Development of a simple high performance liquid chromatography (HPLC)/evaporative light scattering detector (ELSD) method to determine Polysorbate 80 in a pharmaceutical formulation
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Bikash Mondal, Mahesh Kote, Chandrakant Lunagariya, Milan PatelAbstractThe amount of polysorbate 80 in pharmaceutical formulations affects the product quality and efficacy. A reliable test method is required to quantify the amount of Polysorbate 80 present in the drug product formulations. The test method for the determination of Polysorbate 80 may be used during process development and final product quality assessment. A simple, fast and efficient quantitative method, making use of HPLC-ELSD and a C18 column without sample pre...
Source: Saudi Pharmaceutical Journal - February 16, 2020 Category: Drugs & Pharmacology Source Type: research

Promising selective MAO-B inhibition by sesamin, a lignan from Zanthoxylum flavum stems
This study aimed to isolate the secondary metabolites of Zanthoxylum flavum stems and evaluate their recombinant human MAO inhibition, antimicrobial, and antiprotozoal activities. As a result, fourteen compounds were isolated and identified (nine of them were reported from Z. flavum for the first time). Compound 3 (sesamin) exhibited potent selective MAO-B inhibition (IC50 value of 1.45 ± 0.05 µM) which reported herein for the first time. Compound 2 showed selective MAO-A inhibition activity, compound 5 exhibited good trypanocidal activity, and compound 7 displayed moderate antibacterial activity. The promisin...
Source: Saudi Pharmaceutical Journal - February 15, 2020 Category: Drugs & Pharmacology Source Type: research

Adherence to prophylactic dual antiplatelet therapy in patients with acute coronary syndrome – A study conducted at a Saudi university hospital
Publication date: Available online 3 February 2020Source: Saudi Pharmaceutical JournalAuthor(s): Ziyad Alrabiah, Syed Wajid, Ibrahim Alsulaihim, Sultan Alghadeer, Abdulaziz Alhossan, Salmeen D. Babelghaith, Mohamed Al-ArifiAbstractObjectivesThe aim of this study was to evaluate patients’ self-reported adherence to dual antiplatelet therapy (DAPT) and determine the factors associated with premature discontinuation of DAPT.MethodsThe cross-sectional interview-based study was conducted among adult outpatients who visited the outpatient department of King Khalid University Hospital, Cardiac Center in Riyadh, Saudi Arabia...
Source: Saudi Pharmaceutical Journal - February 13, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of bronchodialatory and antimicrobial activities of Otostegia fruticosa: A multi-mechanistic approach
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Mohd Nazam Ansari, Najeeb Ur Rehman, Aman Karim, Tiegsti Bahta, Khalil Y. Abujheisha, Syed Rizwan Ahamad, Faisal ImamAbstractOtostegia fruticosa, a plant belonging to the family Lamiaceae, is endemic to Ethiopia. In Ethiopian traditional medicine, O. fruticosa has been used for the treatment of several respiratory-related disorders. The present study was designed to evaluate the bronchodilatory and antimicrobial activities of O. fruticosa leaves crude extract (Of.Cr). Ex-vivo experiments were conducted on guinea-pig trachea pro...
Source: Saudi Pharmaceutical Journal - February 12, 2020 Category: Drugs & Pharmacology Source Type: research

Prevalence and associated risk factors of acne relapse among Saudi acne vulgaris patients using Isotretinoin
ConclusionAlmost half of the patients showed relapse of acne after using isotretinoin. A lack of understanding regarding relapse and side effects indicates a need to improve public and professional awareness of isotretinoin. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 12, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacy Students Attitude and Perception toward Working in Community Pharmacy
ConclusionsSaudi pharmacy students had a negative attitudes and insufficient knowledge about community pharmacy. Pharmacy school would have an important role to fill the knowledge gap and prepare the student to work in the community pharmacy. In order to successfully “Saudization” the community pharmacy setting, efforts should be made to overcome their perceived barriers. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 5, 2020 Category: Drugs & Pharmacology Source Type: research

