Drug-drug interaction assessment based on a large-scale spontaneous reporting system for hepato- and renal-toxicity, and thrombocytopenia with concomitant low-dose methotrexate and analgesics use
CONCLUSIONS: Studies using spontaneous reporting systems have limitations such as reporting bias or lack of patient background; however, the results of our comprehensive analysis support the results of previous clinical or epidemiological studies. This study also demonstrated the usefulness of FAERS for DDI assessment.PMID:38303016 | PMC:PMC10832291 | DOI:10.1186/s40360-024-00738-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 2, 2024 Category: Drugs & Pharmacology Authors: Takeshi Honma Kenji Onda Koichi Masuyama Source Type: research
Evaluation of the antimicrobial efficacy of different nonsteroidal anti-inflammatory drugs alone or in combination with calcium hydroxide intracanal medicament: an in vitro study
This study explored the antimicrobial effects of ketoprofen, piroxicam, and celecoxib alone or combined with calcium hydroxide (CH) against two strains ofEnterococcus faecalis (E. faecalis) and assessed the influence of such combinations on the pH of CH. Minimum inhibitory concentrations (MICs) of the three tested NSAIDs were determined. Tested pastes were placed into wells punched in seeded agar plates and the bacterial inhibition zones were measured. Antibiofilm activity was assessed against 3 weeks of biofilm induced in bovine dentine blocks. The pH of the pastes was measured at four-time intervals. MIC values were 3.12...
Source: Odontology - January 24, 2024 Category: Dentistry Source Type: research
Mechanistic evaluation of antiarthritic and anti-inflammatory effect of campesterol ester derivatives in complete Freund ’s adjuvant-induced arthritic rats
Conclusion: CED demonstrated promising therapeutic potential as an anti-inflammatory intervention for arthritis in the experimental rat model. Its ability to reduce inflammation, protect tissues, and improve organ function indicates its multifaceted benefits. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 23, 2024 Category: Drugs & Pharmacology Source Type: research
Preparation of Piroxicam nanosuspensions by high pressure homogenization and evaluation of improved bioavailability
CONCLUSIONS: The results in this study indicate that PRX nanosuspension is a promising nanomedicine for enhancing the anti-inflammatory activity of PRX and has a high potential for the treatment of inflammation.PMID:38087641 | DOI:10.1080/03639045.2023.2256856 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - December 13, 2023 Category: Drugs & Pharmacology Authors: Okan Ali Aksoy Merve Zanbak Çotaoğlu Tugba Fatsa Gizem Ruya Topal Özgür Eşim Berk Alp G öksel Tu ğrul Hoşbul Cansel K öse Özkan Ayhan Sava şer Yal çın Özkan Source Type: research
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF- α and COX-2
This study was aimed to explore the antiarthritic potential ofA. dumosus in formaldehyde and complete Freund ’s adjuvant (CFA)-induced arthritic rats. Body weight, arthritic index, hepatic oxidative stress, hematological, biochemical and inflammatory markers were assessed using ELISA, whilst qRT-PCR studies were carried out for the mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2 genes. GCMS and HPLC analysis were performed to identify the secondary metabolites ofA. dumosus. From day 8 to 28 post-administration of formaldehyde and CFA, oral administration ofA. dumosus (600, 300 and 150 mg/kg) showed a notew...
Source: Inflammopharmacology - December 7, 2023 Category: Drugs & Pharmacology Source Type: research
Adding piroxicam to levonorgestrel increased emergency contraception effectiveness
Ann Intern Med. 2023 Dec 5. doi: 10.7326/J23-0098. Online ahead of print.ABSTRACTLi RHW, Lo SST, Gemzell-Danielsson K, et al. Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial. Lancet. 2023;402:851-858. 37597523.PMID:38048581 | DOI:10.7326/J23-0098 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - December 4, 2023 Category: Internal Medicine Authors: Pelin Batur Source Type: research
