Preface.
Authors: Giovagnoli S Abstract PMID: 31418343 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - August 18, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanosuspension Technology: Recent Patents on Drug Delivery and Their characterizations.
CONCLUSION: Nanosuspension contributes a crucial role in administering the different drug entities through a variety of routes involves oral, transdermal, ocular, parenteral, pulmonary, etc. with solving the different issues. This review also confirms the significance of nanosuspension in safety, efficacy, and communal as well as the economic expense associated with healthcare. PMID: 31203813 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - June 19, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Application of Optimization Technique to Develop Nano-Based Carrier of Nigella Sativa Essential Oil: Characterization and Assessment.
Authors: Dawaba AM, Dawaba HM Abstract BACKGROUND: Chitosan, a naturally occurring polymer, has interesting applications in the field of drug delivery due to its plentiful advantages as biodegradability, biocompatibility and nontoxic nature. Nigella Sativa essential oil is unstable, volatile, and insoluble in water and these problems confine its usage in developing new medicines. OBJECTIVE: this study focuses on developing a chitosan-based nanocarrier for the encapsulation of Nigella Sativa essential oil. By using Quality by design outline, the quality target product outline, critical quality attributes and cri...
Source: Recent Patents on Drug Delivery and Formulation - May 18, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Pharmaceutical Cocrystal: A Novel Approach to Tailor the Biopharmaceutical Properties of a Poorly Water Soluble Drug.
Authors: Srivastava D, Fatima Z, Kaur CD, Tulsankar SL, Nashik SS Abstract AIM AND BACKGROUND: The present study reports the formation of a cocrystal of candesartan with the coformer methyl paraben,its characterization and determination of its bioavailability.Candesartan is a poorly water soluble drug having an anti-hypertensive activity. The recent patents on the cocrystals of the drugs Progesterone (US9982007B2), Epalrestat (EP2326632B1), Gefitinib (WO2015170345A1), Valsartan(CN102702118B) for enhancement of solubility helped in selection of the drug for this work. METHODS: Candesartan cocrystal was prepared ...
Source: Recent Patents on Drug Delivery and Formulation - March 9, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Scientific Papers and Patents on Substances with Unproven Effects.
Authors: Jargin SV Abstract It is evident from reviewing of scientific literature that the quality of argumentation in some areas of medical research has deteriorated during last decades. Publication of series of questionable reliability have been continued without making references to the published criticism; examples are discussed in this review. Another tendency is that drugs without proven efficiency are advertised, corresponding products patented and marketed as evidence-based medications. Professional publications are required to register drugs and dietary supplements to obtain permissions for the practical u...
Source: Recent Patents on Drug Delivery and Formulation - March 9, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Synthesis and characterization of Valcyclovir HCl hybrid solid lipid nanoparticles by using Natural oils.
Authors: Archana C, Amaldoss MJN Abstract BACKGROUND: The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients which have an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil is also used in this preparation which also has some remarkable medicinal properties such as antioxidant, astringent and as a moisturizer. The Valacyclovir solid lipid nanoparticles (SLN) were prepared in combination. OBJECTIVE: The prime objective of the study is to prepare a nano dispersion with good stability indicating zeta potential. The formulations were prepared by varyin...
Source: Recent Patents on Drug Delivery and Formulation - March 8, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview.
CONCLUSION: The practice of nanotechnology in the arena of medicine will transform the strategies of detection and treatment of a wide range of diseases in the upcoming years. The findings of this review confirm the importance of bilayer tablet based chronotherapy in nocturnal asthma. PMID: 30827275 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 5, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Progress in Drug and Formulation development for Chemoprevention of Oral Squamous Cell Carcinoma: A review.
CONCLUSION: Use of chemopreventive agents, either synthetic or natural origin, to prevent carcinogenesis is a worthy concept in the management of cancers. Preventive measures are helpful in controlling the occurrence or severity of the disease. The demonstrated results of preventive agents have opened an arena for the development of promising chemopreventive agents in the management of oral squamous cell carcinoma. PMID: 30806332 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 28, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanocarriers for vaginal drug delivery.
CONCLUSION: Recently nanotechnology based drug delivery approach has promised better therapeutic outcomes by providing enhanced permeation and sustained drug release activity. Different nanoplatforms based on drugs, peptides, proteins, antigens, hormones, nucleic material, and microbicides are gaining momentum for vaginal therapeutics. PMID: 30767755 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 16, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

A review on enteric coated pellets composed of core pellets prepared by extrusion-spheronization.