Gender Effect on the Pharmacokinetics of Thymoquinone: Preclinical Investigation and in Silico Modeling in Male and Female Rats
In this study, the gender-dependent pharmacokinetic behavior of thymoquinone in rats was investigated. Thymoquinone was administered orally (20 mg/kg) and intravenously (5 mg/kg) to male and female rats and blood samples were collected at specific time points. Plasma concentration-time curves were plotted and pharmacokinetic parameters were determined using the non-compartmental analysis. In addition, simulations of steady state concentrations of thymoquinone in male and female rats were performed using GastroPlus PK software. After oral administration, the maximum plasma concentration (Cmax) of thymoquinone was 4.52 &plus...
Source: Saudi Pharmaceutical Journal - February 5, 2020 Category: Drugs & Pharmacology Source Type: research

Advanced and multifaceted stability profiling of the first-line antidiabetic drugs metformin, gliclazide and glipizide under various controlled stress conditions
Publication date: Available online 3 February 2020Source: Saudi Pharmaceutical JournalAuthor(s): Ahmed Gedawy, Hani Al-Salami, Crispin R. DassAbstractThe antidiabetic drugs metformin, gliclazide and glipizide have been widely used and studied in terms of pharmacological and antidiabetic effects, and their individual stability has been studied in the literature. However, the drugs’ combined stability profiling remains poorly understood, and hence the aim of this study was to investigate the collective stability profiling of different combinations at various controlled conditions. Degradation assessments were carried o...
Source: Saudi Pharmaceutical Journal - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Adherence to prophylactic dual antiplatelet therapy in patients with acute coronary syndrome: – a study conducted at a Saudi university hospital
Publication date: Available online 3 February 2020Source: Saudi Pharmaceutical JournalAuthor(s): Ziyad Alrabiah, Syed Wajid, Ibrahim Alsulaihim, Sultan Alghadeer, Abdulaziz Alhossan, Salmeen D Babelghaith, Mohamed Al-ArifiAbstractObjectivesThe aim of this study was to evaluate patients’ self-reported adherence to dual antiplatelet therapy (DAPT) and determine the factors associated with premature discontinuation of DAPT.MethodsThe cross-sectional interview-based study was conducted among adult outpatients who visited the outpatient department of King Khalid University Hospital, Cardiac Center in Riyadh, Saudi Arabia,...
Source: Saudi Pharmaceutical Journal - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Design and encapsulation of anticancer dual HSP27 and HER2 inhibitor into low density lipoprotein to target ovarian cancer cells
Publication date: Available online 3 February 2020Source: Saudi Pharmaceutical JournalAuthor(s): Laila J. Alhadad, Gamaleldin I. Harisa, Fars K. AlanaziAbstractTumor cells overexpress low-density lipoprotein (LDL) receptors (LDL-r). Hence, LDL is proposed as a targeting shuttle of anticancer drugs. Therefore, the objective of this study was to synthesize a dual inhibitor of heat shock protein 27 (HSP27) and human epidermal growth factor receptor 2 (HER2) conjugated with cholesterol and encapsulated into LDL for selective targeting of ovarian cancer cells. In the present study, the anticancer agent and its cholesterol conju...
Source: Saudi Pharmaceutical Journal - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Formulation and Evaluation of Cyclodextrin-Based Nanosponges of Griseofulvin as Pediatric Oral Liquid Dosage Form for Enhancing Bioavailability and Masking Bitter Taste
Publication date: Available online 3 February 2020Source: Saudi Pharmaceutical JournalAuthor(s): Samia M. Omar, Fares Ibrahim, Aliaa IsmailAbstractThe aim of this study was the development of griseofulvin (GRI) loaded β-cyclodextrin (β–CD) based nanosponges for bitter taste masking, improving dissolution rate and oral bioavailability. Plain NS (NS1 NS2 and NS3) were fabricated by reacting β-CD with the cross-linker diphenyl carbonate at different molar ratios (1:2, 1:4 and 1:6, respectively) using ultrasonication method. The NS2 provided both highest %yield and GRI solubilization enhancement. Thus, the...
Source: Saudi Pharmaceutical Journal - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of burn wound healing activity of novel fusidic acid loaded microemulsion based gel in male Wistar albino rats
In conclusion, FA loaded microemulsion based gel could be offered as encouraging strategy as dermal systems for the burn wound treatment. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Adverse drug reaction prevalence and mechanisms of action of first-line anti-tubercular drugs
ConclusionsDirectly Observed Treatment (DOT) is effective and safe compared to daily treatment regimens. Patients receiving DOTS therapy needed close monitoring for adverse events. Therefore, a pharmacovigilance program should be added at the National level to accesses the adverse event incidence. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

