Early-Stage Translational Research in Perinatal Medicine
Conclusion: Improved scientific rigour in the use of animal research will increase the likelihood that pre-clinical research will continue to translate into improved neonatal outcomes.Neonatology 2019;115:182 –188 (Source: Neonatology)
Source: Neonatology - December 6, 2018 Category: Perinatology & Neonatology Source Type: research

Early-Stage Translational Research in Perinatal Medicine.
CONCLUSION: Improved scientific rigour in the use of animal research will increase the likelihood that pre-clinical research will continue to translate into improved neonatal outcomes. PMID: 30522108 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - December 6, 2018 Category: Perinatology & Neonatology Authors: Alsweiler JM, Bloomfield FH, Harding JE Tags: Neonatology Source Type: research

The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction
Conclusions: This is the first work that demonstrates that urinary NGAL concentration and urinary NGAL/Cr are significantly higher in infants that are small for gestational age than in appropriate-for-gestational-age infants. This might indicate subclinical kidney damage in newborns with IUGR.Neonatology 2019;115:169 –174 (Source: Neonatology)
Source: Neonatology - December 4, 2018 Category: Perinatology & Neonatology Source Type: research

Nasal High-Flow Therapy as Primary Respiratory Support for Preterm Infants without the Need for Rescue with Nasal Continuous Positive Airway Pressure
Conclusion: Use of nHFT for primary respiratory support, without use of nasal continuous positive airway pressure as “rescue” treatment, resulted in intubation rates lower or comparable to published data from randomised controlled trials.Neonatology 2019;115:175 –181 (Source: Neonatology)
Source: Neonatology - December 4, 2018 Category: Perinatology & Neonatology Source Type: research

Nasal High-Flow Therapy as Primary Respiratory Support for Preterm Infants without the Need for Rescue with Nasal Continuous Positive Airway Pressure.
Abstract AIM: To evaluate the effectiveness of nasal high-flow therapy (nHFT) as primary respiratory support for preterm infants with respiratory distress syndrome (RDS) in two tertiary neonatal units. METHODS: A retrospective outcome analysis of initial respiratory support strategies was performed in two tertiary neonatal units in the UK: John Radcliffe Hospital (JRH), Oxford and St Peter's Hospital (SPH), Chertsey. Infants born between 28+0 and 36+6 weeks gestational age (GA) between May 2013 and June 2015 were included. RESULTS: A total of 381 infants, 191 from JRH and 190 from SPH, were analysed. Inf...
Source: Neonatology - December 4, 2018 Category: Perinatology & Neonatology Authors: Zivanovic S, Scrivens A, Panza R, Reynolds P, Laforgia N, Ives KN, Roehr CC Tags: Neonatology Source Type: research

The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction.
CONCLUSIONS: This is the first work that demonstrates that urinary NGAL concentration and urinary NGAL/Cr are significantly higher in infants that are small for gestational age than in appropriate-for-gestational-age infants. This might indicate subclinical kidney damage in newborns with IUGR. PMID: 30513528 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - December 4, 2018 Category: Perinatology & Neonatology Authors: Kamianowska M, Szczepański M, Kulikowska EE, Bebko B, Wasilewska A Tags: Neonatology Source Type: research

The Impact of Late Onset Arterial Hypotension on Respiratory Outcome in Extremely Premature Infants
Conclusions: In this cohort of extremely premature infants, LOH was associated with an increased the risk for BPD. This association could be secondary to underlying factors that predispose to LOH and BPD or to the deleterious effects of LOH or its treatments on the lung. Further investigation is needed to assess causality.Neonatology 2019;115:164 –168 (Source: Neonatology)
Source: Neonatology - November 28, 2018 Category: Perinatology & Neonatology Source Type: research

The Impact of Late Onset Arterial Hypotension on Respiratory Outcome in Extremely Premature Infants.
Abstract BACKGROUND: In extremely premature infants, arterial hypotension in the first days after birth has been associated with an increased risk for bronchopulmonary dysplasia (BPD). Some infants present with hypotension at a later postnatal age, but the relationship between late onset hypotension (LOH) and BPD has not been evaluated. OBJECTIVE: To evaluate the association between LOH and BPD and to identify pre- and postnatal factors associated with LOH. METHODS: Prospectively collected data from a cohort of 23-28 weeks gestational age (GA) infants born during years 2005-2015 and alive at day 28 were ...
Source: Neonatology - November 28, 2018 Category: Perinatology & Neonatology Authors: Kurtom W, Jain D, Quan M, Vanbuskirk S, Bancalari E, Claure N Tags: Neonatology Source Type: research

