Cancers, Vol. 16, Pages 1559: Pressurised Intraperitoneal Aerosolised Chemotherapy & mdash;Results from the First Hundred Consecutive Procedures
Cancers, Vol. 16, Pages 1559: Pressurised Intraperitoneal Aerosolised Chemotherapy—Results from the First Hundred Consecutive Procedures
Cancers doi: 10.3390/cancers16081559
Authors:
David Hoskovec
Zdeněk Krška
Michal Vočka
Soňa Argalácsová
Petr Dytrych
PIPAC is a new and promising technique for the intraperitoneal administration of chemotherapy. It can be used in patients with various peritoneal cancer metastases. It is mainly a palliative treatment, but there is some neoadjuvant treatment potential. We have operated on 41 patients with various intra-abdominal cancers. PIPAC was performed e...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: David Hoskovec Zden ěk Krška Michal Vo čka So ňa Argalácsová Petr Dytrych Tags: Article Source Type: research
Population pharmacokinetics of intraperitoneal irinotecan and SN ‐38 in patients with peritoneal metastases from colorectal origin
AbstractPeritoneal metastases (PM) are common in patients with colorectal cancer. Patients with PM have a poor prognosis, and for those who are not eligible for cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC), palliative chemotherapy is currently the only option. Recently, we conducted a phase I trial (INTERACT) in which irinotecan was administered intraperitoneally (IP) to 18 patients ineligible for CRS-HIPEC. The primary objective was to evaluate covariates influencing the PK profile of irinotecan and SN-38 after IP administration. Secondly, a population PK model was develope...
Source: CPT: Pharmacometrics and Systems Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Pascale C. S. Rietveld,
Sebastiaan D. T. Sassen,
Niels A. D. Guchelaar,
Ruben A. G. van Eerden,
Nadine L. de Boer,
Teun B. M. van den Heuvel,
Jacobus W. A. Burger,
Ron H. J. Mathijssen,
Birgit C. P. Koch,
Stijn L. W. Koolen Tags: ARTICLE Source Type: research
Neoadjuvant chemotherapy does not improve survival for patients with high volume colorectal peritoneal metastases undergoing cytoreductive surgery
Colorectal peritoneal metastases (CRPM) affects 15% of patients at initial colorectal cancer diagnosis. Neoadjuvant chemotherapy (NAC) prior to cytoreductive surgery (CRS) has been demonstrated to be a safe an... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 18, 2024 Category: Cancer & Oncology Authors: Mina Sarofim, Ruwanthi Wijayawardana, Nima Ahmadi, Shoma Barat, Winston Liauw and David L Morris Tags: Research Source Type: research
Real World Analysis of Peritoneal Metastasis From Renal Cell Carcinoma. Meet-Uro27
CONCLUSION: We report one of the largest case series regarding PM from RCC. Characteristics of patients suggest a more aggressive behavior of PM from mRCC. Outcome data suggest that TKI-IO as first line treatment, and TKI as second line, confirm their activity for these patients with dismal prognosis.PMID:38631104 | DOI:10.1016/j.clgc.2024.102078 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Marco Stellato Sebastiano Buti Marco Maruzzo Maria Bassanelli Melissa Bersanelli Marilena Di Napoli Michele Dionese Martina Fanelli Roberto Filippi Giuseppe Fotia Luca Galli Francesco Grillone Michele Maffezzoli Brigida Anna Maiorano Cecilia Nasso Sara El Source Type: research
Repeat cytoreductive surgery with HIPEC for colorectal peritoneal metastases: a systematic review
Colorectal peritoneal metastases (CRPM) are present in 10 –20% of patients at the time of their initial cancer diagnosis, and affects over 20% of those who develop colorectal cancer recurrence. Cytoreductive su... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 17, 2024 Category: Cancer & Oncology Authors: Mina Sarofim, Ruwanthi Wijayawardana, Nima Ahmadi and David L. Morris Tags: Review Source Type: research
Rates of paclitaxel hypersensitivity reactions using a modified Markman’s infusion protocol as primary prophylaxis
ConclusionThe modified Markman ’s desensitisation protocol as primary prophylaxis did not reduce the rate or severity of paclitaxel hypersensitivity reactions, although all patients could be successfully rechallenged. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 17, 2024 Category: Cancer & Oncology Source Type: research
Detection of Residual Peritoneal Metastases Following Cytoreductive Surgery Using Pegsitacianine, a pH-Sensitive Imaging Agent: Final Results from a Phase II Study
CONCLUSIONS: Pegsitacianine was well tolerated and facilitated the recognition of occult residual disease following CRS. The high rate of residual disease detected suggests that the use of pegsitacianine augmented surgeon assessment and performance during CRS.PMID:38622456 | DOI:10.1245/s10434-024-15165-4 (Source: Ann Oncol)
Source: Ann Oncol - April 15, 2024 Category: Cancer & Oncology Authors: Patrick Wagner Edward A Levine Alex C Kim Perry Shen Nicole D Fleming Shannon N Westin Laurel K Berry Giorgos C Karakousis Janos L Tanyi Madeline T Olson Brian Madajewski Brian Ostrander Kartik Krishnan Charles M Balch David L Bartlett Source Type: research
