No increased pain among opioid-dependent individuals treated with extended-release naltrexone or buprenorphine-naloxone: A 3-month randomized study and 9-month open-treatment follow-up study.
CONCLUSIONS: Among individuals with opioid use disorder, switching from daily opioid use to long-acting naltrexone did not induce pain, or aggravate mild-to-moderate chronic pain. SCIENTIFIC SIGNIFICANCE: In opioid-dependent individuals, mild-to-moderate chronic pain was not influenced by opioid agonist or antagonist treatment. TRIAL REGISTRATION: Clinicaltrials.gov #NCT01717963, first registered: Oct 28, 2012. Protocol version # 3C, June 12th 2012. (Am J Addict 2018;XX:1-9). PMID: 30701613 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - January 31, 2019 Category: Addiction Authors: Latif ZE, Solli KK, Opheim A, Kunoe N, Benth JŠ, Krajci P, Sharma-Haase K, Tanum L Tags: Am J Addict Source Type: research

Review article: Effective management of opioid withdrawal symptoms: A gateway to opioid dependence treatment.
CONCLUSIONS: Non-opioid medications to treat OWS provides a gateway into long-term treatment with naltrexone or psychosocial therapies. For opioid dependent patients without OUD, non-opioid treatments like α-2 adrenergic agonists can facilitate opioid tapering. SCIENTIFIC SIGNIFICANCE: For the millions who are physically dependent on opioids, new treatments for OWS can enhance recovery from OUD and prevent relapse. (© 2019 The Authors. The American Journal on Addictions Published by Wiley Periodicals, Inc.;XX:1-8). PMID: 30701615 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - January 31, 2019 Category: Addiction Authors: Kosten TR, Baxter LE Tags: Am J Addict Source Type: research

Preclinical efficacy of an anti-methamphetamine vaccine using E6020 adjuvant.
We examined a novel adjuvant, E6020, a Toll-like receptor-4 (TLR-4) agonist combined with tetanus-toxoid conjugated to succinyl-methamphetamine (TT-SMA) adsorbed on aluminum hydroxide (alum). Adult BALB/c female mice received the vaccine and booster injections at weeks 0, 3, and 6. The efficacy of the vaccine was assessed by the level and affinity of anti-MA antibodies elicited, its ability to attenuate MA induced locomotor activation and its reduction in the amount of MA entering the brains of vaccinated mice. RESULTS: The TT-SMA vaccine containing alum and E6020 adjuvant produced anti-MA antibodies with nanomolar af...
Source: American Journal on Addictions - January 31, 2019 Category: Addiction Authors: Arora R, Haile CN, Kosten TA, Wu Y, Ramakrishnan M, Hawkins LD, Orson FM, Kosten TR Tags: Am J Addict Source Type: research

Prescription opioid misuse and comorbid substance use: Past 30-day prevalence, correlates and co-occurring behavioral indicators in the 2016 National Survey on Drug Use and Health.
Abstract BACKGROUND AND OBJECTIVES: Prescription opioid misuse has not been well examined in the context of comorbid substance use in representative samples of substance users. Past 30-day comorbid prescription opioid misuse and recreational substance use (eg, alcohol, marijuana, cocaine, etc.) was studied in a representative sample of substance users in the United States using the 2016 National Survey on Drug Use and Health (NSDUH). METHODS: Prevalence of prescription opioid misuse with and without comorbid substance use was estimated with the 2016 NSDUH. Generalized linear modeling was used to describe demo...
Source: American Journal on Addictions - January 31, 2019 Category: Addiction Authors: Grigsby TJ, Howard JT Tags: Am J Addict Source Type: research

Comparison of opioid use disorder among male veterans and non-veterans: Disorder rates, socio-demographics, co-morbidities, and quality of life.
Abstract BACKGROUND AND OBJECTIVES: Amidst a surging national crisis of opioid use, concern has been expressed about its impact on veterans, but no study has presented a population-based comparison of opioid use disorder (OUD) among veterans and non-veterans. We analyzed national epidemiologic data to compare rates, correlates and impacts of the opioid crisis on male veterans and non-veterans. METHODS: Restricted data from 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) were used to compare veteran and non-veteran men on rates of OUD, as well as correlates of OUD ...
Source: American Journal on Addictions - January 21, 2019 Category: Addiction Authors: Rhee TG, Rosenheck RA Tags: Am J Addict Source Type: research