UPLC–MS/MS assay for quantification of an inhibitor of kinases (Foretinib) in plasma: Application to a pharmacokinetic study in rats
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Essam Ezzeldin, Muzaffar Iqbal, Yousif A. Asiri, Azza A. Ali, Toqa El NahhasAbstractForetinib, an oral multikinase inhibitor, is known to have anti-tumor effects against cancers. The doses and the levels of foretinib vary based on the type of cancer to be treated. An accurate and precise method is required to determine the level of foretinib and its pharmacokinetics. Here, we developed such a method, which was validated based on the guidelines of the FDA and EMA. Foretinib and ibrutinib (the internal standard (IS)) were extract...
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

Development of a simple high performance liquid chromatography (HPLC) /evaporative light scattering detector (ELSD) method to determine Polysorbate 80 in a pharmaceutical formulation
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Bikash Mondal, Mahesh Kote, Chandrakant Lunagariya, Milan PatelAbstractThe amount of polysorbate 80 in pharmaceutical formulations affects the product quality and efficacy. A reliable test method is required to quantify the amount of Polysorbate 80 present in the drug product formulations. The test method for the determination of Polysorbate 80 may be used during process development and final product quality assessment. A simple, fast and efficient quantitative method, making use of HPLC-ELSD and a C18 column without sample pre...
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of Bronchodilator and antimicrobial activities of Otostegia fruticose: A multi-mechanistic approach
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Mohd Nazam Ansari, Najeeb-ur Rehman, Aman Karim, Tiegsti Bahta, Khalil Y. Abujheisha, Syed Rizwan Ahamad, Faisal ImamAbstractOtostegia fruticose, a plant belonging to the family Lamiaceae, is endemic to Ethiopia. In Ethiopian traditional medicine, O. fruticose has been used for the treatment of several respiratory-related disorders. The present study was designed to evaluate the bronchodilator and antimicrobial activities of O. fruticose leaves crude extract (Of.Cr). Ex-vivo experiments were conducted on guinea-pig trachea prov...
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

Bioresorbable hydrogels prepared by photo-initiated crosslinking of diacrylated PTMC-PEG-PTMC triblock copolymers as potential carrier of antitumor drugs
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Yuandou Wang, Laishun Xi, Baogang Zhang, Qingzhen Zhu, Feng Su, Katarzyna Jelonek, Arkadiusz Orchel, Janusz Kasperczyk, Suming LiAbstractPTMC-PEG-PTMC triblock copolymers were prepared by ring-opening polymerization of trimethylene carbonate (TMC) in the presence of dihydroxylated poly(ethylene glycol) (PEG) with Mn of 6000 and 10 000 as macro-initiator. The copolymers with different PTMC block Lengths and the two PEGs were end functionalized with acryloyl chloride. The resulting diacrylated PEG-PTMC-DA and PEG-DA were characte...
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

The use of quantitative analysis and Hansen solubility parameter predictions for the selection of excipients for lipid nanocarriers to be loaded with water soluble and insoluble compounds
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Pedzisai A. Makoni, Janeeta Ranchhod, Kasongo Wa. Kasongo, Sandile M. Khamanga, Roderick B. WalkerAbstractThe aim of these studies was to determine the miscibility of different API with lipid excipients to predict drug loading and encapsulation properties for the production of solid lipid nanoparticles and nanostructured lipid carriers. Five API exhibiting different physicochemical characteristics, viz., clarithromycin, efavirenz, minocycline hydrochloride, mometasone furoate, and didanosine were used and six solid lipids as we...
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

