Intravenous Migraine Treatment in Children and Adolescents
AbstractPurpose of ReviewPediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents. Outpatient management is not always effective, and intravenous migraine management may be necessary for headache treatment in the pediatric emergency department. Most current treatment is based on retrospective evidence and there is a lack of well-designed randomized double-blinded controlled pediatric studies. Intravenous drug treatment agents including intravenous fluids, prochlorperazine, diphenhydramine, metoclopramide, dexamethasone, magnesium, valproate and propofol, and dihydroergotamine...
Source: Current Pain and Headache Reports - July 7, 2020 Category: Neurology Source Type: research
Ketamine for Migraine in the Emergency Department
Ketamine is utilized often in the emergency department (ED) for rapid sequence intubation, procedural sedation, and acute pain management. The treatment of migraine headache in the ED varies widely and is dependent on several factors including migraine cause, previous successful abortive methods, and provider preference. Several medications are currently employed to treat acute migraine including nonsteroidal anti-inflammatory drugs, triptans, antihistamines, prochlorperazine, and corticosteroids, among others. Interest in ketamine as an abortive agent to treat migraine has increased as evidenced by recent studies evaluati...
Source: Advanced Emergency Nursing Journal - April 1, 2020 Category: Emergency Medicine Tags: APPLIED PHARMACOLOGY Source Type: research
Case Series: Rapid Induction Onto Long Acting Buprenorphine Injection for High Potency Synthetic Opioid Users.
CONCLUSION: All five participants were retained at least 1-month postinduction.
SCIENTIFIC SIGNIFICANCE: It may be feasible to provide BXR treatment to HPSO-positive heroin users rapidly to achieve clinical stabilization. (Am J Addict 2020;00:00-00).
PMID: 32167629 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - March 12, 2020 Category: Addiction Authors: Mariani JJ, Mahony A, Iqbal MN, Luo SX, Naqvi NH, Levin FR Tags: Am J Addict Source Type: research
The Real-World Safety and Effectiveness of Prochlorperazine in Indian Patients with Dizziness.
Conclusion: Prochlorperazine was well-tolerated in the management of acute dizziness when administered at a mean dose of 14.9 mg/day, and mean duration of 7.2 days. Additionally, prochlorperazine was effective in providing significant symptomatic relief from dizziness and associated vomiting and nausea.
PMID: 32009365 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - February 6, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Acute dystonic reactions in children treated for headache with prochlorperazine or metoclopramide
The incidences of dystonic reactions to metoclopramide and prochlorperazine have not been well characterized in children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 2, 2020 Category: Neurology Authors: Laura Kirkpatrick, Yoshimi Sogawa, Catalina Cleves Tags: Short Communication Source Type: research
A week-long outpatient induction onto XR-naltrexone in patients with opioid use disorder.
Conclusion: The results support the feasibility of a week-long outpatient induction onto XR-naltrexone with ascending doses of naltrexone and standing doses of adjunctive medications. By circumventing the need for a protracted period of abstinence and mitigating the severity of withdrawal symptoms experienced during naltrexone titration, this strategy has the potential to increase patient acceptability and access to relapse prevention treatment with XR-naltrexone.
PMID: 31860366 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - December 19, 2019 Category: Addiction Authors: Sibai M, Mishlen K, Nunes EV, Levin FR, Mariani JJ, Bisaga A Tags: Am J Drug Alcohol Abuse Source Type: research
A Brief Look at Urgent Care Visits for Migraine: The Care Received and Ideas to Guide Migraine Care in this Proliferating Medical Setting.
CONCLUSIONS: The majority of patients in our study who sought medical treatment for migraine in these 2 urgent care centers were not established patients within the urgent care centers' healthcare system. While 93.6% (73/78) of patients were experiencing current pain upon presentation to the urgent care centers, only 12.3% (9/73) received administration of the medications with the highest level of evidence by the American Headache Society (Level B) for acute migraine treatment in an ED. In addition, the majority of patients with a migraine history presenting to the urgent care setting were not given triptans or anti-emetic...
Source: Headache - December 3, 2019 Category: Neurology Authors: Minen MT, Zhou K, Miller L Tags: Headache Source Type: research
Forskrivning av antipsykotika til hjemmeboende eldre 2006 –18.
Forskrivning av antipsykotika til hjemmeboende eldre 2006–18.
Tidsskr Nor Laegeforen. 2019 Nov 05;139(16):
Authors: Tveito M, Handal M, Engedal K, Smith RL, Høiseth G, Skurtveit S
Abstract
BACKGROUND: It is generally agreed that prescribing of antipsychotic drugs to older patients should be reduced, but figures for the prescribing of these drugs to older patients living at home in Norway are not available. The study aimed to investigate developments in prescribing of antipsychotic drugs among older patients living at home from 2006 to 2018, and whether there were differences in...
Source: Tidsskrift for den Norske Laegeforening - November 4, 2019 Category: General Medicine Authors: Tveito M, Handal M, Engedal K, Smith RL, Høiseth G, Skurtveit S Tags: Tidsskr Nor Laegeforen Source Type: research
Prochlorperazine for treatment of acute migraines in adults.
Abstract
Migraine headache results in over 1 million emergency department visits per year in the United States.1-3 Several treatments have been offered to treat the headache.4-6 Prochlorperazine has been tested in randomized trials and, despite adverse effects such as dystonic reactions several societies recommend its use.4,6.
PMID: 31592565 [PubMed - as supplied by publisher] (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - October 7, 2019 Category: Emergency Medicine Authors: Long B, Koyfman A, Gottlieb M Tags: Acad Emerg Med Source Type: research
Transdermal Delivery of Antipsychotics: Rationale and Current Status
AbstractThe aim of this article is to provide the rationale for the development of transdermal formulations of antipsychotics by highlighting their main advantages, starting with an overview of the antipsychotic formulations that are currently available on the market. Progress regarding transdermal antipsychotic formulations was investigated by performing a search of papers, patents and clinical trials published in the last 10 years. Available data on antipsychotic transdermal formulations are reported and discussed, focusing on the characteristics of the dosage forms and their ability to promote drug absorption. Despite...
Source: CNS Drugs - September 5, 2019 Category: Neurology Source Type: research
Ondansetron for Acute Migraine in the Pediatric Emergency Department
Migraines are a common illness presenting to pediatric emergency departments (PED). Significant research has been devoted towards establishing treatment regimens for treating migraines. Much of this research involves antidopaminergic antiemetics such as prochlorperazine and metoclopramide. Despite a comparably more favorable side effect profile, no research has been directed towards examining ondansetron, a selective type three 5-hydroxytryptamine receptor antagonist, in the treatment of migraines. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 4, 2019 Category: Neurology Authors: Afsaneh Talai, Benjamin Heilbrunn Tags: Research Paper Source Type: research
Cost of prochlorperazine rose 700% after drug companies colluded, alleges watchdog
(Source: BMJ News)
Source: BMJ News - May 29, 2019 Category: General Medicine Source Type: research
Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex
Publication date: Available online 27 May 2019Source: Journal of Pharmacological SciencesAuthor(s): Keisuke Obara, Saki Horiguchi, Toma Shimada, Takumi Ikarashi, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio TanakaAbstractAntipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat dementia. We investigated the inhibitory effects of 26 antipsychotics on [N-Methyl-3H]scopolamine specific binding in mouse cerebral cortex. At 1...
Source: Journal of Pharmacological Sciences - May 29, 2019 Category: Drugs & Pharmacology Source Type: research
