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Opportunities and Challenges in Global Perinatal Research
Conclusions: While the challenges are undeniable, the need to make the perinatal period healthier for babies worldwide has never been clearer.Neonatology 2018;114:93 –102 (Source: Neonatology)
Source: Neonatology - May 16, 2018 Category: Perinatology & Neonatology Source Type: research

Opportunities and Challenges in Global Perinatal Research.
CONCLUSIONS: While the challenges are undeniable, the need to make the perinatal period healthier for babies worldwide has never been clearer. PMID: 29768264 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 16, 2018 Category: Perinatology & Neonatology Authors: Duby J, Sharma R, Bhutta ZA Tags: Neonatology Source Type: research

The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity
Conclusion: In addition to improved oxygenation, MIST results in a decrease in neural breathing effort measured by dEMG activity in the majority of preterm infants with RDS.Neonatology 2018;114:76 –81 (Source: Neonatology)
Source: Neonatology - May 2, 2018 Category: Perinatology & Neonatology Source Type: research

Evaluating Otherwise-Discarded Umbilical Cord Blood as a Source for a Neonate ’s Complete Blood Cell Count at Various Time Points
Conclusions: If cord blood is used for a neonate ’s initial CBC, the blood should be drawn within 10 min of the placental delivery when it is taken from the umbilical vein on or near the placenta. If an umbilical cord segment is obtained, the phlebotomy can be delayed for up to 30 min.Neonatology 2018;114:82 –86 (Source: Neonatology)
Source: Neonatology - May 2, 2018 Category: Perinatology & Neonatology Source Type: research

Preterm Glycosuria – New Data from a Continuous Glucose Monitoring System
Conclusions: The renal glucose threshold in VLBW infants is between 150 and 180 mg/dL. A negative result for glycosuria is a reliable screening test to exclude hyperglycemia. Occurrence of glycosuria ≥1+ is an indication to test blood glucose.Neonatology 2018;114:87 –92 (Source: Neonatology)
Source: Neonatology - May 2, 2018 Category: Perinatology & Neonatology Source Type: research

The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity.
Abstract BACKGROUND: Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. OBJECTIVES: To describe the effect of MIST on neural breathing effort assessed with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants with RDS. METHODS: Preterm infants with a gestational age
Source: Neonatology - May 2, 2018 Category: Perinatology & Neonatology Authors: de Waal CG, Hutten GJ, de Jongh FH, van Kaam AH Tags: Neonatology Source Type: research

Evaluating Otherwise-Discarded Umbilical Cord Blood as a Source for a Neonate's Complete Blood Cell Count at Various Time Points.
CONCLUSIONS: If cord blood is used for a neonate's initial CBC, the blood should be drawn within 10 min of the placental delivery when it is taken from the umbilical vein on or near the placenta. If an umbilical cord segment is obtained, the phlebotomy can be delayed for up to 30 min. PMID: 29719291 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - May 2, 2018 Category: Perinatology & Neonatology Authors: Carroll PD, Livingston E, Baer VL, Karkula K, Christensen RD Tags: Neonatology Source Type: research

Preterm Glycosuria - New Data from a Continuous Glucose Monitoring System.
Abstract BACKGROUND: Careful control of glucose homeostasis is essential for infants with very low birth weight (VLBW). In clinical practice, blood and urine glucose levels are monitored; however, their correlation has not been fully investigated in VLBW infants. OBJECTIVES: To evaluate the correlation between interstitial fluid glucose concentration (ISFG), glycosuria, and urine output among VLBW infants through continuous glucose monitoring (CGM). METHODS: A prospective, single-center, open cohort study enrolled 74 VLBW infants with a mean birth weight of 1,066 g. CGM (Guardian Real-Time CGM®; Medt...
Source: Neonatology - May 2, 2018 Category: Perinatology & Neonatology Authors: Jagła M, Szymońska I, Starzec K, Kwinta P Tags: Neonatology Source Type: research