Ophthalmic Insert versus Eye Drops for Mydriasis in Neonates: A Randomized Clinical Trial
Conclusions: The degree of mydriasis achieved with Mydriasert ® was noninferior to that obtained with eye drops. The insert appears to be safe to use in neonates without a history of increased vagal tone or gastrointestinal reflux.Neonatology 2019;115:142 –148 (Source: Neonatology)
Source: Neonatology - November 27, 2018 Category: Perinatology & Neonatology Source Type: research

Platelet-Neutrophil Interactions Are Lower in Cord Blood of Premature Newborns
Conclusions: The potential formation of PNAs correlates with gestational age. This suggests that the development of functional competencies of platelets and neutrophils continues throughout gestation, progressively enabling interactions between them.Neonatology 2019;115:149 –155 (Source: Neonatology)
Source: Neonatology - November 27, 2018 Category: Perinatology & Neonatology Source Type: research

A Randomized Controlled Trial of Immediate versus Delayed Umbilical Cord Clamping in Multiple-Birth Infants Born Preterm
Conclusion: DCC for 30 –60 s did not improve placental transfusion or increase systemic blood flow in multiple-birth infants born preterm, mostly by CS, when compared with ICC. The finding of a higher PPH rate in the DCC group raises concerns about the maternal safety of this procedure in this patient population.Neonatology 2019;115:156 –163 (Source: Neonatology)
Source: Neonatology - November 27, 2018 Category: Perinatology & Neonatology Source Type: research

A Randomized Controlled Trial of Immediate versus Delayed Umbilical Cord Clamping in Multiple-Birth Infants Born Preterm.
CONCLUSION: DCC for 30-60 s did not improve placental transfusion or increase systemic blood flow in multiple-birth infants born preterm, mostly by CS, when compared with ICC. The finding of a higher PPH rate in the DCC group raises concerns about the maternal safety of this procedure in this patient population. PMID: 30481760 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - November 27, 2018 Category: Perinatology & Neonatology Authors: Ruangkit C, Bumrungphuet S, Panburana P, Khositseth A, Nuntnarumit P Tags: Neonatology Source Type: research

Platelet-Neutrophil Interactions Are Lower in Cord Blood of Premature Newborns.
Abstract OBJECTIVE: To quantify platelet-neutrophil interaction by flow cytometry, in newborn cord blood, as a function of gestational age. RATIONALE: Little is known about platelet function markers in the newborn, and developmental variations in these markers are not well described. METHODS: Cord blood samples were obtained from 64 newborns between 23 and 40 weeks' gestation. The neonates were grouped into three categories: preterm (
Source: Neonatology - November 27, 2018 Category: Perinatology & Neonatology Authors: Esiaba I, Angeles DM, Milford TM, Salto LM, Payne KJ, Kidder MY, Boskovic DS Tags: Neonatology Source Type: research

Ophthalmic Insert versus Eye Drops for Mydriasis in Neonates: A Randomized Clinical Trial.
sp;FO Study Group Abstract BACKGROUND: Eye drop treatment routinely used to obtain mydriasis prior to fundoscopy in neonates requires repeated instillations of mydriatic agents that can lead to systemic side effects. OBJECTIVES: The aim of this study was to compare the mydriatic efficacy and tolerance of administration of phenylephrine and tropicamide via the ophthalmic insert Mydriasert® versus standard eye drop treatment in neonates. METHODS: In this prospective, single-blinded, noninferiority study, 80 hospitalized neonates (age
Source: Neonatology - November 27, 2018 Category: Perinatology & Neonatology Authors: Bremond-Gignac D, Jacqz-Aigrain E, Abdoul H, Daruich A, Beresniak A, Baud O, Alberti C, on behalf of the CLAIR FO Study Group Tags: Neonatology Source Type: research

Disulphide Bridges in Surfactant Protein B Analogues Affect Their Activity in Synthetic Surfactant Preparations
Conclusion: The helix-loop-helix SP-B analogues tested in this study require the presence of 2 disulphide bridges for optimal activity in a rabbit RDS model.Neonatology 2019;115:134 –141 (Source: Neonatology)
Source: Neonatology - November 20, 2018 Category: Perinatology & Neonatology Source Type: research

