Cancers, Vol. 16, Pages 871: CA125 Kinetics as a Potential Biomarker for Peritoneal Metastasis Progression following Taxane-Plus-Ramucirumab Administration in Patients with Advanced Gastric Cancer
In conclusion, this study highlights that CA125 kinetics can serve as an early predictor for the progression of peritoneal metastasis during TAX/RAM treatment. (Source: Cancers)
Source: Cancers - February 22, 2024 Category: Cancer & Oncology Authors: Akira Ueda Satoshi Yuki Takayuki Ando Ayumu Hosokawa Naokatsu Nakada Yosuke Kito Iori Motoo Ken Ito Miho Sakumura Yurika Nakayama Yuko Ueda Shinya Kajiura Koji Nakashima Kazuaki Harada Yasuyuki Kawamoto Yoshito Komatsu Ichiro Yasuda Tags: Article Source Type: research
Case Report on Endometriosis Associated Peritoneal Endometrioid Carcinoma
We report a case of 43 years female with chief complaints of menorrhagia, dysmenorrhoea and dyspareunia. Her imaging revealed an endometriotic cyst of in left ovary al ong with iso to hyperechoic nodular area seen in right iliac fossa. Laparoscopic exploration validated it to be a case of grade IV endometriosis along with presence of peritoneal nodule of 5.5 × 4.5 cm in right iliac fossa. The peritoneal nodular lesion was removed with en bloc wide local exci sion with clinically disease-free margin. Histopathology report of peritoneal nodule shows endometrioid adenocarcinoma. Complete surgical staging for peritoneal...
Source: The Journal of Obstetrics and Gynecology of India - February 19, 2024 Category: OBGYN Source Type: research
ASO Visual Abstract: Normal CEA Levels After Neoadjuvant Chemotherapy and Cytoreduction with Hyperthermic Intraperitoneal Chemoperfusion Predict Improved Survival from Colorectal Peritoneal Metastases
Ann Surg Oncol. 2024 Feb 14. doi: 10.1245/s10434-024-15065-7. Online ahead of print.NO ABSTRACTPMID:38353796 | DOI:10.1245/s10434-024-15065-7 (Source: Ann Oncol)
Source: Ann Oncol - February 14, 2024 Category: Cancer & Oncology Authors: Michael M Wach Geoffrey Nunns Ahmed Hamed Joshua Derby Mark Jelinek Curtis Tatsuoka Matthew P Holtzman Amer H Zureikat David L Bartlett Steven A Ahrendt James F Pingpank M Haroon A Choudry Melanie Ongchin Source Type: research
Risk factors of chronic kidney disease in cisplatin-based hyperthermia intraperitoneal chemotherapy
CONCLUSION: Intraoperative use of parecoxib during cisplatin-based HIPEC emerged as a significant risk factor for postoperative CKD. Clinicians should exercise caution in prescribing parecoxib during HIPEC procedures. Additionally, maintaining intraoperative body temperature below 38.5°C might be crucial to mitigate the risk of CKD development. This study underscores the importance of identifying and preventing specific risk factors to improve long-term renal outcomes in patients undergoing cisplatin-based HIPEC.PMID:38342495 | DOI:10.1080/02656736.2024.2304250 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 11, 2024 Category: Internal Medicine Authors: Chih-Chung Cheng Hung-Chieh Yeh Pei-Wen Su Chien-Lin Ho Sheng-Chi Chang Source Type: research
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy to Treat Pseudomyxoma Peritonei of Ovarian Origin: A Retrospective French RENAPE Group Study
CONCLUSION: These results suggested that a primary therapeutic strategy using complete CRS/HIPEC for patients with OPMP led to favorable long-term outcomes.PMID:38341381 | DOI:10.1245/s10434-023-14850-0 (Source: Ann Oncol)
Source: Ann Oncol - February 10, 2024 Category: Cancer & Oncology Authors: Alexis Trecourt Naoual Bakrin Olivier Glehen Witold Gertych Laurent Villeneuve Sylvie Isaac Nazim Benzerdjeb Juliette Fontaine Catherine Genestie Peggy Dartigues Agn ès Leroux Fran çois Quenet Frederic Marchal Cecile Odin Lakhdar Khellaf Magali Svrcek S Source Type: research
Trends in ovarian, fallopian tube, and primary peritoneal cancer incidence, mortality, and survival: A 15-year population-based analysis
CONCLUSION: There has been a decrease in the incidence and incidence-based mortality of ovarian, fallopian tube, and primary peritoneal cancer, primarily due to reductions in advanced stage epithelial cancers originating in the ovary, fallopian tube, or peritoneum.PMID:38330833 | DOI:10.1016/j.ygyno.2024.01.034 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 8, 2024 Category: Cancer & Oncology Authors: Sahana Somasegar Ravali A Reddy Stephanie Chow Oliver Dorigo Malte Renz Amer Karam Source Type: research
Genes, Vol. 15, Pages 219: Genetic Basis of Breast and Ovarian Cancer: Approaches and Lessons Learnt from Three Decades of Inherited Predisposition Testing
Anita Luberto
Patrizia Caggiati
Davide Martorana
Vera Uliana
Antonio Percesepe
Antonino Musolino
Benedetta Pellegrino
Germline variants occurring in BRCA1 and BRCA2 give rise to hereditary breast and ovarian cancer (HBOC) syndrome, predisposing to breast, ovarian, fallopian tube, and peritoneal cancers marked by elevated incidences of genomic aberrations that correspond to poor prognoses. These genes are in fact involved in genetic integrity, particularly in the process of homologous recombination (HR) DNA repair, a high-fidelity repair system for mending DNA double-strand breaks. In addition to its impli...