Oxygenation of the Immature Infant: A Commentary and Recommendations for Oxygen Saturation Targets and Alarm Limits
Conclusions: The ideal oxygen saturation targets for infants #x3c; 28 weeks GA are not known. Mortality, ROP, and NEC seem to be particularly oxygen-sensitive outcome variables. The optimal oxygen saturation for premature infants #x3e; 28 weeks GA has not been carefully studied.Neonatology 2018;114:69 –75 (Source: Neonatology)
Source: Neonatology - April 18, 2018 Category: Perinatology & Neonatology Source Type: research

Oxygenation of the Immature Infant: A Commentary and Recommendations for Oxygen Saturation Targets and Alarm Limits.
Abstract BACKGROUND: For 70 years, there has been a search for the optimal oxygenation of premature infants. In spite of the lack of evidence, guidelines have successively reduced oxygenation targets during these years. OBJECTIVES: (1) To present a summary of previously published meta-analyses of 5 randomized studies (NeOProM) which tested a low (85-89%) versus a high (91-95%) oxygen saturation target the first weeks after birth on outcome of immature newborn infants. (2) To present international recommendations for oxygenation the first weeks after birth. METHODS: Data were retrieved from meta-analyses ...
Source: Neonatology - April 18, 2018 Category: Perinatology & Neonatology Authors: Saugstad OD Tags: Neonatology Source Type: research

Antenatal Corticosteroid Exposure Disrupts Myelination in the Auditory Nerve of Preterm Sheep
Conclusions: In preterm sheep, ACS exposure increased auditory nerve myelin area, potentially due to disruption of normal myelin deposition.Neonatology 2018;114:62 –68 (Source: Neonatology)
Source: Neonatology - April 17, 2018 Category: Perinatology & Neonatology Source Type: research

Antenatal Corticosteroid Exposure Disrupts Myelination in the Auditory Nerve of Preterm Sheep.
MW Abstract BACKGROUND: Antenatal corticosteroids (ACS) improve preterm neonatal outcomes. However, uncertainty remains regarding the safety of ACS exposure for the developing fetus, particularly its neurosensory development. OBJECTIVES: We investigated the effect of single and multiple ACS exposures on auditory nerve development in an ovine model of pregnancy. METHODS: Ewes with a single fetus (gestational age [GA] 100 days) received an intramuscular injection of 150 mg medroxyprogesterone-acetate, followed by intramuscular (i) betamethasone (0.5 mg/kg) on days 104, 111, and 118 GA; (ii) betamethasone ...
Source: Neonatology - April 17, 2018 Category: Perinatology & Neonatology Authors: Rittenschober-Böhm J, Rodger J, Jobe AH, Kallapur SG, Doherty DA, Kramer BW, Payne MS, Archer M, Rittenschober C, Newnham JP, Miura Y, Berger A, Matthews SG, Kemp MW Tags: Neonatology Source Type: research

Respiratory Management of Extremely Preterm Infants: An International Survey
Conclusions: There are marked variations but also similarities in respiratory management of extremely preterm infants between networks. Further collaboration and exploration is needed to better understand the association of these variations in practice with pulmonary outcomes.Neonatology 2018;114:28 –36 (Source: Neonatology)
Source: Neonatology - April 13, 2018 Category: Perinatology & Neonatology Source Type: research

Respiratory Management of Extremely Preterm Infants: An International Survey.
ternational Network for Evaluating Outcomes of Neonates Abstract BACKGROUND: There are significant international variations in chronic lung disease rates among very preterm infants yet there is little data on international variations in respiratory strategies. OBJECTIVE: To evaluate practice variations in the respiratory management of extremely preterm infants born at
Source: Neonatology - April 13, 2018 Category: Perinatology & Neonatology Authors: Beltempo M, Isayama T, Vento M, Lui K, Kusuda S, Lehtonen L, Sjörs G, Håkansson S, Adams M, Noguchi A, Reichman B, Darlow BA, Morisaki N, Bassler D, Pratesi S, Lee SK, Lodha A, Modi N, Helenius K, Shah PS, on behalf of the International Network fo Tags: Neonatology Source Type: research

