Antipsychotic drugs and risk of idiopathic venous thromboembolism: a nested case–control study using the CPRD
ConclusionThe risk of VTE with typical and atypical antipsychotics varies with type of drug and is highest just after starting the drug. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - September 1, 2014 Category: Drugs & Pharmacology Authors: Chieko Ishiguro, Xi Wang, Lin Li, Susan Jick Tags: Original Report Source Type: research
The Case Files: CrossFit-Induced Carotid Artery Dissection
By Fox, Alex MD; King, Andrew MD
CrossFit has become a workout phenomenon with more than 5,500 gyms and millions of staunch followers. Developed by Greg Glassman, CrossFit defines itself as “that which optimizes fitness, constantly varied functional movements performed at relatively high intensity.” The craze has been embraced by fitness enthusiasts and weekend warriors alike.
These intense workouts can be dangerous for those with less experience who do not have trainers to help ease them into the routine. A 2005 New York Times article, “Getting Fit, Even If It Kills You,” criticized CrossFit for placing ...
Source: The Case Files - July 8, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research
The Case Files: CrossFit-Induced Carotid Artery Dissection
By Fox, Alex MD; King, Andrew MD
CrossFit has become a workout phenomenon with more than 5,500 gyms and millions of staunch followers. Developed by Greg Glassman, CrossFit defines itself as “that which optimizes fitness, constantly varied functional movements performed at relatively high intensity.” The craze has been embraced by fitness enthusiasts and weekend warriors alike.
These intense workouts can be dangerous for those with less experience who do not have trainers to help ease them into the routine. A 2005 New York Times article, “Getting Fit, Even If It Kills You,” criticized CrossFit for placing emph...
Source: The Case Files - July 8, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Appropriateness of Dopamine Antagonist Prescribing in Hospitalized Patients with Dopamine Requiring Diseases after Implementation of an Automated Prescribing Alert System (S49.005)
CONCLUSIONS: An automated alert system that identifies concurrent dopamine antagonists and levodopa prescription in an academic medical center had little impact on physician prescribing behavior. Inappropriate dopamine antagonists were prescribed more often on the psychiatry service and at night. This study highlights the need for improved education of health care providers and possibly greater supervision of residents at night.Disclosure: Dr. Morris has nothing to disclose. Dr. Willis has nothing to disclose. Dr. McCann has nothing to disclose. Dr. Birke has nothing to disclose. Dr. Racette has received research support f...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Morris, M., Willis, A., McCann, F., Birke, A., Racette, B. Tags: Practice, Policy, and Ethics Source Type: research
Appropriateness of Dopamine Antagonist Prescribing in Hospitalized Patients with Dopamine Requiring Diseases after Implementation of an Automated Prescribing Alert System (I8-2.002)
CONCLUSIONS: An automated alert system that identifies concurrent dopamine antagonists and levodopa prescription in an academic medical center had little impact on physician prescribing behavior. Inappropriate dopamine antagonists were prescribed more often on the psychiatry service and at night. This study highlights the need for improved education of health care providers and possibly greater supervision of residents at night.Disclosure: Dr. Morris has nothing to disclose. Dr. Willis has nothing to disclose. Dr. McCann has nothing to disclose. Dr. Birke has nothing to disclose. Dr. Racette has received research support f...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Morris, M., Willis, A., McCann, F., Birke, A., Racette, B. Tags: Clinical Decision Making After the Dust Settles on Clinical Trials Data Blitz Presentations Source Type: research
Combined drug therapy in the management of granulomatous amoebic encephalitis due to Acanthamoeba spp., and Balamuthia mandrillaris.
Abstract
Granulomatous amoebic encephalitis (GAE) is caused by two protist pathogens, Acanthamoeba spp., and Balamuthia mandrillaris. Although rare, it almost always results in death. In the present study, amoebae were treated with various combinations of clinically-approved drugs, targeting vital cellular receptors and biochemical pathways. The results revealed that among the seven different combinations tested, three proved highly effective against both A. castellanii as well as B. mandrillaris at a concentration of 100μM. These combinations included (i) prochlorperazine plus loperamide; (ii) prochlorpe...
Source: Experimental Parasitology - April 8, 2014 Category: Parasitology Authors: Kulsoom H, Baig AM, Siddiqui R, Khan NA Tags: Exp Parasitol Source Type: research
Chlorpromazine for the treatment of migraine in a pediatric emergency department.
CONCLUSIONS: This is the first study that has examined the use of chlorpromazine as a therapy in pediatric migraines. Abortive therapy for migraine headache in the PED with chlorpromazine is associated with greater need for rescue medication and hospitalization, and higher rates of hypotension.
PMID: 24512578 [PubMed - in process] (Source: Headache)
Source: Headache - February 1, 2014 Category: Neurology Authors: Kanis JM, Timm NL Tags: Headache Source Type: research
Field-amplified sample injection coupled with pseudo-isotachophoresis technique for sensitive determination of selected psychiatric drugs in human urine samples after dispersive liquid-liquid microextraction.