Source: Genes - February 8, 2024 Category: Genetics & Stem Cells Authors: Valeria Barili Enrico Ambrosini Beatrice Bortesi Roberta Minari Erika De Sensi Ilenia Rita Cannizzaro Antonietta Taiani Maria Michiara Angelica Sikokis Daniela Boggiani Chiara Tommasi Olga Serra Francesco Bonatti Alessia Adorni Anita Luberto Patrizia Cagg Tags: Review Source Type: research
Role of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Colorectal Peritoneal Metastases
Clin Colon Rectal Surg. 2023 Mar 13;37(2):90-95. doi: 10.1055/s-0042-1758759. eCollection 2024 Mar.ABSTRACTPeritoneal metastases from colon cancer are a particularly challenging disease process given the limited response to systemic chemotherapy. In patients with isolated peritoneal metastases, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy offers a potential treatment option to these patients with limited peritoneal metastases as long as a complete cytoreduction is achieved. Decision about a patient's candidacy for this treatment modality should be undertaken by a multidisciplinary group at expert ce...
Source: Clinical Colorectal Cancer - February 7, 2024 Category: Cancer & Oncology Authors: Rupen Shah Alexandra Gangi Source Type: research
Immune cell infiltrates in peritoneal metastases from colorectal cancer
ConclusionImmune cells were present in all PMs from CRC examined. Although infiltrating T cells express markers of exhaustion, they produce Th1-type cytokines when stimulated. These results indicate the possibility to augment tumor-specific immune responses within PMs using checkpoint blockade inhibitors. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 7, 2024 Category: Allergy & Immunology Source Type: research
Use of Ultrasound-Assisted, Catheter-Directed Thrombolysis in a Patient With High-Risk Pulmonary Embolism
This report describes a case in which ultrasound-assisted, catheter-directed thrombolysis was successfully used to treat high-risk PE in a female patient with extensive peritoneal metastases from gastric adenocarcinoma. Other examples from the literature, in which ultrasound-assisted, catheter-directed thrombolysis was used to treat high-risk PE, are also provided.PMID:38317350 | DOI:10.14503/THIJ-23-8235 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - February 6, 2024 Category: Cardiology Authors: Karam P S Gill Daniel P O'Brien Jonathan E Soverow Source Type: research
Long-Term Survival of an Adolescent and Young Adult Patient with Unresectable Advanced Gastric Cancer in Whom Multidisciplinary Treatment Was Effective
We report the case of a long-term-surviving adolescent and young adult patient with unresectable advanced gastric cancer for whom multidisciplinary treatment was effective. A 29-year-old woman was referred to our hospital for further examination following a diagnosis of gastric cancer by a local physician. Esophagogastroduodenoscopy showed a deep ulcerated lesion in the lower third of the stomach, and analysis of biopsy specimens revealed an adenocarcinoma. Abdominal contrast- enhanced computed tomography showed gastric wall thickening in the lower third of the stomach. The patient underwent distal gastrectomy with lymph n...
Source: Pain Physician - February 2, 2024 Category: Anesthesiology Authors: Tsutomu Namikawa Masato Utsunomiya Keiichiro Yokota Yasuhiro Kawanishi Sachi Yamaguchi Masaya Munekage Hiromichi Maeda Hiroyuki Kitagawa Yusuke Nagata Michiya Kobayashi Kazuhiro Hanazaki Satoru Seo Source Type: research
