A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
Hyperkalemia Recurrence Following Medical Nutrition Therapy in Patients with Stage 3-4 Chronic Kidney Disease: The REVOLUTIONIZE I Real-World Study
CONCLUSION: Most patients with stage 3-4 CKD had hyperkalemia recurrence, and MNT alone was inadequate to prevent recurrence. These patients may require additional long-term treatment, such as novel potassium binders, to maintain normokalemia and prevent hyperkalemia recurrence following MNT. Infographic available for this article. INFOGRAPHIC.PMID:38687454 | DOI:10.1007/s12325-024-02835-8 (Source: Adv Data)
Source: Adv Data - April 30, 2024 Category: Epidemiology Authors: Christopher G Rowan Abiy Agiro K Arnold Chan Ellen Colman Katie White Pooja Desai Jamie P Dwyer Source Type: research
Intercalating a potassium-aqua complex cation into an α-MoO < sub > 3 < /sub > layer without reducing molybdenum: a potential storage system
Chem Commun (Camb). 2024 Apr 30. doi: 10.1039/d4cc01400f. Online ahead of print.ABSTRACTWe have demonstrated a green aqueous synthesis of rod-shaped MoO3 material, [MoVI3O9{K(H2O)4}(CH3COO)]·H2O (2) intercalating potassium-aqua-complex acetate into its lamellar space, simply by ion-exchange of Co(II)-aqua-complex in compound [MoVI4O12(CH3COO)2{CoII(H2O)6}]·2H2O (1) by {K(H2O)4}+ in an aqueous solution of 1 and KCl. Compound 2 acts as a potential storage system of alkali metal ions.PMID:38686497 | DOI:10.1039/d4cc01400f (Source: Chemical Communications)
Source: Chemical Communications - April 30, 2024 Category: Chemistry Authors: Debu Jana Shalini Sanjay Mishra Samar K Das Source Type: research
Partitioning recombinant chitinase from Nicotiana benthamiana by an aqueous two-phase system based on polyethylene glycol and phosphate salts
The objectives of this study were to purify 42 kDa chitinase derived from Trichoderma asperellum SH16 produced in Nicotiana benthamiana by a polyethylene glycol (PEG)/salt aqueous two-phase system (ATPS). The specific activities of the crude chitinase and the partially purified chitinase from N. benthamiana were about 251 unit/mg and 386 unit/mg, respectively. The study found the 300 g/L PEG 6000 + 200 g/L potassium phosphate (PP) and 300 g/L PEG 6000 + 150 g/L sodium phosphate (SP) systems had the highest partitioning efficiency for each salt in primary extraction. However, among the two types of salt, PP displayed higher...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Nguyen Hoang Tue Nguyen Hoang Phuc Phung Thi Bich Hoa Nguyen Quang Duc Tien Nguyen Hoang Loc Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
CONCLUSIONS: KCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC.PMID:38689322 | DOI:10.1186/s40001-024-01844-1 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Wei Zhang Xiao-Song Chen Ying Wei Xiao-Min Wang Xian-Jin Chen Bang-Teng Chi Lin-Qing Huang Rong-Quan He Zhi-Guang Huang Qi Li Gang Chen Juan He Mei Wu Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
Molecules, Vol. 29, Pages 2078: Fabrication of an Fe-Doped ZIF-67 Derived Magnetic Fe/Co/C Composite for Effective Removal of Congo Red
This study demonstrates that this Fe-doped, ZIF-67 derived magnetic material has potential application prospects for dye adsorption. (Source: Molecules)
Source: Molecules - April 30, 2024 Category: Chemistry Authors: Yu Cao Zeming Dai Xuan Zhou Yuting Lin Jianhua Hou Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2081: Transforming Waste into Wealth: Advanced Carbon-Based Electrodes Derived from Refinery and Coal By-Products for Next-Generation Energy Storage
Bari
Aziz
This comprehensive review addresses the need for sustainable and efficient energy storage technologies against escalating global energy demand and environmental concerns. It explores the innovative utilization of waste materials from oil refineries and coal processing industries as precursors for carbon-based electrodes in next-generation energy storage systems, including batteries and supercapacitors. These waste-derived carbon materials, such as semi-coke, coal gasification fine ash, coal tar pitch, petroleum coke, and petroleum vacuum residue, offer a promising alternative to conventional electrode mate...
Source: Molecules - April 30, 2024 Category: Chemistry Authors: Ferdous Shah Shah Johan Al Bari Aziz Tags: Review Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
ConclusionsKCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research
Developing KCNQ (Kv7) Type Channel Openers for Anhedonia and Depression: An Experimental Medicine Approach
Depression is one of the largest causes of disability, and mechanistically new treatment approaches are urgently needed to address this public health problem. Basic research suggests that enhancing signaling at KCNQ (a.k.a., Kv7) type potassium channels in the brain may represent a promising new strategy for drug discovery for depression and related conditions. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: James Murrough, Laurel Morris, Sarah Boukezzi, Sara Costi, Yael Jacob, Ramiro Salas, Dan Iosifescu, Sanjay Mathew Source Type: research
CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT
CONCLUSIONS: Our study identifies unbridled turnover of the potassium channel hERG as a mechanism supporting the interindividual susceptibility underlying diLQT development and demonstrates how this phenomenon is finely tuned by CAVIN1.PMID:38682330 | DOI:10.1161/CIRCULATIONAHA.123.063917 (Source: Circulation)
Source: Circulation - April 29, 2024 Category: Cardiology Authors: Zeina R Al Sayed C éline Pereira R émi Le Borgne Christine Viaris de Lesegno Charl ène Jouve Esthel P énard Adeline Mallet Nihar Masurkar Gildas Loussouarn Jean-Marc Verbavatz Christophe Lamaze David-Alexandre Tr égouët Jean-S ébastien Hulot Source Type: research
From swamp to field: how genes from mangroves and its associates can enhance crop salinity tolerance
Mol Biol Rep. 2024 Apr 29;51(1):598. doi: 10.1007/s11033-024-09539-w.ABSTRACTSalinity stress is a critical challenge in crop production and requires innovative strategies to enhance the salt tolerance of plants. Insights from mangrove species, which are renowned for their adaptability to high-salinity environments, provides valuable genetic targets and resources for improving crops. A significant hurdle in salinity stress is the excessive uptake of sodium ions (Na+) by plant roots, causing disruptions in cellular balance, nutrient deficiencies, and hampered growth. Specific ion transporters and channels play crucial roles ...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Ganesan Govindan Prakash Harini Vinoth Alphonse Madasamy Parani Source Type: research
