Waste-green infrastructure nexus: Green roof promotion by digestate and digestate biochar from food waste
This study demonstrated that food waste could be regenerated to promote urban green infrastructure to form a circular bio-economy by the Waste-Green Infrastructure Nexus.PMID:38754559 | DOI:10.1016/j.biortech.2024.130845 (Source: Bioresource Technology)
Source: Bioresource Technology - May 16, 2024 Category: Biotechnology Authors: Juan Zhou Qianlin Deng Qiuyi Chen Baohua Chu Yanbang Li Zhaolong Wang Source Type: research
Dermatophytomas in Onychomycosis: A Scoping Review of Prevalence, Diagnosis, and Treatment
CONCLUSIONS: There is little published information regarding dermatophytomas in onychomycosis. More clinical research and physician education are needed. Although dermatophytomas have historically been considered difficult to treat, the efficacy data gathered in this scoping review have demonstrated that newer topical treatments are effective, as are oral antifungals in combination with chemical or surgical methods.PMID:38753536 | DOI:10.7547/22-161 (Source: Journal of the American Podiatric Medical Association)
Source: Journal of the American Podiatric Medical Association - May 16, 2024 Category: Podiatry Authors: Shari R Lipner Tracey Vlahovic Mahmoud A Ghannoum Boni Elewski Warren S Joseph Source Type: research
Novel synthesis of the first new class of triazine sulfonamide thioglycosides and the evaluation of their anti-tumor and anti-viral activities against human coronavirus
Nucleosides Nucleotides Nucleic Acids. 2024 May 16:1-18. doi: 10.1080/15257770.2024.2341406. Online ahead of print.ABSTRACTNovel class of triazine sulfonamide thioglycosides was designed and synthesized. Those novel structures comprising three essential and pharmacological significant moieties such as the triazine, sulfonamide, and thioglycosidic scaffolds. The triazine sulfonamides were furnished via a direct approach starting from potassium cyanocarbonimidodithioate, then the corresponding triazine sulfonamide thioglycosides were generated using the peracylated α-d-gluco- and galacto-pyranosyl bromides. Anti-viral evalu...
Source: Nucleosides, Nucleotides and Nucleic Acids - May 16, 2024 Category: Biochemistry Authors: Reham A Mohamed-Ezzat Galal H Elgemeie Source Type: research
Assembly of In-Situ Gel Containing Nano-Spanlastics of an Angiotensin II Inhibitor as a Novel Epitome for Hypertension Management: Factorial Design Optimization, In-vitro Gauging, Pharmacokinetics, and Pharmacodynamics Appraisal
AAPS PharmSciTech. 2024 May 16;25(5):115. doi: 10.1208/s12249-024-02823-9.ABSTRACTMore than 1 billion people worldwide suffer from hypertension; therefore, hypertension management has been categorized as a global health priority. Losartan potassium (LP) is an antihypertensive drug with a limited oral bioavailability of about 33% since it undergoes the initial metabolic cycle. Thus, nasal administration is a unique route to overcome first-pass metabolism. The investigation focused on the potential effects of LP-loaded spanlastic vesicles (SNVs) on LP pharmacodynamics and pharmacokinetic parameters, utilizing a thin-film hyd...
Source: AAPS PharmSciTech - May 16, 2024 Category: Drugs & Pharmacology Authors: Heba F Salem Mohamed M Nafady Essam M Eissa Hend Hassan Abdel-Sattar Rasha A Khallaf Source Type: research
Dermatophytomas in Onychomycosis: A Scoping Review of Prevalence, Diagnosis, and Treatment
CONCLUSIONS: There is little published information regarding dermatophytomas in onychomycosis. More clinical research and physician education are needed. Although dermatophytomas have historically been considered difficult to treat, the efficacy data gathered in this scoping review have demonstrated that newer topical treatments are effective, as are oral antifungals in combination with chemical or surgical methods.PMID:38753536 | DOI:10.7547/22-161 (Source: Journal of the American Podiatric Medical Association)
Source: Journal of the American Podiatric Medical Association - May 16, 2024 Category: Podiatry Authors: Shari R Lipner Tracey Vlahovic Mahmoud A Ghannoum Boni Elewski Warren S Joseph Source Type: research
Waste-green infrastructure nexus: Green roof promotion by digestate and digestate biochar from food waste
This study demonstrated that food waste could be regenerated to promote urban green infrastructure to form a circular bio-economy by the Waste-Green Infrastructure Nexus.PMID:38754559 | DOI:10.1016/j.biortech.2024.130845 (Source: Bioresource Technology)
Source: Bioresource Technology - May 16, 2024 Category: Biotechnology Authors: Juan Zhou Qianlin Deng Qiuyi Chen Baohua Chu Yanbang Li Zhaolong Wang Source Type: research
Novel synthesis of the first new class of triazine sulfonamide thioglycosides and the evaluation of their anti-tumor and anti-viral activities against human coronavirus
Nucleosides Nucleotides Nucleic Acids. 2024 May 16:1-18. doi: 10.1080/15257770.2024.2341406. Online ahead of print.ABSTRACTNovel class of triazine sulfonamide thioglycosides was designed and synthesized. Those novel structures comprising three essential and pharmacological significant moieties such as the triazine, sulfonamide, and thioglycosidic scaffolds. The triazine sulfonamides were furnished via a direct approach starting from potassium cyanocarbonimidodithioate, then the corresponding triazine sulfonamide thioglycosides were generated using the peracylated α-d-gluco- and galacto-pyranosyl bromides. Anti-viral evalu...
