ARIA II: a randomized controlled trial of near-infrared Angiography during RectosIgmoid resection and Anastomosis in women with ovarian cancer
Int J Gynecol Cancer. 2024 Mar 21:ijgc-2024-005395. doi: 10.1136/ijgc-2024-005395. Online ahead of print.ABSTRACTBACKGROUND: Ovarian cancer with extensive metastatic disease involving pelvic structures often requires rectosigmoid resection for complete gross resection; however, it is associated with increased surgical morbidity. There are limited data, and none in ovarian cancer, on near-infrared assessment of perfusion in rectosigmoid resections with anastomosis.PRIMARY OBJECTIVE: To compare the rate of pelvic complications (pelvic abscesses, anastomotic leaks, and infections) within 30 days of surgery with and without ne...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Mario M Leitao Alexia Iasonos Morgan Tomberlin Lea A Moukarzel Hannah Price Gabrielle Bennetti Bhavani Ramesh Dennis S Chi Kara Long Roche Yukio Sonoda Ahmed Al-Niami Jennifer J Mueller Ginger J Gardner Vance Broach Elizabeth L Jewell Sarah Kim Jacqueline Source Type: research
TGFbeta signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
CONCLUSION: Our results suggest the TGFβ pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still not fully understood, these shed light on yet another clinical implication of this complex pathway.PMID:38498101 | DOI:10.1007/s10585-024-10277-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Sven Jacob Ilja Balonov Vindi Jurinovic Christian Heiliger Tengis Tschaidse J örg Kumbrink Thomas Kirchner Jens Werner Martin K Angele Marlies Michl Jens Neumann Source Type: research
ASO Author Reflections: Addressing Hospital-Based Disparities in Access to Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) and Survival in Patients with Isolated Colorectal Peritoneal Metastases
Ann Surg Oncol. 2024 Mar 18. doi: 10.1245/s10434-024-15193-0. Online ahead of print.NO ABSTRACTPMID:38498087 | DOI:10.1245/s10434-024-15193-0 (Source: Ann Oncol)
Source: Ann Oncol - March 18, 2024 Category: Cancer & Oncology Authors: Roos G F M van der Ven Teun B M van den Heuvel Koen P B Rovers Simon W Nienhuijs Felice N van Erning Ignace H J T de Hingh Source Type: research
TGFbeta signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
CONCLUSION: Our results suggest the TGFβ pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still not fully understood, these shed light on yet another clinical implication of this complex pathway.PMID:38498101 | DOI:10.1007/s10585-024-10277-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Sven Jacob Ilja Balonov Vindi Jurinovic Christian Heiliger Tengis Tschaidse J örg Kumbrink Thomas Kirchner Jens Werner Martin K Angele Marlies Michl Jens Neumann Source Type: research
Cancers, Vol. 16, Pages 1182: Systemic Chemotherapy in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery: Systematic Review and Meta-Analysis
Conclusions. Systemic chemotherapy administration in patients undergoing radical surgery for colorectal peritoneal metastases is associated with increased survival only in the adjuvant/post-operative setting. Considering the limitations of the included studies, further trials are needed to answer this unresolved question. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Marco Tonello Carola Cenzi Elisa Pizzolato Riccardo Fiscon Paola Del Bianco Pierluigi Pilati Antonio Sommariva Tags: Systematic Review Source Type: research
TGF β signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
ConclusionOur results suggest the TGF β pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still n ot fully understood, these shed light on yet another clinical implication of this complex pathway. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 18, 2024 Category: Cancer & Oncology Source Type: research
Retrospective Evaluation of the Prognostic Value of Histological Growth Pattern in Patients with Colorectal Peritoneal Metastases Undergoing Curative-Intent Cytoreductive Surgery
CONCLUSIONS: This study confirms the prognostic value and reproducibility of the two previously reported HGPs in PMCRC. Dominant P-HGP is associated with better DFS and OS in patients undergoing curative-intent CRS ± HIPEC compared with I-HGP, independently of the extent of peritoneal disease burden.PMID:38491312 | DOI:10.1245/s10434-024-15125-y (Source: Ann Oncol)
Source: Ann Oncol - March 16, 2024 Category: Cancer & Oncology Authors: Leonel Kamdem Antoine El Asmar Pieter Demetter Ismael Coulibaly Zana Charif Khaled Francesco Sclafani Vincent Donckier Peter Vermeulen Gabriel Liberale Source Type: research
Retrospective Evaluation of the Prognostic Value of Histological Growth Pattern in Patients with Colorectal Peritoneal Metastases Undergoing Curative-Intent Cytoreductive Surgery
CONCLUSIONS: This study confirms the prognostic value and reproducibility of the two previously reported HGPs in PMCRC. Dominant P-HGP is associated with better DFS and OS in patients undergoing curative-intent CRS ± HIPEC compared with I-HGP, independently of the extent of peritoneal disease burden.PMID:38491312 | DOI:10.1245/s10434-024-15125-y (Source: Ann Oncol)
Source: Ann Oncol - March 16, 2024 Category: Cancer & Oncology Authors: Leonel Kamdem Antoine El Asmar Pieter Demetter Ismael Coulibaly Zana Charif Khaled Francesco Sclafani Vincent Donckier Peter Vermeulen Gabriel Liberale Source Type: research
DNA Methylation of a Group of Long Non-Coding RNA Genes at Different Stages of Ovarian Cancer Dissemination
There are three types of metastases in ovarian cancer: lymphogenous, hematogenous, and peritoneal. Dissemination of the tumor in the peritoneum is directly related with the development of ascites and a poor prognosis. The purpose of this study is to determine changes in the methylation level of a group of long non-coding RNA (lncRNA) genes at different stages of ovarian cancer progression. The methylation level of 7 lncRNA genes (LINC00472,LINC00886,MAFG-DT,SNHG1,SNHG6,TP53TG1, andTUG1) was studied by quantitative methyl-specific PCR in 93 samples of ovarian tumors and 75 paired samples of histologically normal tissue, as ...