Buprenorphine for the treatment of posttraumatic stress disorder.
CONCLUSIONS: Buprenorphine may help decrease PTSD symptoms more than SSRIs or opioids alone. Prospective studies are needed to determine whether these effects are reproducible. SCIENTIFIC SIGNIFICANCE: Pharmacotherapy advancements in PTSD treatment have been limited and the kappa opioid receptor system presents a new target that warrants further research. (Am J Addict 2019;XX:1-6). PMID: 30664299 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - January 21, 2019 Category: Addiction Authors: Lake EP, Mitchell BG, Shorter DI, Kosten T, Domingo CB, Walder AM Tags: Am J Addict Source Type: research

Impulsiveness as a predictor of topiramate response for cocaine use disorder.
CONCLUSION: The results indicate an association between higher within-group impulsiveness and response to topiramate for CUD. The subscore findings may suggest a complex interaction between effectiveness and known cognitive side effects. The finding that trait impulsiveness is associated with treatment response is a promising discovery that may help guide treatment for CUD. SCIENTIFIC SIGNIFICANCE: This analysis suggests a possible endophenotype based on impulsiveness that can predict treatment response to topiramate. (Am J Addict 2019;XX:1-6). PMID: 30664303 [PubMed - as supplied by publisher] (Source: American ...
Source: American Journal on Addictions - January 21, 2019 Category: Addiction Authors: Blevins D, Wang XQ, Sharma S, Ait-Daoud N Tags: Am J Addict Source Type: research

The association of tobacco use with prescription of muscle relaxants, benzodiazepines, and opioid analgesics for non-cancer pain.
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Tobacco users were more likely to receive prescriptions for opioid analgesics with muscle relaxants and/or benzodiazepines than non-users. Healthcare professionals need to limit co-prescription of opioid analgesics with muscle relaxants and/or benzodiazepines among tobacco users and provide a comprehensive approach to pain management. (Am J Addict 2019;XX:1-8). PMID: 30623502 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - January 9, 2019 Category: Addiction Authors: Takaki H, Ieiri I, Shibuta H, Onozuka D, Hagihara A Tags: Am J Addict Source Type: research

Issue Information - Editorial Board.
Authors: PMID: 30578726 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 25, 2018 Category: Addiction Tags: Am J Addict Source Type: research

Issue Information - ToC.
Authors: PMID: 30578727 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 25, 2018 Category: Addiction Tags: Am J Addict Source Type: research

Substance use disorder and posttraumatic stress disorder symptomology on behavioral outcomes among juvenile justice youth.
CONCLUSIONS: Findings suggest that the association between SUD symptoms and externalizing behaviors among juvenile offenders may be best explained by the presence of PTSD symptomology. SCIENTIFIC SIGNIFICANCE: Addressing PTSD rather than SUD symptoms may be a better target for reducing risk for externalizing behaviors among this population of youth (Am J Addict 2019;28:29-35). PMID: 30576034 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 23, 2018 Category: Addiction Authors: Winningham RD, Banks DE, Buetlich MR, Aalsma MC, Zapolski TCB Tags: Am J Addict Source Type: research

Drug use and hazardous drinking are associated with PTSD symptoms and symptom clusters in US Army Reserve/National Guard Soldiers.
CONCLUSION: Soldiers experiencing PTSD symptoms are reporting current drug and hazardous alcohol use, suggestive of self-medication. SCIENTIFIC SIGNIFICANCE: It is imperative to consider the impact of PTSD on substance use broadly, as this work shows that overall symptoms and symptom clusters have an impact on male and female USAR/NG soldiers. (Am J Addict 2018;XX:1-7). PMID: 30548523 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 12, 2018 Category: Addiction Authors: Homish GG, Hoopsick RA, Heavey SC, Homish DL, Cornelius JR Tags: Am J Addict Source Type: research

