Evaluation of Extended-Release of Piroxicam Loaded Pectin-Zein Hydrogel Microspheres: In Vitro, Ex Vivo, and In Vivo Studies
CONCLUSION: P/Z HM had different drug release behaviors in in vitro and in vivo conditions. However, the ex vivo and in vivo characteristics were similar (R² = 0.99). This seemed reasonable to use the ex vivo method to predict the in vivo drug absorption behavior during the polymeric drug delivery system developmental studies. The P/Z HM formulation maintained the drug dose at the colon site for a long duration and could be applied for delivery of active pharmaceutical and food ingredients to the colon site.PMID:35249486 | DOI:10.2174/1567201819666220304092012 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 7, 2022 Category: Drugs & Pharmacology Authors: Jamshed Bobokalonov Zayniddin Muhidinov Abubakr Nasriddinov Abduvaly Jomnurodov Farangis Khojaeva Gulnora Komilova Salomudin Yusufi LinShu Liu Source Type: research
Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis
In this study, 32 BALB/c male mice were distributed to four groups: the control group, the Piroxicam group which was given 0.8 mg Piroxicam, SP and SB groups which were given 0.8 mg Piroxicam, and plus Lactobacillus plantarum and Bifidobacterium longum selenium-enriched mutants, respectively. Bodyweight; serum content of IgG, IgM, TNF-α, IL-2, IL-6, and IL-10; CBC; myeloperoxidase enzyme activity; histopathological examination of colon and spleen; and expression of TNF-α, IL-2, IL-6, and IL-10 genes in colon and spleen with qRT-PCR were determined. Bodyweight was found to reduce in the Piroxicam group and then recovery i...
Source: Biological Trace Element Research - February 22, 2022 Category: Biology Authors: Abd El-Nasser Khattab Ahmed M Darwish Sarah I Othman Ahmed A Allam Haifa A Alqhtani Source Type: research
Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis
In this study, 32 BALB/c male mice were distributed to four groups: the control group, the Piroxicam group which was given 0.8 mg Piroxicam, SP and SB groups which were given 0.8 mg Piroxicam, and plus Lactobacillus plantarum and Bifidobacterium longum selenium-enriched mutants, respectively. Bodyweight; serum content of IgG, IgM, TNF-α, IL-2, IL-6, and IL-10; CBC; myeloperoxidase enzyme activity; histopathological examination of colon and spleen; and expression of TNF-α, IL-2, IL-6, and IL-10 genes in colon and spleen with qRT-PCR were determined. Bodyweight was found to reduce in the Piroxicam group and then recovery i...
Source: Cell Research - February 22, 2022 Category: Cytology Authors: Abd El-Nasser Khattab Ahmed M Darwish Sarah I Othman Ahmed A Allam Haifa A Alqhtani Source Type: research
Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis
In this study, 32 BALB/c male mice were distributed to four groups: the control group, the Piroxicam group which was given 0.8 mg Piroxicam, SP and SB groups which were given 0.8 mg Piroxicam, and plus Lactobacillus plantarum and Bifidobacterium longum selenium-enriched mutants, respectively. Bodyweight; serum content of IgG, IgM, TNF-α, IL-2, IL-6, and IL-10; CBC; myeloperoxidase enzyme activity; histopathological examination of colon and spleen; and expression of TNF-α, IL-2, IL-6, and IL-10 genes in colon and spleen with qRT-PCR were determined. Bodyweight was found to reduce in the Piroxicam group and then recovery i...
