Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF- κB, MMP-1, TNF-α, IL-1β and IL-6 expression in Sprague- Dawley rats
CONCLUSIONS: Chymotrypsin alleviates the joint damage of AIA rats, probably by reducing the expression of MMP-1, TNF-α, IL-1β and IL-6 through TLR4/NF-κB signaling pathway.PMID:35737007 | DOI:10.1080/08923973.2022.2093743 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 23, 2022 Category: Allergy & Immunology Authors: Jianqiang Li Linlin Wang Guangting Zeng Huilan Li Jia Luo Qijun Tian Zanling Zhang Source Type: research
Time to consider topical capsaicin for acute trauma pain?
J Fam Pract. 2022 May;71(4):176-177. doi: 10.12788/jfp.0403.ABSTRACTTopical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries.PMID:35730712 | DOI:10.12788/jfp.0403 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - June 22, 2022 Category: Practice Management Authors: Dillon Cleary Samuel Burton Brock Cardon Source Type: research
Time to consider topical capsaicin for acute trauma pain?
J Fam Pract. 2022 May;71(4):176-177. doi: 10.12788/jfp.0403.ABSTRACTTopical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries.PMID:35730712 | DOI:10.12788/jfp.0403 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - June 22, 2022 Category: Practice Management Authors: Dillon Cleary Samuel Burton Brock Cardon Source Type: research
Time to consider topical capsaicin for acute trauma pain?
J Fam Pract. 2022 May;71(4):176-177. doi: 10.12788/jfp.0403.ABSTRACTTopical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries.PMID:35730712 | DOI:10.12788/jfp.0403 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - June 22, 2022 Category: Practice Management Authors: Dillon Cleary Samuel Burton Brock Cardon Source Type: research
Time to consider topical capsaicin for acute trauma pain?
J Fam Pract. 2022 May;71(4):176-177. doi: 10.12788/jfp.0403.ABSTRACTTopical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries.PMID:35730712 | DOI:10.12788/jfp.0403 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - June 22, 2022 Category: Practice Management Authors: Dillon Cleary Samuel Burton Brock Cardon Source Type: research
Time to consider topical capsaicin for acute trauma pain?
J Fam Pract. 2022 May;71(4):176-177. doi: 10.12788/jfp.0403.ABSTRACTTopical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries.PMID:35730712 | DOI:10.12788/jfp.0403 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - June 22, 2022 Category: Practice Management Authors: Dillon Cleary Samuel Burton Brock Cardon Source Type: research
Time to consider topical capsaicin for acute trauma pain?
J Fam Pract. 2022 May;71(4):176-177. doi: 10.12788/jfp.0403.ABSTRACTTopical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries.PMID:35730712 | DOI:10.12788/jfp.0403 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - June 22, 2022 Category: Practice Management Authors: Dillon Cleary Samuel Burton Brock Cardon Source Type: research
Multi ‐phase Multi‐Layer Mechanistic Dermal Absorption (MPML MechDermA) Model to predict local and systemic exposure of drug products applied on skin
AbstractPhysiologically based pharmacokinetic (PBPK) models combine knowledge about physiology, drug product properties such as physicochemical parameters, absorption, distribution, metabolism, excretion (ADME) characteristics, formulation attributes, and trial design or dosing regimen to mechanistically simulate drug pharmacokinetics. The current work describes the development of a multi-phase, multi-layer mechanistic dermal absorption (MPML MechDermA) model within the Simcyp ® Simulator capable of simulating uptake and permeation of drugs through human skin following application of drug products to the skin. The model w...
Source: CPT: Pharmacometrics and Systems Pharmacology - June 8, 2022 Category: Drugs & Pharmacology Authors: Nikunjkumar Patel,
James F. Clarke,
Farzaneh Salem,
Tariq Abdulla,
Frederico Martins,
Sumit Arora,
Eleftheria Tsakalozou,
Arran Hodgkinson,
Omid Arjmandi ‐Tash,
Sinziana Cristea,
Priyanka Ghosh,
Khondoker Alam,
Sam G. Raney,
Masoud Jamei,
Tags: ARTICLE Source Type: research
Multiple session mesotherapy for management of coxofemoral osteoarthritis pain in 10 working dogs: A case series
Can Vet J. 2022 Jun;63(6):597-602.ABSTRACTThe aim of this study was to document the effects of mesotherapy in working dogs diagnosed with hip osteoarthritis (OA) and related pain. Ten police working dogs with hip OA and related pain were treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in multiple intradermal points. Seven treatment sessions were conducted. The Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS) were used in the assessment of response to treatment compared to evaluation before treatment (T0), after 15 d, 30 d, 60 d, 90 d, 120 d, 150 d, and 180 d ...
Source: The Canadian Veterinary Journal - June 3, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge Pilar Lafuente Source Type: research
Multiple session mesotherapy for management of coxofemoral osteoarthritis pain in 10 working dogs: A case series
Can Vet J. 2022 Jun;63(6):597-602.ABSTRACTThe aim of this study was to document the effects of mesotherapy in working dogs diagnosed with hip osteoarthritis (OA) and related pain. Ten police working dogs with hip OA and related pain were treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in multiple intradermal points. Seven treatment sessions were conducted. The Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS) were used in the assessment of response to treatment compared to evaluation before treatment (T0), after 15 d, 30 d, 60 d, 90 d, 120 d, 150 d, and 180 d ...
Source: The Canadian Veterinary Journal - June 3, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge Pilar Lafuente Source Type: research
Multiple session mesotherapy for management of coxofemoral osteoarthritis pain in 10 working dogs: A case series
Can Vet J. 2022 Jun;63(6):597-602.ABSTRACTThe aim of this study was to document the effects of mesotherapy in working dogs diagnosed with hip osteoarthritis (OA) and related pain. Ten police working dogs with hip OA and related pain were treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in multiple intradermal points. Seven treatment sessions were conducted. The Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS) were used in the assessment of response to treatment compared to evaluation before treatment (T0), after 15 d, 30 d, 60 d, 90 d, 120 d, 150 d, and 180 d ...
Source: The Canadian Veterinary Journal - June 3, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge Pilar Lafuente Source Type: research
Multiple session mesotherapy for management of coxofemoral osteoarthritis pain in 10 working dogs: A case series
Can Vet J. 2022 Jun;63(6):597-602.ABSTRACTThe aim of this study was to document the effects of mesotherapy in working dogs diagnosed with hip osteoarthritis (OA) and related pain. Ten police working dogs with hip OA and related pain were treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in multiple intradermal points. Seven treatment sessions were conducted. The Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS) were used in the assessment of response to treatment compared to evaluation before treatment (T0), after 15 d, 30 d, 60 d, 90 d, 120 d, 150 d, and 180 d ...
Source: The Canadian Veterinary Journal - June 3, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge Pilar Lafuente Source Type: research