Comparison of Different Compression to Ventilation Ratios (2: 1, 3: 1, and 4: 1) during Cardiopulmonary Resuscitation in a Porcine Model of Neonatal Asphyxia
Conclusions: Different C:V ratios resulted in similar ROSC, mortality, oxygen, and epinephrine administration during resuscitation in a porcine model of neonatal asphyxia.Neonatology 2018;114:37 –45 (Source: Neonatology)
Source: Neonatology - April 12, 2018 Category: Perinatology & Neonatology Source Type: research

Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants
Conclusion: Any stage of ROP in preterm infants was associated with a reduced brain volume and an impaired developmental outcome. These results suggest that common pathways may lead to impaired neural and neurovascular development in the brain and retina and that all stages of ROP may be considered in future studies on ROP and development.Neonatology 2018;114:46 –52 (Source: Neonatology)
Source: Neonatology - April 12, 2018 Category: Perinatology & Neonatology Source Type: research

End-Organ Saturation Differences in Early Neonatal Transition for Left- versus Right-Sided Congenital Heart Disease
Conclusion: NIRS Csat measures were better preserved in LL compared to RL. Rsat decreased in both groups through time. The correlation between the descending aorta VTI and Rsat suggests an association between NIRS measures of renal saturation and renal perfusion.Neonatology 2018;114:53 –61 (Source: Neonatology)
Source: Neonatology - April 12, 2018 Category: Perinatology & Neonatology Source Type: research

Comparison of Different Compression to Ventilation Ratios (2: 1, 3: 1, and 4: 1) during Cardiopulmonary Resuscitation in a Porcine Model of Neonatal Asphyxia.
CONCLUSIONS: Different C:V ratios resulted in similar ROSC, mortality, oxygen, and epinephrine administration during resuscitation in a porcine model of neonatal asphyxia. PMID: 29649792 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - April 12, 2018 Category: Perinatology & Neonatology Authors: Pasquin MP, Cheung PY, Patel S, Lu M, Lee TF, Wagner M, O'Reilly M, Schmölzer GM Tags: Neonatology Source Type: research

End-Organ Saturation Differences in Early Neonatal Transition for Left- versus Right-Sided Congenital Heart Disease.
CONCLUSION: NIRS Csat measures were better preserved in LL compared to RL. Rsat decreased in both groups through time. The correlation between the descending aorta VTI and Rsat suggests an association between NIRS measures of renal saturation and renal perfusion. PMID: 29649824 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - April 12, 2018 Category: Perinatology & Neonatology Authors: Altit G, Bhombal S, Tacy TA, Chock VY Tags: Neonatology Source Type: research

Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants.
This study included 52 very preterm infants (gestational age [mean ± SD]: 26.4 ± 1.9 weeks). Total brain, gray matter, unmyelinated white matter (UWMV), and cerebellar volumes were estimated in 51 out of 52 infants by magnetic resonance imaging at term-equivalent age. Bayley Scales of Infant Development were used to assess developmental outcomes in 49 out of 52 infants at a mean corrected age of 24.6 months. RESULTS: Nineteen out of 52 infants developed any stage of ROP. Infants with ROP had a lower median (IQR) UWMV (173 [156-181] vs. 204 [186-216] mL, p
Source: Neonatology - April 12, 2018 Category: Perinatology & Neonatology Authors: Sveinsdóttir K, Ley D, Hövel H, Fellman V, Hüppi PS, Smith LEH, Hellström A, Hansen Pupp I Tags: Neonatology Source Type: research

Is High-Flow Nasal Cannula Useful as Primary Respiratory Support in Preterm Infants?
Neonatology 2018;114:25 –25 (Source: Neonatology)
Source: Neonatology - April 5, 2018 Category: Perinatology & Neonatology Source Type: research

