The Associations between Antenatal Corticosteroids and In-Hospital Outcomes of Preterm Singleton Appropriate for Gestational Age Neonates according to the Presence of Maternal Histologic Chorioamnionitis.
CONCLUSION: In neonates with HCA, ACS treatment was associated with reduced morbidities. However, increased sepsis was associated with optimal ACS use. PMID: 31593959 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 8, 2019 Category: Perinatology & Neonatology Authors: Ryu YH, Oh S, Sohn J, Lee J Tags: Neonatology Source Type: research

Use of a Mechanical Ventilator with Respiratory Function Monitoring Provides More Consistent Ventilation during Simulated Neonatal Resuscitation.
Abstract INTRODUCTION: Positive pressure ventilation (PPV) with T-Piece and self-inflating bag (SIB) during neonatal resuscitation after birth is associated with variability in ventilation. The use of a ventilator with respiratory function monitoring (RFM) for PPV, however, has not been evaluated. OBJECTIVE: To determine if ventilator + RFM can reduce ventilation variability compared to T-Piece and SIB in a preterm manikin at different combinations of target tidal volume (VT) and lung compliance (CL). METHODS: Twenty clinicians provided PPV via mask and endotracheal tube (ETT) using SIB, T-Piece, T-Piece...
Source: Neonatology - October 8, 2019 Category: Perinatology & Neonatology Authors: Jain D, D'Ugard C, Aguilar A, Del Moral T, Bancalari E, Claure N Tags: Neonatology Source Type: research

Diagnosis of Bilirubin Encephalopathy in Preterm Infants with Dyskinetic Cerebral Palsy.
CONCLUSION: For early diagnosis of BE, brain MRI is recommended at a corrected age of between 6 and 18 months, especially for those with abnormal ABR during early infancy, and even with no apparent history of marked neonatal hyperbilirubinemia. PMID: 31587006 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 4, 2019 Category: Perinatology & Neonatology Authors: Kitai Y, Hirai S, Okuyama N, Hirotsune M, Mizutani S, Ogura K, Ohmura K, Okumura A, Arai H Tags: Neonatology Source Type: research

Nitric Oxide in Pulmonary Hypoplasia: Results from the European iNO Registry.
Abstract OBJECTIVES: The aim of this work was to describe treatment response and outcome data for preterm infants with pulmonary hypoplasia treated with inhaled nitric oxide (iNO). We hypothesised that an acute oxygenation response to iNO would be associated with survival. DESIGN: A retrospective observational study design was used to identify cases of pulmonary hypoplasia in preterm infants
Source: Neonatology - October 3, 2019 Category: Perinatology & Neonatology Authors: Kettle R, Subhedar NV, European iNO Registry Tags: Neonatology Source Type: research

Unit-Level Variations in Healthcare Professionals' Availability for Preterm Neonates < 29 Weeks' Gestation: An International Survey.
Unit-Level Variations in Healthcare Professionals' Availability for Preterm Neonates
Source: Neonatology - October 1, 2019 Category: Perinatology & Neonatology Authors: Shahroor M, Lehtonen L, Lee SK, Håkansson S, Vento M, Darlow BA, Adams M, Mori A, Lui K, Bassler D, Morisaki N, Modi N, Noguchi A, Kusuda S, Beltempo M, Helenius K, Isayama T, Reichman B, Shah PS, on behalf of the International Network for Evaluat Tags: Neonatology Source Type: research

Comparison of Neonatal Intubation Practice and Outcomes between the Neonatal Intensive Care Unit and Delivery Room.
vestigators Abstract BACKGROUND: Characteristics of neonatal tracheal intubations (TI) may vary between the neonatal intensive care unit (NICU) and delivery room (DR). The impact of the setting on TI outcomes is not well characterized. OBJECTIVE: The aim of this study was to define variation in neonatal TI practice between settings, and identify the association between setting and TI success and safety outcomes. DESIGN: This was a retrospective cohort study of TIs in the National Emergency Airway Registry for Neonates from October 2014 to September 2017. The setting (NICU vs. DR) was the exposure of inte...
Source: Neonatology - September 27, 2019 Category: Perinatology & Neonatology Authors: Herrick HM, Glass KM, Johnston LC, Singh N, Shults J, Ades A, Nadkarni V, Nishisaki A, Foglia EE, for the NEAR4NEOS Investigators Tags: Neonatology Source Type: research