Source: Biological Trace Element Research - February 22, 2022 Category: Biology Authors: Abd El-Nasser Khattab Ahmed M Darwish Sarah I Othman Ahmed A Allam Haifa A Alqhtani Source Type: research
Jianpi Qingchang Decoction Ameliorates Chronic Colitis in Piroxicam-Induced IL-10 Knockout Mice by Inhibiting Endoplasmic Reticulum Stress
CONCLUSION: JPQCD may play a protective role in UC by regulating the PERK/eIF2α/ATF4/CHOP signaling pathway and relieving endoplasmic reticulum stress.PMID:35186102 | PMC:PMC8849791 | DOI:10.1155/2022/7378807 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - February 21, 2022 Category: Complementary Medicine Authors: Qian Chen Ya-Li Zhang Zi-Wei Zhang Yu-Jun Chen Ying-Jue Tang Dan Qiao Yan-Cheng Dai Zhi-Peng Tang Source Type: research
A novel formulation design based on hetero-templated solid lipid microparticles to improve the solubility of anti-inflammatory piroxicam for oral administration
New J. Chem., 2022, Advance Article DOI: 10.1039/D1NJ05281K, PaperMomoh A. Mumuni, Chime S. Amarachi, Anih C. Victor, Omeh C. Romanus, Josephat Ogbonna, Nafiu Aminu, Oyeniyi Y. James, Achor Muhammed, Kenechukwu C. Franklin, David D íaz Díaz The aim of the work was to formulate piroxicam-loaded solid lipid microparticles (SLMs) using natural biodegradable lipids and to evaluate thein vitro andin vivo properties of the formulations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - February 8, 2022 Category: Chemistry Authors: Momoh A. Mumuni Source Type: research
1-Allyl-4-hydroxy-2,2-dioxo-N-(4-methoxyphenyl)-1H-2 λ 6,1-benzothiazine-3-carboxamide: polymorphic transition due to grinding with the loss of the biological activity
A study of two polymorphic forms of 1-allyl-4-hydroxy-2,2-dioxo-N-(4-methoxyphenyl)-1-2 λ 6,1-benzothiazine-3-carboxamide (a structural analogue of piroxicam) has revealed some regularities in the crystal structure formation due to different evaporation rates from the tested solvents. The monoclinic polymorph crystallized from ethyl acetate is formed due to a large number of very weak C — H...O and C — H... π interactions as well as one strong stacking interaction. The triclinic polymorph crystallized from N,N-dimethylformamide is formed due to a small number of weak specific interactions and a maximal number of stro...
Source: Acta Crystallographica Section B - January 25, 2022 Category: Chemistry Authors: Shishkina, S.V. Shaposhnyk, A.M. Baumer, V.N. Voloshchuk, N.I. Bondarenko, P.S. Ukrainets, I.V. Tags: 2,1-benzothiazines polymorphism antidiuretic activity analgesic activity polymorphic transition grinding DFT calculations N-aryliminocoumarines, crystal packing, isotypism, pairwise interaction energies research papers Source Type: research
A novel formulation design based on hetero-templated solid lipid microparticles to improve solubility of anti-inflammatory piroxicam for oral administration
New J. Chem., 2022, Accepted Manuscript DOI: 10.1039/D1NJ05281K, PaperMumuni A. Momoh, Chime S. Amarachi, Anih C. Victor, Omeh C. Romanus, Josephat Ogbonna, Nafiu Aminu, Oyeniyi James, Achor Muhammed, Kenechukwu C. Franklin, David D íaz Díaz The aim of the work was to formulate piroxicam-solid lipid microparticles (SLMs) using natural biodegradable lipids and to evaluate the in vitro and in vivo properties of the formulations. The... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - January 21, 2022 Category: Chemistry Authors: Mumuni A. Momoh Source Type: research
Gastroprotective Effects of the Aqueous Extract from < em > Taraxacum officinale < /em > in Rats Using Ultrasound, Histology, and Biochemical Analysis
