Towards Equal Access to Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy and Survival in Patients with Isolated Colorectal Peritoneal Metastases: A Nationwide Population-Based Study
CONCLUSION: Previously observed differences in odds of undergoing CRS-HIPEC were no longer present. Increased awareness and the harmonization of treatment for PMCRC may have contributed to equal access to care and a similar chance of survival at a national level.PMID:38453767 | DOI:10.1245/s10434-024-15131-0 (Source: Ann Oncol)
Source: Ann Oncol - March 7, 2024 Category: Cancer & Oncology Authors: Roos G F M van der Ven Teun B M van den Heuvel Koen P B Rovers Simon W Nienhuijs Djamila Boerma Wilhelmina M U van Grevenstein Patrick H J Hemmer Niels F M Kok Eva V E Madsen Philip de Reuver Jurriaan B Tuynman Felice N van Erning Ignace H J T de Hingh Source Type: research
Peritoneal metastases in patients with neuroendocrine neoplasms: a challenging site of metastases with clinical and prognostic implications
ConclusionPeritoneal metastases show low prevalence among NEN patients and are most likely to develop in patients with small intestinal NENs and advanced metastatic disease. The presence of PM does seem to be associated with a negative prognostic impact on OS of NEN patients and their identification and prompt treatment is of major importance. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 7, 2024 Category: Endocrinology Source Type: research
Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FR α)-targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer
CONCLUSIONS: This triplet regimen (MIRV+carboplatin+bevacizumab) was highly active, with a tolerable AE profile in participants with recurrent, platinum-sensitive, FRα-expressing ovarian cancer. Thrombocytopenia was the primary cause of dose modifications. These outcomes compare favorably to historical data reported for platinum-based chemotherapy plus bevacizumab regimens in similar patient populations.PMID:38447347 | DOI:10.1016/j.ygyno.2024.01.045 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 6, 2024 Category: Cancer & Oncology Authors: Debra L Richardson Kathleen N Moore Ignace Vergote Lucy Gilbert Lainie P Martin Gina M Mantia-Smaldone Cesar M Castro Diane Provencher Ursula A Matulonis James Stec Yuemei Wang Michael Method David M O'Malley Source Type: research
Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FR α)-targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer
CONCLUSIONS: This triplet regimen (MIRV+carboplatin+bevacizumab) was highly active, with a tolerable AE profile in participants with recurrent, platinum-sensitive, FRα-expressing ovarian cancer. Thrombocytopenia was the primary cause of dose modifications. These outcomes compare favorably to historical data reported for platinum-based chemotherapy plus bevacizumab regimens in similar patient populations.PMID:38447347 | DOI:10.1016/j.ygyno.2024.01.045 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 6, 2024 Category: Cancer & Oncology Authors: Debra L Richardson Kathleen N Moore Ignace Vergote Lucy Gilbert Lainie P Martin Gina M Mantia-Smaldone Cesar M Castro Diane Provencher Ursula A Matulonis James Stec Yuemei Wang Michael Method David M O'Malley Source Type: research
The importance of integrating diagnostic modalities in patient selection for CRS-HIPEC in colorectal peritoneal metastases
CONCLUSIONS: A combination of radiological and surgical assessment of the PCI may lead to improved preoperative patient selection for CRS-HIPEC.PMID:38439639 | DOI:10.1177/02841851241229154 (Source: Acta Radiologica)
Source: Acta Radiologica - March 5, 2024 Category: Radiology Authors: Nadine L de Boer Checca Bakkers Alexandra Rm Brandt-Kerkhof Marianne de Vries Joost Nederend Cornelis Verhoef Ignace Hjt de Hingh Jacobus Wa Burger Source Type: research
The importance of integrating diagnostic modalities in patient selection for CRS-HIPEC in colorectal peritoneal metastases
CONCLUSIONS: A combination of radiological and surgical assessment of the PCI may lead to improved preoperative patient selection for CRS-HIPEC.PMID:38439639 | DOI:10.1177/02841851241229154 (Source: Acta Radiologica)
Source: Acta Radiologica - March 5, 2024 Category: Radiology Authors: Nadine L de Boer Checca Bakkers Alexandra Rm Brandt-Kerkhof Marianne de Vries Joost Nederend Cornelis Verhoef Ignace Hjt de Hingh Jacobus Wa Burger Source Type: research
The importance of integrating diagnostic modalities in patient selection for CRS-HIPEC in colorectal peritoneal metastases
CONCLUSIONS: A combination of radiological and surgical assessment of the PCI may lead to improved preoperative patient selection for CRS-HIPEC.PMID:38439639 | DOI:10.1177/02841851241229154 (Source: Acta Radiologica)
Source: Acta Radiologica - March 5, 2024 Category: Radiology Authors: Nadine L de Boer Checca Bakkers Alexandra Rm Brandt-Kerkhof Marianne de Vries Joost Nederend Cornelis Verhoef Ignace Hjt de Hingh Jacobus Wa Burger Source Type: research
Human tissue-resident peritoneal macrophages reveal resistance towards oxidative cell stress induced by non-invasive physical plasma
In the context of multimodal treatments for abdominal cancer, including procedures such as cytoreductive surgery and intraperitoneal chemotherapy, recurrence rates remain high, and long-term survival benefits are uncertain due to post-operative complications. Notably, treatment-limiting side effects often arise from an uncontrolled activation of the immune system, particularly peritoneally localized macrophages, leading to massive cytokine secretion and phenotype changes. Exploring alternatives, an increasing number of studies investigated the potential of plasma-activated liquids (PAL) for adjuvant peritoneal cancer treat...
