Differences in Serum Alkaline Phosphatase Levels in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis with Perforation
Conclusion: A transient increase in serum alkaline phosphatase level is independently associated with SIP when compared to NEC. Studies to confirm the role of alkaline phosphatase in the diagnosis of SIP are necessary and have potentially significant clinical and prognostic implications.Neonatology (Source: Neonatology)
Source: Neonatology - August 4, 2020 Category: Perinatology & Neonatology Source Type: research

Title Page: Sharing Progress in Neonatology (SPIN): Old Favorites: Bronchopulmonary Dysplasia, Patent Ductus Arteriosus and Necrotizing Enterocolitis plus some Global Neonatology and the Future of Clinical Trials.
Authors: PMID: 32702696 [PubMed - in process] (Source: Neonatology)
Source: Neonatology - July 25, 2020 Category: Perinatology & Neonatology Tags: Neonatology Source Type: research

Author Index
Neonatology 2020;117:258 (Source: Neonatology)
Source: Neonatology - July 23, 2020 Category: Perinatology & Neonatology Source Type: research

Title Page: Sharing Progress in Neonatology (SPIN): Old Favorites: Bronchopulmonary Dysplasia, Patent Ductus Arteriosus and Necrotizing Enterocolitis plus some Global Neonatology and the Future of Clinical Trials
Neonatology 2020;117:203 –203 (Source: Neonatology)
Source: Neonatology - July 23, 2020 Category: Perinatology & Neonatology Source Type: research

Lost in Transition: Is Early Respiratory Support in Newborn Infants the Best Option?
Conclusions: Late preterm and term newborn infants without SO requirement at the time of commencing NIV for respiratory distress are at lower risk of requiring treatment escalation. Close observation of these infants (watch and wait strategy) may avoid unnecessary treatment.Neonatology (Source: Neonatology)
Source: Neonatology - July 16, 2020 Category: Perinatology & Neonatology Source Type: research

[Lost in Transition: Is Early Respiratory Support in Newborn Infants the Best Option?]
CONCLUSIONS: Late preterm and term newborn infants without SO requirement at the time of commencing NIV for respiratory distress are at lower risk of requiring treatment escalation. Close observation of these infants (watch and wait strategy) may avoid unnecessary treatment. PMID: 32674103 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 16, 2020 Category: Perinatology & Neonatology Authors: Buckmaster A, Arnolda G, Owen L, Roberts C, Davis P, Manley B Tags: Neonatology Source Type: research

Effect of Fentanyl Boluses on Cerebral Oxygenation and Hemodynamics in Preterm Infants: A Prospective Observational Study
Conclusion: Administration of fentanyl bolus for procedural pain and sedation was not shown to significantly affect cerebral oxygenation, cerebral tissue oxygen extraction or cardiac output in stable preterm infants.Neonatology (Source: Neonatology)
Source: Neonatology - July 8, 2020 Category: Perinatology & Neonatology Source Type: research

Effect of Fentanyl Boluses on Cerebral Oxygenation and Hemodynamics in Preterm Infants: A Prospective Observational Study.
CONCLUSION: Administration of fentanyl bolus for procedural pain and sedation was not shown to significantly affect cerebral oxygenation, cerebral tissue oxygen extraction or cardiac output in stable preterm infants. PMID: 32640456 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 8, 2020 Category: Perinatology & Neonatology Authors: Mitra S, Babadagli ME, Hatfield T, dePalma A, McCord H, El-Naggar W, Schmölzer GM, McMillan DD Tags: Neonatology Source Type: research

Maternal Poppy Seed Tea Ingestion and Ensuing Neonatal Abstinence Syndrome
We report an infant with neonatal abstinence syndrome born to a mother with daily poppy seed tea ingestion for the self-treatment of nausea. A sample of poppy seed tea was replicated using the mother ’s self-reported recipe. The sample was analyzed using liquid chromatography tandem mass spectrometry. This recipe produced a result of approximately 7.8 mg of morphine per serving which she reported to have drank 5–6 days per week, for an estimated 7 months during the course of her pregnancy.Neonatology (Source: Neonatology)
Source: Neonatology - July 6, 2020 Category: Perinatology & Neonatology Source Type: research