A Rare Case of Fetal Onset, Food Protein-Induced Enterocolitis Syndrome.
CONCLUSION: This report might be helpful for prompt diagnosis and treatment and, furthermore, lead to elucidation of the pathogenesis and pathophysiology of FPIES. PMID: 31553974 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - September 25, 2019 Category: Perinatology & Neonatology Authors: Ichimura S, Kakita H, Asai S, Mori M, Takeshita S, Ueda H, Muto T, Kondo T, Yamada Y Tags: Neonatology Source Type: research

The Effect of Continuous Positive Airway Pressure on Cerebral and Splanchnic Oxygenation in Preterm Infants.
This study aimed to investigate how the application of CPAP affects cerebral and splanchnic tissue oxygenation in preterm infants. METHODS: A pilot observational study was conducted in infants using near-infrared spectroscopy while off CPAP and on CPAP. Regional cerebral and splanchnic saturations and variability (coefficient of variability; CV) were evaluated. RESULTS: Twenty-six infants (25-37 weeks gestational age at birth) were studied. The mean cerebral oxygenation did not differ with the application of CPAP (80 ± 4.2% without CPAP; 80 ± 1.9% with CPAP), but variability around the mean was less...
Source: Neonatology - September 19, 2019 Category: Perinatology & Neonatology Authors: Zhong J, Lui K, Schindler T Tags: Neonatology Source Type: research

Initial Observations on the Effect of Repeated Surfactant Dose on Lung Volume and Ventilation in Neonatal Respiratory Distress Syndrome.
CONCLUSIONS: Repeated surfactant dose during invasive ventilation improves oxygenation without measurable changes in EELZ or ventilation distribution. PMID: 31505498 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - September 10, 2019 Category: Perinatology & Neonatology Authors: Kallio M, van der Zwaag AS, Waldmann AD, Rahtu M, Miedema M, Papadouri T, van Kaam AH, Rimensberger PC, Bayford R, Frerichs I Tags: Neonatology Source Type: research

Postnatal Cerebral Hyperoxia Is Associated with an Increased Risk of Severe Retinopathy of Prematurity.
CONCLUSIONS: Cerebral hyperoxia may be a better early predictor of severe ROP than arterial hyperoxia. Moreover, under strict oxygen management, cerebral hyperoxia in these infants may result from cerebral immaturity rather than a high SaO2. Whether reducing cerebral hyperoxia is feasible and might prevent ROP needs to be further examined. PMID: 31487704 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - September 5, 2019 Category: Perinatology & Neonatology Authors: Richter AE, Bos AF, Huiskamp EA, Kooi EMW Tags: Neonatology Source Type: research

NIV NAVA versus Nasal CPAP in Premature Infants: A Randomized Clinical Trial.
Abstract BACKGROUND: Noninvasive ventilation is recommended for neonatal respiratory distress to avoid adverse effects of invasive ventilation. OBJECTIVE: The aim of this study was to compare the feasibility of noninvasive neurally adjusted ventilatory assist (NIV NAVA) and continuous positive airway pressure (CPAP) in preterm newborn infants. METHODS: Forty preterm infants (gestational age 28+0 to 36+6 weeks) requiring CPAP and supplemental oxygen (FiO2>0.23) for respiratory distress at
Source: Neonatology - September 5, 2019 Category: Perinatology & Neonatology Authors: Kallio M, Mahlman M, Koskela U, Aikio O, Suo-Palosaari M, Pokka T, Saarela T, Hallman M Tags: Neonatology Source Type: research

