Bombax costatum enhances piroxicam's efficacy: possible involvement of alpha-2 adrenergic receptor, opioidergic and arachidonic pathways
CONCLUSION: Bombax costatum posses antinociceptive and anti-inflammatory activities and may involve α-2 adrenergic receptor, opioidergic and arachidonic pathways. In addition, Bombax costaum augments the efficacy of piroxicam and could be of clinical benefits if studied on man.PMID:34756927 | DOI:10.1016/j.pharma.2021.10.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 10, 2021 Category: Drugs & Pharmacology Authors: Michael Ikechuwu Oraebosi Gonaka Miracle Good Source Type: research
Piroxicam ‐induced fixed drug eruption in palatal mucosa
ConclusionPiroxicam is a rare culprit drug to fixed drug eruption, especially in oral mucosa. (Source: Oral Surgery)
Source: Oral Surgery - October 19, 2021 Category: ENT & OMF Authors: Saygo Tomo,
Ingrid Silva Santos,
John L. Silva Cunha,
Glauco I. Miyahara,
Ana C. Prado Ribeiro,
Alan R. Santos Silva,
Luciana E. Simonato Tags: CASE REPORT Source Type: research
Application of modified Michaelis - Menten equations for determination of enzyme inducing and inhibiting drugs
CONCLUSION: Hence, pharmacokinetic-pharmacodynamic translation can be optimally achieved by incorporating, newly modified Michaelis-Menten equations into pharmacokinetic formulas for clinical efficacy and safety of the enzyme inducing and inhibiting therapeutic agents used in laboratory and clinical settings.PMID:34635182 | DOI:10.1186/s40360-021-00521-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 12, 2021 Category: Drugs & Pharmacology Authors: Saganuwan Alhaji Saganuwan Source Type: research
Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs
Pharmacokinetics (PK) is the process of absorption, distribution, metabolism and elimination (ADME) of drugs. Some drugs undergo zero-order kinetics (ethyl alcohol), first order kinetics (piroxicam) and mixed ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 11, 2021 Category: Drugs & Pharmacology Authors: Saganuwan Alhaji Saganuwan Tags: Technical advance Source Type: research
Piroxicam induced fixed drug eruption in palatal mucosa
ConclusionPiroxicam is a rare culprit drug to fixed drug eruption, especially in oral mucosa. (Source: Oral Surgery)
Source: Oral Surgery - October 10, 2021 Category: ENT & OMF Authors: Saygo Tomo,
Ingrid da Silva Santos,
John Lennon da Silva Cunha,
Glauco Issamu Miyahara,
Ana Carolina Prado Ribeiro,
Alan Roger dos Santos Silva,
Luciana Estevam Simonato Tags: CASE REPORT Source Type: research
Lack of Major Involvement of Common CYP2C Gene Polymorphisms in the Risk of Developing Cross-Hypersensitivity to NSAIDs
Cross-hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) is a relatively common, non-allergic, adverse drug event triggered by two or more chemically unrelated NSAIDs. Current evidence point to COX-1 inhibition as one of the main factors in its etiopathogenesis. Evidence also suggests that the risk is dose-dependent. Therefore it could be speculated that individuals with impaired NSAID biodisposition might be at increased risk of developing cross-hypersensitivity to NSAIDs. We analyzed common functional gene variants for CYP2C8, CYP2C9, and CYP2C19 in a large cohort composed of 499 patients with cross-hyper...
Source: Frontiers in Pharmacology - September 21, 2021 Category: Drugs & Pharmacology Source Type: research
Effect of a Selection of Skin Penetration Enhancers on Topical Anti-Inflammatory Effect of Boswellic Acids in Carrageenan-Induced Paw Edema in Rats
CONCLUSION: BAs have considerable topical anti-inflammatory effects and olive oil alone or especially in combination with eucalyptus oil can be promising vehicles for skin penetration of topical BAs.PMID:34476226 | PMC:PMC8378444 | DOI:10.4103/abr.abr_222_20 (Source: Biomed Res)
Source: Biomed Res - September 3, 2021 Category: Research Authors: Valiollah Hajhashemi Sadaf Safaei Source Type: research
Design, Synthesis, Docking Study and Biological Evaluation of 4-Hydroxy-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide Derivatives as Anti-HIV Agents
A novel series of benzothiazine-3-carboxamide 1,1-dioxide derivatives by modifying the piroxicam scaffold was designed, synthesized, and evaluated as anti-HIV agents. The 1,2-benzothiazine-3-carboxamide 1,1-dioxide scaffold consists of hydroxy and carboxamide groups as a chelating motif to form an interaction with Mg2+ ions within the integrase active site as a target. Most of the compounds displayed encouraging anti-HIV activity in a cell-based assay. Among them, compounds 13d, 13l and 13m were the most potent with EC50 values ranging from 20-25 mM and SI> 26. Docking study of compounds in integrase active site pro...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research
Design, Synthesis, Docking Study and Biological Evaluation of ...
