2019Source: Saudi Pharmaceutical JournalAuthor(s): Sarfaraz Ahmed, Adnan J. Alrehaily, Perwez Alam, Ali S. Alqahtani, Syed Hidayatullah, Md. Tabish Rehman, Ramzi A. Mothana, Syed Sadiq Abbas, M.U. Khan, Jamal M. Khalid, Nasir A. SiddiquiAbstractThe present study demonstrates the miquelianin or quercetin 3-O-glucuronide (compound 1) isolated from aerial parts of Euphorbia schimperi exhibited significant results for antioxidant and antidiabetic potential. The compound 1 along with kaempferol 3-O-glucuronide (compound 2) and quercetin 3-O- rhamnoside (compound 3) isolated from the s...
Source: Saudi Pharmaceutical Journal - March 20, 2019 Category: Drugs & Pharmacology Source Type: research

Addressing Medication Errors in an Adult Oncology Department in Saudi Arabia: A qualitative study
ConclusionThe adoption of multiple strategies is required to improve the safety of the medication process in the adult oncology department. We argue that the availability of supportive leadership should be prioritized as it plays a crucial role in determining the effectiveness and efficiency of both staff education and communication. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - March 20, 2019 Category: Drugs & Pharmacology Source Type: research

Retraction notice to “Biomedical microelectromechanical systems (BioMEMS): Revolution in drug delivery and analytical techniques” [Saudi Pharm. J. 24 (2016) 1–20]
Publication date: March 2019Source: Saudi Pharmaceutical Journal, Volume 27, Issue 3Author(s): Rishad R. Jivani, Gaurang J. Lakhtaria, Dhaval D. Patadiya, Laxman D. Patel, Nurrudin P. Jivani, Bhagyesh P. Jhala (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - March 15, 2019 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: March 2019Source: Saudi Pharmaceutical Journal, Volume 27, Issue 3Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - March 15, 2019 Category: Drugs & Pharmacology Source Type: research

Contribution of momilactones A and B to diabetes inhibitory potential of rice bran: Evidence from in vitro assays
This study was the first to detect the presence of the two compounds momilactone A (MA) and momilactone B (MB) in rice bran using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). By in vitro assays, both MA and MB exhibited potent inhibitory activities on pancreatic α-amylase and α-glucosidase which were significantly higher than γ-oryzanol, a well-known diabetes inhibitor. Remarkably, MA and MB indicated an effective inhibition on trypsin with the IC50 values of 921.55 and 884.03 µg/mL, respectively. By high-performance liquid chromatography (HPLC), quantities of MA (6.6...
Source: Saudi Pharmaceutical Journal - March 15, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of the in vivo genotoxicity of liposomal formulation for delivering anticancer estrogenic derivative (ESC8) in a mouse model
Publication date: Available online 11 March 2019Source: Saudi Pharmaceutical JournalAuthor(s): Ajaz Ahmad, Basit Latief Jan, Mohammad Raish, Hari Krishna Reddy Rachamalla, Rajkumar Banerjee, Debabrata Mukhopadhyay, Khalid M. AlkharfyAbstractThe genotoxic potential of glucocorticoid receptor (GR)-targeted liposomal formulations of the anticancer drug molecule ESC8 was studied in vivo. A methodical literature review discovered no previous studies on the genotoxicity of ESC8. Genotoxicity was assessed in both male and female mice by various assay systems, such as comet assay, chromosomal aberrations and micronuclei assay, whi...
Source: Saudi Pharmaceutical Journal - March 12, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of the bioavailability of Hydrocortisone when prepared as solid dispersion
This study was conducted to formulate, characterize, and investigate the bioavailability of hydrocortisone (HCT) when prepared as solid dispersions. HCT was mixed in an organic solvent with polyethylene glycol 4000 (PEG 4000) and Kolliphor® P 407. Spray drying technique was employed to form a solid dispersion formulation at a specific ratio. Physical and chemical characterization of the formed particles were achieved using differential scanning calorimetry, scanning electron microscopy, Fourier transform infrared spectroscopy, and powder x-ray diffractometry. Furthermore, comparative in vitro and in vivo studies were c...
Source: Saudi Pharmaceutical Journal - March 7, 2019 Category: Drugs & Pharmacology Source Type: research