Maternal Poppy Seed Tea Ingestion and Ensuing Neonatal Abstinence Syndrome.
We report an infant with neonatal abstinence syndrome born to a mother with daily poppy seed tea ingestion for the self-treatment of nausea. A sample of poppy seed tea was replicated using the mother's self-reported recipe. The sample was analyzed using liquid chromatography tandem mass spectrometry. This recipe produced a result of approximately 7.8 mg of morphine per serving which she reported to have drank 5-6 days per week, for an estimated 7 months during the course of her pregnancy. PMID: 32629445 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 6, 2020 Category: Perinatology & Neonatology Authors: Garcia MR, Swortwood MJ, Aune CN, Ahmad KA Tags: Neonatology Source Type: research

Acetaminophen and the Developing Brain: Reason for Concern?
Neonatology (Source: Neonatology)
Source: Neonatology - July 2, 2020 Category: Perinatology & Neonatology Source Type: research

Acetaminophen and the Developing Brain: Reason for Concern?
PMID: 32615557 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 2, 2020 Category: Perinatology & Neonatology Authors: Saugstad OD Tags: Neonatology Source Type: research

Delivery of Positive End-Expiratory Pressure Using Self-Inflating Bags during Newborn Resuscitation Is Possible Despite Mask Leak
Conclusions: Mask leak up to 80% did not impair the provision of recommended PEEP or tidal volumes during BMV with a self-inflating bag. High or low ventilation rates did not significantly affect PIP or PEEP. Expired volumes were reduced at ventilation rates #x3e;60/min.Neonatology (Source: Neonatology)
Source: Neonatology - July 1, 2020 Category: Perinatology & Neonatology Source Type: research

Sharing Progress in Neonatology (SPIN): Old Favorites – Bronchopulmonary Dysplasia, Patent Ductus Arteriosus, and Necrotizing Enterocolitis plus Some Global Neonatology and the Future of Clinical Trials
Neonatology 2020;117:1 –3 (Source: Neonatology)
Source: Neonatology - July 1, 2020 Category: Perinatology & Neonatology Source Type: research

Publisher's Note
Neonatology (Source: Neonatology)
Source: Neonatology - July 1, 2020 Category: Perinatology & Neonatology Source Type: research

Sharing Progress in Neonatology (SPIN): Old Favorites - Bronchopulmonary Dysplasia, Patent Ductus Arteriosus, and Necrotizing Enterocolitis plus Some Global Neonatology and the Future of Clinical Trials.
PMID: 32610329 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Curstedt T, Halliday HL, Hallman M, Saugstad OD, Speer CP Tags: Neonatology Source Type: research

Publisher's Note.
Authors: PMID: 32610331 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 1, 2020 Category: Perinatology & Neonatology Tags: Neonatology Source Type: research

Delivery of Positive End-Expiratory Pressure Using Self-Inflating Bags during Newborn Resuscitation Is Possible Despite Mask Leak.
, Ersdal HL Abstract BACKGROUND: Ventilation is the key intervention to resuscitate non-breathing newborns. Positive end-expiratory pressure (PEEP) may facilitate lung-liquid clearance and help establish functional residual capacity. OBJECTIVES: The aim of this study was to describe how mask leak and ventilation rates affect delivered PEEP and tidal volumes during newborn resuscitations using a self-inflating bag with an integrated PEEP valve. METHODS: This was an observational study including near-term/term newborns who received bag-mask ventilation (BMV) with a new self-inflating bag with a novel 6 mba...
Source: Neonatology - July 1, 2020 Category: Perinatology & Neonatology Authors: Gomo ØH, Eilevstjønn J, Holte K, Yeconia A, Kidanto H, Ersdal HL Tags: Neonatology Source Type: research

Indoor Climate and Air Quality in a Neonatal Intensive Care Unit
Conclusions: The indoor climate of neonatal intensive care units should be monitored in real time to detect deviations from target parameters quickly. In our neonatal intensive care unit, indoor air quality fluctuated significantly depending on the time of day. We highly suspect that air pollutants are carried into the direct patient environment by visitors and medical staff. The incubator does not protect against PM and VOC exposure but reduces exposure to OG. Cleaning procedures may lead to substantially higher concentrations of VOC inside the incubator and may represent a potentially harmful factor for premature infants...
Source: Neonatology - June 30, 2020 Category: Perinatology & Neonatology Source Type: research

