Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Endocrinology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
Corrigendum to "Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing" European Journal of Pharmaceutical Sciences 188 (2023) 106497
Eur J Pharm Sci. 2023 Sep 4:106575. doi: 10.1016/j.ejps.2023.106575. Online ahead of print.NO ABSTRACTPMID:37673750 | DOI:10.1016/j.ejps.2023.106575 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - September 6, 2023 Category: Drugs & Pharmacology Authors: Rathna Mathiyalagan Erica Sj öholm Sajana Manandhar Satu Lakio Jessica M Rosenholm Martti Kaasalainen Xiaoju Wang Niklas Sandler Source Type: research
Corrigendum to "Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing" European Journal of Pharmaceutical Sciences 188 (2023) 106497
Eur J Pharm Sci. 2023 Sep 4:106575. doi: 10.1016/j.ejps.2023.106575. Online ahead of print.NO ABSTRACTPMID:37673750 | DOI:10.1016/j.ejps.2023.106575 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - September 6, 2023 Category: Drugs & Pharmacology Authors: Rathna Mathiyalagan Erica Sj öholm Sajana Manandhar Satu Lakio Jessica M Rosenholm Martti Kaasalainen Xiaoju Wang Niklas Sandler Source Type: research
Morning-after pill is more effective when taken with anti-inflammatory
The emergency contraceptive levonorgestrel is much more effective at preventing pregnancy if the anti-inflammatory drug piroxicam is taken at the same time (Source: New Scientist - Health)
Source: New Scientist - Health - August 16, 2023 Category: Consumer Health News Source Type: research
Vaccination against Extracellular Vimentin for Treatment of Urothelial Cancer of the Bladder in Client-Owned Dogs
Cancers (Basel). 2023 Aug 3;15(15):3958. doi: 10.3390/cancers15153958.ABSTRACTIt was recently shown that targeting extracellular vimentin (eVim) is safe and effective in preclinical models. Here, we report the safety and efficacy in client-owned dogs with spontaneous bladder cancer of CVx1, an iBoost technology-based vaccine targeting eVim in combination with COX-2 inhibition. This was a single-arm prospective phase 1/2 study with CVx1 in 20 client-owned dogs with spontaneous UC which involved four subcutaneous vaccinations with CVx1 at 2-week intervals for induction of antibody titers, followed by maintenance vaccinations...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Diederik J M Engbersen Judy R van Beijnum Arno Roos Marit van Beelen Jan David de Haan Guy C M Grinwis Jack A Schalken J Alfred Witjes Arjan W Griffioen Elisabeth J M Huijbers Source Type: research
Cancers, Vol. 15, Pages 3958: Vaccination against Extracellular Vimentin for Treatment of Urothelial Cancer of the Bladder in Client-Owned Dogs
beth J. M. Huijbers
It was recently shown that targeting extracellular vimentin (eVim) is safe and effective in preclinical models. Here, we report the safety and efficacy in client-owned dogs with spontaneous bladder cancer of CVx1, an iBoost technology-based vaccine targeting eVim in combination with COX-2 inhibition. This was a single-arm prospective phase 1/2 study with CVx1 in 20 client-owned dogs with spontaneous UC which involved four subcutaneous vaccinations with CVx1 at 2-week intervals for induction of antibody titers, followed by maintenance vaccinations at 2-month intervals. Additionally, daily cyclooxygen...
Source: Cancers - August 3, 2023 Category: Cancer & Oncology Authors: Diederik J. M. Engbersen Judy R. van Beijnum Arno Roos Marit van Beelen Jan David de Haan Guy C. M. Grinwis Jack A. Schalken J. Alfred Witjes Arjan W. Griffioen Elisabeth J. M. Huijbers Tags: Article Source Type: research
Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models
Bioinformation. 2022 Sep 30;18(9):752-756. doi: 10.6026/97320630018752. eCollection 2022.ABSTRACTZaltoprofen, a unique propionic acid group of NSAIDs, works by blocking the enhancing effects of bradykinin along with the COX-2 enzyme. Therefore, it is of interest to evaluate the acute and chronic anti-inflammatory (arthritic) potential of zaltoprofen versus piroxicam in Murine models. A total of 48 Wister rats (200-250 g) of either sex (24 in each model) were used in the present study. The anti-inflammatory and arthritic potential of zaltoprofen was evaluated and compared by Carrageenan-induced acute inflammation and formal...