Morin Attenuates High-Fat Diet Induced-Obesity Related Vascular Endothelial Dysfunction in Wistar Albino Rats
In this study, the protective effect of a flavonol, morin was investigated in high-fat diet (HFD)-induced dyslipidemia and vascular endothelium dysfunction. The dose-dependent attenuating effect of morin was tested at doses of 50 and 100 mg/kg/day in an in-vivo model of HFD-induced dyslipidemia using rats whereas vascular endothelial reactivity was assessed in isolated rat aorta using ex-vivo organ bath setup. Morin administration in HFD-induced dyslipidemic rats for three weeks, resulted in a significant decrease in the body weight, LW/BW ratio as compared to rats treated with HFD only where the increase in body weight wa...
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

Physicians' choices in the first- and second-line management of type 2 diabetes in the Kingdom of Saudi Arabia
ConclusionMetformin, with or without sulfonylureas, is the most commonly prescribed first-line treatment for patients with type 2 diabetes, managed either in state institutions, or in the private sector. The most common second line drugs were DPP4 inhibitors, mainly sitagliptin, followed by the third and second generation of sulfonylureas. Drug affordability was not an issue, since the vast majority of the patients received free medication. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: February 2020Source: Saudi Pharmaceutical Journal, Volume 28, Issue 2Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Dispensing Errors and Self-medication Practice Observed by Community Pharmacists in Jordan
ConclusionDrugs dispensing errors and self-medication practices are widespread in Jordan and they should be regulated and restricted throughout applying strong policies and laws. They should be strictly enforced among pharmacies and there is a great responsibility to increase community awareness regarding appropriate drugs using. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 29, 2020 Category: Drugs & Pharmacology Source Type: research

Medication use patterns in the visually impaired in Saudi Arabia and the importance of applying Braille Labeling
ConclusionThis study investigated medication usage patterns in the visually impaired in Saudi Arabia. These patients face considerable challenges to any efforts to self-administer their own medication and are heavily reliant on caregivers. The current methods for dispensing medications to this population, (and current regulations) do not sufficiently meet their health information needs. The study highlighted the necessity of applying Braille labeling to medicines prescribed to the visually impaired. A reconsideration of the current regulations regarding the application of Braille labeling to medications is warranted. The u...
Source: Saudi Pharmaceutical Journal - January 29, 2020 Category: Drugs & Pharmacology Source Type: research

Molecular interaction of tea catechin with bovine β-lactoglobulin: a spectroscopic and in silico studies
Publication date: Available online 27 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Nasser Abdulatif Al-Shabib, Javed Masood Khan, Ajamaluddin Malik, Md. Tabish Rehman, Mohamed F. AlAjmi, Fohad Mabood Husain, Malik Hisamuddin, Nojood AltwaijryAbstractPolyphenols has attained pronounced attention due to their beneficial values of health and found to prevent several chronic diseases. Here, we elucidated binding mechanism between frequently consumed polyphenol “tea catechin” and milk protein bovine beta-lactoglobulin (β-Lg). We investigated the conformational changes of β-Lg due to interacti...
Source: Saudi Pharmaceutical Journal - January 28, 2020 Category: Drugs & Pharmacology Source Type: research

Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5- isopropyl-5-phenylhydantoin derivatives in human breast cancer cells
In this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivatives were examined on human breast cancer cell line MDA-MB-231. The cells were treated with different concentrations of compounds (from 0.01 µM to 100 µM) during 24 h and 72 h. The proliferation index, nitric oxide production, apoptosis rate, and migration capacity were measured. The cell invasion potential was examined by measuring the level of MMP-9 and COX-2 gene...
Source: Saudi Pharmaceutical Journal - January 25, 2020 Category: Drugs & Pharmacology Source Type: research