Impact of Body Position on Lung Deposition of Nebulized Surfactant in Newborn Piglets on Nasal Continuous Positive Airway Pressure
Conclusions: In spontaneously breathing animals on nCPAP, the prone position yielded the highest lung dose. Higher deposition rates in the dependent lung while on lateral decubitus indicates that deposition was also influenced by gravity.Neonatology (Source: Neonatology)
Source: Neonatology - June 30, 2020 Category: Perinatology & Neonatology Source Type: research

Indoor Climate and Air Quality in a Neonatal Intensive Care Unit.
Abstract INTRODUCTION AND OBJECTIVE: The skin and respiratory system of premature neonates are in permanent contact with indoor room air. We longitudinally analyzed the room air climate and quality in neonatal intensive care inside and outside an incubator. METHODS: Sampling was performed in 2 patient rooms and inside a neonatal incubator (Caleo, Draeger Medical, Lübeck, Germany) over 6 weeks with 5-min resolution resulting in 12,090 samples (U-Monitor, U-Earth Biotech, London, UK). Temperature, humidity, and air pollutants, including particulate matter (
Source: Neonatology - June 30, 2020 Category: Perinatology & Neonatology Authors: Wolf M, Diehl T, Zanni S, Singer D, Deindl P Tags: Neonatology Source Type: research

Impact of Body Position on Lung Deposition of Nebulized Surfactant in Newborn Piglets on Nasal Continuous Positive Airway Pressure.
CONCLUSIONS: In spontaneously breathing animals on nCPAP, the prone position yielded the highest lung dose. Higher deposition rates in the dependent lung while on lateral decubitus indicates that deposition was also influenced by gravity. PMID: 32604091 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 30, 2020 Category: Perinatology & Neonatology Authors: Cunha-Goncalves D, Nord A, Bianco F, Salomone F, Ricci F, Schlun M, Linner R, Perez-de-Sa V Tags: Neonatology Source Type: research

Pressure versus Sudden Wean from Nasal Continuous Positive Airway Pressure in Preterm Infants: A Systematic Review and Meta-Analysis
Conclusion: Sudden wean of NCPAP was associated with a lower PMA at successful wean compared to pressure wean but also with a lower rate of successful wean at first attempt, most likely because of the developmental stage at which weaning is possible.Neonatology (Source: Neonatology)
Source: Neonatology - June 24, 2020 Category: Perinatology & Neonatology Source Type: research

Pressure versus Sudden Wean from Nasal Continuous Positive Airway Pressure in Preterm Infants: A Systematic Review and Meta-Analysis.
CONCLUSION: Sudden wean of NCPAP was associated with a lower PMA at successful wean compared to pressure wean but also with a lower rate of successful wean at first attempt, most likely because of the developmental stage at which weaning is possible. PMID: 32580200 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 24, 2020 Category: Perinatology & Neonatology Authors: Lemieux-Bourque C, Piedboeuf B, Fontela PS, Bornais K, Beltempo M Tags: Neonatology Source Type: research

Neonatal Umbilical Arterial Catheter Removal Is Accompanied by a Marked Decline in Phlebotomy Blood Loss
Conclusion: UAC removal is independently associated with a marked decline in PBL. We speculate the ease and convenience of UAC blood sampling lead to more frequent blood testing and greater PBL.Neonatology (Source: Neonatology)
Source: Neonatology - June 19, 2020 Category: Perinatology & Neonatology Source Type: research

Neonatal Umbilical Arterial Catheter Removal Is Accompanied by a Marked Decline in Phlebotomy Blood Loss.
Abstract BACKGROUND: Umbilical arterial catheters (UACs) are frequently used in critically ill neonates. UAC are convenient, reliable, and allow for caregiver convenience in performing painless arterial blood sampling. We hypothesized that UAC removal in extremely low birth weight (ELBW) neonates will result in significantly less phlebotomy blood loss (PBL) after correcting for severity of illness. STUDY DESIGN AND METHODS: PBL was measured at a single center in 99 ELBW infants who survived to day 28. Individual infant's paired daily PBL for the two 24-h periods before and after UAC removal were compared usin...
Source: Neonatology - June 19, 2020 Category: Perinatology & Neonatology Authors: Carroll PD, Zimmerman MB, Nalbant D, Gingerich EL, An G, Cress GA, Veng-Pedersen P, Widness JA Tags: Neonatology Source Type: research

Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study.
CONCLUSIONS: CC and cerebellar measurements are significantly smaller in FGR neonates with fetal blood flow redistribution, which warrants further study. PMID: 32526754 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 11, 2020 Category: Perinatology & Neonatology Authors: Pharande P, Krishnamurthy M, Whiteley G, Sasi A, Malhotra A Tags: Neonatology Source Type: research

Antenatal Magnesium Sulfate and Preeclampsia Differentially Affect Neonatal Cerebral Oxygenation.
Abstract INTRODUCTION: Magnesium sulfate (MgSO4) is frequently administered for maternal and fetal neuroprotection in preeclampsia (PE) and imminent preterm birth, respectively. OBJECTIVE: To assess whether MgSO4 affects neonatal cerebral oxygenation, blood flow, and cerebral autoregulation (CAR) during the first postnatal days independently from PE. METHODS: 148 neonates 0.5) was determined. Linear mixed models were applied. RESULTS: MgSO4 exposure was recorded in 77 neonates. Twenty-nine neonates were born following PE. MgSO4 independently lowered cFTOE (B: -0.026, 95% CI: -0.050 to 0.002, p
Source: Neonatology - June 9, 2020 Category: Perinatology & Neonatology Authors: Richter AE, Scherjon SA, Dikkers R, Bos AF, Kooi EMW Tags: Neonatology Source Type: research

Effect of Intrauterine Growth Restriction on Cerebral Regional Oxygen Saturation in Preterm and Term Neonates during Immediate Postnatal Transition.
CONCLUSION: Neonates of the IUGR group did show significantly higher crSO2 values and significantly lower cFTOE values already during immediate neonatal transition compared to the AGA group. PMID: 32516786 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 9, 2020 Category: Perinatology & Neonatology Authors: Baik-Schneditz N, Pichler G, Schwaberger B, Binder-Heschl C, Mileder L, Reiss IKH, Avian A, Greimel P, Klaritsch P, Urlesberger B Tags: Neonatology Source Type: research

Neonates Hospitalized with Community-Acquired SARS-CoV-2 in a Colorado Neonatal Intensive Care Unit.
CONCLUSIONS AND RELEVANCE: Infants with community-acquired SARS-CoV-2 may require hospitalization due to rule-out sepsis guidelines if found to have fever and/or hypoxia. Caregivers of neonates should exercise recommended guidelines before contact with neonates to limit community spread of SARS-CoV-2 to this potentially vulnerable population, including isolation, particularly as asymptomatic cases become prevalent. PMID: 32498065 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 4, 2020 Category: Perinatology & Neonatology Authors: White A, Mukherjee P, Stremming J, Sherlock LG, Reynolds RM, Smith D, Asturias EJ, Grover TR, Dietz RM Tags: Neonatology Source Type: research

Prediction of Neurodevelopmental Impairment in Congenital Cytomegalovirus Infection by Early Postnatal Magnetic Resonance Imaging.
Abstract INTRODUCTION: Congenital cytomegalovirus infection (CCMVI) may result in neurodevelopmental impairments (NDIs) such as hearing loss, developmental delay, epilepsy, and cerebral palsy. We aimed to investigate the potential for brain magnetic resonance imaging (MRI) to predict NDI in patients with CCMVI. METHODS: We studied infants with CCMVI who were referred to our hospital from April 2010 to October 2018 and underwent a brain MRI within 3 months since birth. We screened for 6 classic presentations of CCMVI including ventriculomegaly, periventricular cysts, hippocampal dysplasia, cerebellar hypoplasi...
Source: Neonatology - June 3, 2020 Category: Perinatology & Neonatology Authors: Nishida K, Fujioka K, Sugioka Y, Abe S, Ashina M, Fukushima S, Ohyama S, Ikuta T, Tanimura K, Yamada H, Iijima K, Morioka I Tags: Neonatology Source Type: research