Source: Bioinformation - July 10, 2023 Category: Bioinformatics Authors: Balakrishnan Sadasivam Ratinder Jhaj Saman Kumar Saman Pathan Santenna Chenchula Source Type: research
Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models
Bioinformation. 2022 Sep 30;18(9):752-756. doi: 10.6026/97320630018752. eCollection 2022.ABSTRACTZaltoprofen, a unique propionic acid group of NSAIDs, works by blocking the enhancing effects of bradykinin along with the COX-2 enzyme. Therefore, it is of interest to evaluate the acute and chronic anti-inflammatory (arthritic) potential of zaltoprofen versus piroxicam in Murine models. A total of 48 Wister rats (200-250 g) of either sex (24 in each model) were used in the present study. The anti-inflammatory and arthritic potential of zaltoprofen was evaluated and compared by Carrageenan-induced acute inflammation and formal...
Source: Bioinformation - July 10, 2023 Category: Bioinformatics Authors: Balakrishnan Sadasivam Ratinder Jhaj Saman Kumar Saman Pathan Santenna Chenchula Source Type: research
Regional characterisation of TRPV1 and TRPA1 signalling in the mouse colon mucosa
Eur J Pharmacol. 2023 Jun 30:175897. doi: 10.1016/j.ejphar.2023.175897. Online ahead of print.ABSTRACTCapsaicin and allyl isothiocyanate (AITC) activate transient receptor potential (TRP) vanilloid-1 (TRPV1) and TRP ankyrin-1 (TRPA1), respectively. TRPV1 and TRPA1 expression have been identified in the gastrointestinal (GI) tract. GI mucosal functions remain largely undefined for TRPV1 and TRPA1 with side-dependence and regional differences in signalling unclear. Here we investigated TRPV1- and TRPA1-induced vectorial ion transport as changes in short-circuit current (ΔIsc), in defined segments of mouse colon mucosa (asce...
Source: European Journal of Pharmacology - July 2, 2023 Category: Drugs & Pharmacology Authors: Caryl Evans Kathryn Howells Rie Suzuki Alastair J H Brown Helen M Cox Source Type: research
Regional characterisation of TRPV1 and TRPA1 signalling in the mouse colon mucosa
Eur J Pharmacol. 2023 Jun 30:175897. doi: 10.1016/j.ejphar.2023.175897. Online ahead of print.ABSTRACTCapsaicin and allyl isothiocyanate (AITC) activate transient receptor potential (TRP) vanilloid-1 (TRPV1) and TRP ankyrin-1 (TRPA1), respectively. TRPV1 and TRPA1 expression have been identified in the gastrointestinal (GI) tract. GI mucosal functions remain largely undefined for TRPV1 and TRPA1 with side-dependence and regional differences in signalling unclear. Here we investigated TRPV1- and TRPA1-induced vectorial ion transport as changes in short-circuit current (ΔIsc), in defined segments of mouse colon mucosa (asce...