Head-to-head comparison of [18F]FDG PET and [68Ga]Ga-FAPI-04 PET in the diagnosis of gastric and pancreatic cancer: a systematic review and meta-analysis
Conclusion[68Ga]Ga-FAPI-04 PET exhibited a higher positivity rate compared to [18F]FDG PET in the detection of primary gastric cancer, lymph node and peritoneal metastases. For pancreatic cancer, both [18F]FDG PET and [68Ga]Ga-FAPI-04 PET demonstrated comparable, high positivity rates for primary cancer diagnosis and lymph node metastasis detection. There is still a requirement for more extensive and forward-looking research in this field. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 15, 2024 Category: Radiology Source Type: research
Has time to chemotherapy from primary debulking surgery in advanced ovarian cancer an impact on survival? - A population-based nationwide SweGCG study
CONCLUSIONS: For the entire cohort, stage IV, non-serous morphology and residual disease, but not TTC, influenced 5-year relative survival. However, longer TTC was associated with a poorer 2-year survival for those without residual disease after PDS.PMID:38603954 | DOI:10.1016/j.ygyno.2024.03.011 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Pernilla Dahm-K ähler Angelique Fl öter Rådestad Erik Holmberg Christer Borgfeldt Maria Bjurberg Camilla Sk öld Kristina Hellman Preben Kj ølhede Karin St ålberg Elisabeth Åvall-Lundqvist Source Type: research
The safety and effectiveness of prophylactic hyperthermic intraperitoneal chemotherapy in patients with pathological T3-4 locally advanced colon cancer
CONCLUSION: Early prophylactic HIPEC based on 5-FU or lobaplatin subsequent to radical resection for patients with pT3-4 locally advanced CC is safe, but not effective in reducing the risk for mPC.PMID:38604861 | DOI:10.1016/j.asjsur.2024.03.143 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Taiwei Mo Xiaofeng Wen Tuo Hu Zongjin Zhang Yaqian Shi Yongle Chen Haidong Xiang Junhua Huang Zhenyu Xian Xiaowen He Source Type: research
Intestinal obstruction secondary to peritoneal metastases: More harm than good with water-soluble contrast study?
Asian J Surg. 2024 Apr 10:S1015-9584(24)00590-6. doi: 10.1016/j.asjsur.2024.03.163. Online ahead of print.NO ABSTRACTPMID:38604855 | DOI:10.1016/j.asjsur.2024.03.163 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Joreen Wen Qi Neo Sachin Mathur Claramae Shulyn Chia Chin-Ann Johnny Ong Source Type: research
Has time to chemotherapy from primary debulking surgery in advanced ovarian cancer an impact on survival? - A population-based nationwide SweGCG study
CONCLUSIONS: For the entire cohort, stage IV, non-serous morphology and residual disease, but not TTC, influenced 5-year relative survival. However, longer TTC was associated with a poorer 2-year survival for those without residual disease after PDS.PMID:38603954 | DOI:10.1016/j.ygyno.2024.03.011 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Pernilla Dahm-K ähler Angelique Fl öter Rådestad Erik Holmberg Christer Borgfeldt Maria Bjurberg Camilla Sk öld Kristina Hellman Preben Kj ølhede Karin St ålberg Elisabeth Åvall-Lundqvist Source Type: research
Has time to chemotherapy from primary debulking surgery in advanced ovarian cancer an impact on survival? - A population-based nationwide SweGCG study
CONCLUSIONS: For the entire cohort, stage IV, non-serous morphology and residual disease, but not TTC, influenced 5-year relative survival. However, longer TTC was associated with a poorer 2-year survival for those without residual disease after PDS.PMID:38603954 | DOI:10.1016/j.ygyno.2024.03.011 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Pernilla Dahm-K ähler Angelique Fl öter Rådestad Erik Holmberg Christer Borgfeldt Maria Bjurberg Camilla Sk öld Kristina Hellman Preben Kj ølhede Karin St ålberg Elisabeth Åvall-Lundqvist Source Type: research
Intestinal obstruction secondary to peritoneal metastases: More harm than good with water-soluble contrast study?
Asian J Surg. 2024 Apr 10:S1015-9584(24)00590-6. doi: 10.1016/j.asjsur.2024.03.163. Online ahead of print.NO ABSTRACTPMID:38604855 | DOI:10.1016/j.asjsur.2024.03.163 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Joreen Wen Qi Neo Sachin Mathur Claramae Shulyn Chia Chin-Ann Johnny Ong Source Type: research
The safety and effectiveness of prophylactic hyperthermic intraperitoneal chemotherapy in patients with pathological T3-4 locally advanced colon cancer
CONCLUSION: Early prophylactic HIPEC based on 5-FU or lobaplatin subsequent to radical resection for patients with pT3-4 locally advanced CC is safe, but not effective in reducing the risk for mPC.PMID:38604861 | DOI:10.1016/j.asjsur.2024.03.143 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Taiwei Mo Xiaofeng Wen Tuo Hu Zongjin Zhang Yaqian Shi Yongle Chen Haidong Xiang Junhua Huang Zhenyu Xian Xiaowen He Source Type: research