Disulphide Bridges in Surfactant Protein B Analogues Affect Their Activity in Synthetic Surfactant Preparations.
CONCLUSION: The helix-loop-helix SP-B analogues tested in this study require the presence of 2 disulphide bridges for optimal activity in a rabbit RDS model. PMID: 30453306 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - November 19, 2018 Category: Perinatology & Neonatology Authors: Basabe-Burgos O, Johansson J, Curstedt T Tags: Neonatology Source Type: research

Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis
Conclusion: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants.Neonatology 2019;115:127 –133 (Source: Neonatology)
Source: Neonatology - November 12, 2018 Category: Perinatology & Neonatology Source Type: research

Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis.
CONCLUSION: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants. PMID: 30419568 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - November 12, 2018 Category: Perinatology & Neonatology Authors: Hakobyan M, Dijkman KP, Laroche S, Naulaers G, Rijken M, Steiner K, van Straaten HLM, Swarte RMC, Ter Horst HJ, Zecic A, Zonnenberg IA, Groenendaal F Tags: Neonatology Source Type: research

Contents Vol. 114, 2018.
Authors: PMID: 30404099 [PubMed - in process] (Source: Neonatology)
Source: Neonatology - November 9, 2018 Category: Perinatology & Neonatology Tags: Neonatology Source Type: research

Neonatal Glycaemia and Neurodevelopmental Outcomes: A Systematic Review and Meta-Analysis
Conclusions: Neonatal hypoglycaemia may have important long-lasting adverse effects on neurodevelopment that may become apparent at later ages. Carefully designed randomized trials are required to determine the optimal management of neonates at risk of hypoglycaemia with long-term follow-up at least to school age.Neonatology 2019;115:116 –126 (Source: Neonatology)
Source: Neonatology - November 8, 2018 Category: Perinatology & Neonatology Source Type: research

Acknowledgement to the Reviewers
Neonatology 2018;114:372 –373 (Source: Neonatology)
Source: Neonatology - November 7, 2018 Category: Perinatology & Neonatology Source Type: research

Contents Vol. 114, 2018
Neonatology 2018;114:I –VI (Source: Neonatology)
Source: Neonatology - November 7, 2018 Category: Perinatology & Neonatology Source Type: research

Accelerated Small-World Property of Structural Brain Networks in Preterm Infants at Term-Equivalent Age
Conclusion: The accelerated small worldness in preterm infants suggests that the structural brain network after preterm birth is reorganized in maximizing integrated and segregated processing, implying resilience against prematurity-associated pathology.Neonatology 2019;115:99 –107 (Source: Neonatology)
Source: Neonatology - November 1, 2018 Category: Perinatology & Neonatology Source Type: research

Prescription Drug Shortages: Impact on Neonatal Intensive Care
Conclusions: Drug shortages affected many agents used in NICUs, which can have quality and safety implications for patient care, especially in extremely low birth weight infants. Neonatologists must be aware of current shortages and implement mitigation strategies to optimize patient care.Neonatology 2019;115:108 –115 (Source: Neonatology)
Source: Neonatology - November 1, 2018 Category: Perinatology & Neonatology Source Type: research

Prescription Drug Shortages: Impact on Neonatal Intensive Care.
CONCLUSIONS: Drug shortages affected many agents used in NICUs, which can have quality and safety implications for patient care, especially in extremely low birth weight infants. Neonatologists must be aware of current shortages and implement mitigation strategies to optimize patient care. PMID: 30384374 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - November 1, 2018 Category: Perinatology & Neonatology Authors: Ziesenitz VC, Fox E, Zocchi M, Samiee-Zafarghandy S, van den Anker JN, Mazer-Amirshahi M Tags: Neonatology Source Type: research

Accelerated Small-World Property of Structural Brain Networks in Preterm Infants at Term-Equivalent Age.
CONCLUSION: The accelerated small worldness in preterm infants suggests that the structural brain network after preterm birth is reorganized in maximizing integrated and segregated processing, implying resilience against prematurity-associated pathology. PMID: 30384384 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - November 1, 2018 Category: Perinatology & Neonatology Authors: Lee JY, Park HK, Lee HJ Tags: Neonatology Source Type: research