Expectations about alcohol, cocaine, and benzodiazepine abstinence following inpatient heroin withdrawal management.
CONCLUSION: Persons with opioid use disorder often do not expect to stop using other substances following withdrawal management, with very few planning cocaine cessation. SCIENTIFIC SIGNIFICANCE: Inpatient heroin withdrawal programs need to address and educate patients about how polysubstance use complicates recovery from heroin use. (Am J Addict 2018;XX:1-7). PMID: 30548526 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 12, 2018 Category: Addiction Authors: Kenney SR, Anderson BJ, Bailey GL, Stein MD Tags: Am J Addict Source Type: research

Neuroactive steroid levels and cocaine use chronicity in men and women with cocaine use disorder receiving progesterone or placebo.
Abstract BACKGROUND AND OBJECTIVES: Neuroactive steroids (NAS) may play a role in addiction, with observed increases in response to acute stress and drug use, but decreases with chronic substance use, suggesting that NAS neuroadaptations may occur with chronic substance use. However, levels of NAS in addicted individuals have not been systematically examined. Here, we evaluated a panel of NAS in men and women with cocaine use disorder (CUD) who participated in a clinical laboratory study of progesterone. METHODS: Forty six CUD individuals were enrolled in a randomized placebo-controlled laboratory study to ev...
Source: American Journal on Addictions - December 11, 2018 Category: Addiction Authors: Milivojevic V, Covault J, Angarita GA, Siedlarz K, Sinha R Tags: Am J Addict Source Type: research

Gender differences in mental health and substance use disorders and related healthcare services utilization.
CONCLUSIONS: Healthcare services utilization significantly varies by gender and type of mental health and substance use diagnosis. There are significant differences by gender in the utilization of healthcare services for the same psychiatric disorders. SCIENTIFIC SIGNIFICANCE: There is a need to address gender differences in psychiatric conditions and their related healthcare needs. (Am J Addict 2018;XX:1-7). PMID: 30536669 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 7, 2018 Category: Addiction Authors: Brand E, Rodriguez-Monguio R, Volber R Tags: Am J Addict Source Type: research

Improving police conceptual knowledge of Mexico's law on cannabis possession: Findings from an assessment of a police education program.
CONCLUSION AND SCIENTIFIC SIGNIFICANCE: PEPs improve police knowledge of cannabis law. Reforms should be bundled with PEPs to improve policy implementation. (Am J Addict 2018;XX:XX-XX). PMID: 30516331 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 1, 2018 Category: Addiction Authors: Mittal ML, Artamonova I, Baker P, Strathdee SA, Cepeda J, Bañuelos A, Morales M, Arredondo J, Rocha-Jimenez T, Clairgue E, Bustamante E, Patiño E, Gaines T, Beletsky L Tags: Am J Addict Source Type: research

Issue Information - ToC.
Authors: PMID: 30516332 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 1, 2018 Category: Addiction Tags: Am J Addict Source Type: research

Ayahuasca: From the Amazon to a city near you.
PMID: 30516333 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 1, 2018 Category: Addiction Authors: Stiffler JD Tags: Am J Addict Source Type: research

Issue Information - Editorial Board.
Authors: PMID: 30516334 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 1, 2018 Category: Addiction Tags: Am J Addict Source Type: research

E-cigarettes and the Nicotine Epidemic.
PMID: 30516335 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 1, 2018 Category: Addiction Authors: Karam-Hage M Tags: Am J Addict Source Type: research

Attitudes toward defendants with substance-related charges: An analysis of a national sample of criminal defense attorneys.
CONCLUSION AND SCIENTIFIC SIGNIFICANCE: Given the magnitude of the incarcerated population with SUDs and the centrality of defense attorneys in the treatment process, especially its initiation, the divergence in attitudes between private and public criminal defense attorneys is concerning. There is a clear need for increased collaboration between physicians and attorneys, with an aim of increasing the number of individuals with SUDs receiving proper treatment (Am J Addict 2018;XX:1-7). PMID: 30516336 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 1, 2018 Category: Addiction Authors: Avery JJ, Starck J, Xu Y, Avery JD, Cooper J Tags: Am J Addict Source Type: research

