Characterizing the Immune Environment in Peritoneal Carcinomatosis: Insights for Novel Immunotherapy Strategies

CONCLUSIONS: The peritoneal immune microenvironment in carcinomatosis favors innate immunity, presenting a challenging environment for effective antitumor response. High levels of proinflammatory mediators suggest potential targets for intervention, such as the IL-6 axis, FGF2, IL-8, and CCL2; these could be explored as potential mitigators of malignant ascites and enhance anti-tumor immune responses. These findings provide valuable insights for developing immunotherapy strategies and improving outcomes in patients with peritoneal carcinomatosis.PMID:37996643 | DOI:10.1245/s10434-023-14553-6

Source: Ann Oncol - November 23, 2023 Category: Cancer & Oncology Authors: Patrick L Wagner Chelsea M Knotts Vera S Donneberg Neda Dadgar Christian Cruz Pico Kunhong Xiao Ali Zaidi Suzanne C Schiffman Casey J Allen Albert D Donnenberg David L Bartlett Source Type: research