Novel Functionalized β-Nitrostyrenes: Promising Candidates for New Antibacterial Drugs
Publication date: Available online 6 March 2019Source: Saudi Pharmaceutical JournalAuthor(s): Anna Boguszewska-Czubara, Karolina Kula, Artur Wnorowski, Anna Biernasiuk, Łukasz Popiołek, Dawid Miodowski, Oleg M. Demchuk, Radomir JasińskiAbstractThe process of searching for new antibacterial agents is more and more challenging due to the increasing drug resistance which has become a major concern in the field of infection management. Our study presents a synthesis and characterization by IR, UV, 1H-NMR and 13C-NMR spectra of a homogenous series of 1-EWG functionalized 2-aryl-1-nitroethenes which could prove good candidate...
Source: Saudi Pharmaceutical Journal - March 7, 2019 Category: Drugs & Pharmacology Source Type: research

The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer
In this study, chitosan (CS)-coated flexible liposomes (chitosomes) containing 5-fluorouracil (5-FU) were designed and characterized for use as a novel approach to target colon cancer cells. 5-FU-loaded flexible liposomes (F1, F2, and F3) and 5-FU-loaded chitosomes (F4, F5, and F6) were prepared using film hydration and electrostatic deposition techniques, respectively. The particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE%), morphology, and in vitro drug release ability, and cytotoxicity of the formulations were determined. The results revealed that the size of chitosomes ranged from 212...
Source: Saudi Pharmaceutical Journal - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Rapid, cost-effective and organic solvent-free production of biologically active essential oil from Mediterranean wild Origanum syriacum
ConclusionThe current study supports the use of MUAHD as a time-saving, cost-effective, environment-friendly method for production of high quality O. syriacum EO for potential use as a natural complementary treatment and in the prevention of bacterial infections as well as oxidation by free radicals without compromising the quantity. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Lebanese community-based pharmacists’ interest, practice, knowledge, and barriers towards pharmacy practice research: A cross-sectional study
Publication date: Available online 10 February 2019Source: Saudi Pharmaceutical JournalAuthor(s): Rouba Karen Zeidan, Souheil Hallit, Rony M. Zeenny, Pascale SalamehAbstractObjectiveTo assess the interest, knowledge, practice and barriers of Lebanese community-based pharmacists towards research, and to examine factors associated with interest.MethodsA cross-sectional survey, conducted between January and May 2017, enrolled community pharmacists using a proportionate random sample of community pharmacies in the five districts of Lebanon, using the list of pharmacies provided by the Lebanese Order of Pharmacists. In the abse...
Source: Saudi Pharmaceutical Journal - February 14, 2019 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and cytotoxic activity of naturally isolated naringin-metal complexes
Publication date: Available online 13 February 2019Source: Saudi Pharmaceutical JournalAuthor(s): Emad M. Atta, Khaled H. Hegab, Ahmed A.M. Abdelgawad, Abdelghany A. YoussefAbstractHigh-purity naringin was isolated form the fruit peels of Citrus maxima and characterized by various spectroscopic methods like UV and NMR. The isolated compound ligand (HL) was used as ligand-metal complexes synthesis after using Ag (I), Y (III) and Ru (III) metals. These ligand-metal complexes were characterized by elemental analysis, FT-IR, UV-VIS, TGA, molar conductance and magnetic properties. Cytotoxic activity of the isolated naringin and...
Source: Saudi Pharmaceutical Journal - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Assessment of patient counselling on the common cold treatment at Slovak community pharmacies using mystery shopping
Publication date: Available online 11 February 2019Source: Saudi Pharmaceutical JournalAuthor(s): Daniela Mináriková, Tomáš Fazekaš, Peter Minárik, Erika JurišováAbstractBackgroundUp to now, there have been no data on patient counselling in the Slovak community pharmacies. The literature provides a wide range of activities for which mystery shopping methodology be used, including assessment of patient counselling.Aims and objectivesTo assess patient counselling on the common cold treatment with OTC medicine containing zinc provided by Slovak community pharmacists. To ...
Source: Saudi Pharmaceutical Journal - February 12, 2019 Category: Drugs & Pharmacology Source Type: research