Reply to the Letter to the Editor: “Is High-Flow Nasal Cannula Useful as Primary Respiratory Support in Preterm Infants?”
Neonatology 2018;114:26 –27 (Source: Neonatology)
Source: Neonatology - April 5, 2018 Category: Perinatology & Neonatology Source Type: research

Identifying Risk Factors Shared by Bronchopulmonary Dysplasia, Severe Retinopathy, and Cystic Periventricular Leukomalacia in Very Preterm Infants for Targeted Intervention
Conclusions: BPD and sROP were most strongly associated. Most risk factors contributed to BPD, with differentially shared effects on sROP and cPVL. Prolonged MV was the only risk factor shared by all 3 morbidities, and avoiding it potentially reduced the risk of having at least 1 of them.Neonatology 2018;114:17 –24 (Source: Neonatology)
Source: Neonatology - April 5, 2018 Category: Perinatology & Neonatology Source Type: research

Is High-Flow Nasal Cannula Useful as Primary Respiratory Support in Preterm Infants?
PMID: 29621748 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - April 5, 2018 Category: Perinatology & Neonatology Authors: Shaw SC, Venkatnarayan K, Gupta R Tags: Neonatology Source Type: research

Reply to the Letter to the Editor: "Is High-Flow Nasal Cannula Useful as Primary Respiratory Support in Preterm Infants?"
Reply to the Letter to the Editor: "Is High-Flow Nasal Cannula Useful as Primary Respiratory Support in Preterm Infants?" Neonatology. 2018 Apr 05;114(1):26-27 Authors: Murki S, Kabra NS PMID: 29621755 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - April 5, 2018 Category: Perinatology & Neonatology Authors: Murki S, Kabra NS Tags: Neonatology Source Type: research

Identifying Risk Factors Shared by Bronchopulmonary Dysplasia, Severe Retinopathy, and Cystic Periventricular Leukomalacia in Very Preterm Infants for Targeted Intervention.
bsp;Collaborative Study Group Abstract BACKGROUND: Bronchopulmonary dysplasia (BPD), severe retinopathy of prematurity (sROP), and cystic periventricular leukomalacia (cPVL) are 3 major morbidities with long-term neurodevelopmental impairments in preterm infants. OBJECTIVE: To investigate the strength of associations and identify key risk factors shared by BPD, sROP, and cPVL for targeted intervention. METHODS: We studied the Taiwanese very-preterm-infant registry data on 3,507 infants admitted to neonatal intensive care units and discharged at postmenstrual age ≥36 weeks between 2008 and 20...
Source: Neonatology - April 5, 2018 Category: Perinatology & Neonatology Authors: Wang LW, Lin YC, Wang ST, Huang CC, on behalf of the Taiwan Premature Infant Developmental Collaborative Study Group Tags: Neonatology Source Type: research

The Research Cycle: Improving Care and Outcomes for Newborn Infants
Ensuring that policies and practice in perinatal care are informed by evidence from high-quality research is fundamental to improving outcomes for newborn infants and their families. Effective interventions in the perinatal period can have a life-long impact disproportionate to their costs. Many of the major advances in care that have transformed outcomes for preterm and sick newborn infants have been informed by empirical and applied health research. Conversely, there are examples of life-long adverse consequences for infants and families that are a legacy of practices based on poor-quality evidence. The challenge in the ...
Source: Neonatology - March 22, 2018 Category: Perinatology & Neonatology Source Type: research

The Research Cycle: Improving Care and Outcomes for Newborn Infants.
Abstract Ensuring that policies and practice in perinatal care are informed by evidence from high-quality research is fundamental to improving outcomes for newborn infants and their families. Effective interventions in the perinatal period can have a life-long impact disproportionate to their costs. Many of the major advances in care that have transformed outcomes for preterm and sick newborn infants have been informed by empirical and applied health research. Conversely, there are examples of life-long adverse consequences for infants and families that are a legacy of practices based on poor-quality evidence. The...
Source: Neonatology - March 22, 2018 Category: Perinatology & Neonatology Authors: McGuire W, Halliday HL Tags: Neonatology Source Type: research