Source: Nucleosides, Nucleotides and Nucleic Acids - May 16, 2024 Category: Biochemistry Authors: Reham A Mohamed-Ezzat Galal H Elgemeie Source Type: research
Assembly of In-Situ Gel Containing Nano-Spanlastics of an Angiotensin II Inhibitor as a Novel Epitome for Hypertension Management: Factorial Design Optimization, In-vitro Gauging, Pharmacokinetics, and Pharmacodynamics Appraisal
AAPS PharmSciTech. 2024 May 16;25(5):115. doi: 10.1208/s12249-024-02823-9.ABSTRACTMore than 1 billion people worldwide suffer from hypertension; therefore, hypertension management has been categorized as a global health priority. Losartan potassium (LP) is an antihypertensive drug with a limited oral bioavailability of about 33% since it undergoes the initial metabolic cycle. Thus, nasal administration is a unique route to overcome first-pass metabolism. The investigation focused on the potential effects of LP-loaded spanlastic vesicles (SNVs) on LP pharmacodynamics and pharmacokinetic parameters, utilizing a thin-film hyd...
Source: AAPS PharmSciTech - May 16, 2024 Category: Drugs & Pharmacology Authors: Heba F Salem Mohamed M Nafady Essam M Eissa Hend Hassan Abdel-Sattar Rasha A Khallaf Source Type: research
Novel synthesis of the first new class of triazine sulfonamide thioglycosides and the evaluation of their anti-tumor and anti-viral activities against human coronavirus
Nucleosides Nucleotides Nucleic Acids. 2024 May 16:1-18. doi: 10.1080/15257770.2024.2341406. Online ahead of print.ABSTRACTNovel class of triazine sulfonamide thioglycosides was designed and synthesized. Those novel structures comprising three essential and pharmacological significant moieties such as the triazine, sulfonamide, and thioglycosidic scaffolds. The triazine sulfonamides were furnished via a direct approach starting from potassium cyanocarbonimidodithioate, then the corresponding triazine sulfonamide thioglycosides were generated using the peracylated α-d-gluco- and galacto-pyranosyl bromides. Anti-viral evalu...
Source: Nucleosides, Nucleotides and Nucleic Acids - May 16, 2024 Category: Biochemistry Authors: Reham A Mohamed-Ezzat Galal H Elgemeie Source Type: research
Assembly of In-Situ Gel Containing Nano-Spanlastics of an Angiotensin II Inhibitor as a Novel Epitome for Hypertension Management: Factorial Design Optimization, In-vitro Gauging, Pharmacokinetics, and Pharmacodynamics Appraisal
AAPS PharmSciTech. 2024 May 16;25(5):115. doi: 10.1208/s12249-024-02823-9.ABSTRACTMore than 1 billion people worldwide suffer from hypertension; therefore, hypertension management has been categorized as a global health priority. Losartan potassium (LP) is an antihypertensive drug with a limited oral bioavailability of about 33% since it undergoes the initial metabolic cycle. Thus, nasal administration is a unique route to overcome first-pass metabolism. The investigation focused on the potential effects of LP-loaded spanlastic vesicles (SNVs) on LP pharmacodynamics and pharmacokinetic parameters, utilizing a thin-film hyd...
