Cancers, Vol. 16, Pages 254: Prognostic Significance of Preoperative Inflammation Markers on the Long-Term Outcomes in Peritoneal Carcinomatosis from Ovarian Cancer
In conclusion, patients presenting higher levels of MLR and SII preoperatively are expected to have a poorer outcome even if complete debulking surgery is performed and should be instead considered candidates for neoadjuvant systemic therapy followed by interval surgery. (Source: Cancers)
Source: Cancers - January 5, 2024 Category: Cancer & Oncology Authors: Irina Balescu Mihai Eftimie Sorin Petrea Camelia Diaconu Bogdan Gaspar Lucian Pop Valentin Varlas Adrian Hasegan Cristina Martac Ciprian Bolca Marilena Stoian Cezar Stroescu Anca Zgura Nicolae Bacalbasa Tags: Article Source Type: research
Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities
CONCLUSIONS: As to our knowledge, our study provides the first evidence on the role of lactadherin in metastatic BC cell-secreted sEVs as promoter of: (i) metastatic capacities in less aggressive recipient cells, and ii) the formation of malignant ascites and metastatic tumor nodules. These results increase our understanding on the role of lactadherin in sEVs as promoter of metastatic capacities which can be used as a therapeutic option for BC and other malignancies.PMID:38173019 | DOI:10.1186/s40659-023-00477-8 (Source: Cell Research)
Source: Cell Research - January 4, 2024 Category: Cytology Authors: Eduardo Dur án-Jara Mat ías Del Campo Valentina Guti érrez Ignacio Wichmann C ésar Trigo Marcelo Ezquer Lorena Lobos-Gonz ález Source Type: research
Prognostic value of HE4 in advanced-stage, high-grade serous ovarian cancer: Analysis of HE4 kinetics during NACT, predicting surgical outcome and recurrence in comparison to CA125
CONCLUSION: Monitoring HE4 or CA-125 levels has low prognostic value in patients with advanced-stage, high-grade serous ovarian cancer who are treated with NACT followed by IDS. However, the preoperative level of the HE4 biomarker may be useful in identifying patients at higher risk for suboptimal cytoreductive surgery or who may require more extensive surgery. Further prospective studies are warranted to explore the prognostic utility of eventual combinations of clinical, radiological, and biological parameters, notably by using artificial intelligence-based models.PMID:38176127 | DOI:10.1016/j.ygyno.2023.12.021 (Source: ...
Source: Gynecologic Oncology - January 4, 2024 Category: Cancer & Oncology Authors: Amal AlSomairi Samah Himayda Ahmed Altelmesani Yong Jae Lee Jung-Yun Lee Source Type: research
Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers
CONCLUSIONS: Both intra- and interpatient drug response heterogeneity exist in patients undergoing CRS/HIPEC for nongynecologic abdominal cancers. Caution must be used when interpreting patient response to chemotherapeutic agents based on a single site of testing in those with metastatic disease.PMID:38175427 | DOI:10.1245/s10434-023-14696-6 (Source: Ann Oncol)
Source: Ann Oncol - January 4, 2024 Category: Cancer & Oncology Authors: Shannon N Radomski Matthew Dunworth Junior J West Jonathan B Greer Fabian M Johnston Andrew J Ewald Source Type: research
Prognostic value of HE4 in advanced-stage, high-grade serous ovarian cancer: Analysis of HE4 kinetics during NACT, predicting surgical outcome and recurrence in comparison to CA125
CONCLUSION: Monitoring HE4 or CA-125 levels has low prognostic value in patients with advanced-stage, high-grade serous ovarian cancer who are treated with NACT followed by IDS. However, the preoperative level of the HE4 biomarker may be useful in identifying patients at higher risk for suboptimal cytoreductive surgery or who may require more extensive surgery. Further prospective studies are warranted to explore the prognostic utility of eventual combinations of clinical, radiological, and biological parameters, notably by using artificial intelligence-based models.PMID:38176127 | DOI:10.1016/j.ygyno.2023.12.021 (Source: ...