Doxapram Treatment and Diaphragmatic Activity in Preterm Infants
Conclusion: Doxapram infusion does not alter diaphragmatic activity measured with transcutaneous dEMG in preterm infants with AOP, indicating that its working mechanism is primarily on respiratory drive and not on respiratory muscle activity.Neonatology 2019;115:85 –88 (Source: Neonatology)
Source: Neonatology - October 24, 2018 Category: Perinatology & Neonatology Source Type: research

Pulseless Electrical Activity Complicating Neonatal Resuscitation
Conclusion: Further prospective studies are needed to determine the true incidence of PEA in the delivery room setting as well as its prognosis in newborns.Neonatology 2019;115:95 –98 (Source: Neonatology)
Source: Neonatology - October 24, 2018 Category: Perinatology & Neonatology Source Type: research

The Value of Autopsy in Neonates in the 21st Century
Conclusions: Our results emphasize the still very important role of autopsy in the NICU setting and show that conventional autopsy could probably not be completely substituted by postmortem MRI.Neonatology 2019;115:89 –93 (Source: Neonatology)
Source: Neonatology - October 24, 2018 Category: Perinatology & Neonatology Source Type: research

Pulseless Electrical Activity Complicating Neonatal Resuscitation.
CONCLUSION: Further prospective studies are needed to determine the true incidence of PEA in the delivery room setting as well as its prognosis in newborns. PMID: 30352434 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 23, 2018 Category: Perinatology & Neonatology Authors: Sillers L, Handley SC, James JR, Foglia EE Tags: Neonatology Source Type: research

The Value of Autopsy in Neonates in the 21st Century.
CONCLUSIONS: Our results emphasize the still very important role of autopsy in the NICU setting and show that conventional autopsy could probably not be completely substituted by postmortem MRI. PMID: 30352441 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 23, 2018 Category: Perinatology & Neonatology Authors: de Sévaux JLH, Nikkels PGJ, Lequin MH, Groenendaal F Tags: Neonatology Source Type: research

Doxapram Treatment and Diaphragmatic Activity in Preterm Infants.
CONCLUSION: Doxapram infusion does not alter diaphragmatic activity measured with transcutaneous dEMG in preterm infants with AOP, indicating that its working mechanism is primarily on respiratory drive and not on respiratory muscle activity. PMID: 30352445 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 23, 2018 Category: Perinatology & Neonatology Authors: de Waal CG, Hutten GJ, Kraaijenga JV, de Jongh FH, van Kaam AH Tags: Neonatology Source Type: research

Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy
Conclusion: Babies with neonatal encephalopathy have striking differences in gene expression profiles compared with healthy control and septic babies. Gene expression profiles may be useful for disease stratification and for developing personalized neuroprotective therapies.Neonatology 2019;115:68 –76 (Source: Neonatology)
Source: Neonatology - October 10, 2018 Category: Perinatology & Neonatology Source Type: research

Lung Ultrasound for the Differential Diagnosis of Respiratory Distress in Neonates
Conclusion: LUS and CXR have a high concordance in the differential diagnosis of neonatal RD in the first 24 h of life. LUS has a shorter operation time than CXR.Neonatology 2019;115:77 –84 (Source: Neonatology)
Source: Neonatology - October 10, 2018 Category: Perinatology & Neonatology Source Type: research

Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy.
CONCLUSION: Babies with neonatal encephalopathy have striking differences in gene expression profiles compared with healthy control and septic babies. Gene expression profiles may be useful for disease stratification and for developing personalized neuroprotective therapies. PMID: 30304723 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 10, 2018 Category: Perinatology & Neonatology Authors: Montaldo P, Kaforou M, Pollara G, Hervás-Marín D, Calabria I, Panadero J, Pedrola L, Lally PJ, Oliveira V, Kage A, Atreja G, Mendoza J, Soe A, Pattnayak S, Shankaran S, Vento M, Herberg J, Thayyil S Tags: Neonatology Source Type: research

