3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases
We present a robust method for the production of biodegradable liposome-loaded hydrogel microbeads that can overcome the pharmacokinetic limitations of small molecules with fast clearance rates, a current bottleneck for the intraperitoneal (IP) administration of these therapeutics. By means of an electromagnetic droplet printhead, we 3D printed microbeads employing an alginate-based ink loaded with GEF-containing multilamellar vesicles (MLVs). The sustained release of GEF from microbeads was demonstrated. In vitro studies on an immortalized human hepatic cancer cell line (Huh-7) proved concentration-dependent cell death. T...
Source: Cell Research - November 25, 2023 Category: Cytology Authors: Remo Eugster Aymar Abel Ganguin Amirmohammad Seidi Simone Aleandri Paola Luciani Source Type: research
Characterizing the Immune Environment in Peritoneal Carcinomatosis: Insights for Novel Immunotherapy Strategies
CONCLUSIONS: The peritoneal immune microenvironment in carcinomatosis favors innate immunity, presenting a challenging environment for effective antitumor response. High levels of proinflammatory mediators suggest potential targets for intervention, such as the IL-6 axis, FGF2, IL-8, and CCL2; these could be explored as potential mitigators of malignant ascites and enhance anti-tumor immune responses. These findings provide valuable insights for developing immunotherapy strategies and improving outcomes in patients with peritoneal carcinomatosis.PMID:37996643 | DOI:10.1245/s10434-023-14553-6 (Source: Ann Oncol)
Source: Ann Oncol - November 23, 2023 Category: Cancer & Oncology Authors: Patrick L Wagner Chelsea M Knotts Vera S Donneberg Neda Dadgar Christian Cruz Pico Kunhong Xiao Ali Zaidi Suzanne C Schiffman Casey J Allen Albert D Donnenberg David L Bartlett Source Type: research
Characterizing the Immune Environment in Peritoneal Carcinomatosis: Insights for Novel Immunotherapy Strategies
CONCLUSIONS: The peritoneal immune microenvironment in carcinomatosis favors innate immunity, presenting a challenging environment for effective antitumor response. High levels of proinflammatory mediators suggest potential targets for intervention, such as the IL-6 axis, FGF2, IL-8, and CCL2; these could be explored as potential mitigators of malignant ascites and enhance anti-tumor immune responses. These findings provide valuable insights for developing immunotherapy strategies and improving outcomes in patients with peritoneal carcinomatosis.PMID:37996643 | DOI:10.1245/s10434-023-14553-6 (Source: Ann Oncol)
Source: Ann Oncol - November 23, 2023 Category: Cancer & Oncology Authors: Patrick L Wagner Chelsea M Knotts Vera S Donneberg Neda Dadgar Christian Cruz Pico Kunhong Xiao Ali Zaidi Suzanne C Schiffman Casey J Allen Albert D Donnenberg David L Bartlett Source Type: research
Characterizing the Immune Environment in Peritoneal Carcinomatosis: Insights for Novel Immunotherapy Strategies
CONCLUSIONS: The peritoneal immune microenvironment in carcinomatosis favors innate immunity, presenting a challenging environment for effective antitumor response. High levels of proinflammatory mediators suggest potential targets for intervention, such as the IL-6 axis, FGF2, IL-8, and CCL2; these could be explored as potential mitigators of malignant ascites and enhance anti-tumor immune responses. These findings provide valuable insights for developing immunotherapy strategies and improving outcomes in patients with peritoneal carcinomatosis.PMID:37996643 | DOI:10.1245/s10434-023-14553-6 (Source: Ann Oncol)
Source: Ann Oncol - November 23, 2023 Category: Cancer & Oncology Authors: Patrick L Wagner Chelsea M Knotts Vera S Donneberg Neda Dadgar Christian Cruz Pico Kunhong Xiao Ali Zaidi Suzanne C Schiffman Casey J Allen Albert D Donnenberg David L Bartlett Source Type: research
CT texture analysis for differentiating between peritoneal carcinomatosis and peritoneal tuberculosis: a cross-sectional study
ConclusionCT texture parameters of omental lesions differed significantly between patients with PTB and those with PC, which may help clinicians in differentiating between the two entities.Graphical Abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - November 23, 2023 Category: Radiology Source Type: research
Unraveling the potential clinical utility of circulating tumor DNA detection in colorectal cancer - evaluation in a nationwide Danish cohort
CONCLUSIONS: The presented results from 851 stage II-III CRC patients demonstrate that our personalized dPCR approach effectively detects MRD post operation and shows promise for serial ctDNA detection for recurrence surveillance. The ability to adjust sensitivity and specificity shows exciting potential to customize the ctDNA caller for specific clinical settings.PMID:37992872 | DOI:10.1016/j.annonc.2023.11.009 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 22, 2023 Category: Cancer & Oncology Authors: T V Henriksen C Demuth A Frydendahl J Nors M Nesic M H Rasmussen T Reinert O H Larsen C Jaensch U S L øve P V Andersen T Kolbro O Thorlacius-Ussing A Monti M G ögenur J Kildsig P Bondeven N H Schlesinger L H Iversen K A Gotschalck C L Andersen Source Type: research
