Perinatology & Neonatology Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Validity of a Delphi consensus definition of growth restriction in the newborn for identifying neonatal morbidity
Small-for-gestational age (SGA) is defined as a birthweight below a birthweight-percentile threshold, usually the 10th percentile, with the 3rd or 5th percentile used to identify severe SGA. SGA is used as a proxy for growth restriction in the newborn, but SGA newborns can be physiologically small and healthy. This definition also excludes growth restricted newborns who have weights above the 10th percentile. To address these limits, a Delphi study developed a new consensus definition of growth restriction in the newborn based on neonatal anthropometric and clinical parameters, but it has not been evaluated. (Source: Ameri...
Source: American Journal of Obstetrics and Gynecology - April 30, 2024 Category: OBGYN Authors: Isabelle MONIER, Anne EGO, Alice HOCQUETTE, Alexandra BENACHI, Fran çois GOFFINET, Nathalie LELONG, Camille LE RAY, Jennifer ZEITLIN, ENP2021 Study Group Tags: Original Research: Obstetrics Source Type: research

EUROPEAN ASSOCIATION OF PERINATAL MEDICINE (EAPM) Position statement: Screening, diagnosis and management of congenital anomalies of the umbilical cord
Congenital anomalies of the umbilical cord are associated with an increased risk of pregnancy and perinatal complications. Some anomalies of the cord have a higher prevalence than other fetal structural anomalies. The most common anomalies are the absence of an umbilical artery and velamentous insertion of the cord (with or without vasa previa). These anomalies, even when not associated with fetal structural defects, increase the risk of adverse perinatal outcome including, fetal growth restriction and stillbirth. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 30, 2024 Category: OBGYN Authors: Eric Jauniaux, Cathrine Ebbing, Yinka Oyelese, Rony Maymon, Federico Prefumo, Amar Bhide Tags: Expert Opinion Source Type: research

Expectant management of preeclampsia with severe features diagnosed at less than 24 weeks
The recent ACOG practice bulletin offers no guidance on management of preeclampsia with severe features (PreE with SF) less than 24 weeks. Historically, immediate delivery was recommended due to poor perinatal outcomes and high maternal morbidity. Recently, advances in neonatal resuscitation have led to increased survival at peri-viable gestational ages. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 30, 2024 Category: OBGYN Authors: Kristen A. CAGINO, Rylee D. TROTTER, Katherine E. LAMBERT, Saloni C. KUMAR, Baha M. SIBAI Tags: Original Research: Obstetrics Source Type: research

Differences in Neonatal Functional Connectivity Related to Sensory Overresponsivity in Toddlers
Sensory overresponsivity (SOR) is an early risk factor for childhood psychiatric conditions and might arise from neural variation present in early life. To identify candidate neural precursors of SOR in infancy, we analyzed network-level functional connectivity (FC) measures from neonates in relation to their SOR scores at age two. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Rebecca Schwarzlose, Andrew Eck, Michael Myers, Alyssa Labonte, Tara Smyser, Deanna Barch, Cynthia Rogers, Barbara Warner, Christopher Smyser, Chad Sylvester, Joan Luby, Muriah Wheelock Tags: Symposium Source Type: research

Relationship Between Basal Cortisol Level and Structural Brain Development in Infancy
Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, leading to high cortisol production, which is associated with damage to certain brain regions. We investigate the role of basal cortisol in shaping brain development in infancy through 2 questions: Q1) Are basal cortisol levels in early infancy associated with brain development during the first year of life? Q2) Do neonatal hippocampal and amygdala volumes predict cortisol levels later in infancy? (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ann Alex, Mackenzie Green, Claudia Buss, Emil Cornea, Jerod Rasmussen, John Gilmore, Kai Xia, Martin Styner, Pathik Wadhwa, Paul M. Thompson, Sonja Entringer, Gustavo de los Campos, Rebecca Knickmeyer, ENIGMA-ORIGINs Group Tags: SYMPOSIUM Source Type: research

Morphometric Integration of Brain Networks in Young Children Exposed to Maternal Depression in a South African Birth Cohort
Perinatal maternal depression is a mental health concern that disproportionately impacts children in low- and middle-income countries. Altered morphometry of frontal and limbic brain regions has been recorded in exposed children, mostly in high-income settings. The current study investigated morphometric integration between frontolimbic regions, an index of structural brain connectivity, after maternal depression exposure in two-to-three-year-old children from a South African birth cohort. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nynke A. Groenewold, Richard A.I. Bethlehem, Alyssa R. Amod, Emmanuel C. Nwosu, Farai Mberi, Catherine J. Wedderburn, Jennifer A. Pellowski, Annerine Roos, Heather J. Zar, Kirsten A. Donald, Dan J. Stein, Jonathan C. Ipser Source Type: research

Intergenerational Transmission of Maternal Life Stress and Sleep on Infant Neural Circuits and Behavioral Outcomes
This study applies an intergenerational framework to examine the relation between maternal childhood experiences, prenatal maternal sleep quality, neonatal white matter microstructure, and its impact on infant negative emotionality at six months. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Catherine Demers, Melissa Nevarez-Brewster, LillyBelle Deer, Mercedes Hoeflich Haase, Khalid Al-Ali, Maria Bagonis, John Gilmore, M. Camille Hoffman, Martin Styner, Benjamin Hankin, Elysia Davis Source Type: research