A novel series of benzothiazine-3-carboxamide 1,1-dioxide derivatives by modifying the piroxicam scaffold was designed, synthesized, and evaluated as anti-HIV agents. The 1,2-benzothiazine-3-carboxamide 1,1-dioxide scaffold consists of hydroxy and carboxamide groups as a chelating motif to form an interaction with Mg2+ ions within the integrase active site as a target. Most of the compounds displayed encouraging anti-HIV activity in a cell-based assay. Among them, compounds 13d, 13l and 13m were the most potent with EC50 values ranging from 20-25 mM and SI> 26. Docking study of compounds in integrase active site propose...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research
Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
This study demonstrates that it is possible to assess the fasted intestinal equilibrium solubility envelope using a small number of bioequivalent media recipes obtained from a multi-dimensional analysis of fasted HIF. The derivation of the nine bioequivalent SIF media coupled with the lower measured solubility range indicate that the solubility results are more likely to reflect the fasted intestinal solubility envelope than previous DoE studies and highlight that intestinal solubility is a range and not a single value.PMID:34419602 | DOI:10.1016/j.ejpb.2021.08.002 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 22, 2021 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
This study demonstrates that it is possible to assess the fasted intestinal equilibrium solubility envelope using a small number of bioequivalent media recipes obtained from a multi-dimensional analysis of fasted HIF. The derivation of the nine bioequivalent SIF media coupled with the lower measured solubility range indicate that the solubility results are more likely to reflect the fasted intestinal solubility envelope than previous DoE studies and highlight that intestinal solubility is a range and not a single value.PMID:34419602 | DOI:10.1016/j.ejpb.2021.08.002 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 22, 2021 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
This study demonstrates that it is possible to assess the fasted intestinal equilibrium solubility envelope using a small number of bioequivalent media recipes obtained from a multi-dimensional analysis of fasted HIF. The derivation of the nine bioequivalent SIF media coupled with the lower measured solubility range indicate that the solubility results are more likely to reflect the fasted intestinal solubility envelope than previous DoE studies and highlight that intestinal solubility is a range and not a single value.PMID:34419602 | DOI:10.1016/j.ejpb.2021.08.002 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 22, 2021 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Photosensitizing Drug Reactions
Photosensitizing drug reactions are cutaneous eruptions that occur after exposure to UV radiation in patients using photosensitizing medications. They can be broadly classified into phototoxic and photoallergic reactions, with the former being much more common and well-documented. There is an extensive list of photosensitizing medications, especially in the case of phototoxicity; the most common are amiodarone, chlorpromazine, doxycycline, hydrochlorothiazide, nalidixic acid, naproxen, piroxicam, tetracycline, thioridazine, vemurafenib, and voriconazole. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 7, 2021 Category: Dermatology Authors: Simone Montgomery, Scott Worswick Source Type: research
Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney
Biomed Pharmacother. 2020 Oct;130:110627. doi: 10.1016/j.biopha.2020.110627. Epub 2020 Aug 28.ABSTRACTPiroxicam (PM) is an oxicam-NSAID commonly recommended for various pain and associated inflammatory disorders. However, it is reported to have a gastric and hepato-renal toxic effect. Therefore, the current research was planned to investigate the possible mechanisms behind the mitigating action of the coenzyme (CoQ10), a natural, free radical scavenger, against PM tissue injury. Rats were assigned to five equal groups; Control, CoQ10 (10 mg/kg, orally), PM (7 mg/kg, i.p.), CoQ + PM L, and CoQ + PM H group. After 28 days, P...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 29, 2021 Category: Drugs & Pharmacology Authors: Ahmed Abdeen Afaf Abdelkader Dina Elgazzar Mohamed Aboubakr Omnia A Abdulah Khaled Shoghy Mohamed Abdel-Daim Hamed A El-Serehy Agnieszka Najda Amany El-Mleeh Source Type: research
Comparative evaluation of various analgesics in reducing pain in irreversible pulpitis
Bioinformation. 2021 Feb 28;17(2):313-319. doi: 10.6026/97320630017313. eCollection 2021.ABSTRACTIt is of interest to evaluate a single dose of three different analgesics compared to placebo in patients with symptomatic irreversible pulpitis. 120 patients were enrolled with severe pain in this prospective clinical trial. Patients were randomly divided into four groups after shaping and cleaning of root canals. This includes placebo, piroxicam 20mg, acetaminophen 325mg with aceclofenac sodium 100mg and acetaminophen 650mg. Participants were given a questionnaire to note the pain scores at various time intervals (6 hrs, 12 h...
Source: Bioinformation - July 8, 2021 Category: Bioinformatics Authors: Pradeep Solete Sindhu Ramesh Source Type: research