Novel sublingual tablets of Atorvastatin calcium/Trimetazidine hydrochloride combination; HPTLC quantification, in vitro formulation and characterization
ConclusionsThe prepared sublingual tablets combining ATOR and TMZ will be a promising dosage form for coronary heart disease patients with an instant action and improved patient compliance. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lebanese community- based pharmacists’ interest, practice, knowledge, and barriers towards pharmacy practice research: A cross-sectional study
Publication date: Available online 10 February 2019Source: Saudi Pharmaceutical JournalAuthor(s): Rouba Karen Zeidan, Souheil Hallit, Rony M. Zeenny, Pascale SalamehAbstractObjectiveTo assess the interest, knowledge, practice and barriers of Lebanese community-based pharmacists towards research, and to examine factors associated with interest.MethodsA cross-sectional survey, conducted between January-May 2017, enrolled community pharmacists using a proportionate random sample of community pharmacies in the five districts of Lebanon, using the list of pharmacies provided by the Lebanese Order of Pharmacists. In the absence ...
Source: Saudi Pharmaceutical Journal - February 10, 2019 Category: Drugs & Pharmacology Source Type: research

Medicinal plants commonly used against cancer in traditional medicine formulae in Sri Lanka
Publication date: Available online 7 February 2019Source: Saudi Pharmaceutical JournalAuthor(s): Anchala I. Kuruppu, Priyani Paranagama, Charitha GoonasekaraAbstractCancer is a global burden. In low- and middle-income countries around 70% of deaths are due to cancer. For a number of years natural products have been a good source of agents for combatting cancer and plants have played a huge role in anti-cancer product development. For many centuries, indigenous cultures around the world have used traditional herbal medicine to treat a myriad of diseases including cancer. In Sri Lanka, a number of plants have been reported t...
Source: Saudi Pharmaceutical Journal - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

In vitro wound healing activity of 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde (HDNC) and other isolates of Aegle marmelos L.: Enhances keratinocytes motility via Wnt/β-catenin and RAS-ERK pathways
Publication date: Available online 29 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Lubna Azmi, Ila Shukla, Arti Goutam, Allauddin, Ch.V. Rao, Talha Jawaid, Mehnaz Kamal, Amani S. Awaad, Saleh I. Alqasoumi, Osama A. AlKhameesAbstractWound healing is a complex process in which injured skin and tissues repaired by interaction of a complex cascade of cellular events that generates resurfacing, reconstitution and restoration of the tensile strength of injured skin. It follows β-catenin, extracellular signal regulated kinase (ERK) and Akt signaling pathways. Aegle marmelos L., generally known as bael is f...
Source: Saudi Pharmaceutical Journal - February 6, 2019 Category: Drugs & Pharmacology Source Type: research

The in vitro and in vivo anti-hepatotoxic, anti-hepatitis B virus and hepatic CYP450 modulating potential of Cyperus rotundus
Publication date: Available online 5 February 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mohammad K. Parvez, Mohammed S. Al-Dosari, Ahmed H. Arbab, Sakina NiyaziAbstractIn the present study we investigated the hepatotoprotective, hepatitis B virus (HBV) inhibitory and hepatic CYP450 enzyme (CYP3A4) modulatory potential of Cyperus rotundus rhizome fractions. The crude ethanol-extract, including different organic and aqueous fractions were tested for in vitro cytoprotection on HepG2 cells (MTT assay), followed by in vivo evaluation in Wistar rats (serum biochemistry and lipid profile). The in vitro anti-HBV activity ...
Source: Saudi Pharmaceutical Journal - February 6, 2019 Category: Drugs & Pharmacology Source Type: research

Novel sublingual tablets of Atorvastatin calcium/ Trimetazidine hydrochloride combination; HPTLC quantification, in vitro formulation and characterization
ConclusionsThe prepared sublingual tablets combining ATOR and TMZ will be a promising dosage form for coronary heart disease patients with an instant action and improved patient compliance. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 6, 2019 Category: Drugs & Pharmacology Source Type: research

Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts
Publication date: Available online 2 February 2019Source: Saudi Pharmaceutical JournalAuthor(s): Cigdem Kahraman, Gulacti Topcu, Erdal Bedir, I.Irem Tatli, Melike Ekizoglu, Zeliha S. AkdemirAbstractChloroform, ethyl acetate and methanol extracts from the aerial parts of Ferula caspica M. Bieb.were tested for their antioxidant capacities by CUPRAC, ABTS, FRAP, Folin–Ciocalteu and aluminum chloride methods and for antimicrobial activities by the broth microdilution method. Chloroform and ethyl acetate extracts showed the highest antioxidant capacity and antimicrobial activity. Three known sesquiterpene derivatives; 1-(...
Source: Saudi Pharmaceutical Journal - February 3, 2019 Category: Drugs & Pharmacology Source Type: research