Abstract
A field-amplified sample injection (FASI) technique was elaborated for fast and sensitive determination of selected central nervous system drugs in human urine samples. Factors affecting the sensitivity enhancement, such as background electrolyte (BGE) and the analytical matrix composition were optimized and discussed. Pseudo-isotachophoresis (p-ITP) mechanism contribution in preconcentration mechanism was discussed. All separations were performed in uncoated fused silica capillaries 50μm×57cm at 22kV. The optimized analytical matrix was composed of 0.25mM HCOOH in 90% (v/v) methanol, while BGE ...
Source: Analytica Chimica Acta - January 27, 2014 Category: Chemistry Authors: Dziomba S, Kowalski P, Słomińska A, Bączek T Tags: Anal Chim Acta Source Type: research
Antiemetic use in US EDs
While antiemetic medications are frequently administered in US emergency departments (EDs) , concerns have recently been raised over the safety profile of some of these medications, ondansetron (Zofran) for prolonged QT and promethazine (Phenergan) for tissue necrosis and extrapyramidal symptoms, which can be lasting and devastating to the patient . Recent nation drug shortages of other antiemetics, prochlorperazine (Compazine) and metoclopramide (Reglan), may alter physician practices and disproportionately impact specific populations . (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - November 4, 2013 Category: Emergency Medicine Authors: Elizabeth Barlow-Savko, Brett Forehand, Jestin N. Carlson Tags: Correspondence Source Type: research
Chlorpromazine for the Treatment of Migraine in a Pediatric Emergency Department
ConclusionsThis is the first study that has examined the use of chlorpromazine as a therapy in pediatric migraines. Abortive therapy for migraine headache in the PED with chlorpromazine is associated with greater need for rescue medication and hospitalization, and higher rates of hypotension. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 29, 2013 Category: Neurology Authors: Jessica M. Kanis, Nathan L. Timm Tags: Research Submission Source Type: research
The phenothiazine-class antipsychotic drugs prochlorperazine and trifluoperazine are potent allosteric modulators of the human P2X7 receptor.
Abstract
P2X7, an ATP-gated cation channel, is involved in immune cell activation, hyperalgesia and neuropathic pain. By regulating cytokine release in the brain, P2X7 has been linked to the pathophysiology of mood disorders and schizophrenia. We here assess the impact of 123 drugs that act in the central nervous system on human P2X7. Most prominently, the tricyclic antipsychotics prochlorperazine (PCP) and trifluoperazine (TFP) potently inhibited P2X7-mediated Ca(2+) entry, dye permeation and ionic currents. In divalent cation-containing bath solutions or after prolonged incubation, ATP-evoked P2X7 curren...
Source: Neuropharmacology - August 14, 2013 Category: Drugs & Pharmacology Authors: Hempel C, Nörenberg W, Sobottka H, Urban N, Nicke A, Fischer W, Schaefer M Tags: Neuropharmacology Source Type: research
Assessment of the effect of efflux pump inhibitors on in vitro antimicrobial susceptibility of multidrug-resistant Acinetobacter baumannii
In this study, the effects of several EPIs, including carbonyl cyanide m-chlorophenylhydrazone (CCCP), phenylalanine-arginine β-naphthylamide (PAβN) and 1-(1-napthylmethyl)-piperazine (NMP), as well as drugs that may impact bacterial efflux mechanisms, such as omeprazole, verapamil, reserpine and the phenothiazines [prochlorperazine (PCPZ), chlorpromazine (CPZ) and promazine (PMZ)] on the in vitro antimicrobial susceptibility of MDR A. baumannii were assessed. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - July 8, 2013 Category: Drugs & Pharmacology Authors: Yuanyong Yang, Kim Lee Chua Tags: Letters to the Editor Source Type: research
Pharmacogenetic predictors of nausea and vomiting of pregnancy severity and response to antiemetic therapy: a pilot study
The objective of this study was to evaluate the association between response to antiemetics in the treatment of NVP and genetic polymorphisms in the serotonin receptor subunit genes HTR3A and HTR3B.
Methods:
Pregnant women >=18 years of age with NVP starting antiemetic therapy with promethazine, prochlorperazine, metoclopramide, or ondansetron at (Source: BMC Pregnancy and Childbirth - Latest articles)
Source: BMC Pregnancy and Childbirth - Latest articles - June 20, 2013 Category: OBGYN Authors: Amalia LehmannJamie RenbargerCatherine McCormickAriel TopletzCarrie RouseDavid Haas Source Type: research
Physical incompatibility between prochlorperazine, diclofenac and Injekt® syringe
(Source: Anaesthesia)
Source: Anaesthesia - June 13, 2013 Category: Anesthesiology Authors: M. Clayton, A. Ramamoorthy Tags: Correspondence Source Type: research
