Multiple perianal ulcers due to suppositories.

We report a case of long-standing inexplicable perianal ulcers. After exclusion of an inflammatory, infectious or neoplastic origin, a thorough personal history revealed that for many years the patient had been using analgesic suppositories containing indomethacin, caffeine, and prochlorperazine dimaleate, four to five times a week, for migraine. On stopping the suppositories, there was complete healing within 12 weeks. We hypothesize that vasoconstriction and vascular damage were the pathogenetic mechanisms behind the perianal ulcers. PMID: 30039854 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30039854?dopt=Abstract

Source: The Australasian Journal of Dermatology - July 24, 2018 Category: Dermatology Authors: Savoia F, Sechi A, Tabanelli M, Zago S, Leuzzi M, Baraldi C, Patrizi A Tags: Australas J Dermatol Source Type: research