The Thromboelastographic Profile at Birth in Very Preterm Newborns with Patent Ductus Arteriosus.
Abstract BACKGROUND: The role of hemostasis in the closure of patent ductus arteriosus (PDA) in preterm infants is controversial. OBJECTIVE: To assess thromboelastography (TEG) at birth in very-low-birth-weight (VLBW) infants affected by PDA. METHODS: This was an ancillary study of a prospective observational study aimed at defining the TEG profile in healthy VLBW infants in the first month of life. In this analysis, we included neonates of
Source: Neonatology - June 2, 2020 Category: Perinatology & Neonatology Authors: Ghirardello S, Raffaeli G, Crippa BL, Gulden S, Amodeo I, Consonni D, Cavallaro G, Schena F, Mosca F Tags: Neonatology Source Type: research

Using Experimental Models to Identify Pathogenic Pathways and Putative Disease Management Targets in Bronchopulmonary Dysplasia.
Abstract Bronchopulmonary dysplasia (BPD) is a common and serious complication of preterm birth. Limited pharmacological and other medical interventions are currently available for the management of severely affected, very preterm infants. BPD can be modelled in preclinical studies using experimental animals, and experimental animal models have been extremely valuable in the development of hallmark clinical management strategies for BPD, including pulmonary surfactant replacement and single-course antenatal corticosteroids. A gradual move away from large animal models of BPD in favor of term-born rodents has facil...
Source: Neonatology - June 2, 2020 Category: Perinatology & Neonatology Authors: Morty RE Tags: Neonatology Source Type: research

Dynamic Light Scattering: A New Noninvasive Technology for Neonatal Heart Rate Monitoring.
CONCLUSION: The investigated DLS sensor was sensitive to movement, overall providing less accurate HR measurements than ECG and pulse oximetry. In this study population, specific measurement sites provided excellent signal quality and good agreement with ECG-derived HR. PMID: 32464630 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 28, 2020 Category: Perinatology & Neonatology Authors: Gangaram-Panday NH, van Essen T, Goos TG, de Jonge RCJ, Reiss IKM, van Weteringen W Tags: Neonatology Source Type: research

Improving Global Newborn Survival: Building upon Helping Babies Breathe.
Abstract Achieving the targets of the Every Newborn Action Plan by the year 2030 will require accelerating the current reduction in neonatal mortality. Educational programs addressing the three major causes of neonatal death - intrapartum-related events (asphyxia), prematurity and small size at birth, and infection - have the potential to significantly reduce preventable mortality. Helping Babies Breathe is an example of an educational program that not only has given health care providers around the world access to current resuscitation science but has changed provider behavior and patient outcomes and resulted in...
Source: Neonatology - May 26, 2020 Category: Perinatology & Neonatology Authors: Niermeyer S Tags: Neonatology Source Type: research

Postnatal Corticosteroids Policy for Very Preterm Infants and Bronchopulmonary Dysplasia.
CONCLUSION: Up to 49% of NICUs had low PNC use and low BPD rates, without a difference in mortality. Infants hospitalized in NICUs with a stated policy of low PNC use did not have an increased risk of BPD. PMID: 32454484 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 26, 2020 Category: Perinatology & Neonatology Authors: Nuytten A, Behal H, Duhamel A, Jarreau PH, Torchin H, Milligan D, Maier RF, Zemlin M, Zeitlin J, Truffert P, on behalf of the EPICE Research Group Tags: Neonatology Source Type: research

Optimal Ventilation and Surfactant Therapy in Very-Low-Birth-Weight Infants in Resource-Restricted Regions.
This article provides a brief overview on the status of RDS management, mainly nasal CPAP and surfactant therapy in very-low-birth-weight infants, in resource-restricted regions of sub-Saharan Africa. Data from the public health sector, as compared to the private health sector, of the Western Cape province, South Africa, are used to illustrate what RDS management strategies are able to accomplish in a resource-restricted region. Upscaling of all components (antenatal care, antenatal corticosteroids, prevention of hypothermia and RDS management strategies) are required to decrease premature infant mortality rates in resourc...
Source: Neonatology - May 26, 2020 Category: Perinatology & Neonatology Authors: Van Wyk L, Tooke L, Dippenaar R, Rhoda N, Lloyd L, Holgate S, Alexander R, Smith J Tags: Neonatology Source Type: research

