A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.PMID:37504270 | PMC:PMC10378404 | DOI:10.3390/cimb45070354 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Kristina A Sharlo Irina D Lvova Sergey A Tyganov Ksenia V Sergeeva Vitaly Y Kalashnikov Ekaterina P Kalashnikova Timur M Mirzoev Grigoriy R Kalamkarov Tatiana F Shevchenko Boris S Shenkman Source Type: research
A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.PMID:37504270 | PMC:PMC10378404 | DOI:10.3390/cimb45070354 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Kristina A Sharlo Irina D Lvova Sergey A Tyganov Ksenia V Sergeeva Vitaly Y Kalashnikov Ekaterina P Kalashnikova Timur M Mirzoev Grigoriy R Kalamkarov Tatiana F Shevchenko Boris S Shenkman Source Type: research
A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.PMID:37504270 | PMC:PMC10378404 | DOI:10.3390/cimb45070354 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Kristina A Sharlo Irina D Lvova Sergey A Tyganov Ksenia V Sergeeva Vitaly Y Kalashnikov Ekaterina P Kalashnikova Timur M Mirzoev Grigoriy R Kalamkarov Tatiana F Shevchenko Boris S Shenkman Source Type: research
A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.PMID:37504270 | PMC:PMC10378404 | DOI:10.3390/cimb45070354 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Kristina A Sharlo Irina D Lvova Sergey A Tyganov Ksenia V Sergeeva Vitaly Y Kalashnikov Ekaterina P Kalashnikova Timur M Mirzoev Grigoriy R Kalamkarov Tatiana F Shevchenko Boris S Shenkman Source Type: research
Effectiveness and Safety of Prochlorperazine in Indian Patients with Acute Vertigo: Results from a Large, Prospective, Post-marketing Observational Study
ConclusionProchlorperazine showed improvement in severity of symptoms and clinical response in all subsets of vertigo patients, with a good safety and tolerability profile.Trial Registration NumberCTRI/2022/01/039287.Date of Registration10 January 2022. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - June 14, 2023 Category: ENT & OMF Source Type: research
Ondansetron: recommended antiemetics for patients with acute pancreatitis? a population-based study
Conclusion: In ICU acute pancreatitis patients, ondansetron administration was associated with better 90-day outcomes, while results were similar in terms of in-hospital and overall outcomes, and the recommended minimum total dose might be suggested to be 4–8 mg. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 10, 2023 Category: Drugs & Pharmacology Source Type: research
Rethinking Ondansetron as a First Line Agent for Nausea and Vomiting in the Emergency Department
Ondansetron is commonly used as a first-line agent to treat nausea and vomiting in the Emergency Department. The purpose of this study was to test the hypothesis that Odansetron is not superior to other antiemetics, when used to treat nausea and vomiting due to headache or abdominal pain in an emergency department. The medications that were compared in the study include: ondansetron, metoclopramide, haloperidol, prochlorperazine and promethazine. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - March 1, 2023 Category: Emergency Medicine Authors: Melanie Camejo, Monica L. Gaddis, Phi Dinh Source Type: research
The role of phenothiazine derivatives in autophagy regulation: A systematic review
AbstractIn this review, we summarized the current literature on the impact of phenothiazine derivatives on autophagy in vitro. Phenothiazines are antipsychotic drugs used in the treatment of schizophrenia, which is related to altered neurotransmission and dysregulation of neuronal autophagy. Thus, phenothiazine derivatives can impact autophagy. We identified 35 papers, where the use of the phenothiazines in the in vitro autophagy assays on normal and cancer cell lines,Caenorhabditis elegans, and zebrafish were discussed. Chlorpromazine, fluphenazine, mepazine, methotrimeprazine, perphenazine, prochlorperazine, promethazine...
Source: Journal of Applied Toxicology - October 5, 2022 Category: Toxicology Authors: Micha ł Otręba,
Jerzy Stojko,
Anna Rzepecka‐Stojko Tags: REVIEW ARTICLE Source Type: research
The role of phenothiazine derivatives in autophagy regulation: A systematic review
AbstractIn this review, we summarized the current literature on the impact of phenothiazine derivatives on autophagyin vitro. Phenothiazines are antipsychotic drugs used in the treatment of schizophrenia, which is related to altered neurotransmission and dysregulation of neuronal autophagy. Thus, phenothiazine derivatives can impact autophagy. We identified 35 papers, where the use of the phenothiazines in thein vitro autophagy assays on normal and cancer cell lines,C. elegans, and zebrafish were discussed. Chlorpromazine, fluphenazine, mepazine, methotrimeprazine, perphenazine, prochlorperazine, promethazine, thioridazine...
Source: Journal of Applied Toxicology - September 28, 2022 Category: Toxicology Authors: Micha ł Otręba,
Jerzy Stojko,
Anna Rzepecka‐Stojko Tags: REVIEW ARTICLE Source Type: research
Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model
In this study, we sought to evaluate the effect of the acid environment on the Oreochromis niloticus (Nile tilapia) internal microenvironment immune response compare to the mouse macrophage model (J77A.1). The acid environment treated mouse macrophage J774A.1 model have shown that acidic treatment is able to polarize macrophages into M2-like macrophages via an increase in Ym1, Tgm2, Arg1, Fizz1, and IL-10 expression. Metabolic analysis of mouse macrophages (J774A.1) at pH 2 vs. pH 7 and pH 4 vs. pH 7 have been shown to promote the expression of intracellular acetylcholine, choline, prochlorperazine, L-leucine, and bispheno...
Source: Frontiers in Immunology - September 26, 2022 Category: Allergy & Immunology Source Type: research
2022 Taiwan Guidelines for Acute Treatment of Migraine
Acta Neurol Taiwan. 2022 Jun 30;31(2):89-113.ABSTRACTThe Taiwan Headache Society published its guidelines for acute migraine treatment in 2017. Since then, emerging drugs and treatment options have developed rapidly. The migraine-specific drugs gepants and ditans and several noninvasive neuromodulation devices have been approved for use in Europe and the United States. Although not all emerging drugs and treatment options have been approved for use in Taiwan, keeping pace with international trends and updating treatment guidelines are imperative. Therefore, the Treatment Guideline Subcommittee of the Taiwan Headache Societ...
Source: Acta Neurologica Taiwanica - September 25, 2022 Category: Neurology Authors: Chi Ieong Lau Yen-Feng Wang Treatment Guideline Subcommittee of the Taiwan Headache Society Source Type: research