In vitro wound healing activity of 1-hydroxy-5, 7-dimethoxy-2-naphthalene-carboxaldehyde (HDNC) and other isolates of Aegle marmelos L.: Enhances keratinocytes motility via Wnt/β-catenin and RAS-ERK pathways
Publication date: Available online 29 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Lubna Azmi, Ila Shukla, Arti Goutam, Allauddin, Ch.V. Rao, Talha Jawaid, Mehnaz Kamal, Amani S. Awaad, Saleh I. Alqasoumi, Osama A. AlKhameesAbstractWound healing is a complex process in which injured skin and tissues repaired by interaction of a complex cascade of cellular events that generates resurfacing, reconstitution and restoration of the tensile strength of injured skin. It follows β-catenin, extracellular signal regulated kinase (ERK) and Akt signaling pathways. Aegle marmelos L., generally known as bael is f...
Source: Saudi Pharmaceutical Journal - January 30, 2019 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: February 2019Source: Saudi Pharmaceutical Journal, Volume 27, Issue 2Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 30, 2019 Category: Drugs & Pharmacology Source Type: research

Acute disseminated encephalomyelitis due to abrus precatorius poisoning – A case report
We present here a case of a 22 year old lady who developed severe vomiting, diarrhoea and malena at the initial stages and later seizures and acute disseminated encephalomyelitis due to deliberate chewing and swallowing of abrus seeds. She was rescued with several sessions of membrane plasmapheresis and supportive care. The neuropathological process of acute disseminated encephalomyelitis due to abrus poisoning was reversed by plasmapheresis. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 25, 2019 Category: Drugs & Pharmacology Source Type: research

Acute Disseminated Encephalomyelitis Due to Abrus Precatorius Poisoning -A Case Report
We present here a case of a 22 year old lady who developed severe vomiting, diarrhoea and malena at the initial stages and later seizures and acute disseminated encephalomyelitis due to deliberate chewing and swallowing of abrus seeds. She was rescued with several sessions of membrane plasmapheresis and supportive care. The neuropathological process of acute disseminated encephalomyelitis due to abrus poisoning was reversed by plasmapheresis. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 22, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of community pharmacists’ knowledge about drug–drug interaction in Central Saudi Arabia
ConclusionThe results of this study showed that knowledge of community pharmacists about DDIs was inadequate. Community pharmacist should have specific courses in drug interactions to cover the most possible interactions that can be seen in this setting. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 20, 2019 Category: Drugs & Pharmacology Source Type: research

Nano-encapsulation and characterization of baricitinib using poly-lactic-glycolic acid co-polymer
Publication date: Available online 12 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mohammad Javed Ansari, Saad M. AlshahraniAbstractBaricitinib is a recently approved anti-rheumatic drug having very poor aqueous solubility and hence its performance suffers from low or inconsistent oral bioavailability. The purpose of the study was to develop and evaluate poly lactic-co-glycolic acid (PLGA) nanoparticles of baricitinib in order to enhance in vitro dissolution and performance. Nano-suspension of baricitinib with or without PLGA, a biodegradable, FDA approved semi-synthetic polymer, was developed by nanoprecipit...
Source: Saudi Pharmaceutical Journal - January 20, 2019 Category: Drugs & Pharmacology Source Type: research

Measuring the Quality and completeness of Medication-related Information derived from Hospital Electronic Health Records Database
ConclusionThe study findings indicate that the completeness of the data varies by the desired types of data. EHRs can be a potentially great resource to conduct research to assess medication use. Further studies focusing on the content and completeness of EHRs for a specific patient population and evaluate other dimensions of EHRs data quality are needed. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 17, 2019 Category: Drugs & Pharmacology Source Type: research

Attitudes of pharmacy students towards scientific research and academic career in Saudi Arabia
ConclusionsPharmacy students had positive attitudes towards research activities and they desired to be involved more in research publications. However, addressing the barriers and improving student participation will increase their interest in academic research. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 17, 2019 Category: Drugs & Pharmacology Source Type: research

