Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism
The objective of this study was to develop and validate the piroxicam physiologically based pharmacokinetic (PBPK) model related to CYP2C9 genetic polymorphism. PK-Sim® version 10.0 was used for the PBPK modeling. The PBPK model was evaluated by predicted and observed plasma concentration-time profiles, fold errors of predicted to observed pharmacokinetic parameters, and a goodness-of-fit plot. The turnover number (kcat) of CYP2C9 was adjusted to capture the pharmacokinetics of piroxicam in different CYP2C9 genotypes. The population PBPK model overall accurately described and predicted the plasma concentration-time profil...
Source: Archives of Pharmacal Research - May 31, 2022 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Pureum Kang Hye-Jung Park Eunvin Ko Chou Yen Mu Yun Jeong Lee Chang-Ik Choi Hyung Sik Kim Choon-Gon Jang Jung-Woo Bae Seok-Yong Lee Source Type: research
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism
The objective of this study was to develop and validate the piroxicam physiologically based pharmacokinetic (PBPK) model related to CYP2C9 genetic polymorphism. PK-Sim® version 10.0 was used for the PBPK modeling. The PBPK model was evaluated by predicted and observed plasma concentration-time profiles, fold errors of predicted to observed pharmacokinetic parameters, and a goodness-of-fit plot. The turnover number (kcat) of CYP2C9 was adjusted to capture the pharmacokinetics of piroxicam in different CYP2C9 genotypes. The population PBPK model overall accurately described and predicted the plasma concentration-time profil...
Source: Archives of Pharmacal Research - May 31, 2022 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Pureum Kang Hye-Jung Park Eunvin Ko Chou Yen Mu Yun Jeong Lee Chang-Ik Choi Hyung Sik Kim Choon-Gon Jang Jung-Woo Bae Seok-Yong Lee Source Type: research
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism
The objective of this study was to develop and validate the piroxicam physiologically based pharmacokinetic (PBPK) model related to CYP2C9 genetic polymorphism. PK-Sim® version 10.0 was used for the PBPK modeling. The PBPK model was evaluated by predicted and observed plasma concentration-time profiles, fold errors of predicted to observed pharmacokinetic parameters, and a goodness-of-fit plot. The turnover number (kcat) of CYP2C9 was adjusted to capture the pharmacokinetics of piroxicam in different CYP2C9 genotypes. The population PBPK model overall accurately described and predicted the plasma concentration-time profil...
Source: Archives of Pharmacal Research - May 31, 2022 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Pureum Kang Hye-Jung Park Eunvin Ko Chou Yen Mu Yun Jeong Lee Chang-Ik Choi Hyung Sik Kim Choon-Gon Jang Jung-Woo Bae Seok-Yong Lee Source Type: research
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research
Artificial intelligence-assisted development of < em > in situ < /em > forming nanoparticles for arthritis therapy via intra-articular delivery
In conclusion, the use of ISNs for intra-articular injection has demonstrated their effectiveness in piroxicam delivery for RA treatment.PMID:35532141 | DOI:10.1080/10717544.2022.2069882 (Source: Drug Delivery)
Source: Drug Delivery - May 9, 2022 Category: Drugs & Pharmacology Authors: Ahmed S Yacoub Hussein O Ammar Magdy Ibrahim Suzan M Mansour Nada M El Hoffy Source Type: research
Xanthan and alginate-matrix used as transdermal delivery carrier for piroxicam and ketoconazole
This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole). The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles. When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression). The release of the active principles from the materials was best described ...
Source: International Journal of Biological Macromolecules - May 2, 2022 Category: Biochemistry Authors: Alexandra Dimofte Maria Valentina Dinu Narcis Anghel Florica Doroftei Iuliana Spiridon Source Type: research
Xanthan and alginate-matrix used as transdermal delivery carrier for piroxicam and ketoconazole
This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole). The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles. When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression). The release of the active principles from the materials was best described ...
Source: International Journal of Biological Macromolecules - May 2, 2022 Category: Biochemistry Authors: Alexandra Dimofte Maria Valentina Dinu Narcis Anghel Florica Doroftei Iuliana Spiridon Source Type: research
Evaluation of Extended-Release of Piroxicam Loaded Pectin-Zein Hydrogel Microspheres: In Vitro, Ex Vivo, and In Vivo Studies
CONCLUSION: P/Z HM had different drug release behaviors in in vitro and in vivo conditions. However, the ex vivo and in vivo characteristics were similar (R² = 0.99). This seemed reasonable to use the ex vivo method to predict the in vivo drug absorption behavior during the polymeric drug delivery system developmental studies. The P/Z HM formulation maintained the drug dose at the colon site for a long duration and could be applied for delivery of active pharmaceutical and food ingredients to the colon site.PMID:35249486 | DOI:10.2174/1567201819666220304092012 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 7, 2022 Category: Drugs & Pharmacology Authors: Jamshed Bobokalonov Zayniddin Muhidinov Abubakr Nasriddinov Abduvaly Jomnurodov Farangis Khojaeva Gulnora Komilova Salomudin Yusufi LinShu Liu Source Type: research