Red Blood Cell Transfusion in Preterm Infants: Current Evidence and Controversies
The current evidence regarding the indication, advantages and risks of red blood cell transfusion (RBCT) for preterm infants is discussed. This is an important area in Neonatology to be examined given that 90% of extremely low birth weight infants receive RBCT and many controversies remain regarding when to transfuse and the risks of RBCT. The various treatment thresholds and guidelines used are presented and we compare the short-term clinical benefits of liberal and restrictive RBCT in preterm infants; the majority of these are equivocal and sadly long-term outcome data is limited. The latest evidence on how anaemia and b...
Source: Neonatology - March 16, 2018 Category: Perinatology & Neonatology Source Type: research

Red Blood Cell Transfusion in Preterm Infants: Current Evidence and Controversies.
Abstract The current evidence regarding the indication, advantages and risks of red blood cell transfusion (RBCT) for preterm infants is discussed. This is an important area in Neonatology to be examined given that 90% of extremely low birth weight infants receive RBCT and many controversies remain regarding when to transfuse and the risks of RBCT. The various treatment thresholds and guidelines used are presented and we compare the short-term clinical benefits of liberal and restrictive RBCT in preterm infants; the majority of these are equivocal and sadly long-term outcome data is limited. The latest evidence on...
Source: Neonatology - March 16, 2018 Category: Perinatology & Neonatology Authors: Howarth C, Banerjee J, Aladangady N Tags: Neonatology Source Type: research

Editorial: Research Methods in Neonatal Medicine
Neonatology 2018;114:1 –1 (Source: Neonatology)
Source: Neonatology - March 14, 2018 Category: Perinatology & Neonatology Source Type: research

Editorial: Research Methods in Neonatal Medicine.
PMID: 29539611 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - March 14, 2018 Category: Perinatology & Neonatology Authors: Halliday HL, Speer CP Tags: Neonatology Source Type: research

Impact of Xenon on CLIC4 and Bcl-2 Expression in Lipopolysaccharide and Hypoxia-Ischemia-Induced Periventricular White Matter Damage
Conclusions: These results demonstrate that LPS and HI successfully induced WMD, and Xe decreased neuronal apoptosis via Bcl-2- and CLIC4-mediated pathways. Moreover, the therapeutic time window of Xe extended for up to 5 h. These findings suggest that Xe can be used as a protective treatment for WMD in premature infants.Neonatology 2018;113:339 –346 (Source: Neonatology)
Source: Neonatology - March 8, 2018 Category: Perinatology & Neonatology Source Type: research

Impact of Xenon on CLIC4 and Bcl-2 Expression in Lipopolysaccharide and Hypoxia-Ischemia-Induced Periventricular White Matter Damage.
Abstract BACKGROUND: Premature birth is a significant health care burden. Xenon (Xe) is a general anesthetic with neuroprotective effects. OBJECTIVES: Here, we investigate the neuroprotective role of Xe in a lipopolysaccharide (LPS)- and hypoxia-ischemia (HI)-induced white matter damage (WMD) model. METHODS: Three-day-old Sprague-Dawley rats were randomly divided into a sham group (group A, n = 24), an LPS + HI group (group B, n = 24), and an LPS + HI + Xe group (group C, n = 72). The onset of Xe inhalation started at 0, 2, and 5 h in subgroups C1, C2, and C3, respectively. Next, we performed TUNEL and h...
Source: Neonatology - March 8, 2018 Category: Perinatology & Neonatology Authors: Yin X, Zhao J, Jiang H, Li L, Jiang J, Xi H, Peng X, Yin X, Shi X, Zhang L Tags: Neonatology Source Type: research

High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial – Background, Aims, and Study Protocol
Conclusions: Epo has robust neuroprotective effects in preclinical studies, and phase I/II trials suggest that multiple high doses of Epo may provide neuroprotection against brain injury in term infants. The High Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial will evaluate whether high-dose Epo reduces the combined outcome of death or neurodevelopmental disability when given in conjunction with hypothermia to newborns with moderate/severe HIE.Neonatology 2018;113:331 –338 (Source: Neonatology)
Source: Neonatology - March 7, 2018 Category: Perinatology & Neonatology Source Type: research