Authors: Patel H, Gohel M Abstract Enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to the smaller size than tablets and b) Pellets exhibits less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resistance time in the stomach. The present review summarizes the current state of enteric coated pellets where core pellets are prepared by extrusion-spheronizati...
Source: Recent Patents on Drug Delivery and Formulation - February 14, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis.
CONCLUSION: The developed mucoadhesive buccal film having adequate physicochemical properties was capable to provide prolonged residence time and sustained delivery as compared to existing conventional therapies. PMID: 30706830 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 4, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanocapsules for Drug Delivery: An Updated Review of the Last Decade.
CONCLUSION: The present study discusses and summarizes patents related to preparation methods of and recent studies from the last 10 years on nanocapsules as drug delivery systems. PMID: 30674269 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 26, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Review of Recent Patents and Developments in Skeletal Muscle Regeneration.
Authors: Wang J, Wang GQ, Wang H, Chen QM, Burczynski FJ Abstract Skeletal muscle is a highly-specialized tissue that is capable of contractile function and able to withstand and adapt to daily mechanical and physiological stress. Musculoskeletal disorders, including muscular dystrophies, result in chronic pain and disability, reduced quality of life, burden on family, and increased healthcare costs. Although several mechanisms have been identified for muscle injury and regeneration, mechanisms of these diseases are poorly understood, and targeted and effective pharmacologic treatment(s) not available. More researc...
Source: Recent Patents on Drug Delivery and Formulation - January 5, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Montelukast Sodium Formulation containing Green Tea Extract to Reduce the Oxidative Stress in Guinea Pig model of Chronic Allergic Asthma.
Authors: Singh N, Kulkarni GT, Kumar Y Abstract AIM AND BACKGROUND: The rationale of this study is that, treatment of asthmatic Guinea pig with combined administration of Montelukast sodium and green tea extract (GTE) as a single capsule will mitigate the inflammatory injury in the airways and weaken the asthmatic response. Recent patents for the treatment of asthma researched a polyphenolic alternatives for antiasthmatic combination therapy, especially for those patients who remains unresponsive or poorly responsive for current asthma therapy (US7232585B2). Synergistic activity of green tea polyphenols and therape...
Source: Recent Patents on Drug Delivery and Formulation - December 14, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Mesoporous silica nanoparticles: a versatile platform for biomedical applications.
CONCLUSION: The future success of MSNs is widened because of their valuable characteristic which easily combines with various functionalities which would display enormous potential translational possibilities. PMID: 30501606 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - December 8, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

The Unprecedented Role of Gold Nonmaterial in Diabetes Management.
CONCLUSION: Gold nanoparticles have proved themselves useful in diabetes therapeutics and diagnostics. Due to low inherent toxicity, and high surface area, gold nanoparticles have become a unique aspect of the delivery approach. The key issue that needs to be addressed is the bio pharmaceutics, biocompatibility, and potential clinical applications. PMID: 30430950 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 17, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Self-Emulsifying Drug Delivery System of Simvastatin: Formulation Development, Optimization by Box- Behnken Design, In-Vitro and In-Situ Single-Pass Intestinal Perfusion (SPIP) Studies.
CONCLUSION: SIM SEDDS were successfully developed and evaluated for in-vitro & in-vivo parameters. All the evaluated parameters were in tolerable limits. In vitro release studies from optimized formulation, OF1, exhibited maximum drug release when compared to SIM API and marketed preparation. Moreover, the predicted value of fraction absorbed (Fa) in humans by in-situ SPIP method were also in agreement with in-vitro dissolution studies thus, confirming SEDDS as a suitable drug delivery system for solubility enhancement of SIM. PMID: 30345934 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 24, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Role of Porous Carriers in the Biopharmaceutical Performance of Solid Self-microemulsion Preconcentrates of Canagliflozin1.
CONCLUSION: The present investigation reveals immense potential of solid SMEDDS in augmenting the oral bioavailability profile of poorly water soluble drug canagliflozin. PMID: 30295193 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 10, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Antibacterial and in vitro growth inhibition study of struvite urinary stones using Oxalis corniculata Linn. leaf extract and its biofabricated silver nanoparticles.
CONCLUSION: The present work confirms the inhibitory activity of the aqueous extract of edible O. corniculata and its biofabricated silver nanoparticles against urinary tract infection (UTI) causing bacteria and urolithiasis. Therefore, the consumption of O. corniculata in our daily diet may reduce the risk of UTI and urolithiasis. PMID: 30039767 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - July 27, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Clinical application of polysialylated therapeutic proteins.
