Multiple session mesotherapy for management of coxofemoral osteoarthritis pain in 10 working dogs: A case series
Can Vet J. 2022 Jun;63(6):597-602.ABSTRACTThe aim of this study was to document the effects of mesotherapy in working dogs diagnosed with hip osteoarthritis (OA) and related pain. Ten police working dogs with hip OA and related pain were treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in multiple intradermal points. Seven treatment sessions were conducted. The Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS) were used in the assessment of response to treatment compared to evaluation before treatment (T0), after 15 d, 30 d, 60 d, 90 d, 120 d, 150 d, and 180 d ...
Source: The Canadian Veterinary Journal - June 3, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge Pilar Lafuente Source Type: research
Multiple session mesotherapy for management of coxofemoral osteoarthritis pain in 10 working dogs: A case series
Can Vet J. 2022 Jun;63(6):597-602.ABSTRACTThe aim of this study was to document the effects of mesotherapy in working dogs diagnosed with hip osteoarthritis (OA) and related pain. Ten police working dogs with hip OA and related pain were treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in multiple intradermal points. Seven treatment sessions were conducted. The Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS) were used in the assessment of response to treatment compared to evaluation before treatment (T0), after 15 d, 30 d, 60 d, 90 d, 120 d, 150 d, and 180 d ...
Source: The Canadian Veterinary Journal - June 3, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge Pilar Lafuente Source Type: research
Multiple session mesotherapy for management of coxofemoral osteoarthritis pain in 10 working dogs: A case series
Can Vet J. 2022 Jun;63(6):597-602.ABSTRACTThe aim of this study was to document the effects of mesotherapy in working dogs diagnosed with hip osteoarthritis (OA) and related pain. Ten police working dogs with hip OA and related pain were treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in multiple intradermal points. Seven treatment sessions were conducted. The Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS) were used in the assessment of response to treatment compared to evaluation before treatment (T0), after 15 d, 30 d, 60 d, 90 d, 120 d, 150 d, and 180 d ...
Source: The Canadian Veterinary Journal - June 3, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge Pilar Lafuente Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
CONCLUSION: JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/ RANKL/OPG signaling pathway, thereby reducing osteoclast activation and bone resorption and improving bone metabolism.PMID:35645540 | PMC:PMC9099185 | DOI:10.3748/wjg.v28.i13.1315 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 1, 2022 Category: Gastroenterology Authors: Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Source Type: research
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism
The objective of this study was to develop and validate the piroxicam physiologically based pharmacokinetic (PBPK) model related to CYP2C9 genetic polymorphism. PK-Sim® version 10.0 was used for the PBPK modeling. The PBPK model was evaluated by predicted and observed plasma concentration-time profiles, fold errors of predicted to observed pharmacokinetic parameters, and a goodness-of-fit plot. The turnover number (kcat) of CYP2C9 was adjusted to capture the pharmacokinetics of piroxicam in different CYP2C9 genotypes. The population PBPK model overall accurately described and predicted the plasma concentration-time profil...
Source: Archives of Pharmacal Research - May 31, 2022 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Pureum Kang Hye-Jung Park Eunvin Ko Chou Yen Mu Yun Jeong Lee Chang-Ik Choi Hyung Sik Kim Choon-Gon Jang Jung-Woo Bae Seok-Yong Lee Source Type: research
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism
The objective of this study was to develop and validate the piroxicam physiologically based pharmacokinetic (PBPK) model related to CYP2C9 genetic polymorphism. PK-Sim® version 10.0 was used for the PBPK modeling. The PBPK model was evaluated by predicted and observed plasma concentration-time profiles, fold errors of predicted to observed pharmacokinetic parameters, and a goodness-of-fit plot. The turnover number (kcat) of CYP2C9 was adjusted to capture the pharmacokinetics of piroxicam in different CYP2C9 genotypes. The population PBPK model overall accurately described and predicted the plasma concentration-time profil...
Source: Archives of Pharmacal Research - May 31, 2022 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Pureum Kang Hye-Jung Park Eunvin Ko Chou Yen Mu Yun Jeong Lee Chang-Ik Choi Hyung Sik Kim Choon-Gon Jang Jung-Woo Bae Seok-Yong Lee Source Type: research