Cardiorespiratory Physiology following Minimally Invasive Surfactant Therapy in Preterm Infants.
Abstract INTRODUCTION: Surfactant replacement therapy through the endotracheal tube has been shown to improve lung compliance and reduce pulmonary pressures. Minimally invasive surfactant therapy (MIST) combines the benefits of continuous positive airway pressure (CPAP) and surfactant for spontaneously breathing preterm infants. We aimed to characterize the haemodynamic changes accompanying the first dose of MIST in preterm infants. METHODS: Poractant alfa (200 mg/kg) was administered as MIST while on CPAP support. Echocardiograms were performed before (T1) and 30 (T2) and 60 min (T3) after MIST to assess ser...
Source: Neonatology - September 5, 2019 Category: Perinatology & Neonatology Authors: Sehgal A, Bhatia R, Roberts CT Tags: Neonatology Source Type: research

Decreasing Number of Conclusive Neonatal Reviews: Increasing Role for Shared Decision-Making?
PMID: 31487740 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - September 5, 2019 Category: Perinatology & Neonatology Authors: Lai NM, Ong JM, Chen KH, Chaiyakunapruk N, Ovelman C, Soll R Tags: Neonatology Source Type: research

Reduced Cerebellar Size at Term-Equivalent Age Is Related to a 17% Lower Mental Developmental Index in Very Preterm Infants without Brain Injury.
DISCUSSION: We found that reduced TCD was associated with a 17% lower mean MDI at a corrected age of 2 years. Thus, TCD at TEA may be used as an imaging marker for adverse cognitive outcome in the apparently low-risk group of preterm infants without brain injury. PMID: 31480070 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - September 3, 2019 Category: Perinatology & Neonatology Authors: Hammerl M, Zagler M, Griesmaier E, Janjic T, Gizewski ER, Kiechl-Kohlendorfer U, Neubauer V Tags: Neonatology Source Type: research

Response to the Letter "RE: Commentary on 'Pulse Oximetry Screening for Critical Congenital Heart Defects'".
Response to the Letter "RE: Commentary on 'Pulse Oximetry Screening for Critical Congenital Heart Defects'". Neonatology. 2019 Aug 30;:1 Authors: Oddie S, McGuire W PMID: 31473740 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 30, 2019 Category: Perinatology & Neonatology Authors: Oddie S, McGuire W Tags: Neonatology Source Type: research

Surfactant Administration via Thin Catheter: A Practical Guide.
We present here a contemporary review of surfactant administration via thin catheter, in a practical guide format that reflects the individual and collective scientific opinions of the clinicians who participated in formulating the guide. PMID: 31461712 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 28, 2019 Category: Perinatology & Neonatology Authors: Vento M, Bohlin K, Herting E, Roehr CC, Dargaville PA Tags: Neonatology Source Type: research

The Association of Intraventricular Hemorrhage and Acute Kidney Injury in Premature Infants from the Assessment of the Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) Study.
sp;Collaborative (NKC) Abstract BACKGROUND: Acute kidney injury (AKI) and intraventricular hemorrhage (IVH) are common in premature infants. We previously demonstrated that infants with AKI have a higher hazards ratio to develop grade ≥2 IVH when controlling for confounders. However, that single-center study was unable to show an overall association. OBJECTIVES: To test the hypothesis that infants diagnosed with AKI have an increased risk of IVH independent of variables associated with both AKI and IVH, we performed a study on 825 infants from the Assessment of Worldwide Acute Kidney Injury Epidemiolo...
Source: Neonatology - August 28, 2019 Category: Perinatology & Neonatology Authors: Stoops C, Boohaker L, Sims B, Griffin R, Selewski DT, Askenazi D, on behalf of the National Kidney Collaborative (NKC) Tags: Neonatology Source Type: research