Authors: Meng H, Lockshin C, Jain S, Shaligram U, Martinez J, Genkin D, Hill DB, Ehre C, Clark D, Hoppe H Abstract While protein therapeutics are invaluable in managing numerous diseases, many require frequent injections to maintain therapeutically effective concentrations, due to their short half-life in circulation. PolyXen™, a platform technology employing biodegradable, non-immunogenic and hydrophilic polysialic acids (PSA) for drug delivery, is being utilized to overcome such limitations, thereby enabling the clinical utility of a broad range of protein therapeutics. Here, we report the recent progress o...
Source: Recent Patents on Drug Delivery and Formulation - July 20, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Preparation, Characterization and In Vivo Assessment of Repaglinide Nanosuspension for Oral Bioavailability Improvement.
CONCLUSION: The outcomes of the study revealed significant enhancement in dissolution rate and oral bioavailability of RPG due to size reduction to nano range by HPH. PMID: 30003863 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - July 15, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Comparative Study on Photodynamic Activation of Ortho-Toluidine Blue and Methylene Blue Loaded Mesoporous Silica Nanoparticles Against Resistant Microorganisms.
CONCLUSION: MB and O-TB adsorbed on APTES functionalized mesoporous silica nanoparticles were capable of efficiently inactivating E. coli, P. aeruginosa, S. aureus bacteria upon exposure to red light (620± 20nm wavelength) at a much lower concentration. Mesoporous silica nanoparticles played an important role in aPDT due to its high surface area and porous structure. Also APTES functionalization resulted in the pore expansion of MSN, thereby increasing the loading capacity of the photosensitizer on MSN. From the results obtained it can be concluded that O-TB loaded MSN showed higher activity against all three gram n...
Source: Recent Patents on Drug Delivery and Formulation - June 30, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Preface.
Authors: Donnelly RF PMID: 29879875 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - June 9, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Patent Selections.
Authors: PMID: 29879876 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - June 9, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Orodispersible films: A systematic patent review.
CONCLUSION: It was observed that judicial selection of polymers and polymers blends and method of preparation are key parameters in formulation of orodispersible film. PMID: 29745346 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - May 11, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanocarriers for the Effective Treatment of Cervical Cancer: Research Advancements and Patent Analysis.
CONCLUSION: Nanocarriers results in transforming drug distribution that can overpower drug resistance. Further, nanocarriers based drug delivery systems can particularly target drugs to cellular, subcellular and tissue sites. By enhancing the drug's bioavailability at the desired site, these systems result in therapeutic benefits like enhanced safety and efficacy. Also, in combination with other treatment approaches like radiation, photothermal and gene therapy, nanocarriers are reported to be quite effective and can define novel strategies to combat cervical cancer. PMID: 29611489 [PubMed - as supplied by publisher] (...
Source: Recent Patents on Drug Delivery and Formulation - April 4, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

An Overview On Various Approaches And Recent Patents On Gastroretentive Drug Delivery Systems.
Authors: Kumar M, Kaushik D Abstract Drugs having absorption window in the stomach or upper small intestine has restricted bioavailability with conventional dosage forms. The gastric residence time of these dosage forms is usually short and they do not show drug release for prolonged period of time. To avoid these problems and to enhance the bioavailability and gastric retention time of these drugs, controlled drug delivery systems with prolonged gastric retention time are currently being developed. This review highlights the various pharmaceutical approaches for gastroretention such as floating drug delivery syste...
Source: Recent Patents on Drug Delivery and Formulation - March 11, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Development of Microemulsion Based Nabumetone Transdermal Delivery For Treatment of Arthritis.
Conclusion Nabumetone microemulgel exhibiting good in-vitro and ex-vivo controlled drug release was optimized. PMID: 29485013 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 1, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Formulation And In-Vitro And Ex-Vivo Evaluation Of Tretinoin Loaded Cubosomal Gel For Acne Treatment.
CONCLUSION: At the end, it can be concluded that cubosomes offer benefits of quick onset as well as the maximal release of drug with fewer side effects. Thus, cubosomes represents a capable transporter having the property of sustained release of the drug, potential to localize the drug in the skin with a possible clinical application for acne vulgaris treatment due to cubosome depot effect on the epidermis. PMID: 29437029 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 15, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Novel Ternary Polymeric Blends for Controlled Release Matrices Containing Weakly Basic Model Drug.
The objective of this study was to evaluate the suitability of a novel matrix tablet formulation made of ternary mixture of smart polymers comprised of Eudragit®E100, Eudragit®L100, and sodium alginate to sustain the release of a weakly basic drug Metronidazole. Recent patents on Metronidazole controlled/sustained release matrices include US7790755, US8784885, US8628797 and US7476403. Matrix tablets formulations were prepared by either direct compression or by wet granulation. Dissolution studies were conducted using USP XXΠ rotating paddle apparatus at paddle speed of 50 rpm, and dissolution medium temperature ...
