Forecasting of potential anti-inflammatory targets of some immunomodulatory plants and their constituents using in vitro, molecular docking and network pharmacology-based analysis
Sci Rep. 2023 Jun 12;13(1):9539. doi: 10.1038/s41598-023-36540-3.ABSTRACTMost synthetic immunomodulatory medications are extremely expensive, have many disadvantages and suffer from a lot of side effects. So that, introducing immunomodulatory reagents from natural sources will have great impact on drug discovery. Therefore, this study aimed to comprehend the mechanism of the immunomodulatory activity of some natural plants via network pharmacology together with molecular docking and in vitro testing. Apigenin, luteolin, diallyl trisulfide, silibinin and allicin had the highest percentage of C-T interactions while, AKT1, CA...
Source: Atherosclerosis - June 12, 2023 Category: Cardiology Authors: Asmaa Khairy Doaa A Ghareeb Ismail Celik Hala M Hammoda Hala H Zaatout Reham S Ibrahim Source Type: research
Starch modified NiFe layered double hydroxide composites for better adsorption and photocatalytic removal of reactive dye and piroxicam-20 drug
In this study, starch (S) modified NiFe-layered double hydroxide (LDH) composites were successfully synthesized by the co-precipitation method and have been examined as a catalyst for the effective adsorption of reactive blue 19 dye, reactive orange 16 dye, and piroxicam-20 NSAID from wastewater and photocatalytic degradation of reactive red 120 dye. The physicochemical properties of the prepared catalyst were assessed by XRD, FTIR, HRTEM, FE-SEM, DLS, ZETA, and BET. The coarser and more porous micrographs are shown in FESEM, indicating the homogeneous dispersion of layered double hydroxide on starch polymer chains. The S/...
Source: Environmental Science and Pollution Research International - May 17, 2023 Category: Environmental Health Authors: Mehak Bansal Bonamali Pal Source Type: research
Bio-guided isolation of potential anti-inflammatory constituents of some endophytes isolated from the leaves of ground cherry (Physalis pruinosa L.) via ex-vivo and in-silico studies
CONCLUSIONS: The results obtained suggested alternariol derivatives may serve as naturally occurring potent anti-inflammatory candidates. This study opens new avenues for the design and development of innovative anti-inflammatory drugs that specifically target INF-γ, IL-1β and INF-γ.PMID:37013553 | PMC:PMC10069101 | DOI:10.1186/s12906-023-03934-9 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 4, 2023 Category: Information Technology Authors: Asmaa Mahana Hala M Hammoda Mona M G Saad Mohamed M Radwan Mahmoud A ElSohly Doaa A Ghareeb Fathallah M Harraz Eman Shawky Source Type: research
Bio-guided isolation of potential anti-inflammatory constituents of some endophytes isolated from the leaves of ground cherry (Physalis pruinosa L.) via ex-vivo and in-silico studies
CONCLUSIONS: The results obtained suggested alternariol derivatives may serve as naturally occurring potent anti-inflammatory candidates. This study opens new avenues for the design and development of innovative anti-inflammatory drugs that specifically target INF-γ, IL-1β and INF-γ.PMID:37013553 | PMC:PMC10069101 | DOI:10.1186/s12906-023-03934-9 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 4, 2023 Category: Information Technology Authors: Asmaa Mahana Hala M Hammoda Mona M G Saad Mohamed M Radwan Mahmoud A ElSohly Doaa A Ghareeb Fathallah M Harraz Eman Shawky Source Type: research
[ASAP] Development of Electro-Reduced AgNPs/MnO < sub > 2 < /sub > /rGO Composite toward a Robust Sensor for the Simultaneous Determination of Piroxicam and Ofloxacin
Industrial& Engineering Chemistry ResearchDOI: 10.1021/acs.iecr.2c04610 (Source: Industrial and Engineering Chemical Research)
Source: Industrial and Engineering Chemical Research - March 10, 2023 Category: Chemistry Authors: Xuan Anh Vu Ho, My Uyen Dao, Trung Hieu Le, Thi Hong Chuong Nguyen, Minh Tuan Nguyen Dinh, Quang Man Nguyen, Thanh Minh Tran, Thi Thanh Huyen Nguyen, Thanh-Tam Ho, Hai Phong Nguyen, and Chinh Chien Nguyen Source Type: research
Model-based Optimization of Drug Release Rate from a Size Distributed Population of Biodegradable Polymer Carriers
Eur J Pharm Biopharm. 2023 Mar 2:S0939-6411(23)00056-5. doi: 10.1016/j.ejpb.2023.02.014. Online ahead of print.ABSTRACTIn the present study, a comprehensive polymer degradation-drug diffusion model is developed to describe the polymer degradation kinetics and quantify the release rate of an active pharmaceutical ingredient (API) from a size-distributed population of drug-loaded poly(lactic-co-glycolic) acid (PLGA) carriers in terms of material and morphological properties of the drug carriers. To take into account the spatial-temporal variation of the drug and water diffusion coefficients, three new correlations are develo...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 4, 2023 Category: Drugs & Pharmacology Authors: Athina C Vasileiadou Filippos F Karageorgos Costas Kiparissides Source Type: research
Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity
Drug Deliv. 2023 Dec;30(1):2174208. doi: 10.1080/10717544.2023.2174208.ABSTRACTCyclodextrin nanosponges are solid nanoparticles, designed by cross-linking of cyclodextrin polymer; it has been used widely as a good delivery system for water insoluble drugs. The aim of this study is to enhance the solubility of Piroxicam (PXM) using β-Cyclodextrin based nanosponges formulations. PXM nanosponge (PXM-NS) formulations were prepared using β-cyclodextrin and carbonyldiimidazole as a cross linker, three ratios of β-cyclodextrin to crosslinker in addition to three drug to nanosponges ratios were tested. Piroxicam nanosponge form...
Source: Drug Delivery - February 6, 2023 Category: Drugs & Pharmacology Authors: Dalia A Gaber Mahasen A Radwan Danah A Alzughaibi Jenan A Alail Rafa S Aljumah Reema M Aloqla Sara A Alkhalifah Siham A Abdoun Source Type: research
Comparison of prilocaine/lidocaine cream with piroxicam gel for reducing pain during cannulation of arteriovenous fistula for adults undergoing haemodialysis: A randomized crossover clinical trial
CONCLUSION: Prilocaine/lidocaine cream provides better pain relief than piroxicam gel during arteriovenous fistula needling.PMID:36573703 | DOI:10.1177/11297298221142375 (Source: The Journal of Vascular Access)
Source: The Journal of Vascular Access - December 27, 2022 Category: Surgery Authors: Samia Shaheen Abdul Rehman Arshad Muhammad Adnan Khan Khattak Source Type: research
