Evaluation of Extended-Release of Piroxicam Loaded Pectin-Zein Hydrogel Microspheres: In Vitro, Ex Vivo, and In Vivo Studies

CONCLUSION: P/Z HM had different drug release behaviors in in vitro and in vivo conditions. However, the ex vivo and in vivo characteristics were similar (R² = 0.99). This seemed reasonable to use the ex vivo method to predict the in vivo drug absorption behavior during the polymeric drug delivery system developmental studies. The P/Z HM formulation maintained the drug dose at the colon site for a long duration and could be applied for delivery of active pharmaceutical and food ingredients to the colon site.PMID:35249486 | DOI:10.2174/1567201819666220304092012
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research