Source: Recent Patents on Drug Delivery and Formulation - January 25, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Crystalline ethylene oxide and propylene oxide triblock copolymer solid dispersion enhance solubility, stability and promoting time-controllable release of Curcumin.
CONCLUSION: Thus, these SDs, specifically CUR:P-407 1:2 w/w, can overcome the barriers of poor bioavailability to reap its many beneficial properties. PMID: 29345599 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 20, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Editorial.
Authors: Donnelly RF PMID: 29332561 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 17, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

A New Approach To Enhance The Solubility Of Famotidine Tablet By Using Naturally Isolated Pear Starch.
CONCLUSIONS- The results from various evaluations show that pear starch has significant binding characteristics. Hence it can be used as tablet binder in pharmaceutical formulations. PMID: 29303081 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 7, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Aripiprazole-Loaded Polymeric Micelles: Fabrication, Optimization and Evaluation using Response Surface Method.
CONCLUSION: It is concluded that the prepared polymeric micellar system has an excellent potentialto be used as delivery carrier for Aripiprazole with increased solubility. PMID: 29303082 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 7, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Patented and approval scenario of nanopharmaceuticals with relevancy to biomedical application, manufacturing procedure and safety aspects.
Authors: Agarwal V, Bajpai M, Sharma A Abstract A term 'nanopharmaceuticals' give the emphasis on the discovery, development and delivery of the drugs to the specific site using different delivery systems. Nanopharmaceutical field is a thrust area in which the development is going on progressively but the many new challenges are also arises continuously, such as regulatory requirements, identification of therapeutic targets, cost-effective and efficient tools for delivering the drug, standardization of different characterization method, etc. Some products related to this area that can be consistently and reproducib...
Source: Recent Patents on Drug Delivery and Formulation - January 7, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems.
Authors: Battu S, Yalavarthi PR, Subbareddy GV, Rao UM, Katamreddy JD, Vadlamudi HC Abstract Poor oral absorption of budesonide limits design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study. Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Uniform sized non-pariel seeds (~400 µm) were coated with solid dispersions to obtain immediate (BMP) and controlled release pellets by solution layering technique. Pulsatile dr...
Source: Recent Patents on Drug Delivery and Formulation - December 15, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Natural product formulations for prevention and treatment of Alzheimer's disease: a patent review.
CONCLUSION: It is becoming now well accepted that multiple factors contribute to the progression of AD. The pathogenesis of the disease involves amyloid-β cascade, tau hyperphosphorylation, oxidative stress, inflammation, mitochondrial dysfunction, protein misfolding, gene mutation, etc. It has been suggested that the multifactorial nature of AD pathogenesis requires the design of medicines with a wide spectrum of activity. Medicinal herbs are known to consist of multiple compounds and may influence multiple mechanisms, thus being advantageous over the simple single-target drugs in the treatment of complex diseases. I...
Source: Recent Patents on Drug Delivery and Formulation - December 10, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Enhanced both in vitro and in vivo kinetics by SLNs induced transdermal system of furosemide: A novel approach.
CONCLUSIONS: The SLNs induced transdermal patch was found to beneficial in enhancing kinetic properties both in-vitro and in-vivo. PMID: 29189185 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - December 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Furosemide - Soluplus ® Solid Dispersion: Development and Characterization.
Furosemide - Soluplus® Solid Dispersion: Development and Characterization. Recent Pat Drug Deliv Formul. 2017 Nov 29;: Authors: Patwa R, Praveen R, Singh SK, Verma PRP Abstract Recent patents reveal that Soluplus® has proved to be a promising excipient that modulates dissolution characteristics of many active pharmaceutical ingredients (WO 2016161995 A1, WO 2016169534 A1, WO 2016165676 A1). Current article investigate on stable solid solution of furosemide with Soluplus to enhance the dissolution properties of the drug. Drug:carrier ratios to prepare solid dispersion was selected based on the p...
Source: Recent Patents on Drug Delivery and Formulation - December 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Thymoquinone (TQ) a potential therapeutic molecule: Role of colloidal carriers in its effective delivery.
Authors: Negi P, Rathore C, Sharma G, Bhoop BS, Katare OP Abstract From the past few decades, remarkable awareness has been laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella sativa (NS) plant has been extensively explored and revealed an array of therapeutic benefits in different in vitro and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ and NS viz. anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, gastro-protective, hepato-protective, anti-microbial and anti-histaminic. Besides, a...
