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Perfluorocarbons Prevent Lung Injury and Promote Development during Artificial Placenta Support in Extremely Premature Lambs
Conclusion: During AP support, intratracheal PFC prevents lung injury and promotes normal lung development better than crystalloid or amniotic fluid with TO.Neonatology 2018;113:313 –321 (Source: Neonatology)
Source: Neonatology - February 23, 2018 Category: Perinatology & Neonatology Source Type: research

Vitamin D and Its Role in Neonatal Hypoxic-Ischemic Brain Injury
Emerging evidence has demonstrated that vitamin D plays an important role in many adult neurologic disorders, but is also critical in neuronal development and pruning in the neonatal and pediatric populations. Neonates are at a particularly high risk of vitamin D deficiency, in part due to the high prevalence of maternal deficiency during pregnancy. Several preclinical studies have demonstrated that infants born to vitamin D-deficient mothers are at a high risk of developing neonatal brain injury, and recent clinical studies have shown that neonates with hypoxic-ischemic encephalopathy (HIE) tend to be vitamin D-deficient....
Source: Neonatology - February 21, 2018 Category: Perinatology & Neonatology Source Type: research

The Predictive Value of Amplitude-Integrated Electroencephalography in Preterm Infants for IQ and Other Neuropsychological Outcomes at Early School Age
Conclusions: In relatively healthy preterm infants the value of aEEG in predicting neuropsychological outcomes at early school age is limited. The presence of cyclicity directly after birth tends to be associated with better cognition.Neonatology 2018;113:287 –295 (Source: Neonatology)
Source: Neonatology - February 13, 2018 Category: Perinatology & Neonatology Source Type: research

The Predictive Value of Amplitude-Integrated Electroencephalography in Preterm Infants for IQ and Other Neuropsychological Outcomes at Early School Age.
CONCLUSIONS: In relatively healthy preterm infants the value of aEEG in predicting neuropsychological outcomes at early school age is limited. The presence of cyclicity directly after birth tends to be associated with better cognition. PMID: 29439269 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - February 13, 2018 Category: Perinatology & Neonatology Authors: Middel RG, Brandenbarg N, Van Braeckel KNJA, Bos AF, Ter Horst HJ Tags: Neonatology Source Type: research

A Combination of the Aerosolized PPAR- γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats
Conclusions: Nebulized PPAR- γ agonist PGZ with a synthetic lung surfactant accelerates lung maturation and prevents neonatal hyperoxia-induced lung injury more than either modality alone, with the potential to provide more effective prevention of BPD.Neonatology 2018;113:296 –304 (Source: Neonatology)
Source: Neonatology - February 9, 2018 Category: Perinatology & Neonatology Source Type: research

A Combination of the Aerosolized PPAR- γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats.
CONCLUSIONS: Nebulized PPAR-γ agonist PGZ with a synthetic lung surfactant accelerates lung maturation and prevents neonatal hyperoxia-induced lung injury more than either modality alone, with the potential to provide more effective prevention of BPD. PMID: 29428947 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - February 9, 2018 Category: Perinatology & Neonatology Authors: Sakurai R, Lee C, Shen H, Waring AJ, Walther FJ, Rehan VK Tags: Neonatology Source Type: research

Upregulation of Vascular Endothelial Growth Factor in Amniotic Fluid Stem Cells Enhances Their Potential to Attenuate Lung Injury in a Preterm Rabbit Model of Bronchopulmonary Dysplasia
Conclusion: hAF-SC with upregulated VEGF expression display enhanced potential to prevent/reverse lung injury in preterm rabbits, whereas na ïve hAF-SC only show a moderate therapeutic potential. These results point towards an added value of VEGF delivered by hAF-SC in the treatment of BPD.Neonatology 2018;113:275 –285 (Source: Neonatology)
Source: Neonatology - February 1, 2018 Category: Perinatology & Neonatology Source Type: research

Upregulation of Vascular Endothelial Growth Factor in Amniotic Fluid Stem Cells Enhances Their Potential to Attenuate Lung Injury in a Preterm Rabbit Model of Bronchopulmonary Dysplasia.
CONCLUSION: hAF-SC with upregulated VEGF expression display enhanced potential to prevent/reverse lung injury in preterm rabbits, whereas naïve hAF-SC only show a moderate therapeutic potential. These results point towards an added value of VEGF delivered by hAF-SC in the treatment of BPD. PMID: 29393249 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Jiménez J, Lesage F, Richter J, Nagatomo T, Salaets T, Zia S, Mori Da Cunha MG, Vanoirbeek J, Deprest JA, Toelen J Tags: Neonatology Source Type: research