Flavonoids from Camellia sinensis (L.) O. Kuntze seed ameliorates TNF-α induced insulin resistance in HepG2 cells
Publication date: Available online 17 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Fu-Chih Chen, Kuo-Ping Shen, Liang-Yin Ke, Hui-Li Lin, Chia-Chang Wu, Shyh-Yu ShawAbstractThe aim of this study is to discuss the non-catechin flavonoids (NCF) from Camellia sinensis (L.) O. Kuntze seed improving TNF-α impaired insulin stimulated glucose uptake and insulin signaling. Flavonoids had anti-metabolic syndrome and anti-inflammatory properties. It had widely been known for biological activity of catechins in tea, but very few research reports discussed the biological activity of non-catechin flavonoids in tea s...
Source: Saudi Pharmaceutical Journal - January 17, 2019 Category: Drugs & Pharmacology Source Type: research

Nano encapsulation and characterization of baricitinib using poly-lactic-glycolic acid co-polymer
Publication date: Available online 12 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mohammad Javed Ansari, Saad M AlshahraniAbstractBaricitinib is recently approved anti-rheumatic drug with very poor aqueous solubility and thus low and inconsistent oral bioavailability. The purpose of the study was to develop and evaluate poly lactic acid glycolic acid (PLGA) nanoparticles of baricitinib in order to enhance in vitro dissolution and performance. Nano-suspension of baricitinib with or without PLGA, a biodegradable, FDA approved semi synthetic polymer, was developed by nanoprecipitation method. Research methodolo...
Source: Saudi Pharmaceutical Journal - January 12, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of CYP2C9 and VKORC1 Polymorphisms on Warfarin Sensitivity and Responsiveness during the Stabilization Phase of Therapy
This study was conducted at the Queen Alia Heart Institute (QAHI) anticoagulation clinic in Amman, Jordan. We assessed three CYP2C9 (rs1799853, rs1057910, rs4086116) and four VKORC1 (rs10871454, rs8050894, rs9934438, rs17708472) polymorphisms in 139 Jordanian cardiovascular patients. Demographic and clinical data were also collected. Of the 139 patients in the cohort, 80% had the VKORC1 polymorphisms rs10871454 and rs9934438, while 22.3% and 24.5% of patients had the rs1799853 and rs1057910 CYP2C9 alleles, respectively. Carriers of the CYP2C9 polymorphisms rs1057910 and rs4086116 had an increased risk of warfarin sensitivi...
Source: Saudi Pharmaceutical Journal - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

Career Choices and Preferences of Saudi Pharmacy Undergraduates: A Cross Sectional Study
ConclusionBy identifying these gaps and pharmacy students' goals and needs, we aim to draw the government’s attention to these to ensure a future balance between supply and demand and effective pharmacy workforce planning, which is mandatory. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

Assessment of knowledge, attitude and practice among community pharmacists towards dental care: A National Cross Sectional Survey
ConclusionsPharmacists have the overall required knowledge and attitude to play an important role in the patients’ counseling towards dental care. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

A new perspective on evaluation of medicinal plant biological activities: The correlation between phytomics and matrix metalloproteinases activities of some medicinal plants
In conclusion, phytomics can be a more useful tool for the evaluation of the activities than investigating a single metabolite. This new perspective can also provide a better understanding of plant metabolomics and can be easily employed for future research on plant activity. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

The environmental monitoring in hospital pharmacy cleanroom and microbiota catalogue preparation
Publication date: Available online 11 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mateja Tršan, Katja Seme, Stanko SrčičAbstractKnowing the normal cleanroom microbiota is the basis for ensuring microbiological quality; assess changes and the introduction of new sampling methods. During our study, we prepared a catalogue of cleanroom microorganisms located in four different cleanrooms in University Clinical Centre Ljubljana Pharmacy. Catalogue is prepared as a basis for assessing the suitability of the new rapid microbiological method and subsequent correlation of the results of both methods. The res...
Source: Saudi Pharmaceutical Journal - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

Physicochemical, pharmacokinetics, and histological evaluation of new naproxen-quercetin co-lyophilizate to diminish drug-induced gastric irritations in rats
Publication date: Available online 8 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mohamed Abbas Ibrahim, Gamal A. Shazly, Gehan M. Elossaily, Essam Ezzeldin, Fadilah S. AleanizyAbstractQuercetin (QUE) is a flavonoid found in several plants and commonly distributed in edible vegetables and fruits. To evaluate the effect of co-lyophilization of naproxen (NPX) with QUE at different weight ratios on physicochemical characteristics induced gastric irritation, and drug pharmacokinetics. NPX binary systems with QUE in different weight ratios were prepared by freeze-drying alkalinized solutions, and were characterize...
Source: Saudi Pharmaceutical Journal - January 9, 2019 Category: Drugs & Pharmacology Source Type: research

