Perinatology & Neonatology Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Swallowing-like activity elicited in neonatal rat medullary slice preparation
Brain Res. 2024 Apr 26:148955. doi: 10.1016/j.brainres.2024.148955. Online ahead of print.ABSTRACTSwallowing is induced by a central pattern generator in the nucleus tractus solitarius (NTS). We aimed to create a medullary slice preparation to elucidate the neural architecture of the central pattern generator of swallowing (Sw-CPG) and record its neural activities. Experiments were conducted on 2-day-old Sprague-Dawley rats (n = 46). The brainstem-spinal cord was transected at the pontomedullary and cervicothoracic junctions; the medulla was sliced transversely at thicknesses of 600, 700, or 800 μm. The rostral end of the...
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Takahide Kondo Tadashi Yamanishi Takahiro Nishio Yusuke Yokota Tetsuya Seikai Akifumi Enomoto Takeshi Harada Tadataka Tsuji Susumu Tanaka Source Type: research

Timing of administration of antenatal magnesium sulphate and correlation with umbilical cord blood magnesium levels in preterm babies
CONCLUSION: Mean cord blood magnesium levels served as a tool to determine the timing and duration of Neuroprophylaxis. Mean cord blood magnesium of 3.8 mg/dl should be achieved to serve the purpose of Neuroprotection. To achieve this, Bolus followed by Infusion should be administered for at-least 6 h prior to delivery.PMID:38678795 | DOI:10.1016/j.ejogrb.2024.04.031 (Source: Reproductive Biology)
Source: Reproductive Biology - April 28, 2024 Category: Reproduction Medicine Authors: Mrudhula Tummala Rekha Upadhya Muralidhar V Pai Source Type: research

Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial
Lancet Respir Med. 2024 Apr 25:S2213-2600(24)00079-1. doi: 10.1016/S2213-2600(24)00079-1. Online ahead of print.ABSTRACTBACKGROUND: Systematic reviews have reported conflicting evidence on whether macrolide antibiotics reduce rates of chronic lung disease of prematurity (CLD) in at-risk preterm infants born at less than 30 weeks' gestation, including in those colonised with pulmonary Ureaplasma spp. Since an adequately powered trial has been lacking, we aimed to assess if the macrolide azithromycin improved survival without the development of physiologically defined moderate or severe CLD in preterm infants.METHODS: AZTEC ...
Source: Respiratory Care - April 28, 2024 Category: Respiratory Medicine Authors: John Lowe David Gillespie Ali Aboklaish Tin Man Mandy Lau Claudia Consoli Malavika Babu Mark Goddard Kerenza Hood Nigel Klein Emma Thomas-Jones Mark Turner Marie Hubbard Julian Marchesi Janet Berrington Sailesh Kotecha Source Type: research

Neuroinflammation in the Rat Brain After Exposure to Diagnostic Ultrasound
To date there have been no studies exploring the potential for neuroinflammation as an intracranial bio-effect associated with diagnostic ultrasound during neonatal cranial scans in a mammalian in vivo model. The study described here was aimed at investigating the effects of B-mode and Doppler mode ultrasound on inflammation in the rat brain. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - April 28, 2024 Category: Radiology Authors: Assema Lalzad, Flora Wong, Michal Schneider Tags: Original Contribution Source Type: research

Maternal positional therapy for fetal growth and customised birth weight centile benefit in a Bayesian reanalysis of a double-blind, sham-controlled, randomised clinical trial
Conclusions Maternal nightly PT throughout the third-trimester did not have a statistically significant effect on CBWC on a frequentist analysis using the latest fetal growth standard. However, from a Bayesian analysis, clinicians can infer that PT is likely to benefit fetal growth but with a modest effect size. Trial registration number NCT02379728. (Source: BMJ Open)
Source: BMJ Open - April 28, 2024 Category: General Medicine Authors: Coleman, J., Grewal, S., Warland, J., Hobson, S., Liu, K., Kember, A. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research

Inequalities in birth before arrival at hospital in South West England: a multimethods study of neonatal hypothermia and emergency medical services call-handler advice
Conclusions Findings identified factors associated with BBA and neonatal hypothermia following BBA. Improvements to EMS call-handler advice could reduce the number of babies arriving at hospital hypothermic. (Source: BMJ Open)
Source: BMJ Open - April 28, 2024 Category: General Medicine Authors: Goodwin, L., Kirby, K., McClelland, G., Beach, E., Bedson, A., Benger, J. R., Deave, T., Osborne, R., McAdam, H., McKeon-Carter, R., Miller, N., Taylor, H., Voss, S. Tags: Open access, Emergency medicine Source Type: research