Reply to the Letter to the Editor "Accurate Direct Measures Are Required to Validate Derived Measures".
Reply to the Letter to the Editor "Accurate Direct Measures Are Required to Validate Derived Measures". Neonatology. 2018 Jan 31;113(3):267-268 Authors: Clark RH, Olsen IE, Ferguson AN, Lawson ML PMID: 29393210 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 31, 2018 Category: Perinatology & Neonatology Authors: Clark RH, Olsen IE, Ferguson AN, Lawson ML Tags: Neonatology Source Type: research

Accurate Direct Measures Are Required to Validate Derived Measures.
PMID: 29393265 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 31, 2018 Category: Perinatology & Neonatology Authors: Pereira-da-Silva L, Virella D Tags: Neonatology Source Type: research

Variation in the Phototherapy Practices and Irradiance of Devices in a Major Metropolitan Area.
CONCLUSIONS: Despite established PT guidelines, local protocols and practices vary. Based on an assessment of 7 local hospitals, intensive PT was suboptimal for 62% of devices. Straightforward changes, such as decreasing the distance between an infant and the light source and establishing a consistent irradiance-based protocol, could substantially improve the quality of the intervention. PMID: 29393277 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 31, 2018 Category: Perinatology & Neonatology Authors: Borden AR, Satrom KM, Wratkowski P, George TN, Adkisson CA, Vreman HJ, Johnson AP, Nichols KJ, Slusher TM Tags: Neonatology Source Type: research

Variation in the Phototherapy Practices and Irradiance of Devices in a Major Metropolitan Area
Conclusions: Despite established PT guidelines, local protocols and practices vary. Based on an assessment of 7 local hospitals, intensive PT was suboptimal for 62% of devices. Straightforward changes, such as decreasing the distance between an infant and the light source and establishing a consistent irradiance-based protocol, could substantially improve the quality of the intervention.Neonatology 2018;113:269-274 (Source: Neonatology)
Source: Neonatology - January 30, 2018 Category: Perinatology & Neonatology Source Type: research

Reply to the Letter to the Editor “Accurate Direct Measures Are Required to Validate Derived Measures”
Neonatology 2018;113:267-268 (Source: Neonatology)
Source: Neonatology - January 30, 2018 Category: Perinatology & Neonatology Source Type: research

Accurate Direct Measures Are Required to Validate Derived Measures
Neonatology 2018;113:266 (Source: Neonatology)
Source: Neonatology - January 30, 2018 Category: Perinatology & Neonatology Source Type: research

Revived for Paradise: A History of Respite Sanctuaries
Infant baptism originated when St. Augustine proclaimed the doctrine of original sin in 412 CE. Neonates stillborn or deceased before baptism were declared to go down to Hell and were buried outside of sacred ground. From the 15th century, parents carried these infants to “respite sanctuaries” in remote mountain chapels, where miraculous images were believed to revive the infant in order to allow baptism and a Christian burial. Monasteries made fortunes out of the parents’ anguish. In 1528, the abuse of the Oberbüren image ignited iconoclasm and heralded the b eginning of the Reformation. From 1740, ...
Source: Neonatology - January 26, 2018 Category: Perinatology & Neonatology Source Type: research

Revived for Paradise: A History of Respite Sanctuaries.
Abstract Infant baptism originated when St. Augustine proclaimed the doctrine of original sin in 412 CE. Neonates stillborn or deceased before baptism were declared to go down to Hell and were buried outside of sacred ground. From the 15th century, parents carried these infants to "respite sanctuaries" in remote mountain chapels, where miraculous images were believed to revive the infant in order to allow baptism and a Christian burial. Monasteries made fortunes out of the parents' anguish. In 1528, the abuse of the Oberbüren image ignited iconoclasm and heralded the beginning of the Reformation. Fr...
Source: Neonatology - January 26, 2018 Category: Perinatology & Neonatology Authors: Obladen M Tags: Neonatology Source Type: research

Vitamin D Intake in Preterm Infants: Too Little, Too Much, or Just the Right Amount?
PMID: 29393224 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 24, 2018 Category: Perinatology & Neonatology Authors: Greer FR Tags: Neonatology Source Type: research

Dose-Response Effects of Early Vitamin D Supplementation on Neurodevelopmental and Respiratory Outcomes of Extremely Preterm Infants at 2 Years of Age: A Randomized Trial.
CONCLUSION: In extremely preterm infants, early vitamin D supplementation did not significantly improve cognitive scores. Though underpowered for clinically meaningful differences in early childhood outcomes, this trial may help determine dosing for further investigation of vitamin D supplementation. PMID: 29393233 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 24, 2018 Category: Perinatology & Neonatology Authors: Salas AA, Woodfin T, Phillips V, Peralta-Carcelen M, Carlo WA, Ambalavanan N Tags: Neonatology Source Type: research

