Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF- κB, MMP-1, TNF-α, IL-1β and IL-6 expression in Sprague- Dawley rats

CONCLUSIONS: Chymotrypsin alleviates the joint damage of AIA rats, probably by reducing the expression of MMP-1, TNF-α, IL-1β and IL-6 through TLR4/NF-κB signaling pathway.PMID:35737007 | DOI:10.1080/08923973.2022.2093743

Source: Immunopharmacology and Immunotoxicology - June 23, 2022 Category: Allergy & Immunology Authors: Jianqiang Li Linlin Wang Guangting Zeng Huilan Li Jia Luo Qijun Tian Zanling Zhang Source Type: research