Women and opioid use disorders.
PMID: 30516337 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - December 1, 2018 Category: Addiction Authors: Greenfield SF Tags: Am J Addict Source Type: research

Methadone to buprenorphine/naloxone induction without withdrawal utilizing transdermal fentanyl bridge in an inpatient setting-Azar method.
CONCLUSIONS: Our experience indicates a transdermal depot of fentanyl allows for slow release and elimination while buprenorphine doses are introduced during an induction without presence of withdrawal, as quantified by serial clinical opiate withdrawal score. SCIENTIFIC SIGNIFICANCE: This case report highlights ways to minimize barriers to induction of first-line opioid substitution therapy, buprenorphine/naloxone, by eliminating withdrawal during induction phase utilizing a fentanyl bridge within the limitations of a transdermal fentanyl bridge in an inpatient setting. (Am J Addict 2018;XX:1-4). PMID: 30387894 ...
Source: American Journal on Addictions - November 2, 2018 Category: Addiction Authors: Azar P, Nikoo M, Miles I Tags: Am J Addict Source Type: research

Neuropsychological changes in patients with substance use disorder after completion of a one month intensive outpatient treatment program.
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Patients with SUD often manifest high levels of executive dysfunction upon entry into SUD treatment that, while improving minimally, appears to persist despite intensive outpatient treatment at 1 month. These persistent EF deficits may affect patient engagement and participation in treatment, thus necessitating SUD programs to assess and accommodate EF issues throughout treatment. (Am J Addict 2018;XX:1-7). PMID: 30387896 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - November 2, 2018 Category: Addiction Authors: McKowen JW, Isenberg BM, Carrellas NW, Zulauf CA, Ward NE, Fried RS, Wilens TE Tags: Am J Addict Source Type: research

Prescription opioid medication misuse among university students.
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: This study identifies a number of risk factors for those misusing prescription opioids that can be used to develop and refine prescription opioid misuse screening tools for university health centers. It also identifies a number of concurring behaviors that can simultaneously be addressed when prescription opioid misusers are identified. (Am J Addict 2018;XX:1-7). PMID: 30328218 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - October 17, 2018 Category: Addiction Authors: Harries MD, Lust K, Christenson GA, Redden SA, Grant JE Tags: Am J Addict Source Type: research

Commentary: The opioid overdose epidemic: Evidence-based interventions.
CONCLUSIONS: Sharp opioid dose restriction in outpatient treatment increases heroin and fentanyl use, explaining why recent years' decrease in United States opioid prescriptions has not reduced national mortality rates. Although Harm Reduction is the safest, most effective single approach, combining three interventions while improving pain and addiction prescribing practices is optimal. SCIENTIFIC SIGNIFICANCE: Scientific research needs to inform choice of opioid overuse interventions. (Am J Addict 2018;XX:1-3). PMID: 30311993 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - October 12, 2018 Category: Addiction Authors: Barglow P Tags: Am J Addict Source Type: research

Feasibility and validity of mobile cognitive testing in patients with substance use disorders and healthy controls.
Conclusions The use of mobile cognitive testing is feasible and valid in this population. Scientific Significance Mobile cognitive tests provide new opportunities for both research and clinical intervention. (Am J Addict 2018;27:553-556). PMID: 30260085 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - September 29, 2018 Category: Addiction Authors: Bouvard A, Dupuy M, Schweitzer P, Revranche M, Fatseas M, Serre F, Misdrahi D, Auriacombe M, Swendsen J Tags: Am J Addict Source Type: research

Trends in DMT and other tryptamine use among young adults in the United States.
Abstract BACKGROUND AND OBJECTIVES: The popularity of tryptamines such as N,N-dimethyltryptamine (DMT) appears to be increasing in the United States (US), but epidemiologic literature on prevalence of use is scant. This paper aims to determine trends in prevalence and correlates of past-year tryptamine use among a nationally representative sample of young adults in the US. METHODS: Participants in the National Survey on Drug Use and Health survey were queried about past-year use of tryptamines-specifically DMT, α-methyltryptamine (AMT), and 5-MeO-DIPT ("Foxy"). Data were examined from young ad...
Source: American Journal on Addictions - September 29, 2018 Category: Addiction Authors: Palamar JJ, Le A Tags: Am J Addict Source Type: research

