MR Spectroscopy Shows Long Propylene Glycol Half-Life in Neonatal Brain
Conclusion: This study showed a long cerebral PG half-life of 40.7 h in neonates, unrelated to perinatal asphyxia, infection, or stroke. These findings should increase awareness of possible toxic PG concentrations in neonatal brain due to intravenous PG-containing drugs.Neonatology (Source: Neonatology)
Source: Neonatology - October 20, 2021 Category: Perinatology & Neonatology Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.PMID:34628413 | DOI:10.1159/000519283 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Jennifer Peterson Maria C den Boer Charles Christoph Roehr Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
CONCLUSION: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.PMID:34628414 | DOI:10.1159/000518060 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Manuela Capozza Silvia Salvatore Maria Elisabetta Baldassarre Silvia Inting Raffaella Panza Margherita Fanelli Simona Perniciaro Laura Morlacchi Antonella Vimercati Massimo Agosti Nicola Laforgia Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.PMID:34628413 | DOI:10.1159/000519283 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Jennifer Peterson Maria C den Boer Charles Christoph Roehr Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
CONCLUSION: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.PMID:34628414 | DOI:10.1159/000518060 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Manuela Capozza Silvia Salvatore Maria Elisabetta Baldassarre Silvia Inting Raffaella Panza Margherita Fanelli Simona Perniciaro Laura Morlacchi Antonella Vimercati Massimo Agosti Nicola Laforgia Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.PMID:34628413 | DOI:10.1159/000519283 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Jennifer Peterson Maria C den Boer Charles Christoph Roehr Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
CONCLUSION: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.PMID:34628414 | DOI:10.1159/000518060 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Manuela Capozza Silvia Salvatore Maria Elisabetta Baldassarre Silvia Inting Raffaella Panza Margherita Fanelli Simona Perniciaro Laura Morlacchi Antonella Vimercati Massimo Agosti Nicola Laforgia Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.PMID:34628413 | DOI:10.1159/000519283 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Jennifer Peterson Maria C den Boer Charles Christoph Roehr Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
CONCLUSION: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.PMID:34628414 | DOI:10.1159/000518060 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Manuela Capozza Silvia Salvatore Maria Elisabetta Baldassarre Silvia Inting Raffaella Panza Margherita Fanelli Simona Perniciaro Laura Morlacchi Antonella Vimercati Massimo Agosti Nicola Laforgia Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.PMID:34628413 | DOI:10.1159/000519283 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Jennifer Peterson Maria C den Boer Charles Christoph Roehr Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
CONCLUSION: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.PMID:34628414 | DOI:10.1159/000518060 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Manuela Capozza Silvia Salvatore Maria Elisabetta Baldassarre Silvia Inting Raffaella Panza Margherita Fanelli Simona Perniciaro Laura Morlacchi Antonella Vimercati Massimo Agosti Nicola Laforgia Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.PMID:34628413 | DOI:10.1159/000519283 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Jennifer Peterson Maria C den Boer Charles Christoph Roehr Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
CONCLUSION: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.PMID:34628414 | DOI:10.1159/000518060 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Manuela Capozza Silvia Salvatore Maria Elisabetta Baldassarre Silvia Inting Raffaella Panza Margherita Fanelli Simona Perniciaro Laura Morlacchi Antonella Vimercati Massimo Agosti Nicola Laforgia Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.PMID:34628413 | DOI:10.1159/000519283 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Jennifer Peterson Maria C den Boer Charles Christoph Roehr Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
CONCLUSION: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.PMID:34628414 | DOI:10.1159/000518060 (Source: Neonatology)
Source: Neonatology - October 10, 2021 Category: Perinatology & Neonatology Authors: Manuela Capozza Silvia Salvatore Maria Elisabetta Baldassarre Silvia Inting Raffaella Panza Margherita Fanelli Simona Perniciaro Laura Morlacchi Antonella Vimercati Massimo Agosti Nicola Laforgia Source Type: research

To Sedate or Not to Sedate for Less Invasive Surfactant Administration: An Ethical Approach
This article explores the ethical arguments pertaining to analgesia and sedation during the LISA technique, concluding that a standardized approach to the usage of pharmacological sedation is undesirable. Moreover, we maintain that procedural analgesia and sedation should be based on individualized, infant-centred assessment, rather than on a rigid, standardized approach.Neonatology (Source: Neonatology)
Source: Neonatology - October 8, 2021 Category: Perinatology & Neonatology Source Type: research

Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions
Conclusion: According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.Neonatology (Source: Neonatology)
Source: Neonatology - October 7, 2021 Category: Perinatology & Neonatology Source Type: research

Normal Values for Cerebrospinal Fluid in Neonates: A Systematic Review
Conclusion: The normal range for CSF parameters in neonates is different to that in older infants, and some parameters are influenced by gestational and chronological age. CSF parameters alone are not sufficiently reliable to exclude meningitis.Neonatology (Source: Neonatology)
Source: Neonatology - October 5, 2021 Category: Perinatology & Neonatology Source Type: research

Continuous Deep Sedation in the Newborn: Knowledge and Need
Neonatology (Source: Neonatology)
Source: Neonatology - September 28, 2021 Category: Perinatology & Neonatology Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: David Balakirouchenane Nihel Khoudour Laurent Chouchana Lucie Chevillard Sophie Parat Xavier Decl èves Source Type: research

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study
CONCLUSIONS: In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.PMID:34569541 | DOI:10.1159/000518986 (Source: Neonatology)
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Francesco Cavallin Giorgia Carlone Nicoletta Doglioni Paolo Ernesto Villani Luca Vecchiato Paola Lago Daniele Trevisanuto Source Type: research

Signal Quality of Electrical Cardiometry and Perfusion Index in Very Preterm Infants
Neonatology. 2021 Sep 22:1-6. doi: 10.1159/000518061. Online ahead of print.ABSTRACTOBJECTIVE: The use of noninvasive monitoring of neonatal hemodynamics is increasing in neonatal care. Methods include noninvasive cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as perfusion index (PI) using pulse oximetry. Our aim was to evaluate the feasibility to continuously monitor preterm infants with EC and PI during the first 2 postnatal days and the effects of averaging EC data in signal quality (SigQ) analysis.DESIGN: Prospective observational study.SETTING: Tertiary neonatal academic hospital.PATI...
Source: Neonatology - September 27, 2021 Category: Perinatology & Neonatology Authors: Christoph E Schwarz John M O'Toole Vicki Livingstone Andreea M Pavel Eugene M Dempsey Source Type: research

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report
We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days wi...
Source: Neonatology - September 23, 2021 Category: Perinatology & Neonatology Source Type: research