Source: Gynecologic Oncology - January 4, 2024 Category: Cancer & Oncology Authors: Amal AlSomairi Samah Himayda Ahmed Altelmesani Yong Jae Lee Jung-Yun Lee Source Type: research
Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers
CONCLUSIONS: Both intra- and interpatient drug response heterogeneity exist in patients undergoing CRS/HIPEC for nongynecologic abdominal cancers. Caution must be used when interpreting patient response to chemotherapeutic agents based on a single site of testing in those with metastatic disease.PMID:38175427 | DOI:10.1245/s10434-023-14696-6 (Source: Ann Oncol)
Source: Ann Oncol - January 4, 2024 Category: Cancer & Oncology Authors: Shannon N Radomski Matthew Dunworth Junior J West Jonathan B Greer Fabian M Johnston Andrew J Ewald Source Type: research
Prognostic value of HE4 in advanced-stage, high-grade serous ovarian cancer: Analysis of HE4 kinetics during NACT, predicting surgical outcome and recurrence in comparison to CA125
CONCLUSION: Monitoring HE4 or CA-125 levels has low prognostic value in patients with advanced-stage, high-grade serous ovarian cancer who are treated with NACT followed by IDS. However, the preoperative level of the HE4 biomarker may be useful in identifying patients at higher risk for suboptimal cytoreductive surgery or who may require more extensive surgery. Further prospective studies are warranted to explore the prognostic utility of eventual combinations of clinical, radiological, and biological parameters, notably by using artificial intelligence-based models.PMID:38176127 | DOI:10.1016/j.ygyno.2023.12.021 (Source: ...
Source: Gynecologic Oncology - January 4, 2024 Category: Cancer & Oncology Authors: Amal AlSomairi Samah Himayda Ahmed Altelmesani Yong Jae Lee Jung-Yun Lee Source Type: research
Metastatic Colorectal Cancer Treated with Combined Liver Resection, Cytoreductive Surgery, and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Predictive Factors for Early Recurrence
CONCLUSIONS: In colorectal cancer patients with concomitant PM and LM, an advanced primary tumor (pT4 and/or pN2) was associated with a higher risk of early recurrence following a radical multimodal treatment, whereas RLN metastases was strongly detrimental for OS.PMID:38170409 | DOI:10.1245/s10434-023-14840-2 (Source: Ann Oncol)
Source: Ann Oncol - January 3, 2024 Category: Cancer & Oncology Authors: R émi Grange Pascal Rousset Nicolas Williet Mathias Guesnon Laurent Milot Guillaume Passot Jean-Marc Phelip Bertrand Le Roy Olivier Glehen Vahan Kepenekian Source Type: research
Cancers, Vol. 16, Pages 170: Oligometastatic Gastric Cancer: Clinical Data from the Meta-Gastro Prospective Register of the Italian Research Group on Gastric Cancer
Conclusions: META-GASTRO supports the two-fold definition of oligometastatic gastric cancer: the quantitative/anatomical one, which accounts for 30% of our population, and the dynamic one, observed in 16% of our cases. (Source: Cancers)
Source: Cancers - December 29, 2023 Category: Cancer & Oncology Authors: Maria Bencivenga Silvia Ministrini Paolo Morgagni Gianni Mura Daniele Marrelli Carlo Milandri Maria Antonietta Mazzei Mattia Berselli Manlio Monti Luigina Graziosi Rossella Reddavid Fausto Rosa Leonardo Solaini Annibale Donini Uberto Fumagalli Romario Fra Tags: Perspective Source Type: research
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage IV colorectal cancer
J Clin Invest. 2023 Dec 28:e169576. doi: 10.1172/JCI169576. Online ahead of print.ABSTRACTMetastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in UICC (Union for International Cancer Control) stage IV CRC patients. Insights into differential site-specific reconstitution of tumour cells and the corresponding tumour microenvironment are still missing. Here, we analysed the transcriptome of single cells derived from murine multivisceral CRC and delineated the inter-metastatic cellular heterogene...
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Christopher Berlin Bernhard Mauerer Pierre Cauchy Jost Luenstedt Roman Sankowski Lisa Marx Reinhild Feuerstein Luisa Sch äfer Florian R Greten Marina Pesic Olaf Gro ß Marco Prinz Naomi R ühl Laura Miketiuk Dominik Jauch Claudia Laessle Andreas Jud Esth Source Type: research
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage IV colorectal cancer
J Clin Invest. 2023 Dec 28:e169576. doi: 10.1172/JCI169576. Online ahead of print.ABSTRACTMetastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in UICC (Union for International Cancer Control) stage IV CRC patients. Insights into differential site-specific reconstitution of tumour cells and the corresponding tumour microenvironment are still missing. Here, we analysed the transcriptome of single cells derived from murine multivisceral CRC and delineated the inter-metastatic cellular heterogene...
Source: Clinical Colorectal Cancer - December 28, 2023 Category: Cancer & Oncology Authors: Christopher Berlin Bernhard Mauerer Pierre Cauchy Jost Luenstedt Roman Sankowski Lisa Marx Reinhild Feuerstein Luisa Sch äfer Florian R Greten Marina Pesic Olaf Gro ß Marco Prinz Naomi R ühl Laura Miketiuk Dominik Jauch Claudia Laessle Andreas Jud Esth Source Type: research
