CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT
CONCLUSIONS: Our study identifies unbridled turnover of the potassium channel hERG as a mechanism supporting the interindividual susceptibility underlying diLQT development and demonstrates how this phenomenon is finely tuned by CAVIN1.PMID:38682330 | DOI:10.1161/CIRCULATIONAHA.123.063917 (Source: Circulation)
Source: Circulation - April 29, 2024 Category: Cardiology Authors: Zeina R Al Sayed C éline Pereira R émi Le Borgne Christine Viaris de Lesegno Charl ène Jouve Esthel P énard Adeline Mallet Nihar Masurkar Gildas Loussouarn Jean-Marc Verbavatz Christophe Lamaze David-Alexandre Tr égouët Jean-S ébastien Hulot Source Type: research
Sustained release delivery of favipiravir through statistically optimized, chemically cross-linked, pH-sensitive, swellable hydrogel
In conclusion, the hydrogel-based technology proved to be an excellent option for creating the sustained-release dosage form of the antiviral drug favipiravir.PMID:38685129 | DOI:10.1186/s40360-024-00752-8 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 29, 2024 Category: Drugs & Pharmacology Authors: Arooj Khan Muhammad Zaman Muhammad Ahsan Waqar Asif Mahmood Talal Shaheer Rai Muhammad Sarfraz Kanwal Shahzadi Azmat Ali Khan Amer M Alanazi Milton Kumar Kundu Md Rabiul Islam Athanasios Alexiou Marios Papadakis Source Type: research
From swamp to field: how genes from mangroves and its associates can enhance crop salinity tolerance
Mol Biol Rep. 2024 Apr 29;51(1):598. doi: 10.1007/s11033-024-09539-w.ABSTRACTSalinity stress is a critical challenge in crop production and requires innovative strategies to enhance the salt tolerance of plants. Insights from mangrove species, which are renowned for their adaptability to high-salinity environments, provides valuable genetic targets and resources for improving crops. A significant hurdle in salinity stress is the excessive uptake of sodium ions (Na+) by plant roots, causing disruptions in cellular balance, nutrient deficiencies, and hampered growth. Specific ion transporters and channels play crucial roles ...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Ganesan Govindan Prakash Harini Vinoth Alphonse Madasamy Parani Source Type: research
Sustained release delivery of favipiravir through statistically optimized, chemically cross-linked, pH-sensitive, swellable hydrogel
In conclusion, the hydrogel-based technology proved to be an excellent option for creating the sustained-release dosage form of the antiviral drug favipiravir.PMID:38685129 | PMC:PMC11057099 | DOI:10.1186/s40360-024-00752-8 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 29, 2024 Category: Drugs & Pharmacology Authors: Arooj Khan Muhammad Zaman Muhammad Ahsan Waqar Asif Mahmood Talal Shaheer Rai Muhammad Sarfraz Kanwal Shahzadi Azmat Ali Khan Amer M Alanazi Milton Kumar Kundu Md Rabiul Islam Athanasios Alexiou Marios Papadakis Source Type: research