Polymeric nanocarriers as stimuli-responsive systems for targeted tumor (cancer) therapy: Recent advances in drug delivery
Publication date: Available online 24 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Mosa AlsehliAbstractIn the last decade, considerable attention has been devoted to the use of biodegradable polymeric materials as potential drug delivery carriers. However, bioavailability and drug release at the disease site remain uncontrollable even with the use of polymeric nanocarriers. To address this issue, successful methodologies have been developed to synthesize polymeric nanocarriers incorporated with regions exhibiting a response to stimuli such as redox potential, temperature, pH, and light. The resultant stimuli-...
Source: Saudi Pharmaceutical Journal - January 25, 2020 Category: Drugs & Pharmacology Source Type: research

In Vitro and In Vivo Characterization of Domperidone-Loaded Fast Dissolving Buccal Films
In conclusion, the produced DMP buccal film formulation showed high absorption rate, rapid onset of action, and improved bioavailability compared with the conventional tablet. Our findings may support the development of novel dosage forms for the transmucosal delivery of DMP for convenient, rapid, and effective treatment of nausea and vomiting. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 25, 2020 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: January 2020Source: Saudi Pharmaceutical Journal, Volume 28, Issue 1Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 9, 2020 Category: Drugs & Pharmacology Source Type: research

The prevalence and severity of potential drug-drug interactions among adult polypharmacy patients at outpatient clinics in Jordan
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mohammad B. Nusair, Sayer I. Al-Azzam, Rasha M. Arabyat, Haneen A. Amawi, Karem H. Alzoubi, Asma A. RabahAbstractObjectiveTo assess the prevalence of potential drug-drug interactions (pDDIs) among polypharmacy patients in Jordan using Lexicomp®. Additionally, this study aims to categorize and rate the identified pDDIs according to interaction risk, severity, and reliability.MethodsA descriptive cross-sectional study was conducted at six different hospitals representing different public health sectors in Jordan (ministry of ...
Source: Saudi Pharmaceutical Journal - December 28, 2019 Category: Drugs & Pharmacology Source Type: research

Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects
Publication date: December 2019Source: Saudi Pharmaceutical Journal, Volume 27, Issue 8Author(s): Anas Ahmad, Rakesh Kumar Mishra, Akshay Vyawahare, Ajay Kumar, Muneeb U. Rehman, Wajhul Qamar, Abdul Quaiyoom Khan, Rehan KhanAbstractCancer remains the topmost disorder of the mankind and number of cases is unceasingly growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the largest market in the modern treatment of cancer, natural agents have always been tried and tested for potential anti-cancer properties. Thymoquinone (TQ), a monoterpene and main ingredient in the essential oil of Nigell...
Source: Saudi Pharmaceutical Journal - December 28, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of β-cyclodextrin encapsulation on cytotoxic activity of acetylshikonin against HCT-116 and MDA-MB-231 cancer cell lines
In conclusion, AcSh/β-CD binary system showed better performances regarding cytotoxic activity against tested tumor cell lines. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 20, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of -cyclodextrin encapsulation on cytotoxic activity of acetylshikonin against HCT-116 and MDA-MB-231 cancer cell lines
In conclusion, AcSh/β-CD binary system showed better performances regarding cytotoxic activity against tested tumor cell lines. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 17, 2019 Category: Drugs & Pharmacology Source Type: research

Inside Front Cover - Editorial Board
Publication date: December 2019Source: Saudi Pharmaceutical Journal, Volume 27, Issue 8Author(s): (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 13, 2019 Category: Drugs & Pharmacology Source Type: research