Intravenous immunoglobulin (IVIg) ameliorates disease in a murine model of anti-laminin 332 mucous membrane pemphigoid
Intravenous immunoglobulin (IVIg) is used to treat mucous membrane pemphigoid (MMP), although its therapeutic effectivity is not sufficiently supported by randomized controlled clinical trials and its mode of action is only insufficiently understood. We have examined the effect of IVIg in a mouse model of anti-laminin 332 MMP and found that IVIg ameliorates both cutaneous and mucosal inflammatory lesions. Our investigation into the modes of action of IVIg in MMP indicated effective antiinflammatory mechanisms beyond the enhanced degradation of IgG mediated through inhibition of the neonatal Fc receptor. (Source: Journal of...
Source: Journal of Investigative Dermatology - April 28, 2024 Category: Dermatology Authors: Sripriya Murthy, Sabrina Patzelt, Axel K ünstner, Hauke Busch, Enno Schmidt, Christian D. Sadik Tags: Original Article Source Type: research

Genes, Vol. 15, Pages 568: Prenatal Genome-Wide Cell-Free DNA Screening: Three Years of Clinical Experience in a Hospital Prenatal Diagnostic Unit in Spain
In conclusion, our study showed strong performance for genome-wide cfDNA screening in a large cohort of pregnancy patients in Spain. (Source: Genes)
Source: Genes - April 28, 2024 Category: Genetics & Stem Cells Authors: Laia Pedrola Vidal M ónica Roselló Piera Carla Mart ín-Grau Juan S. Rubio Moll Rosa G ómez Portero Beatriz Marcos Puig Jose V. Cervera Zamora Ramiro Quiroga Carmen Orellana Alonso Tags: Article Source Type: research

Examining the associations between microglia genetic capacity, early life exposures and white matter development at the level of the individual
Brain Behav Immun. 2024 Apr 25:S0889-1591(24)00387-8. doi: 10.1016/j.bbi.2024.04.038. Online ahead of print.ABSTRACTThere are inter-individual differences in susceptibility to the influence of early life experiences for which the underlying neurobiological mechanisms are poorly understood. Microglia play a role in environmental surveillance and may influence individual susceptibility to environmental factors. As an index of neurodevelopment, we estimated individual slopes of mean white matter fractional anisotropy (WM-FA) across three time-points (age 4.5, 6.0, and 7.5 years) for 351 participants. Individual variation in m...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Shi Yu Chan Eamon Fitzgerald Zhen Ming Ngoh Janice Lee Jasmine Chuah Joanne Shu Ming Chia Marielle V Fortier Elizabeth Huiwen Tham Juan H Zhou Patricia P Silveira Michael J Meaney Ai Peng Tan Source Type: research

Enteral plasma supports brain repair in newborn pigs after birth asphyxia
We present a new clinically relevant animal model of moderate birth asphyxia inducing structural and functional brain damage. The components in plasma that support brain repair remain to be identified but may represent a therapeutic potential for infants and animals after birth asphyxia.PMID:38677626 | DOI:10.1016/j.bbi.2024.04.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Gemma Chavarria Ventura Nadiya Dyshliuk Oksana Dmytriyeva Mads Jacob Bagi Nordsten Maria Mathilde Haugaard Line Iadsatian Christiansen Thomas Thymann Per Torp Sangild Stanislava Pankratova Source Type: research

Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placental < em > NR3C1 < /em > and < em > FKBP5 < /em > methylation
Stress. 2024 Jan;27(1):2321595. doi: 10.1080/10253890.2024.2321595. Epub 2024 Apr 26.ABSTRACTPerinatal stress is associated with altered placental methylation, which plays a critical role in fetal development and infant outcomes. This proof-of-concept pilot study investigated the impact of lifetime trauma exposure and perinatal PTSD symptoms on epigenetic regulation of placenta glucocorticoid signaling genes (NR3C1 and FKBP5). Lifetime trauma exposure and PTSD symptoms during pregnancy were assessed in a racially/ethnically diverse sample of pregnant women (N = 198). Participants were categorized into three groups: (1) No ...
Source: Stress - April 27, 2024 Category: Research Authors: Laura R Stroud Nancy C Jao L G Ward Sharon Y Lee Carmen J Marsit Source Type: research

Intrahepatic Cholestasis of Pregnancy during COVID-19 Pandemic
Conclusions: During the COVID-19 pandemic, the total incidence of ICP appeared to be lower. However, this reduction was primarily observed in cases of mild ICP, potentially indicating challenges in detection or reduced access to medical services during this period. The incidence of moderate and severe ICP remained unchanged, suggesting that these forms of the condition were unaffected by the pandemic's circumstances.PMID:38674322 | PMC:PMC11052128 | DOI:10.3390/medicina60040676 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Paulina Malarkiewicz Urszula Nowacka Aleksandra Januszaniec Alicja Mankiewicz Szymon Koz łowski Tadeusz Issat Source Type: research

Association between Antenatal Vaginal Bleeding and Adverse Perinatal Outcomes in Placenta Accreta Spectrum
Conclusions: Antenatal vaginal bleeding in the setting of PAS is associated with increased emergent deliveries, earlier gestational ages, and maternal composite morbidity. This important antenatal event may aid in not only counseling patients but also in the coordination of multidisciplinary teams caring for these complex patients.PMID:38674323 | PMC:PMC11052054 | DOI:10.3390/medicina60040677 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: J Connor Mulhall Kayla E Ireland John J Byrne Patrick S Ramsey Georgia A McCann Jessian L Munoz Source Type: research