Impulsivity and decision making in older and younger cocaine-dependent participants: A preliminary study.
CONCLUSION: Higher state impulsivity in older cocaine participants suggests that cocaine use may have accelerating effects on the aging brain. SCIENTIFIC SIGNIFICANCE: This preliminary study adds the limited research on how cocaine use affects normal aging. Current treatments are based on younger adults, therefore the needs of older adults should be taken into consideration and studied more. (Am J Addict 2018;27:557-559). PMID: 30260087 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - September 29, 2018 Category: Addiction Authors: Johns SE, Wang Q, Straub LK, Moeller FG Tags: Am J Addict Source Type: research

Population-level patterns and mental health and substance use correlates of alcohol, marijuana, and tobacco use and co-use in US young adults and adults: Results from the population assessment for tobacco and health.
This study identified the most common patterns of current alcohol and marijuana use with the spectrum of tobacco products (cigarettes, hookah, e-cigarettes, cigars/little cigars, and other products), among US young adults and older adults and examined associations of mental health and substance use problems with each pattern. METHODS: Wave 1 adult dataset (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study. Weighted analyses estimated the prevalence of the top 10 patterns of current alcohol, marijuana, and tobacco use and co-use separately by young adults aged 18-24 (n = 9,112) an...
Source: American Journal on Addictions - August 30, 2018 Category: Addiction Authors: Cohn AM, Johnson AL, Rose SW, Pearson JL, Villanti AC, Stanton C Tags: Am J Addict Source Type: research

Substance use disorders and their effect on the psychiatric and justice systems.
Abstract BACKGROUND AND OBJECTIVES: A high proportion of persons in institutionalized settings such as the criminal justice system and psychiatric hospitals have substance use disorders (SUDs). We explored the association between substance use, demographics, and criminal justice involvement in a population of patients placed on involuntary 72-h holds in a psychiatric facility. METHODS: We retrospectively identified patients aged 18 through 57 years who had been placed on 72-h holds during an acute psychiatric hospitalization during a 1-year period. Data were analyzed with standard descriptive statistics, and ...
Source: American Journal on Addictions - August 28, 2018 Category: Addiction Authors: Schmidt KA, Lamoureux IC, Schak KM, Lachner C, Burton MC, Larrabee BR, Rummans TA Tags: Am J Addict Source Type: research

Patterns of opioid use during initial buprenorphine/naloxone treatment in relation to changes in opioid management laws in Kentucky.
CONCLUSIONS: After the passage of HB1, there was a significant increase in patients reporting heroin use and opioid agonists compared to non-heroin opioids when presenting for treatment. SIGNIFICANT SIGNIFICANCE: There has been a notable shift in the opioid epidemic, which is evident in the outpatient treatment settings. (Am J Addict 2018;XX:1-7). PMID: 30152574 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - August 28, 2018 Category: Addiction Authors: Dhanda A, O'Connor SS, McGuire H, Knox E, Ruth E Tags: Am J Addict Source Type: research

FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration.
Abstract BACKGROUND AND OBJECTIVES: The endogenous cannabinoid anandamide (AEA), an agonist at type-1 cannabinoid (CB1) receptors, is metabolized by fatty acid amide hydrolase (FAAH). The common variant rs324420 C->A within the FAAH gene on chromosome 1 codes for a missense substitution (Pro129Thr), resulting in decreased FAAH activity and increased endocannabinoid potentiation. This FAAH variant has been linked to alterations in mood and stress reactivity, as well as being independently linked to increased risk for addiction. We hypothesized that cocaine use disordered (CUD) participants with the FAAH Pro129 T...
Source: American Journal on Addictions - August 20, 2018 Category: Addiction Authors: Patel MM, Nielsen DA, Kosten TR, De La Garza R, Newton TF, Verrico CD Tags: Am J Addict Source Type: research