Exploring the Value of a Doctor of Philosophy Program in Pharmaceutical Outcomes and Policy Research in Saudi Arabia
ConclusionsThe obtained results indicate a significant interest among different stakeholders in introducing a Ph.D. program in POPR in Saudi Arabia. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats
ConclusionThe findings suggest that chitosan, as a prime drug-delivery carrier, significantly alleviates the acute and sub-acute toxic effects of 6-MP. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic, Hani Al-SalamiAbstractBile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and anti-inflammatory drugs, such as probucol (PB). Thus, this study aimed to design and tes...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population
ConclusionABCB1 C3435T and ABCG2 C421A might represent a potential risk factor for breast cancer for Turkish women. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Anroop B. Nair, Bandar E. Al-Dhubiab, Jigar Shah, Shery Jacob, Saraiya Vismay, Mahesh Attimarad, Nagaraja SreeHarsha, Sabah H. Akrawi, Tamer M. ShehataAbstractAdministration of almotriptan as an oral therapy is largely limited because of poor aqueous solubility and rather low bioavailability. The aim of present investigation was to formulate oral mucoadhesive film of almotriptan to improve the drug delivery and desired therapeutic effects. Placebo films (F1-F8) were prepared by varying the concentrations of Proloc 15 (7.5% w/v-...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Coumarin-Piperazine Derivatives as Biologically Active Compounds
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Kinga OstrowskaAbstractA number of psychiatric disorders, including anxiety, schizophrenia, Parkinson’s disease, depression and others CNS diseases are known to induce defects in the function of neural pathways sustained by the neurotransmitters, like dopamine and serotonin. N-arylpiperazine moiety is important for CNS-activity, particularly for serotonergic and dopaminergic activity. In the scientific literature there are many examples of coumarin-piperazine derivatives, particularly with arylpiperazines linked to a coum...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Cell proliferation activity delineated by molecular docking of four new compounds isolated from the aerial parts of Suaeda monoica Forssk. ex. J.F. Gmel
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Nasir A. Siddiqui, Ramzi A. Mothana, Mansour S. Al-Said, Mohammad K. Parvez, Perwez Alam, M. Tabish Rehman, Mohd. Ali, Mohamed F. Alajmi, Mohammed S. Al-Dosari, Adnan J. Al-Rehaily, Fahd A. Nasr, Jamal M. KhalidAbstractUsing different chromatographic methods, four new compounds were isolated from the aerial parts of Suaeda monoica (Chenopodiaceae) along with 2-hydroxy-1-naphthoic acid (SCM-3). The structures of the new compounds were established as 6'-hydroxy-10'-geranilanyl naphtha-1-oate (SMC-1), 4,4,8β,10β-Tetramet...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

The prevalence and severity of potential drug- drug interactions among polypharmacy patients in Jordan
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Mohammad B. Nusair, Sayer I. Al-azzam, Rasha. M. Arabyat, Haneen A. Amawi, Karem H. Alzoubi, Asma Rabah (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Comparative evaluation of biphasic insulin with metformin and triple oral hypoglycemic agents (OHA) in type 2 diabetes patients
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Sirajudeen Shaik Alavudeen, Moteb Khobrani, C.K. Dhanapal, Javid Iqbal Mir, Sultan Mohammed Alshahrani, Noohu Abdullah Khan, Abdulaziz Alhossan (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