Sharing Progress in Neonatology (SPIN): Old Favorites: Bronchopulmonary Dysplasia, Patent Ductus Arteriosus and Necrotizing Enterocolitis plus some Global Neonatology and the Future of Clinical Trials.
Authors: PMID: 32454498 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 26, 2020 Category: Perinatology & Neonatology Tags: Neonatology Source Type: research

Defining "Haemodynamic Significance" of the Patent Ductus Arteriosus: Do We Have All the Answers?
Defining "Haemodynamic Significance" of the Patent Ductus Arteriosus: Do We Have All the Answers? Neonatology. 2020 May 25;:1-8 Authors: Smith A, El-Khuffash AF Abstract Optimum management of the patent ductus arteriosus (PDA) in preterm infants remains one of the most debated topics within the field of neonatology. Despite numerous observational studies and over 60 randomized control trials, consensus on PDA management remains elusive. In order to make meaningful progress on the controversial issue of PDA management, several key factors must be thoroughly addressed; namely (1) accurate iden...
Source: Neonatology - May 25, 2020 Category: Perinatology & Neonatology Authors: Smith A, El-Khuffash AF Tags: Neonatology Source Type: research

Improving the Efficiency and Impact of Clinical Research: A Game Changer for 21st Century Neonatology.
Abstract Every clinician is aware of the many uncertainties that exist in everyday clinical care. These contribute to variation and inequity in outcomes and pose dangers to patient wellbeing and safety. Evidence generation is still too slow, too expensive, too much left to chance, too ad hoc, and wholly inadequate. Modern technologies can drive faster, more efficient evidence generation and implementation of findings. However, professional and public buy-in are also needed for success; in short, a new conceptual framework aimed at reducing uncertainties effectively, efficiently, and incrementally in clinical pract...
Source: Neonatology - May 25, 2020 Category: Perinatology & Neonatology Authors: Modi N Tags: Neonatology Source Type: research

Cerebral Hemodynamics Are Not Affected by the Size of the Patent Ductus Arteriosus.
CONCLUSIONS: In this cohort, CBFv and cerebral autoregulation during systole were not influenced by PDA size. Intact cerebral autoregulation may play a role in maintaining CBFv regardless of PDA size and differences in ABP. PMID: 32434188 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 20, 2020 Category: Perinatology & Neonatology Authors: Kim ES, Kaiser JR, Rios DR, Bornemeier RA, Rhee CJ Tags: Neonatology Source Type: research

Supratentorial Brain Metrics Predict Neurodevelopmental Outcome in Very Preterm Infants without Brain Injury at Age 2 Years.
Abstract INTRODUCTION: Very preterm infants are at risk for adverse neurodevelopmental outcome. To better identify children without brain injury at risk for developmental sequelae, we assessed predictive values of supratentorial brain metrics in relation to outcome. METHODS: Very preterm infants underwent magnetic resonance imaging (MRI) at term-equivalent age. Infants with any grade of supra- or infratentorial brain injury according to Kidokoro et al. [Pediatrics 2014;134:e444-53] were excluded. Supratentorial brain metrics (biparietal width, extracerebral space, interhemispheric distance) were measured and ...
Source: Neonatology - May 12, 2020 Category: Perinatology & Neonatology Authors: Hammerl M, Zagler M, Zimmermann M, Griesmaier E, Janjic T, Gizewski ER, Kiechl-Kohlendorfer U, Neubauer V Tags: Neonatology Source Type: research

A Comparison of UK Preterm Anthropometric Charts and INTERGROWTH-21st: Is It Time to Change Growth Charts?
CONCLUSION: Existing UK NICM reference charts are significantly different to the growth standards of INTERGROWTH-21st. The choice of which growth chart to adopt in the UK could have important consequences on premature infants' future adult health and therefore requires further prospective observational studies with larger data sets including length measurements and more comprehensive population characteristics. PMID: 32396901 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 12, 2020 Category: Perinatology & Neonatology Authors: Bendor-Samuel OM, Zivanovic S, Odd D, Roehr CC Tags: Neonatology Source Type: research