Source: European Journal of Pharmacology - July 2, 2023 Category: Drugs & Pharmacology Authors: Caryl Evans Kathryn Howells Rie Suzuki Alastair J H Brown Helen M Cox Source Type: research
Regional characterisation of TRPV1 and TRPA1 signalling in the mouse colon mucosa
Eur J Pharmacol. 2023 Jun 30:175897. doi: 10.1016/j.ejphar.2023.175897. Online ahead of print.ABSTRACTCapsaicin and allyl isothiocyanate (AITC) activate transient receptor potential (TRP) vanilloid-1 (TRPV1) and TRP ankyrin-1 (TRPA1), respectively. TRPV1 and TRPA1 expression have been identified in the gastrointestinal (GI) tract. GI mucosal functions remain largely undefined for TRPV1 and TRPA1 with side-dependence and regional differences in signalling unclear. Here we investigated TRPV1- and TRPA1-induced vectorial ion transport as changes in short-circuit current (ΔIsc), in defined segments of mouse colon mucosa (asce...
Source: European Journal of Pharmacology - July 2, 2023 Category: Drugs & Pharmacology Authors: Caryl Evans Kathryn Howells Rie Suzuki Alastair J H Brown Helen M Cox Source Type: research
Identifying hub genes and common biological pathways between COVID-19 and benign prostatic hyperplasia by machine learning algorithms
ConclusionOur findings reveal common signaling pathways, possible biological targets, and promising small molecule drugs for BPH and COVID-19. This is crucial to understand the potential common pathogenic and susceptibility pathways between them. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - June 23, 2023 Category: Allergy & Immunology Source Type: research
Personalizing Oral Delivery of Nanoformed Piroxicam by Semi-Solid Extrusion 3D Printing
Eur J Pharm Sci. 2023 Jun 15:106497. doi: 10.1016/j.ejps.2023.106497. Online ahead of print.ABSTRACTSemi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized dosage forms. Controlled Expansion of Supercritical Solution (CESS®) is a particle size reduction technology, and it produces particles of a pure active pharmaceutical ingredient (API) in a dry state, suspendable in the printing ink. In the current study, as a model API of poorly water-soluble drug, nanoformed piroxicam (nanoPRX) prepared by CESS® was accommodated in hyd...
Source: European Journal of Pharmaceutical Sciences - June 17, 2023 Category: Drugs & Pharmacology Authors: Rathna Mathiyalagan Erica Sj öholm Sajana Manandhar Satu Lakio Jessica M Rosenholm Martti Kaasalainen Xiaoju Wang Niklas Sandler Source Type: research
Personalizing Oral Delivery of Nanoformed Piroxicam by Semi-Solid Extrusion 3D Printing
Eur J Pharm Sci. 2023 Jun 15:106497. doi: 10.1016/j.ejps.2023.106497. Online ahead of print.ABSTRACTSemi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized dosage forms. Controlled Expansion of Supercritical Solution (CESS®) is a particle size reduction technology, and it produces particles of a pure active pharmaceutical ingredient (API) in a dry state, suspendable in the printing ink. In the current study, as a model API of poorly water-soluble drug, nanoformed piroxicam (nanoPRX) prepared by CESS® was accommodated in hyd...
Source: European Journal of Pharmaceutical Sciences - June 17, 2023 Category: Drugs & Pharmacology Authors: Rathna Mathiyalagan Erica Sj öholm Sajana Manandhar Satu Lakio Jessica M Rosenholm Martti Kaasalainen Xiaoju Wang Niklas Sandler Source Type: research
Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing
Eur J Pharm Sci. 2023 Jun 16;188:106497. doi: 10.1016/j.ejps.2023.106497. Online ahead of print.ABSTRACTSemi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized dosage forms. Controlled Expansion of Supercritical Solution (CESS®) is a particle size reduction technology, and it produces particles of a pure active pharmaceutical ingredient (API) in a dry state, suspendable in the printing ink. In the current study, as a model API of poorly water-soluble drug, nanoformed piroxicam (nanoPRX) prepared by CESS® was accommodated in...
Source: European Journal of Pharmaceutical Sciences - June 17, 2023 Category: Drugs & Pharmacology Authors: Rathna Mathiyalagan Erica Sj öholm Sajana Manandhar Satu Lakio Jessica M Rosenholm Martti Kaasalainen Xiaoju Wang Niklas Sandler Source Type: research