In conclusion, the gastroprotective effect of AETo involves reduction in oxidative stress and inflammatory injury and increase in mucin content. This study advances in the elucidation of mechanisms of gastric protection of T. officinale, contributes to the prospection of new molecules gastroprotective, and proposes the ultrasonographic analyses as a new gastroprotective assessment tool in preclinical studies.PMID:34970327 | PMC:PMC8714386 | DOI:10.1155/2021/8987232 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 31, 2021 Category: Complementary Medicine Authors: Maria Eduarda D C Zanatta Daniela Miorando Amanda M Stefller N átali Roos Jackeline Ernetti Ana J úlia Predebon Helo ísa Lindemann Aline M ânica Beatriz M M Oliveira Patr ícia Z Serpa Lilian Bohnen Viviane Simomura Denise B Gomes Max Vidal-Guti érre Source Type: research
Design, Synthesis, Docking Study and Biological Evaluation of 4-Hydroxy-2 < em > H < /em > -benzo[ < em > e < /em > ][1,2]thiazine-3-carboxamide 1,1-dioxide Derivatives as Anti-HIV Agents
Iran J Pharm Res. 2021 Summer;20(3):1-12. doi: 10.22037/ijpr.2020.114153.14695.ABSTRACTA novel series of benzothiazine-3-carboxamide 1,1-dioxide derivatives by modifying the piroxicam scaffold was designed, synthesized, and evaluated as anti-HIV agents. The 1,2-benzothiazine-3-carboxamide 1,1-dioxide scaffold consists of hydroxy and carboxamide groups as a chelating motif to form an interaction with Mg2+ ions within the integrase active site as a target. Most of the compounds displayed encouraging anti-HIV activity in a cell-based assay. Among them, compounds 13d, 13l and 13m were the most potent with EC50 values ranging f...
Source: Cell Research - December 14, 2021 Category: Cytology Authors: Ali Imani Sepehr Soleymani Rouhollah Vahabpour Zahra Hajimahdi Afshin Zarghi Source Type: research
Molecules, Vol. 26, Pages 7375: Modulating Properties of Piroxicam, Meloxicam and Oxicam Analogues against Macrophage-Associated Chemokines in Colorectal Cancer
ystek-Korpacka
The mechanisms underlying the antineoplastic effects of oxicams have not been fully elucidated. We aimed to assess the effect of classic and novel oxicams on the expression/secretion of macrophage-associated chemokines (RTqPCR/Luminex xMAP) in colorectal adenocarcinoma cells, and on the expression of upstream the non-steroidal anti-inflammatory drug (NSAID)-activated genes NAG1, NFKBIA, MYD88, and RELA, as well as at the chemokine profiling in colorectal tumors. Meloxicam downregulated CCL4 9.9-fold, but otherwise the classic oxicams had a negligible/non-significant effect. Novel analogues with a thiazin...
Source: Molecules - December 5, 2021 Category: Chemistry Authors: Paulina Lewandowska Izabela Szczuka Iwona Bednarz-Misa Berenika M. Szcz ęśniak-Sięga Katarzyna Neubauer Magdalena Mierzcha ła-Pasierb Marek Zawadzki Wojciech Witkiewicz Ma łgorzata Krzystek-Korpacka Tags: Article Source Type: research
Bombax costatum enhances piroxicam's efficacy: possible involvement of alpha-2 adrenergic receptor, opioidergic and arachidonic pathways
CONCLUSION: Bombax costatum posses antinociceptive and anti-inflammatory activities and may involve α-2 adrenergic receptor, opioidergic and arachidonic pathways. In addition, Bombax costaum augments the efficacy of piroxicam and could be of clinical benefits if studied on man.PMID:34756927 | DOI:10.1016/j.pharma.2021.10.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 10, 2021 Category: Drugs & Pharmacology Authors: Michael Ikechuwu Oraebosi Gonaka Miracle Good Source Type: research
Bombax costatum enhances piroxicam's efficacy: possible involvement of alpha-2 adrenergic receptor, opioidergic and arachidonic pathways
CONCLUSION: Bombax costatum posses antinociceptive and anti-inflammatory activities and may involve α-2 adrenergic receptor, opioidergic and arachidonic pathways. In addition, Bombax costaum augments the efficacy of piroxicam and could be of clinical benefits if studied on man.PMID:34756927 | DOI:10.1016/j.pharma.2021.10.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 10, 2021 Category: Drugs & Pharmacology Authors: Michael Ikechuwu Oraebosi Gonaka Miracle Good Source Type: research