What do we know about the pharmacotheraputic management of insomnia in cannabis withdrawal: A systematic review.
CONCLUSION: There is not sufficient evidence for any of the reviewed treatment options. Methodological limitations in a majority of the studies rendered their findings preliminary. Of the twelve investigated pharmacological agents, Gabapentin, Lofexidine, Mirtazapine, Quetiapine, and Zolpidem showed some primary benefits for treatment of sleep difficulties associated with cannabis withdrawal; however, future prospective studies are required to confirm such results. SCIENTIFIC SIGNIFICANCE: This review examines the current evidence for potential pharmacological options for treatment of cannabis withdrawal and associate...
Source: American Journal on Addictions - August 16, 2018 Category: Addiction Authors: Zhand N, Milin R Tags: Am J Addict Source Type: research

Suicidality among gambling helpline callers: A consideration of the role of financial stress and conflict.
CONCLUSIONS: Family and social conflict may be one important way in which financial problems confer risk for suicidality among problem gamblers. These results align with findings from the substance use disorder (SUD) literature and highlight one potential factor that may merit further assessment and/or intervention. SCIENTIFIC SIGNIFICANCE: Researchers and clinicians may want to consider the overall level of conflict a patient is experiencing when assessing suicide risk among individuals with gambling problems. Professionals may also want to consider the suitability of interventions to address conflict within the cont...
Source: American Journal on Addictions - August 16, 2018 Category: Addiction Authors: Carr MM, Ellis JD, Ledgerwood DM Tags: Am J Addict Source Type: research

Adherence to extended release naltrexone: Patient and treatment characteristics.
Abstract BACKGROUND AND OBJECTIVES: Despite the promise of extended release naltrexone in the treatment of the opioid and alcohol use disorders, challenges with initiation and subsequent adherence have limited its potential. The purpose of this study is to identify the patient and treatment characteristics associated with adherence to extended release naltrexone. METHODS: Retrospective cohort study of 155 veterans who initiated the medication in FY 2014 and FY2015. Medical records were abstracted for patient and treatment data including preferred drug and utilization of substance use treatment in the year bef...
Source: American Journal on Addictions - August 14, 2018 Category: Addiction Authors: Chang G, Crawford M, Pitts M, Schein AZ, Goodwin K, Enggasser JL Tags: Am J Addict Source Type: research

Brief Report: Gender differences in demographic and clinical characteristics of patients with opioid use disorder entering a comparative effectiveness medication trial.
CONCLUSIONS: Findings underscore economic, psychiatric, and infection vulnerability among women with OUD. SCIENTIFIC SIGNIFICANCE: Interventions targeting these disparities should be explored, as women may face complicated treatment initiation, retention, and recovery. (Am J Addict 2018;XX:1-6). PMID: 30106494 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - August 14, 2018 Category: Addiction Authors: Campbell ANC, Barbosa-Leiker C, Hatch-Maillette M, Mennenga SE, Pavlicova M, Scodes J, Saraiya T, Mitchell SG, Rotrosen J, Novo P, Nunes EV, Greenfield SF Tags: Am J Addict Source Type: research

Cognitive functioning and treatment outcomes in a randomized controlled trial of internet-delivered drug and alcohol treatment.
CONCLUSIONS: The benefit of internet delivered treatment over standard care was unchanged across a range of cognitive functioning. Consistent with previous research, mild to moderate impairment in reasoning and cognitive flexibility were associated with lower retention across both treatment arms. SCIENTIFIC SIGNIFICANCE: An internet-delivered cognitive behavioral intervention for substance use disorders, TES, is equally effective across a spectrum of cognitive functioning among diverse patients. (Am J Addict 2018;XX:1-7). PMID: 30091814 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - August 9, 2018 Category: Addiction Authors: Shulman M, Campbell A, Pavlicova M, Hu MC, Aharonovich E, Nunes EV Tags: Am J Addict Source Type: research