Source: Recent Patents on Drug Delivery and Formulation - December 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Phytochemicals Formulated as Nanoparticles: Inventions,Recent Patents and Future Prospects.
CONCLUSION: If bioavailability constraint is overcome, diseases like cancer, alzheimer, diabetes, liver disorder etc. can be effectively targeted. By doing so, the largely affected society, will breathe the relief. The present article is an attempt to elaborate and conclude on how nanoparticles have been serving as a tool to enhance the effectiveness of phytochemicals, by solubilization, dissolution and consequent bioavailability enhancements, along with in vivo targeting. To further facilitate understanding, the review has been structured as disease/disorder and phytochemical wise with focus on their nanoparticles. PM...
Source: Recent Patents on Drug Delivery and Formulation - November 24, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Development of Floating Delivery for Solid Self Micro-Emulsifying Drug Delivery System of Prochlorperazine Maleate.
Conclusion It can be concluded that SMEDD enhanced the solubility of drug and floating capsule gave site specific drug release of PCM with the advantages of reduced dosing frequency and better compliance. PMID: 29119940 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 11, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Recent Patent Advances For Neurodegenerative Disorders And Its Treatment.
CONCLUSION: The review will attract the interest of academics, researchers, students and pharmaceutical companies in the recent on-going activities in neurodegenerative disorders. PMID: 29032765 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 18, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

A Review of Patents on Therapeutic Potential and Delivery of Hydrogen Sulfide.
Authors: Verma R, Akhtar Y, Singh S Abstract Hydrogen sulfide (H2S) is a colorless gas with a characteristic smell of rotten eggs. Once only thought of as a toxic gas, evidence now shows that H2S plays major roles in pathological and physiological activities. These roles are being utilized to treat diseases and disorders ranging from hypertension, inflammation, edema, cardiovascular issues, chronic pain, cancer, and many more. Challenges facing the use of H2S currently involve achieving the optimum therapeutic concentrations, synthesizing chemically and physiologically stable donors, and developing clinically appro...
Source: Recent Patents on Drug Delivery and Formulation - September 15, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Editorial.
Authors: Donnelly RF PMID: 28877660 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - September 8, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Formulation, Characterization and In-Vitro Evaluation of Fast Dissolving Tablets Containing Gliclazide Hydrotropic Solid Dispersions.
CONCLUSION: It was concluded that the enhancement in solubility of GLZ is clear indication of the potential of mixed hydrotropy which is a novel, safe and cost-effective technique to be employed for other poorly water-soluble drugs having low bioavailability. PMID: 28460615 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - May 5, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Bronchoscopy in children for research with questionable indications: an overview of Russian patents and publications.
Authors: Jargin SV Abstract This letter is a continuation of preceding reviews on invasive methods applied with questionable clinical indications and/or research purposes. It aims to serve as a reminder that the risk-to-benefit ratio should be kept as low as possible. The use of bronchoscopy for diagnostics and treatment of asthma and bronchitis in children is discussed in more detail. Various bronchoscopic methods applied in children and adults have been patented; several patents are presented here as examples. The concept of informed consent and assent applied to children and adolescents is also discussed. Signif...
Source: Recent Patents on Drug Delivery and Formulation - May 5, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Environmentally responsive systems for drug delivery.
CONCLUSION: Therefore, in this review, since 1975 to 2016, we have categorized, reviewed and discussed the patents, applications, pharmaceutical dosage forms, the importance and perspectives of this environmentally responsive approach as potentially useful therapeutic modality. PMID: 28355996 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - April 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Magnetic nanoparticles: A review on stratagems of fabrication and its biomedical applications.
Authors: Srivastava P, Sharma PK, Muheem A, Warsi MH Abstract The aim of this review is to provide an insight to the underlying biomedical applications of magnetic nanoparticles (MNPs).. The most specific characteristic of MNPs is their response to an applied magnetic force, and this property of MNPs has been utilized in applications such as diagnosis of diseases, drug delivery and drug targeting. Currently, MNPs have attracted great attention because of their potential as contrast agents for magnetic resonance imaging (MRI) and heat mediators for cancer therapy (hyperthermia). Furthermore, the MNPs are also being ...
Source: Recent Patents on Drug Delivery and Formulation - April 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Probiotics as a Tool to Biosynthesize Metallic Nanoparticles: Research Reports and Patents Survey.
CONCLUSION: Use of probiotic bacteria in synthesizing metallic nanoparticles is an effective biosynthetic approach. However, the technique needs wider exploration for newer metallic/nonmetallic/metalloid NPs for therapeutic applications. PMID: 28294074 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 17, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research