Adding piroxicam to levonorgestrel increased emergency contraception effectiveness
Ann Intern Med. 2023 Dec 5. doi: 10.7326/J23-0098. Online ahead of print.ABSTRACTLi RHW, Lo SST, Gemzell-Danielsson K, et al. Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial. Lancet. 2023;402:851-858. 37597523.PMID:38048581 | DOI:10.7326/J23-0098 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - December 4, 2023 Category: Internal Medicine Authors: Pelin Batur Source Type: research
Adding piroxicam to levonorgestrel increased emergency contraception effectiveness
Ann Intern Med. 2023 Dec 5. doi: 10.7326/J23-0098. Online ahead of print.ABSTRACTLi RHW, Lo SST, Gemzell-Danielsson K, et al. Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial. Lancet. 2023;402:851-858. 37597523.PMID:38048581 | DOI:10.7326/J23-0098 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - December 4, 2023 Category: Internal Medicine Authors: Pelin Batur Source Type: research
Ibuprofen modulates tetrodotoxin-resistant persistent Na < sup > + < /sup > currents at acidic pH in rat trigeminal ganglion neurons
Eur J Pharmacol. 2023 Nov 20:176218. doi: 10.1016/j.ejphar.2023.176218. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve various symptoms such as headache, arthralgia, and dental pain. While the primary mechanism of NSAID-based pain relief is the inhibition of cyclooxygenase-2, several NSAIDs also modulate other molecular targets related to nociceptive transmission such as voltage-gated Na+ channels. In the present study, we examined the effects of NSAIDs on persistent Na+ current (INaP) mediated by tetrodotoxin-resistant (TTX-R) Na+ channels in small-to medium-sized t...
Source: European Journal of Pharmacology - November 22, 2023 Category: Drugs & Pharmacology Authors: Jin-Hwa Cho Il-Sung Jang Source Type: research
Ibuprofen modulates tetrodotoxin-resistant persistent Na < sup > + < /sup > currents at acidic pH in rat trigeminal ganglion neurons
Eur J Pharmacol. 2023 Nov 20:176218. doi: 10.1016/j.ejphar.2023.176218. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve various symptoms such as headache, arthralgia, and dental pain. While the primary mechanism of NSAID-based pain relief is the inhibition of cyclooxygenase-2, several NSAIDs also modulate other molecular targets related to nociceptive transmission such as voltage-gated Na+ channels. In the present study, we examined the effects of NSAIDs on persistent Na+ current (INaP) mediated by tetrodotoxin-resistant (TTX-R) Na+ channels in small-to medium-sized t...
Source: European Journal of Pharmacology - November 22, 2023 Category: Drugs & Pharmacology Authors: Jin-Hwa Cho Il-Sung Jang Source Type: research
Medication overuse headache is associated with elevated lipopolysaccharide binding protein and pro-inflammatory molecules in the bloodstream
ConclusionElevated serum LBP, VE-cadherin and occludin levels indicating disrupted intestinal barrier function and leakage of LPS into the systemic circulation were shown in female rats with MOH. LPS induced low-grade inflammation and elevated nociceptive and/or pro-inflammatory molecules such as HMGB1, IL-6, IL-17 and CGRP may play a role in the development and maintenance of MOH. Interference with leaky gut and pro-inflammatory nociceptive molecules could also be a target for sustained management of MOH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 8, 2023 Category: Neurology Source Type: research
Small is Powerful: Demonstration of the Impact of Nanoformed Piroxicam in a Controlled Clinical Study
ConclusionsThe results show that nanoforming enabled more rapid absorption in comparison to a typical marketed tablet and indicate that nanoforming is an alternative to complex formulation such as cyclodextrins based products. The study outcomes support the potential of nanoforming for producing fast-acting dosage forms of poorly soluble drugs. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - November 1, 2023 Category: Drugs & Pharmacology Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research
Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Endocrinology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