Immune System Regulation Affected by a Murine Experimental Model of Bronchopulmonary Dysplasia: Genomic and Epigenetic Findings.
CONCLUSIONS: Oxygen damage could be partly responsible for the increased susceptibility and abnormal response to respiratory viruses and infections seen in premature babies with BPD through dysregulated genes. PMID: 31454811 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 27, 2019 Category: Perinatology & Neonatology Authors: Revhaug C, Bik-Multanowski M, Zasada M, Rognlien AGW, Günther CC, Ksiązek T, Madetko-Talowska A, Szewczyk K, Grabowska A, Kwinta P, Pietrzyk JJ, Baumbusch LO, Saugstad OD Tags: Neonatology Source Type: research

Are Simple Magnetic Resonance Imaging Biomarkers Predictive of Neurodevelopmental Outcome at Two Years in Very Preterm Infants?
uuml;ning B Abstract BACKGROUND: Preterm infants are at increased risk of neurodevelopmental impairment due to the vulnerability of the immature brain. Early risk stratification is necessary for predicting outcome in the period of highest neuroplasticity. Several biomarkers in magnetic resonance imaging (MRI) at term equivalent age (TEA) have therefore been suggested. OBJECTIVE: To assess the predictive value of simple brain metrics and the total abnormality score (TAS) - a modified score for brain injury and growth - in relation to neurodevelopmental outcome of very preterm infants in MRI at TEA. METHOD...
Source: Neonatology - August 27, 2019 Category: Perinatology & Neonatology Authors: Dewan MV, Herrmann R, Schweiger B, Sirin S, Müller H, Storbeck T, Dransfeld F, Felderhoff-Müser U, Hüning B Tags: Neonatology Source Type: research

Life-Threatening Extreme Methemoglobinemia during Standard Dose Nitric Oxide Therapy.
We report the first case of life-threatening extreme neonatal-acquired methemoglobinemia that occurred during inhaled nitric oxide (iNO) at the standard 20 ppm dose in a neonate with early onset sepsis and suprasystemic pulmonary hypertension. Life-threatening methemoglobinemia has been efficaciously treated with methylene blue and ascorbic acid, while stopping iNO and starting iloprost and sildenafil. The patient was subjected to various tests (including gene sequencing and hemoglobin electrophoresis) and did not have any known genetic cause or predisposition for methemoglobinemia. Neuroimaging and the 2-year clinical fol...
Source: Neonatology - August 27, 2019 Category: Perinatology & Neonatology Authors: Centorrino R, Shankar-Aguilera S, Foligno S, De Luca D Tags: Neonatology Source Type: research

Reply to Commentary on "Pulse Oximetry Screening for Critical Congenital Heart Defects".
Reply to Commentary on "Pulse Oximetry Screening for Critical Congenital Heart Defects". Neonatology. 2019 Aug 27;:1-2 Authors: Ewer AK, Thangaratinam S, Plana N, Zamora J PMID: 31454814 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 27, 2019 Category: Perinatology & Neonatology Authors: Ewer AK, Thangaratinam S, Plana N, Zamora J Tags: Neonatology Source Type: research

Evidence-Based Medicine in Neonatology: The Need for Multifaceted Improvements.
PMID: 31454816 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 27, 2019 Category: Perinatology & Neonatology Authors: Meyer S Tags: Neonatology Source Type: research

Early Predictors for INtubation-SURfactant-Extubation Failure in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Systematic Review.
In conclusion, extremely low BW, low GA, and severe RDS appear to be risk factors for INSURE failure. However, evidence is inconsistent due to important methodological heterogeneity. Therefore, clinical applicability of these results is limited and implies the need for future large cohort studies on this subject. PMID: 31437836 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 22, 2019 Category: Perinatology & Neonatology Authors: De Bisschop B, Derriks F, Cools F Tags: Neonatology Source Type: research

[Developmental Outcomes following Topical Coconut Oil in Very Preterm Infants].
PMID: 31401634 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 9, 2019 Category: Perinatology & Neonatology Authors: Strunk T, Nathan E, Sharp M, Doherty D, Patole S Tags: Neonatology Source Type: research