Genetic, Pre-And-Perinatal, and Negative Early Life Risks Shape Children ’s Brain Dis/Similarity to Mental Illnesses
Genetic, pre-and-perinatal, and early-life environmental risks for severe mental disorders (SMI) alter normal cerebral development leading to formation of characteristic brain deficit patterns prior to onset of symptoms. We hypothesized that the insidious effects of these risks may increase brain similarity to adult SMI deficit patterns in prepubescent children. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Peter Kochunov, Yizhou Ma, Si Gao, Neda Jahanshad, Paul M. Thompson, Bhim Adhikari, Elliot Hong Source Type: research

56. Charting the Influence of Maternal Depression Throughout Pregnancy on Neonatal Thalamocortical White Matter Connectivity
Thalamocortical pathways, critical for sensory integration and brain maturation, are associated with neurodevelopmental disorders such as schizophrenia and autism. Studies indicating a correlation between prenatal depression and an increase in autism spectrum traits in offspring suggest that thalamocortical pathway disruptions could be a potential mechanistic link. However, research specifically investigating the influence of maternal depression on thalamocortical development in neonates is notably scarce. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yun Wang, Anthony Gagnon, Elizabeth Raffanello, Yanming Xiu, Virginie Bouchard, Ardesheer Talati, Jonathan Posner Source Type: research

27. Investigating Neural Markers of Maternal Psychological Risk
Substance use and mental health during the perinatal period may influence maternal neural development. Given our prior work, we propose the face-specific N170 event-related potential as a neurobiological marker of vulnerability for mother-infant outcomes. Specifically, the amplitude and latency of the N170 response to infant faces is a neural correlate of the strength and timing of a mother ’s response to infant cues. Attenuated neural response to infant cues may have downstream negative implications on caregiving, and consequently child development. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kathryn Wall, Francesca Penner, Jaclyn Dell, Amanda Lowell, Marc Potenza, Linda Mayes, Helena Rutherford Source Type: research

220. Pre-Pregnancy Overweight or Obesity Moderates the Association Between Prenatal Maternal Depression and Infant Cord Blood Omega-3 Levels
Empirical evidence has demonstrated associations between pre-pregnancy obesity and perinatal maternal depressive symptoms. Omega-3 is an essential fatty acid derived from dietary sources that is critical for fetal brain development. Pre-pregnancy obesity is associated with higher omega-3 intake, but a weaker association between dietary intake and respective maternal and cord blood omega-3 levels. Further, lower intake of omega-3 during pregnancy has been linked to higher depressive symptoms. Yet, prior studies have not examined the interactive effects of pre-pregnancy overweight or obesity (OWOB) and prenatal maternal depr...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lauren Costello, Katherine Ziegler, Lacey McCormack, Anahid Akbaryan, Julianna Collazo Vargas, William Harris, Kristina Jackson, Santiago Morales, Amy Elliott, Christine Hockett, Lauren Shuffrey Source Type: research

171. A Comparison Between Self-Reported EPDS and the Gold Standard SCID
Roughly 1 in 8 women experience symptoms of postpartum depression after giving birth (CDC, 2023). Screening for postpartum depression is critical for providing appropriate and timely treatment interventions. The Edinburgh Postnatal Depression Scale (EPDS) is a self-report scale widely used to screen for depression throughout the perinatal period. While the EPDS is well-validated as a screening tool and easy to administer, it has limitations due to its self-report nature. The Structured Clinical Interview for DSM Disorders (SCID) is administered by trained professionals and is regarded as the gold standard in psychiatric as...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Cristela Lopez, Juliana Camacho Castro, Kendall Moore, Rebecca H. Jessel, Sharely Fred Torres, Adriana Bruges-Boude, Emma Smith, Margaret McNamara-McClure, Veerle Bergink, Anna Rommel, Lotje De Witte, M. Mercedes Perez-Rodriguez Source Type: research

Feasibility and effectiveness of preconception check-ups at workplaces in Japan
CONCLUSIONS: We developed a preconception check-up package that can be integrated into workplace health examinations, complemented by tailored counselling. This novel check-up package is a feasible and effective approach for improving preconception health and fertility awareness.PMID:38684110 | DOI:10.1093/joccuh/uiae021 (Source: Journal of Occupational Health)
Source: Journal of Occupational Health - April 29, 2024 Category: Occupational Health Authors: Akiko Fujishima Eri Maeda Koki Sato Hidekazu Saito Chihiro Ozeki Yukihiro Terada Source Type: research

Machine Learning to Improve Accuracy of Transcutaneous Bilirubinometry
CONCLUSION: Using machine learning with transcutaneous bilirubin, total serum bilirubin estimation error was reduced by 25%. This integration could increase accuracy, lessen infant discomfort, and simplify procedures, offering a smart alternative to blood draws by accurately estimating phototherapy thresholds.PMID:38684146 | DOI:10.1159/000535970 (Source: Neonatology)
Source: Neonatology - April 29, 2024 Category: Perinatology & Neonatology Authors: Daisaku Morimoto Yosuke Washio Kana Fukuda Takeshi Sato Tomoka Okamura Hirokazu Watanabe Junko Yoshimoto Maki Tanioka Hirokazu Tsukahara Source Type: research

Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma
Malays J Pathol. 2024 Apr;46(1):91-94.ABSTRACTIntraplacental choriocarcinoma is a rare tumour, with approximately 62 reported cases. It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare cases of intraplacental choriocarcinoma with extremely varied clinical presentations. The extremely varied clinical presentations of both patients described in the case series complicated the process of arriving at the diagnosis. In both cases, subsequent investigations showed no mater...
Source: Malaysian Journal of Pathology - April 29, 2024 Category: Pathology Authors: C C W Lim L S Punjabi A Bhatia Q J Ng G P Jevon I M Aggarwal Source Type: research