TGF β signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer

ConclusionOur results suggest the TGF β pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still n ot fully understood, these shed light on yet another clinical implication of this complex pathway.
Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research