Lung Ultrasound for the Differential Diagnosis of Respiratory Distress in Neonates.
Abstract BACKGROUND: Respiratory distress (RD) is the most common neonatal illness. Lung ultrasound (LUS) is a technique previously tested in neonatal studies on RD, but literature regarding its routine clinical applicability is still lacking. OBJECTIVE: To assess the concordance between LUS performed by neonatologists with different training levels and chest X-ray (CXR) for the diagnosis of RD in newborns during the first 24 h of life. METHODS: We enrolled newborns with RD during the first 24 h of life. Patients underwent LUS and CXR. LUS and CXR diagnosis were compared to evaluate concordance. Twenty p...
Source: Neonatology - October 10, 2018 Category: Perinatology & Neonatology Authors: Corsini I, Parri N, Gozzini E, Coviello C, Leonardi V, Poggi C, Giacalone M, Bianconi T, Tofani L, Raimondi F, Dani C Tags: Neonatology Source Type: research

Can Fetal Umbilical Venous Blood Be a Reliable Source for Admission Complete Blood Count and Culture in NICU Patients?
Conclusions: FUVB is suitable for obtaining CBC/diff. FUVB is an appropriate second source for BCX as it yields additional true pathogens. Our findings may support the presence of “culture-negative sepsis” in some neonates.Neonatology 2019;115:49 –58 (Source: Neonatology)
Source: Neonatology - October 9, 2018 Category: Perinatology & Neonatology Source Type: research

Prognostic Accuracy of Heart Rate Variability Analysis in Neonatal Encephalopathy: A Systematic Review
Conclusions: HRV metrics are a promising bedside tool for early prediction of brain injury and neurodevelopmental outcome in babies with NE. Due to the small number of studies available, their heterogeneity and methodological limitations, further research is needed to refine this tool so that it can be used in clinical practice.Neonatology 2019;115:59 –67 (Source: Neonatology)
Source: Neonatology - October 9, 2018 Category: Perinatology & Neonatology Source Type: research

Prognostic Accuracy of Heart Rate Variability Analysis in Neonatal Encephalopathy: A Systematic Review.
CONCLUSIONS: HRV metrics are a promising bedside tool for early prediction of brain injury and neurodevelopmental outcome in babies with NE. Due to the small number of studies available, their heterogeneity and methodological limitations, further research is needed to refine this tool so that it can be used in clinical practice. PMID: 30300885 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 9, 2018 Category: Perinatology & Neonatology Authors: Oliveira V, Martins R, Liow N, Teiserskas J, von Rosenberg W, Adjei T, Shivamurthappa V, Lally PJ, Mandic D, Thayyil S Tags: Neonatology Source Type: research

Can Fetal Umbilical Venous Blood Be a Reliable Source for Admission Complete Blood Count and Culture in NICU Patients?
Abstract BACKGROUND: Minimizing initial neonatal blood draws and their associated pain is important. The placenta has ample fetal blood that is otherwise discarded; obtaining admission laboratory evaluations from fetal umbilical venous blood (FUVB) may provide a suitable alternative. OBJECTIVE: We hypothesized that obtaining an aerobic bacterial blood culture (BCX) and a complete blood count with manual differential (CBC/diff) from FUVB is feasible and yields results comparable to those obtained directly from the neonate. STUDY DESIGN: BCX and CBC/diff were attempted on paired samples from FUVB (in the d...
Source: Neonatology - October 9, 2018 Category: Perinatology & Neonatology Authors: Greer R, Safarulla A, Koeppel R, Aslam M, Bany-Mohammed FM Tags: Neonatology Source Type: research

Comparison of Bubble CPAP Devices Using RAM Cannula for Extubation Failure in Very Low Birth Weight Infants: Randomized and Cohort Studies
Conclusions: There were no clinical differences at extubation between the Bamp;B Bubbler© and BabiPlus© devices. Oxygenation may predict bCPAP failure. The use of the RAM© cannula as a bCPAP interface should be more closely examined.Neonatology 2019;115:28 –35 (Source: Neonatology)
Source: Neonatology - October 5, 2018 Category: Perinatology & Neonatology Source Type: research

Effect of Delayed Cord Clamping of Term Babies on Neurodevelopment at 12 Months: A Randomized Controlled Trial
Conclusions: DCC after 3 min was associated with an improvement of the overall neurodevelopment assessed at 12 months of age as compared to infants in the group with cord clamping within 1 min.Neonatology 2019;115:36 –42 (Source: Neonatology)
Source: Neonatology - October 5, 2018 Category: Perinatology & Neonatology Source Type: research