The inhibitory effects of isolated constituents from Plantago major subsp. major L. on collagenase, elastase and hyaluronidase enzymes: Potential wound healer
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Yasin Genc, Fatma Tugce Guragac Dereli, Iclal Saracoglu, Esra Kupeli AkkolAbstractPlantago major L. which is a medicinal plant with important biological activities, commonly used as traditional medicine. Potential inhibitory activities of the aqueous extract and three isolated constituents calceorioside B (1), homoplantaginin (hispidulin-7-O-glucoside) (2) and plantamajoside (3) from the aerial parts of Plantago major subsp. major L. (Plantaginaceae) have been tested against hyaluronidase, collagenase, and elastase, which play ...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Identifying Factors and Target Preventive Therapies for Middle East Respiratory Syndrome Sucsibtable Patients
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Khalid A. Alburikan, Hatem A. AbuelizzAbstractBackgroundMiddle East Respiratory Syndrome (MERS) is a respiratory disease caused by a novel coronavirus that was identified in 2012 in Saudi Arabia. It is associated with significant mortality and morbidity. We identified factors associated with the Middle East Respiratory Syndrome-Coronavirus (MERS‐CoV) infection among suspected cases presented with sign and symptoms of upper respiratory infection or exposure to the virus. We also looked at the impact of medication history on vi...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Association of OprF mutant and disturbance of biofilm and pyocyanin virulence in pseudomonas aeruginosa
This study investigating a multiphenotypic approach, based on the comparative study of a wild type strain of P. aeruginosa, its isogenic OprF mutant. Both P. aeruginosa PAO1 and OprF mutant strains were grown in same condition and cultures were subjected to further analysis by SDS PAGE, pyocyanin production and biofilm formation that was analyse using scanning electron microscopy. Based on biofilm formation essay and pyocyanin production, the study showed that OprF plays a dynamic role in P. aeruginosa virulence. The absence of OprF results in slow growth rate corresponded to elongated lag phase and reduced biofilm product...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Propolis ameliorates cerebral injury in focal cerebral ischemia/reperfusion (I/R) rat model via upregulation of TGF-β1
In this study, focal cerebral ischemia model was built by middle cerebral artery occlusion (MCAO) for 2h followed by reperfusion. The investigation was carried out on 48 rats that were arranged into four groups (n=12): the sham group, I/R control group, I/R+propolis (50 mg/kg) group and I/R+propolis (100 mg/kg) group. The results revealed that propolis preserved rats against neuronal injury induced by cerebral I/R. It significantly reduced neurological deficit scores and improved motor coordination and locomotor activity in I/R rats. Propolis antagonized the damage induced by cerebral I/R through suppression of malondialde...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Antibacterial, antioxidant and enzyme inhibition activity capacities of Doronicum macrolepis (FREYN&SINT): An endemic plant from Turkey
In conclusion, the results suggest that, because of its bioactivity including the antioxidant, antimicrobial, and enzyme inhibition properties, the D. macrolepis can be accepted as a promising and natural source for the industrial applications. The present study is the first study, in which the bioactive components and the antioxidant, antimicrobial, and enzyme inhibition properties of endemic D. macrolepis plant were determined. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Time and sex dependency of hemodynamic, renal, and survivability effects of endotoxemia in rats
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Abdalla M. Wedn, Sahar M. El-Gowilly, Mahmoud M. El-MasAbstractWidely different exposure times to endotoxic insults have been employed in reported studies. The current experimental study systematically evaluated the time-course and sex influences of endotoxic insult on survivability and cardiovascular and renal functions. Rats received i.p. lipopolysaccharide (LPS, 5 mg/kg) once or twice (over 2 successive days). Systolic blood pressure (SBP), biomarkers of renal function and inflammation, and vasodilator responsiveness of isol...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

The effect of alcohol on ionizing and non-ionizing drug release from hydrophilic, lipophilic and dual matrix tablets
This study is focused on comparison of the dissolution behavior of matrix tablets (based on hypromellose and/or glyceryl behenate as retarding agent) of the same composition containing different type of drug – ionizing tramadol hydrochloride (TH) and non-ionizing pentoxifylline (PTX). The dissolution tests were performed in acidic medium (pH 1.2) and in alcoholic medim (20%, 40% of ethanol) and the changes of tablets were observed also photographically.It was found that the alcohol resistence of the hydrophilic-lipophilic formulations with TH and the hydrophilic-lipophilic formulations with PTX containing a higher am...
Source: Saudi Pharmaceutical Journal - December 7, 2019 Category: Drugs & Pharmacology Source Type: research

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate
Publication date: Available online 13 November 2019Source: Saudi Pharmaceutical JournalAuthor(s): María Esperanza Adrover, Marisa Pedernera, Magali Bonne, Bénédicte Lebeau, Verónica Bucalá, Loreana GalloAbstractAlbendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous si...
Source: Saudi Pharmaceutical Journal - November 23, 2019 Category: Drugs & Pharmacology Source Type: research