Predictors of initiation of nicotine, alcohol, cannabis, and cocaine use: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).
CONCLUSIONS: Although the age of substance use initiation varies by substance, in more than 50% of cases initiation of use occurs in the first two decades of life. Although most risk factors for substance use initiation are common across substances, some are substance-specific. SCIENTIFIC SIGNIFICANCE: This information may help in the development of empirically-based preventive interventions. (Am J Addict 2018;XX:1-8). PMID: 30088294 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - August 7, 2018 Category: Addiction Authors: Blanco C, Flórez-Salamanca L, Secades-Villa R, Wang S, Hasin DS Tags: Am J Addict Source Type: research

A longitudinal evaluation of the role of alcohol self-concept in alcohol use, motives, negative affect, and alcohol-related problems among emerging adults.
CONCLUSIONS: Results from this study underscore the importance of motivation for alcohol use and internalization of alcohol identity in predicting changes in behavior across emerging adulthood and suggest future avenues of research. SCIENTIFIC SIGNIFICANCE: Alcohol self-concept may be a risk factor and intervention target. (Am J Addict 2018;XX:1-8). PMID: 30039892 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - July 24, 2018 Category: Addiction Authors: Blevins CE, Abrantes AM, Anderson BJ, Caviness CM, Herman DS, Stein MD Tags: Am J Addict Source Type: research

Nonmedical benzodiazepine use in adults with alcohol use disorder: The role of anxiety sensitivity and polysubstance use.
CONCLUSIONS: These results replicate findings from research on opioid use disorder suggesting that anxiety sensitivity is associated with nonmedical benzodiazepine use in women and not men. SCIENTIFIC SIGNIFICANCE: Targeted intervention to those with polysubstance use-including education on overdose risk when benzodiazepines are combined with other substances-is indicated in men and women with alcohol use disorder. Anxiety sensitivity may be a potential therapeutic target to reduce nonmedical benzodiazepine use among women with alcohol use disorder. (Am J Addict 2018;XX:1-6). PMID: 30028048 [PubMed - as supplied ...
Source: American Journal on Addictions - July 20, 2018 Category: Addiction Authors: McHugh RK, Geyer R, Karakula S, Griffin ML, Weiss RD Tags: Am J Addict Source Type: research

Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone.
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Early opioid withdrawal changes may be a useful indicator of treatment response, helping adjust the transition protocol to the individual patients' need and gather valuable information for a better understanding of the relationship between initiating and remaining in treatment. (Am J Addict 2018;XX:1-6). PMID: 30028058 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - July 20, 2018 Category: Addiction Authors: Mannelli P, Swartz M, Wu LT Tags: Am J Addict Source Type: research

Comparison of three measurement models of discounting among individuals with methamphetamine use disorder.
CONCLUSION: To our knowledge, the current study is the first to report significantly greater discounting in a MA-M relative to M-M discounting task among individuals with MAUD, an outcome consistent with other psychomotor stimulants and drugs of abuse. SCIENTIFIC SIGNIFICANCE: The differential results observed across the three discounting models reaffirm potential issues with AUC noted in recent studies and highlight that researchers must be cautious when deciding on their final model of discounting. (Am J Addict 2018;XX:1-8). PMID: 30024076 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - July 19, 2018 Category: Addiction Authors: Yoon JH, Weaver MT, De La Garza R, Suchting R, Nerumalla CS, Omar Y, Brown GS, Haliwa I, Newton TF Tags: Am J Addict Source Type: research

Pregnancy intention and opioid use disorder treatment retention in the MOTHER study.
CONCLUSIONS: Unintended pregnancies intersect with OUD and may modify one's treatment outcomes. SCIENTIFIC SIGNIFICANCE: OUD treatment may be a setting to help women implement informed family planning choices. (Am J Addict 2018;XX:1-3). PMID: 29995313 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - July 11, 2018 Category: Addiction Authors: Martin CE, Terplan M, O'Grady KE, Jones HE Tags: Am J Addict Source Type: research