Source: Bulletin of Experimental Biology and Medicine - March 16, 2024 Category: Biology Source Type: research
Compliance With NCCN Guidelines for Evaluation and Treatment of Anemia Among Patients With Solid Tumors
CONCLUSIONS: Anemia is common in patients with solid tumors; yet, compliance with NCCN Guidelines for evaluation and treatment of anemia remains low. There are opportunities to improve compliance with guidelines across the spectrum of cancer care.PMID:38489926 | DOI:10.6004/jnccn.2023.7108 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - March 15, 2024 Category: Cancer & Oncology Authors: Demetra Hypatia Hufnagel Lia Manfredi Bos Alaina Johnson Brown Lauren Shore Prescott Source Type: research
Neoadjuvant chemotherapy for high-grade serous ovarian cancer: radiologic –pathologic correlation of response assessment and predictors of progression
ConclusionHGSC response to neoadjuvant therapy by CT S-PCI did not predict pathologic CRS score, optimal debulking, or progression, revealing discordance between imaging, pathologic, biochemical, and surgical assessments of tumor response. (Source: Abdominal Imaging)
Source: Abdominal Imaging - March 13, 2024 Category: Radiology Source Type: research
Improved Postoperative Pain Management Outcomes After Implementation of Enhanced Recovery After Surgery (ERAS) Protocol for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC)
CONCLUSIONS: ERAS implementation for CRS-HIPEC was associated with increased epidural use, decreased oral and IV opioid use, and earlier bowel function return. Our study demonstrates that epidural analgesia provides adequate pain control while significantly decreasing oral and IV opioid use, which may promote gastrointestinal recovery postoperatively. These findings support the implementation of an ERAS protocol for effective pain management in patients undergoing CRS-HIPEC.PMID:38466484 | DOI:10.1245/s10434-024-15120-3 (Source: Ann Oncol)
Source: Ann Oncol - March 11, 2024 Category: Cancer & Oncology Authors: Tiffany M Yue Beatrice J Sun Nova Xu Rika Ohkuma Cedar Fowler Byrne Lee Source Type: research
Remarkable response to capmatinib in a patient with intrahepatic cholangiocarcinoma harboring TFG-MET fusion
AbstractDysregulation of mesenchymal-epithelial transition factor (MET) gene due to amplification, mutation, and fusion has been reported in various types of human cancers. Recently, the efficacy of small-molecule tyrosine kinase inhibitors (TKIs) targeting MET has been demonstrated in a wide range ofMET-dysregulated tumors. The majority of biliary tract cancers including intrahepatic cholangiocarcinoma (iCCA) are diagnosed at an advanced stage, and the utility of conventional chemotherapy is limited. Here, we present a case of metastatic iCCA harboringTFG-MET gene fusion, which demonstrated a remarkable response to treatm...
Source: International Cancer Conference Journal - March 9, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1098: Local Treatment of Colorectal Liver Metastases in the Presence of Extrahepatic Disease: Survival Outcomes from the Amsterdam Colorectal Liver Met Registry (AmCORE)
Conclusions: In this comparative series, OS was inferior for patients with multi-organ metastatic CRC versus patients with CRLMs alone. Nonetheless, the long-term survival curve plateau seemed to justify local treatment in a subset of patients with multi-organ metastatic CRC, especially for patients with CRLMs and pulmonary or lymph node metastases. (Source: Cancers)
Source: Cancers - March 8, 2024 Category: Cancer & Oncology Authors: Hannah H. Schulz Madelon Dijkstra Susan van der Lei Danielle J. W. Vos Florentine E. F. Timmer Robbert S. Puijk Hester J. Scheffer M. Petrousjka van den Tol Birgit I. Lissenberg-Witte Tineke E. Buffart Kathelijn S. Versteeg Rutger-Jan Swijnenburg Martijn Tags: Article Source Type: research
