Safety and effectiveness of intravenous prochlorperazine for intractable vomiting in children with gastroenteritis

Prochlorperazine (PCZ) was first introduced as an anti-psychotic in the 1950s, and subsequently found to be effective to control vomiting. It is a weak dopamine receptor blocker and depresses the chemoreceptor trigger zone (1). Although pediatric studies are limited, research suggests the medication is effective to prevent vomiting, the need for intravenous fluids, and hospital admission. The majority of recent literature has focused on the use of PCZ for the treatment of migraine headaches in young people [2-4].
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research