Lost in virtual gaming worlds: Grit and its prognostic value for online game addiction.
Abstract BACKGROUND AND OBJECTIVES: The personality construct grit is defined as the ability to be persistent in pursuit of long-term goals in spite of challenges or obstacles. Grit is an emerging concept in positive psychology and has gained much attention because of its relevance for success and well-being across different domains. The aim of the present study was to examine the prognostic value of grit for online game addiction. METHODS: We surveyed German speaking online gamers (N = 305: 193 males and 112 females, Mage  = 28.44 years, SDage  = 8.88) in an online c...
Source: American Journal on Addictions - July 11, 2018 Category: Addiction Authors: Borzikowsky C, Bernhardt F Tags: Am J Addict Source Type: research

A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: This review suggests that GxE findings may advance our knowledge regarding which developmentally specific conditions result in the expression of candidate genes that influence youth alcohol use and misuse. However, since a significant number of studies had small sample sizes and most studies had small effect sizes, findings need replication across independent studies with large samples. (Am J Addict 2018;XX:1-19). PMID: 29992684 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - July 10, 2018 Category: Addiction Authors: Kim J, Park A Tags: Am J Addict Source Type: research

Choreoathetoid movements associated with methamphetamine: A case report and review of literature.
CONCLUSIONS: Evidence for treatment of methamphetamine induced choreoathetosis is limited. Expectant management of such symptoms is a viable option if there are no additional comorbidities that require therapy. SCIENTIFIC SIGNIFICANCE: Clinicians should be alert to the possibility of movement disorders in methamphetamine users and familiar with treatment options. (Am J Addict 2018;XX:1-4). PMID: 29968954 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - July 3, 2018 Category: Addiction Authors: Das A, Price D, Clothier J Tags: Am J Addict Source Type: research

Dual use of alcohol and marijuana and condomless sex in young adult men and women: A within-subject day-level analysis.
CONCLUSIONS: Young persons who use alcohol and/or marijuana experience heightened likelihood of condomless sex. This increased likelihood is greater for women than for men on days with alcohol or marijuana use, each alone but especially when combined. SCIENTIFIC SIGNIFICANCE: Young women may be especially susceptible to the influence of alcohol and/or marijuana use on sexual behavior. (Am J Addict 2018;XX:1-6). PMID: 29923270 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Source: American Journal on Addictions - June 20, 2018 Category: Addiction Authors: Hayaki J, Anderson BJ, Stein MD Tags: Am J Addict Source Type: research

Positive and negative affect in cocaine use disorder treatment: Change across time and relevance to treatment outcome.
Abstract BACKGROUND: Cognitive-behavior therapy (CBT) for substance use disorder is empirically supported, and may be associated with change in affect over time. OBJECTIVES: Understanding the role of affect in cocaine use disorder could help to improve CBT outcomes. METHODS: This secondary analysis included 140 adults with cocaine use disorder, 57.9% female, drawn from two randomized controlled studies of web-based cognitive-behavior therapy who completed the Positive and Negative Affect Scale (PANAS) before and during treatment. RESULTS: In mixed-effects regression models, baseline negative affect ...
Source: American Journal on Addictions - June 20, 2018 Category: Addiction Authors: Decker SE, Morie KP, Malin-Mayo B, Nich C, Carroll KM Tags: Am J Addict Source Type: research

Positive expectancies mediate the association between sensation seeking and marijuana outcomes in at-risk young adults: A test of the acquired preparedness model.
CONCLUSIONS: Our findings are consistent with the APM and suggest that higher sensation seeking is related to increased positive beliefs about marijuana outcomes, which is related to higher marijuana use and more MUD symptoms. SCIENTIFIC SIGNIFICANCE: These findings suggest that positive expectancies are an important risk factor for marijuana use and misuse, particularly for at-risk individuals with elevated rates of sensation seeking. Positive marijuana expectancies may be important to address in interventions for at-risk individuals. (Am J Addict 2018;XX:1-6). PMID: 29873863 [PubMed - as supplied by publisher] ...
Source: American Journal on Addictions - June 6, 2018 Category: Addiction Authors: Curry I, Trim RS, Brown SA, Hopfer CJ, Stallings MC, Wall TL Tags: Am J Addict Source Type: research