Source: Frontiers in Immunology - March 5, 2024 Category: Allergy & Immunology Source Type: research
Correction: Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer
British Journal of Cancer, Published online: 04 March 2024; doi:10.1038/s41416-024-02628-4Correction: Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer (Source: British Journal of Cancer)
Source: British Journal of Cancer - March 4, 2024 Category: Cancer & Oncology Authors: Dana M. Roque Eric R. Siegel Natalia Buza Stefania Bellone Dan-Arin Silasi Gloria S. Huang Vaagn Andikyan Mitchell Clark Masoud Azodi Peter E. Schwartz Gautam G. Rao Jocelyn C. Reader Pei Hui Joan R. Tymon-Rosario Justin Harold Dennis Mauricio Burak Zeybe Source Type: research
Initial Experience Using Laparoscopic HIPEC for Gastric Cancer with Peritoneal Metastasis: Safety and Outcomes
CONCLUSIONS: Laparoscopic HIPEC appears to be safe with minimal perioperative complications. Approximately one third of the patients undergoing initial laparoscopic HIPEC ultimately proceeded to cytoreduction and gastrectomy. Preliminary survival data from this highly selected cohort suggest that the addition of laparoscopic HIPEC to systemic chemotherapy does not compromise other treatment options. These initial results suggest that laparoscopic HIPEC may offer benefit to patients with GC and PM and aid in the selection of patients who may benefit from curative-intent resection.PMID:38430428 | DOI:10.1245/s10434-024-15102...
Source: Ann Oncol - March 2, 2024 Category: Cancer & Oncology Authors: Meagan D Read Justin Drake Ghazal Hashemipour Benjamin D Powers Rutika Mehta Andrew Sinnamon Jose M Pimiento Sean P Dineen Source Type: research
Initial Experience Using Laparoscopic HIPEC for Gastric Cancer with Peritoneal Metastasis: Safety and Outcomes
CONCLUSIONS: Laparoscopic HIPEC appears to be safe with minimal perioperative complications. Approximately one third of the patients undergoing initial laparoscopic HIPEC ultimately proceeded to cytoreduction and gastrectomy. Preliminary survival data from this highly selected cohort suggest that the addition of laparoscopic HIPEC to systemic chemotherapy does not compromise other treatment options. These initial results suggest that laparoscopic HIPEC may offer benefit to patients with GC and PM and aid in the selection of patients who may benefit from curative-intent resection.PMID:38430428 | DOI:10.1245/s10434-024-15102...
Source: Ann Oncol - March 2, 2024 Category: Cancer & Oncology Authors: Meagan D Read Justin Drake Ghazal Hashemipour Benjamin D Powers Rutika Mehta Andrew Sinnamon Jose M Pimiento Sean P Dineen Source Type: research
Initial Experience Using Laparoscopic HIPEC for Gastric Cancer with Peritoneal Metastasis: Safety and Outcomes
ConclusionsLaparoscopic HIPEC appears to be safe with minimal perioperative complications. Approximately one third of the patients undergoing initial laparoscopic HIPEC ultimately proceeded to cytoreduction and gastrectomy. Preliminary survival data from this highly selected cohort suggest that the addition of laparoscopic HIPEC to systemic chemotherapy does not compromise other treatment options. These initial results suggest that laparoscopic HIPEC may offer benefit to patients with GC and PM and aid in the selection of patients who may benefit from curative-intent resection. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stage IV CRC patients. Insights into differential site-specific reconstitution of tumor cells and the corresponding tumor microenvironment are still missing. Here, we analyzed the transcriptome of single cells derived from murine multivisceral CRC and delineated the intermetastatic cellular heterogeneity regarding tumor epithelium, stroma, and immune cells. Interestingly, we found an intercel...
Source: Journal of Clinical Investigation - March 1, 2024 Category: Biomedical Science Authors: Christopher Berlin, Bernhard Mauerer, Pierre Cauchy, Jost Luenstedt, Roman Sankowski, Lisa Marx, Reinhild Feuerstein, Luisa Schaefer, Florian R. Greten, Marina Pesic, Olaf Groß, Marco Prinz, Naomi Ruehl, Laura Miketiuk, Dominik Jauch, Claudia Laessle, An Source Type: research
GSE238257 SMYD5 regulates mRNA translation to promote gastric adenocarcinoma (GAC)
Contributors : Juhyung Park ; Jibo Wu ; Krzysztof J Szkop ; Jinho Jeong ; Dylan Husmann ; Natasha M Flores ; Joel W Francis ; Ying-Jiun C Chen ; Ana Morales Benitez ; Emily Zahn ; Shumei Song ; Jaffer A Ajani ; Linghua Wang ; Kamini Singh ; Ola Larsson ; Benjamin A Garcia ; Ivan Topisirovic ; Pawel K Mazur ; Or GozaniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulated transcription due to disruption in histone lysine methylation dynamics is an established contributor to tumorigenesis. However, whether analogous pathologic epigenetic mechanisms act directly on the ...
Source: GEO: Gene Expression Omnibus - March 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