Randomized Controlled Trial on the Effects of Morning versus Evening Primary Vaccination on Episodes of Hypoxemia and Bradycardia in Very Preterm Infants.
CONCLUSIONS: We did not identify a difference in CER between morning and evening vaccination but could confirm increased body temperatures and vaccination titers following vaccination. PMID: 31394525 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - August 8, 2019 Category: Perinatology & Neonatology Authors: Gottlob S, Gille C, Poets CF Tags: Neonatology Source Type: research

Mitochondrial Disease Caused by a Novel Homozygous Mutation (Gly106del) in the SCO1 Gene.
Abstract The cytochrome C oxidase assembly protein SCO1 gene encodes a mitochondrial protein essential for the mammalian energy metabolism. Only three pedigrees of SCO1mutations have thus far been reported. They all presented with lactate acidosis and encephalopathy. Two had hepatopathy and hypotonia, and the other presented with intrauterine growth retardation and hypertrophic cardiomyopathy leading to cardiac failure. Mitochondrial disease may manifest in neonates, but early diagnosis has so far been difficult. Here, we present a novel mutation in the SCO1 gene: in-frame deletion (Gly106del)with a different phen...
Source: Neonatology - July 26, 2019 Category: Perinatology & Neonatology Authors: Brix N, Jensen JM, Pedersen IS, Ernst A, Frost S, Bogaard P, Petersen MB, Bender L Tags: Neonatology Source Type: research

Topical Coconut Oil Contributes to Systemic Monolaurin Levels in Very Preterm Infants.
PMID: 31330518 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 22, 2019 Category: Perinatology & Neonatology Authors: Strunk T, Gummer JPA, Abraham R, Abraham S, Hibbert J, Patole S, Currie A Tags: Neonatology Source Type: research

Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants.
CONCLUSIONS: CO measured by USCOM consistently overestimated the results obtained from echocardiography. USCOM is not adequate to provide absolute estimates of CO. However, it may allow longitudinal hemodynamic assessment of sick neonates. PMID: 31326967 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 19, 2019 Category: Perinatology & Neonatology Authors: Fraga MV, Dysart KC, Rintoul N, Chaudhary AS, Ratcliffe SJ, Fedec A, Kren S, Cohen MS, Kirpalani H Tags: Neonatology Source Type: research

Early versus Delayed Fortification of Human Milk in Preterm Infants: A Systematic Review.
The objective of this systematic review was to compare the effect of early fortification (EF) versus that of delayed introduction of human milk fortifier (DF) on short-term outcomes including growth, feeding intolerance, length of hospital stay, and maturity at discharge in very-low-birth-weight infants. The search was carried out until March 2019 using 5 electronic databases (PubMed, Ovid Medline, Web of Science, Ovid Embase, and the Cochrane Library). The search was supplemented with a search of the clinical trial registry and reference lists. Eligible studies involved randomized controlled trials that had been designed ...
Source: Neonatology - July 19, 2019 Category: Perinatology & Neonatology Authors: Alyahya W, Simpson J, Garcia AL, Mactier H, Edwards CA Tags: Neonatology Source Type: research

The Clinical Risk Index for Babies II for Prediction of Time-Dependent Mortality and Short-Term Morbidities in Very Low Birth Weight Infants.
CONCLUSION: Certain CRIB II cutoffs were significantly associated with time-dependent mortality, particularly within the first 90 days after birth as well as with short-term morbidities. PMID: 31307048 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 15, 2019 Category: Perinatology & Neonatology Authors: Lee SM, Lee MH, Chang YS, and the Korean Neonatal Network Tags: Neonatology Source Type: research

Control of Bias Has Been Recognized as Important for a Long Time – but Are We Finally in Control?
Neonatology (Source: Neonatology)
Source: Neonatology - July 5, 2019 Category: Perinatology & Neonatology Source Type: research

Control of Bias Has Been Recognized as Important for a Long Time - but Are We Finally in Control?
PMID: 31280265 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 5, 2019 Category: Perinatology & Neonatology Authors: Kirpalani H Tags: Neonatology Source Type: research