Implementation of the Neonatal Sepsis Calculator in an Australian Tertiary Perinatal Centre
Conclusions: The implementation of the Neonatal Sepsis Calculator was feasible and safe in our unit. Application of this clinical decision support tool may reduce the number of infants undergoing investigations and empirical treatment for suspected EOS.Neonatology 2018;113:379 –382 (Source: Neonatology)
Source: Neonatology - March 7, 2018 Category: Perinatology & Neonatology Source Type: research

Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia
The objective of this review is to compile, update, and interpret what is known about vitamin E isoforms and BPD since these first studies were conducted, and suggest future research directions.Neonatology 2018;113:366 –378 (Source: Neonatology)
Source: Neonatology - March 7, 2018 Category: Perinatology & Neonatology Source Type: research

Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia.
The objective of this review is to compile, update, and interpret what is known about vitamin E isoforms and BPD since these first studies were conducted, and suggest future research directions. PMID: 29514147 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - March 7, 2018 Category: Perinatology & Neonatology Authors: Stone CA, McEvoy CT, Aschner JL, Kirk A, Rosas-Salazar C, Cook-Mills JM, Moore PE, Walsh WF, Hartert TV Tags: Neonatology Source Type: research

Implementation of the Neonatal Sepsis Calculator in an Australian Tertiary Perinatal Centre.
CONCLUSIONS: The implementation of the Neonatal Sepsis Calculator was feasible and safe in our unit. Application of this clinical decision support tool may reduce the number of infants undergoing investigations and empirical treatment for suspected EOS. PMID: 29514161 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - March 7, 2018 Category: Perinatology & Neonatology Authors: Strunk T, Buchiboyina A, Sharp M, Nathan E, Doherty D, Patole S Tags: Neonatology Source Type: research

High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial - Background, Aims, and Study Protocol.
CONCLUSIONS: Epo has robust neuroprotective effects in preclinical studies, and phase I/II trials suggest that multiple high doses of Epo may provide neuroprotection against brain injury in term infants. The High Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial will evaluate whether high-dose Epo reduces the combined outcome of death or neurodevelopmental disability when given in conjunction with hypothermia to newborns with moderate/severe HIE. PMID: 29514165 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - March 7, 2018 Category: Perinatology & Neonatology Authors: Juul SE, Comstock BA, Heagerty PJ, Mayock DE, Goodman AM, Hauge S, Gonzalez F, Wu YW Tags: Neonatology Source Type: research

Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy
Conclusion: MEN during hypothermia was associated with a reduced length of stay and time to full feeds, but did not increase feeding complications or systemic inflammation.Neonatology 2018;113:347 –352 (Source: Neonatology)
Source: Neonatology - March 6, 2018 Category: Perinatology & Neonatology Source Type: research

Newborn Plasma Glucose Concentration Nadirs by Gestational-Age Group
Conclusion: Plasma glucose nadirs occurred at different times among gestational-age groups during the early postnatal period as follows: ELGAN #x3c; PT #x3c; LPT ≈ FT. In order to potentially prevent low glucose concentrations at the time of the nadir, exogenous glucose should be provided to all newborns as soon as possible after birth.Neonatology 2018;113:353 –359 (Source: Neonatology)
Source: Neonatology - March 6, 2018 Category: Perinatology & Neonatology Source Type: research

The Neuroprotective Effects of Hypothermia on Bilirubin-Induced Neurotoxicity in vitro
Conclusions: We conclude that hypothermia reduces the cell death induced by bilirubin toxicity in neuronal cells. Although moderate hypothermia has a better outcome than mild hypothermia, deep hypothermia as low as 29 °C has adverse effects on neuronal cell viability.Neonatology 2018;113:360 –365 (Source: Neonatology)
Source: Neonatology - March 6, 2018 Category: Perinatology & Neonatology Source Type: research