Unraveling the potential clinical utility of circulating tumor DNA detection in colorectal cancer - evaluation in a nationwide Danish cohort
CONCLUSIONS: The presented results from 851 stage II-III CRC patients demonstrate that our personalized dPCR approach effectively detects MRD post operation and shows promise for serial ctDNA detection for recurrence surveillance. The ability to adjust sensitivity and specificity shows exciting potential to customize the ctDNA caller for specific clinical settings.PMID:37992872 | DOI:10.1016/j.annonc.2023.11.009 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - November 22, 2023 Category: Cancer & Oncology Authors: T V Henriksen C Demuth A Frydendahl J Nors M Nesic M H Rasmussen T Reinert O H Larsen C Jaensch U S L øve P V Andersen T Kolbro O Thorlacius-Ussing A Monti M G ögenur J Kildsig P Bondeven N H Schlesinger L H Iversen K A Gotschalck C L Andersen Source Type: research
Unraveling the potential clinical utility of circulating tumor DNA detection in colorectal cancer - evaluation in a nationwide Danish cohort
CONCLUSIONS: The presented results from 851 stage II-III CRC patients demonstrate that our personalized dPCR approach effectively detects MRD post operation and shows promise for serial ctDNA detection for recurrence surveillance. The ability to adjust sensitivity and specificity shows exciting potential to customize the ctDNA caller for specific clinical settings.PMID:37992872 | DOI:10.1016/j.annonc.2023.11.009 (Source: Ann Oncol)
Source: Ann Oncol - November 22, 2023 Category: Cancer & Oncology Authors: T V Henriksen C Demuth A Frydendahl J Nors M Nesic M H Rasmussen T Reinert O H Larsen C Jaensch U S L øve P V Andersen T Kolbro O Thorlacius-Ussing A Monti M G ögenur J Kildsig P Bondeven N H Schlesinger L H Iversen K A Gotschalck C L Andersen Source Type: research
Actual 5-Year Survival After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Patients with Peritoneal Carcinomatosis of Colorectal Origin
CONCLUSIONS: Actual 5-year OS was 36% and median OS was 42.5 months. Our study demonstrates that patients with PC from CRC origin with low PCI who undergo complete surgical resection can achieve favorable long-term survival.PMID:37989953 | DOI:10.1245/s10434-023-14608-8 (Source: Ann Oncol)
Source: Ann Oncol - November 22, 2023 Category: Cancer & Oncology Authors: Elad Sarfaty Nazanin Khajoueinejad Allen T Yu Spiros Hiotis Benjamin J Golas Umut Sarpel Daniel M Labow Noah A Cohen Source Type: research
Actual 5-Year Survival After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Patients with Peritoneal Carcinomatosis of Colorectal Origin
CONCLUSIONS: Actual 5-year OS was 36% and median OS was 42.5 months. Our study demonstrates that patients with PC from CRC origin with low PCI who undergo complete surgical resection can achieve favorable long-term survival.PMID:37989953 | DOI:10.1245/s10434-023-14608-8 (Source: Ann Oncol)
Source: Ann Oncol - November 22, 2023 Category: Cancer & Oncology Authors: Elad Sarfaty Nazanin Khajoueinejad Allen T Yu Spiros Hiotis Benjamin J Golas Umut Sarpel Daniel M Labow Noah A Cohen Source Type: research
Unraveling the potential clinical utility of circulating tumor DNA detection in colorectal cancer - evaluation in a nationwide Danish cohort
CONCLUSIONS: The presented results from 851 stage II-III CRC patients demonstrate that our personalized dPCR approach effectively detects MRD post operation and shows promise for serial ctDNA detection for recurrence surveillance. The ability to adjust sensitivity and specificity shows exciting potential to customize the ctDNA caller for specific clinical settings.PMID:37992872 | DOI:10.1016/j.annonc.2023.11.009 (Source: Ann Oncol)
Source: Ann Oncol - November 22, 2023 Category: Cancer & Oncology Authors: T V Henriksen C Demuth A Frydendahl J Nors M Nesic M H Rasmussen T Reinert O H Larsen C Jaensch U S L øve P V Andersen T Kolbro O Thorlacius-Ussing A Monti M G ögenur J Kildsig P Bondeven N H Schlesinger L H Iversen K A Gotschalck C L Andersen Source Type: research
The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis
Volume 12, Issue 1, December 2023 . (Source: OncoImmunology)
Source: OncoImmunology - November 21, 2023 Category: Cancer & Oncology Authors: Ángela BellaIgnacio MeleroPedro BerraondoFernando Arandaa Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spainb Navarra Institute for Health Research (IDISNA), Pamplona, Spainc Centro de Investigación Biomédica en Red d Source Type: research
A retrospective study of Pipelle endometrial biopsy for ovarian, fallopian tube, and peritoneal cancers
CONCLUSION: Although the positive rate of Pipelle endometrial biopsy in ovarian, fallopian tube, and peritoneal cancers is low, Pipelle endometrial biopsy may enable prompt histological diagnosis and initiation of chemotherapy while collecting tumour tissue for genetic testing in some cases with advanced disease.PMID:37983014 | DOI:10.1080/01443615.2023.2283162 (Source: Journal of Obstetrics and Gynaecology)
Source: Journal of Obstetrics and Gynaecology - November 20, 2023 Category: OBGYN Authors: Ryo Tamura Yohei Kitani Kotaro Takahashi Masayuki Yamaguchi Nobumichi Nishikawa Takashi Kawasaki Akira Kikuchi Source Type: research