Patent Ductus Arteriosus and the Effects of Its Late Closure in Preterm Infants with Severe Bronchopulmonary Dysplasia
Conclusions: The majority of conservatively treated late PDAs closed spontaneously or decreased in size.PDA surgery was not associated with severe adverse clinical outcomes.Neonatology (Source: Neonatology)
Source: Neonatology - July 3, 2019 Category: Perinatology & Neonatology Source Type: research

Patent Ductus Arteriosus and the Effects of Its Late Closure in Preterm Infants with Severe Bronchopulmonary Dysplasia.
Abstract BACKGROUND: The natural history and optimal management of a patent ductus arteriosus (PDA) among infants with established severe bronchopulmonary dysplasia (sBPD) remains uncertain. OBJECTIVES: To describe the characteristics of PDA present at ≥36 weeks' postmenstrual age (PMA) and the effects of late surgical PDA closure in a referral cohort of very preterm infants with sBPD. STUDY DESIGN: This retrospective cohort study was performed in a tertiary neonatal intensive care unit. Study infants were born at
Source: Neonatology - July 3, 2019 Category: Perinatology & Neonatology Authors: Ansems SM, Kirpalani H, Mercer-Rosa L, Wang Y, Hopper RK, Fraga MV, Jensen EA Tags: Neonatology Source Type: research

Delayed Cord Clamping versus Early Cord Clamping in Elective Cesarean Section: A Randomized Controlled Trial
Conclusions: Delaying cord clamping beyond 60 s increases the hematocrit at day 2 in neonates born through elective CS, without affecting maternal blood losses. Our findings suggest that DCC should be recommended in elective CS, but further studies are warranted to assess long-term outcomes.Neonatology (Source: Neonatology)
Source: Neonatology - July 2, 2019 Category: Perinatology & Neonatology Source Type: research

60 Years of Publishing Fetal and Neonatal Research
Neonatology (Source: Neonatology)
Source: Neonatology - July 2, 2019 Category: Perinatology & Neonatology Source Type: research

60 Years of Publishing Fetal and Neonatal Research.
PMID: 31266020 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - July 2, 2019 Category: Perinatology & Neonatology Authors: Halliday HL, Speer CP Tags: Neonatology Source Type: research

Delayed Cord Clamping versus Early Cord Clamping in Elective Cesarean Section: A Randomized Controlled Trial.
Abstract BACKGROUND: Delaying cord clamping is recommended in order to assure placental transfusion. However, the evidence on cord management in elective cesarean section (CS) is limited. OBJECTIVE: To compare delayed cord clamping (DCC) with early cord clamping (ECC) with regard to postnatal adaptation in neonates born through elective CS. METHODS: All neonates born ≥39 weeks' gestation born through elective CS were assigned to either the DCC or the ECC arm at a 1:1 ratio according to a computer-generated, randomized sequence. The primary outcome was the hematocrit at day 2 of life. Secondary outcome...
Source: Neonatology - July 2, 2019 Category: Perinatology & Neonatology Authors: Cavallin F, Galeazzo B, Loretelli V, Madella S, Pizzolato M, Visentin S, Trevisanuto D Tags: Neonatology Source Type: research

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia
Conclusions: Therapeutic hypothermia does not influence clearance of phenobarbital or midazolam in (near-)term neonates with hypoxic-ischaemic encephalopathy. A phenobarbital dose of 30 mg/kg is advised to reach therapeutic concentrations. Phenobarbital co-administration significantly increased midazolam clearance. Should phenobarbital be substituted by non-CYP3A inducers as first-line anticonvulsant, a 50% lower midazolam maintenance dose might be appropriate to avoid excessive exposure during the first days after birth.Neonatology (Source: Neonatology)
Source: Neonatology - June 28, 2019 Category: Perinatology & Neonatology Source Type: research