The Neuroprotective Effects of Hypothermia on Bilirubin-Induced Neurotoxicity in vitro.
CONCLUSIONS: We conclude that hypothermia reduces the cell death induced by bilirubin toxicity in neuronal cells. Although moderate hypothermia has a better outcome than mild hypothermia, deep hypothermia as low as 29°C has adverse effects on neuronal cell viability. PMID: 29510380 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - March 6, 2018 Category: Perinatology & Neonatology Authors: Kuter N, Aysit-Altuncu N, Ozturk G, Ozek E Tags: Neonatology Source Type: research

Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy.
Abstract BACKGROUND: Withholding enteral feedings during hypothermia lacks supporting evidence. OBJECTIVES: We aimed to determine if minimal enteral nutrition (MEN) during hypothermia in patients with hypoxic-ischemic encephalopathy was associated with a reduced duration of parenteral nutrition, time to full oral feeds, and length of stay, but would not be associated with increased systemic inflammation or feeding complications. METHODS: We performed a pilot, retrospective, matched case-control study within the Florida Neonatal Neurologic Network from December 2012 to May 2016 of patients who received ME...
Source: Neonatology - March 6, 2018 Category: Perinatology & Neonatology Authors: Chang LL, Wynn JL, Pacella MJ, Rossignol CC, Banadera F, Alviedo N, Vargas A, Bennett J, Huene M, Copenhaver N, Sura L, Barnette K, Solomon J, Bliznyuk NA, Neu J, Weiss MD Tags: Neonatology Source Type: research

Newborn Plasma Glucose Concentration Nadirs by Gestational-Age Group.
Abstract BACKGROUND: The glucose concentrations and times to nadir for newborns of all gestational ages when intrapartum glucose-containing solutions are not routinely provided are unknown. OBJECTIVE: To characterize and compare patterns of initial glucose concentration nadirs by gestational-age groups. METHODS: A cross-sectional cohort study of 1,366 newborns born in 1998 at the University of Arkansas for Medical Sciences, appropriate for gestational age, nonasphyxiated, nonpolycythemic, and not infants of diabetic mothers, were included. Initial plasma glucose concentrations, before intravenous fluids ...
Source: Neonatology - March 6, 2018 Category: Perinatology & Neonatology Authors: Kaiser JR, Bai S, Rozance PJ Tags: Neonatology Source Type: research

Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
Conclusion: Combined inhibition of C5 and CD14 attenuates meconium-induced inflammation in vivo and this could become a future therapeutic regimen for MAS.Neonatology 2018;113:322 –330 (Source: Neonatology)
Source: Neonatology - February 27, 2018 Category: Perinatology & Neonatology Source Type: research

Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.
CONCLUSION: Combined inhibition of C5 and CD14 attenuates meconium-induced inflammation in vivo and this could become a future therapeutic regimen for MAS. PMID: 29486477 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - February 27, 2018 Category: Perinatology & Neonatology Authors: Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A Tags: Neonatology Source Type: research

Perfluorocarbons Prevent Lung Injury and Promote Development during Artificial Placenta Support in Extremely Premature Lambs
Conclusion: During AP support, intratracheal PFC prevents lung injury and promotes normal lung development better than crystalloid or amniotic fluid with TO.Neonatology 2018;113:313 –321 (Source: Neonatology)
Source: Neonatology - February 23, 2018 Category: Perinatology & Neonatology Source Type: research

Perfluorocarbons Prevent Lung Injury and Promote Development during Artificial Placenta Support in Extremely Premature Lambs.
CONCLUSION: During AP support, intratracheal PFC prevents lung injury and promotes normal lung development better than crystalloid or amniotic fluid with TO. PMID: 29478055 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - February 23, 2018 Category: Perinatology & Neonatology Authors: Church JT, Perkins EM, Coughlin MA, McLeod JS, Boss K, Bentley JK, Hershenson MB, Rabah R, Bartlett RH, Mychaliska GB Tags: Neonatology Source Type: research