Source: AAPS PharmSciTech - May 16, 2024 Category: Drugs & Pharmacology Authors: Heba F Salem Mohamed M Nafady Essam M Eissa Hend Hassan Abdel-Sattar Rasha A Khallaf Source Type: research
Novel synthesis of the first new class of triazine sulfonamide thioglycosides and the evaluation of their anti-tumor and anti-viral activities against human coronavirus
Nucleosides Nucleotides Nucleic Acids. 2024 May 16:1-18. doi: 10.1080/15257770.2024.2341406. Online ahead of print.ABSTRACTNovel class of triazine sulfonamide thioglycosides was designed and synthesized. Those novel structures comprising three essential and pharmacological significant moieties such as the triazine, sulfonamide, and thioglycosidic scaffolds. The triazine sulfonamides were furnished via a direct approach starting from potassium cyanocarbonimidodithioate, then the corresponding triazine sulfonamide thioglycosides were generated using the peracylated α-d-gluco- and galacto-pyranosyl bromides. Anti-viral evalu...
Source: Nucleosides, Nucleotides and Nucleic Acids - May 16, 2024 Category: Biochemistry Authors: Reham A Mohamed-Ezzat Galal H Elgemeie Source Type: research
GSE232837 Hydroxycitrate promotes muscle regeneration and delays early mortality in mice
Contributors : Isabel Espadas ; Mar ía Ángeles Cáliz-Molina ; Raúl López-Fernández-Sobrino ; Concepción Panadero-Morón ; Alejandro Sola-García ; Mario Soriano-Navarro ; Enrique Martínez-Force ; Monica Venegas-Calderón ; Joaquin J Salas ; Franz Martín ; Benoit R Gauthier ; Clara Alfaro-Cerbelló ; David Martí-Agu ado ; Vivian Capilla-González ; Alejandro Martín-MontalvoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusATP-citrate lyase (ACLY) inhibitors have the potential of modulating central processes in protein, carbohydrate, and lipid metabolism, which can...
Source: GEO: Gene Expression Omnibus - May 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
One ‐shot design elevates functional expression levels of a voltage‐gated potassium channel
We present an automated and web-accessible design algorithm called mPROSS (https://mPROSS.weizmann.ac.il), which uses phylogenetic analysis and an atomistic potential, including an empirical lipophilicity scale, to improve native-state energy. As a stringent test, we apply mPROSS to the Kv1.2 –Kv2.1 paddle chimera voltage-gated potassium channel. Four designs, encoding 9–26 mutations relative to the parental channel, were functional and maintained potassium-selective permeation and voltage dependence inXenopus oocytes with up to 14-fold increase in whole-cell current densities. Additionally, single-channel recordings r...
Source: Protein Science - May 15, 2024 Category: Biochemistry Authors: Jonathan Jacob Weinstein,
Chandamita Saikia,
Izhar Karbat,
Adi Goldenzweig,
Eitan Reuveny,
Sarel Jacob Fleishman Tags: RESEARCH ARTICLE Source Type: research
Alumina - Stabilized SEI and CEI in Potassium Metal Batteries
Angew Chem Int Ed Engl. 2024 May 14:e202402214. doi: 10.1002/anie.202402214. Online ahead of print.ABSTRACTAluminum oxide (Al2O3) nanopowder is spin-coated onto both sides of commercial polypropene separator to create artificial solid-electrolyte interphase (SEI) and artificial cathode electrolyte interface (CEI) in potassium metal batteries (KMBs). This significantly enhances the stability, including of KMBs with Prussian Blue (PB) cathodes. For example, symmetric cells are stable after 1,000 cycles at 0.5 mA/cm2 - 0.5 mAh/cm2 and 3.0 mA/cm2 - 0.5 mAh/cm2. Alumina modified separators promote electrolyte wetting and increa...
Source: Angewandte Chemie - May 15, 2024 Category: Chemistry Authors: Pengcheng Liu Hongchang Hao Aditya Singla Bairav S Vishnugopi John Watt Partha P Mukherjee David Mitlin Source Type: research
Multifunctional laser-induced graphene circuits and laser-printed nanomaterials toward non-invasive human kidney function monitoring
Biosens Bioelectron. 2024 May 13;259:116386. doi: 10.1016/j.bios.2024.116386. Online ahead of print.ABSTRACTFaced with the increasing prevalence of chronic kidney disease (CKD), portable monitoring of CKD-related biomarkers such as potassium ion (K+), creatinine (Cre), and lactic acid (Lac) levels in sweat has shown tremendous potential for early diagnosis. However, a rapidly manufacturable portable device integrating multiple CKD-related biomarker sensors for ease of sweat testing use has yet to be reported. Here, a portable electrochemical sensor integrated with multifunctional laser-induced graphene (LIG) circuits and l...
Source: Biosensors and Bioelectronics - May 15, 2024 Category: Biotechnology Authors: Yangyi Huang Haosong Zhong Rongliang Yang Yexin Pan Jing Lin Connie Kong Wai Lee Siyu Chen Min Tan Xupeng Lu Wing Yan Poon Qiaoyaxiao Yuan Mitch Guijun Li Source Type: research