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.
on behalf of the PharmaCool study group Abstract BACKGROUND: Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrate. Therefore, co-treatment with phenobarbital might impact midazolam clearance. OBJECTIVES: To assess pharmacokinetics and clinical anti-epileptic effectiveness of phenobarbital and midazolam in asphyxiated neonates and to develop dosing...
Source: Neonatology - June 28, 2019 Category: Perinatology & Neonatology Authors: Favié LMA, Groenendaal F, van den Broek MPH, Rademaker CMA, de Haan TR, van Straaten HLM, Dijk PH, van Heijst A, Simons SHP, Dijkman KP, Rijken M, Zonnenberg IA, Cools F, Zecic A, van der Lee JH, Nuytemans DHGM, van Bel F, Egberts TCG, Huitema ADR, on b Tags: Neonatology Source Type: research

Heart Rate Monitoring in Newborn Babies: A Systematic Review
Conclusions: The limitations of existing methods have a potential impact on short- and long-term morbidity and mortality outcomes. The development of a technological solution to determine HR accurately and quickly in babies at birth has immense implications for further research and can guide interventions, such as placental transfusion and resuscitation.Neonatology (Source: Neonatology)
Source: Neonatology - June 27, 2019 Category: Perinatology & Neonatology Source Type: research

Heart Rate Monitoring in Newborn Babies: A Systematic Review.
CONCLUSIONS: The limitations of existing methods have a potential impact on short- and long-term morbidity and mortality outcomes. The development of a technological solution to determine HR accurately and quickly in babies at birth has immense implications for further research and can guide interventions, such as placental transfusion and resuscitation. PMID: 31247620 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 27, 2019 Category: Perinatology & Neonatology Authors: Anton O, Fernandez R, Rendon-Morales E, Aviles-Espinosa R, Jordan H, Rabe H Tags: Neonatology Source Type: research

Phenobarbital Increases Midazolam Clearance in Neonates Treated with Hypothermia: Do We Really Need to Know?
Neonatology (Source: Neonatology)
Source: Neonatology - June 11, 2019 Category: Perinatology & Neonatology Source Type: research

Right Ventricular Size and Function in Neonates after Use of Antidepressants during Pregnancy
Neonatology (Source: Neonatology)
Source: Neonatology - June 11, 2019 Category: Perinatology & Neonatology Source Type: research

Right Ventricular Size and Function in Neonates after Use of Antidepressants during Pregnancy.
PMID: 31185472 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 11, 2019 Category: Perinatology & Neonatology Authors: Meinel K, Sallmon H, Koestenberger M Tags: Neonatology Source Type: research

Phenobarbital Increases Midazolam Clearance in Neonates Treated with Hypothermia: Do We Really Need to Know?
PMID: 31185480 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 11, 2019 Category: Perinatology & Neonatology Authors: Allegaert K, Smits A, van den Anker JN Tags: Neonatology Source Type: research

Evidence-Based Practice: Improving the Quality of Perinatal Care
Conclusions: Effective dissemination and implementation are essential for research evidence to improve quality of care and outcomes for newborn infants and their families. Multifaceted initiatives within network-based collaborative quality improvement programmes facilitate continuous audit and benchmarking cycles to ensure equity of access to evidence-based care practices.Neonatology (Source: Neonatology)
Source: Neonatology - June 5, 2019 Category: Perinatology & Neonatology Source Type: research

Contents Vol. 115, 2019
Neonatology 2019;115:I –0 (Source: Neonatology)
Source: Neonatology - June 5, 2019 Category: Perinatology & Neonatology Source Type: research

Author Index
Neonatology 2019;115:456 (Source: Neonatology)
Source: Neonatology - June 5, 2019 Category: Perinatology & Neonatology Source Type: research

Title Page: Sharing Progress in Neonatology (SPIN): A Critical Appraisal of Our Current Knowledge
Neonatology 2019;115:379 (Source: Neonatology)
Source: Neonatology - June 5, 2019 Category: Perinatology & Neonatology Source Type: research