The Evaluation of Sterile Solutions of Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. on Antiviral, Antinociceptive and Anti-inflammatory Activities
Publication date: Available online 7 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): N. Yagmur Diker, Cigdem Kahraman, Esra Kupeli Akkol, M. Taner Karaoglu, Tansel Comoglu, Zeliha S. Akdemir, I. Irem Tatli CankayaAbstractAntiviral, antinociceptive and anti-inflammatory activities of the 1% sterile solutions of Ilwensisaponin A and C isolated from the methanolic extract of the flowers of Verbascum pterocalycinum var. mutense Hub.-Mor. were investigated. Antiviral activities of sterile solutions were evaluated against Bovine Herpes Virus Type-1 (BHV-1) (Cooper strain). Both solutions showed cytotoxic effects. Howe...
Source: Saudi Pharmaceutical Journal - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

The onus of cannabinoids in interrupting the molecular odyssey of breast cancer: A critical perspective on UPRER and beyond
Publication date: Available online 7 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Safikur Rahman, Ayyagari Archana, Durgashree Dutta, Vijay Kumar, Jihoe Kim, Arif Tasleem Jan, Rinki MinakshiAbstractCannabinoids, commonly used for medicinal and recreational purposes, consist of various complex hydrophobic molecules obtained from Cannabis sativa L. Acting as an inhibitory molecule; they have been investigated for their antineoplastic effect in various breast tumor models. Lately, it was found that cannabinoid treatment not only stimulates autophagy mediated apoptotic death of tumor cells through unfolded protei...
Source: Saudi Pharmaceutical Journal - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Gliclazide alone or in combination with atorvastatin ameliorated reproductive damage in streptozotocin-induced type 2 diabetic male rats
Publication date: Available online 7 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Öztaş Ezgi, Yilmaz Ekiz Tugba, Güzel Elif, Sezer Zehra, Okyar Alper, Özhan GülAbstractObjectivesType 2 diabetes (T2DM) is one of the most serious challenges of the 21th century with life-threatening complications and excessive health care costs. In diabetic patients, the main goal in T2DM treatment is the regulation of both blood glucose and lipid levels. For that, Gliclazide (GLZ), an oral antidiabetic, and Atorvastatin (ATV), a lipid lowering agent, are widely used drugs as combination. Diabetes has been r...
Source: Saudi Pharmaceutical Journal - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of pterostilbene on in vitro drug metabolizing enzyme activity
Publication date: Available online 7 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Ahmed A. Albassam, Reginald F. FryeAbstractPterostilbene is a natural polyphenol compound found in small berries that is related to resveratrol, but has better bioavailability and a longer half-life. The purpose of this study was to assess the potential inhibitory effect of pterostilbene on in vitro drug metabolism. The effect of pterostilbene on cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzyme activities were studied using the enzyme-selective substrates amodiaquine (CYP2C8), midazolam (CYP3A4), estradiol (UGT...
Source: Saudi Pharmaceutical Journal - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of community pharmacists’ Knowledge about drug –drug interaction in Central Saudi Arabia
ConclusionThe results of this study showed that knowledge of community pharmacists about DDIs was inadequate. Community pharmacist should have specific courses in drug interactions to cover the most possible interactions that can be seen in this setting. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: January 2019Source: Saudi Pharmaceutical Journal, Volume 27, Issue 1Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 7, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of Antimicrobial activity of secondary metabolites of fungi isolated from Sultanate Oman soil
Publication date: Available online 3 January 2019Source: Saudi Pharmaceutical JournalAuthor(s): Manal M. Alkhulaifi, Amani S. Awaad, Hind A. AL-Mudhayyif, Monerah R. Alothman, Saleh I. Alqasoumi, Sarah M. ZainAbstractSeven fungal species were isolated from soil samples collected from the University of Sultan Qaboos, Muscat, Sultanate of Oman. The fungal isolates were identified as Aspergillus athecius, A. terreus var. africans, A. flavus, A. terreus, A. foetidus, Fusarium chlamydosporum and F. nygamai. Phytochemical and chromatographic investigation showed variety of secondary metabolites in all of the fugal extracts (extr...
Source: Saudi Pharmaceutical Journal - January 4, 2019 Category: Drugs & Pharmacology Source Type: research