Randomized Controlled Trial of Nonsynchronized Nasal Intermittent Positive Pressure Ventilation versus Nasal CPAP after Extubation of VLBW Infants.
CONCLUSIONS: In this population of VLBWI, NS-NIPPV did not decrease extubation failure after RDS compared with NCPAP. PMID: 32388511 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 8, 2020 Category: Perinatology & Neonatology Authors: Estay AS, Mariani GL, Alvarez CA, Milet B, Agost D, Avila CP, Roldan L, Abdala DA, Keller R, Galletti MF, González A, for the NEOCOSUR Neonatal Network Tags: Neonatology Source Type: research

Ampicillin Treatment Increases Placental Interleukin-1 Beta Concentration and Polymorphonuclear Infiltration in Group B Streptococcus-Induced Chorioamnionitis: A Preclinical Study.
ire G Abstract BACKGROUND: Antibiotic therapy during preterm labor with intact membranes has been associated with an increased risk of neonatal death. OBJECTIVES: Using an established rat model of group B Streptococcus (GBS)-induced chorioamnionitis, we hypothesized that ampicillin treatment increases placental inflammation, as shown in other bacterial infections. METHODS: At gestational day 19, 19 Lewis dams were intraperitoneally (i.p.) inoculated by 108 CFU of β-hemolytic serotype Ia GBS (strain #16955 susceptible to ampicillin). Dams were treated i.p. with either 200 mg/kg of ampicillin (n = 9) ...
Source: Neonatology - May 6, 2020 Category: Perinatology & Neonatology Authors: Giraud A, Allard MJ, Segura M, Roche F, Patural H, Sébire G Tags: Neonatology Source Type: research

Infection Control Measures for COVID-19 in the Labour Suite and Neonatal Unit.
PMID: 32348989 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - April 29, 2020 Category: Perinatology & Neonatology Authors: Ng PC Tags: Neonatology Source Type: research

Neonatal Resuscitation Where the Mother Has a Suspected or Confirmed Novel Coronavirus (SARS-CoV-2) Infection: Suggestion for a Pragmatic Action Plan.
Abstract Coronavirus disease 2019 (COVID-19), caused by the novel SARS-CoV-2 virus, is rapidly spreading across the world. As the number of infections increases, those of infected pregnant women and children will rise as well. Controversy exists whether COVID-19 can be transmitted in utero and lead to disease in the newborn. As this chance cannot be ruled out, strict instructions for the management of mothers and newborn infants are mandatory. This perspective aims to be a practical support tool for the planning of delivery and neonatal resuscitation of infants born by mothers with suspected or confirmed COVID-19 ...
Source: Neonatology - April 24, 2020 Category: Perinatology & Neonatology Authors: Trevisanuto D, Moschino L, Doglioni N, Roehr CC, Gervasi MT, Baraldi E Tags: Neonatology Source Type: research

Neonatal Dieulafoy Lesion Requiring Massive Transfusion Protocol and Surgical Intervention.
We present a case of neonatal Dieulafoy lesion that occurred less than 24 h after delivery with hematemesis. The patient required large volume resuscitation and massive transfusion of blood products for acute blood loss. The lesion was successfully treated with surgical ligation after a failed attempt at endoscopic intervention. PMID: 32325456 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - April 23, 2020 Category: Perinatology & Neonatology Authors: Leaderer D, Laconi N, Brown J, Ruoss JL, de la Cruz D, Chan A, Taylor JA Tags: Neonatology Source Type: research

COVID-19 and Neonatal Resuscitation.
PMID: 32325458 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - April 23, 2020 Category: Perinatology & Neonatology Authors: Halliday HL, Speer CP Tags: Neonatology Source Type: research

Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups.
Abstract BACKGROUND: Hospital-acquired viral respiratory tract infections (VRTIs) cause significant morbidity and mortality in neonatal patients. This includes escalation of respiratory support, increased length of hospital stay, and need for home oxygen, as well as higher healthcare costs. To date, no studies have compared population rates of VRTIs across age groups. AIM: Quantify the rates of hospital-acquired VRTIs in our neonatal population compared with other inpatient age groups in Nottinghamshire, UK. METHODS: We compared all hospital inpatient PCR-positive viral respiratory samples between 2007 a...
Source: Neonatology - April 6, 2020 Category: Perinatology & Neonatology Authors: Taylor C, Tan S, McClaughry R, Sharkey D Tags: Neonatology Source Type: research