Evaluation of an Intubation Readiness Score to Assess Neonatal Sedation before Intubation
Conclusions: Preintubation sedation assessment using the IRS can adequately predict optimal conditions during intubation in the majority of neonates. We suggest using the IRS in routine clinical care. Further research combining the IRS with other parameters could further improve the predictability of adequate sedation during intubation.Neonatology 2019;115:43 –48 (Source: Neonatology)
Source: Neonatology - October 5, 2018 Category: Perinatology & Neonatology Source Type: research

Evaluation of an Intubation Readiness Score to Assess Neonatal Sedation before Intubation.
CONCLUSIONS: Preintubation sedation assessment using the IRS can adequately predict optimal conditions during intubation in the majority of neonates. We suggest using the IRS in routine clinical care. Further research combining the IRS with other parameters could further improve the predictability of adequate sedation during intubation. PMID: 30278443 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 2, 2018 Category: Perinatology & Neonatology Authors: de Kort EHM, Andriessen P, Reiss IKH, van Dijk M, Simons SHP Tags: Neonatology Source Type: research

Comparison of Bubble CPAP Devices Using RAM Cannula for Extubation Failure in Very Low Birth Weight Infants: Randomized and Cohort Studies.
CONCLUSIONS: There were no clinical differences at extubation between the B&B Bubbler© and BabiPlus© devices. Oxygenation may predict bCPAP failure. The use of the RAM© cannula as a bCPAP interface should be more closely examined. PMID: 30278459 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 2, 2018 Category: Perinatology & Neonatology Authors: Claassen CC, Hillman NH, Brown K, Williams HL, Strand ML Tags: Neonatology Source Type: research

Effect of Delayed Cord Clamping of Term Babies on Neurodevelopment at 12 Months: A Randomized Controlled Trial.
on O Abstract BACKGROUND: Delayed cord clamping (DCC) is associated with an improved iron status at 8 months, a reduction of anemia at 12 months, and an improved development at 4 years. Assessment of the development after DCC has not been performed earlier in a setting with a high prevalence of iron deficiency. OBJECTIVE: The aim of this paper was to investigate the effects of DCC compared to early cord clamping (ECC) on the development evaluated with the Ages and Stages Questionnaire (ASQ) at 12 months of age. METHOD: We conducted a randomized controlled trial investigating the effect of DCC (≥180 s)...
Source: Neonatology - October 2, 2018 Category: Perinatology & Neonatology Authors: Rana N, Kc A, Målqvist M, Subedi K, Andersson O Tags: Neonatology Source Type: research

Bilirubin Production Is Increased in Newborn Mice Exposed to Isoflurane
Conclusions: ISO exposure can induce HO-1 expression in the liver and may explain the development of severe hyperbilirubinemia in postsurgical infants, especially in those undergoing hemolysis.Neonatology 2019;115:21 –27 (Source: Neonatology)
Source: Neonatology - September 11, 2018 Category: Perinatology & Neonatology Source Type: research

Bilirubin Production Is Increased in Newborn Mice Exposed to Isoflurane.
CONCLUSIONS: ISO exposure can induce HO-1 expression in the liver and may explain the development of severe hyperbilirubinemia in postsurgical infants, especially in those undergoing hemolysis. PMID: 30205413 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - September 11, 2018 Category: Perinatology & Neonatology Authors: Iwatani S, Burgess J, Kalish F, Wong RJ, Stevenson DK Tags: Neonatology Source Type: research

Effect of Delayed Cord Clamping on Cerebral Oxygenation in Very Preterm Infants
Conclusion: Although DCC was not associated with changes in cerebral oxygenation overall, sensitivity analysis suggested a possible effect of an increased rScO2 and a decreased cFTOE with ≥30 s of DCC.Neonatology 2019;115:13 –20 (Source: Neonatology)
Source: Neonatology - September 10, 2018 Category: Perinatology & Neonatology Source Type: research

Effect of Delayed Cord Clamping on Cerebral Oxygenation in Very Preterm Infants.
Abstract BACKGROUND AND OBJECTIVE: The mechanism of reported benefits of delayed cord clamping (DCC) are unclear. We aimed to determine whether DCC compared to immediate cord clamping (ICC) in very preterm infants improves cerebral oxygenation in the first 24 h. STUDY DESIGN: This is a prospective study of a subset of infants at
Source: Neonatology - September 10, 2018 Category: Perinatology & Neonatology Authors: Popat H, Galea C, Evans N, Lingwood B, Colditz PB, Halliday R, Osborn D Tags: Neonatology Source Type: research