Reply to the Commentary "Vitamin D Intake in Preterm Infants: Too Little, Too Much, or Just the Right Amount?"
Reply to the Commentary "Vitamin D Intake in Preterm Infants: Too Little, Too Much, or Just the Right Amount?" Neonatology. 2018 Jan 24;113(3):265 Authors: Salas AA PMID: 29393269 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 24, 2018 Category: Perinatology & Neonatology Authors: Salas AA Tags: Neonatology Source Type: research

High-Flow Nasal Cannula versus Nasal Continuous Positive Airway Pressure for Primary Respiratory Support in Preterm Infants with Respiratory Distress: A Randomized Controlled Trial
Conclusions: When comparing HFNC to nCPAP as a primary noninvasive respiratory support in preterm infants with respiratory distress, HFNC is inferior to nCPAP in avoiding the need for a higher mode of respiratory support in the first 72 h of life.Neonatology 2018;113:235 –241 (Source: Neonatology)
Source: Neonatology - January 23, 2018 Category: Perinatology & Neonatology Source Type: research

Body Composition following Necrotising Enterocolitis in Preterm Infants
Conclusion: The lower weight at term in preterm infants following surgically and medically managed NEC, in comparison to preterm infants that did not develop the disease, was secondary to a reduction in ATV. This suggests that the nutritional regimen received was adequate to preserve non-ATM but not to support the normal third-trimester deposition of adipose tissue in preterm infants.Neonatology 2018;113:242 –248 (Source: Neonatology)
Source: Neonatology - January 23, 2018 Category: Perinatology & Neonatology Source Type: research

Reply to the Commentary “Vitamin D Intake in Preterm Infants: Too Little, Too Much, or Just the Right Amount?”
Neonatology 2018;113:265 (Source: Neonatology)
Source: Neonatology - January 23, 2018 Category: Perinatology & Neonatology Source Type: research

Vitamin D Intake in Preterm Infants: Too Little, Too Much, or Just the Right Amount?
Neonatology 2018;113:263-264 (Source: Neonatology)
Source: Neonatology - January 23, 2018 Category: Perinatology & Neonatology Source Type: research

Dose-Response Effects of Early Vitamin D Supplementation on Neurodevelopmental and Respiratory Outcomes of Extremely Preterm Infants at 2 Years of Age: A Randomized Trial
Conclusion: In extremely preterm infants, early vitamin D supplementation did not significantly improve cognitive scores. Though underpowered for clinically meaningful differences in early childhood outcomes, this trial may help determine dosing for further investigation of vitamin D supplementation.Neonatology 2018;113:256-262 (Source: Neonatology)
Source: Neonatology - January 23, 2018 Category: Perinatology & Neonatology Source Type: research

High-Flow Nasal Cannula versus Nasal Continuous Positive Airway Pressure for Primary Respiratory Support in Preterm Infants with Respiratory Distress: A Randomized Controlled Trial.
CONCLUSIONS: When comparing HFNC to nCPAP as a primary noninvasive respiratory support in preterm infants with respiratory distress, HFNC is inferior to nCPAP in avoiding the need for a higher mode of respiratory support in the first 72 h of life. PMID: 29393237 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 23, 2018 Category: Perinatology & Neonatology Authors: Murki S, Singh J, Khant C, Kumar Dash S, Oleti TP, Joy P, Kabra NS Tags: Neonatology Source Type: research

Body Composition following Necrotising Enterocolitis in Preterm Infants.
The objective here was to evaluate body composition at term in infants following NEC, in comparison with healthy infants. The primary outcome measure was non-adipose tissue mass (non-ATM). METHODS: We compared body composition assessed by magnetic resonance imaging at term in infants born
Source: Neonatology - January 23, 2018 Category: Perinatology & Neonatology Authors: Binder C, Longford N, Gale C, Modi N, Uthaya S Tags: Neonatology Source Type: research

Cyanosis and Stroke due to Functional Cor Triatriatum Dexter in a Neonate.
sch U Abstract Small remnants of the right valve of the sinus venosus are commonly found in adults, but the incidence and risk associated with these embryonic remnants in neonates are not well studied. The following report describes a cyanotic neonate with a large Eustachian valve remnant creating a functional cor triatriatum dexter who was initially diagnosed with persistent pulmonary hypertension of the newborn. The cyanosis in this infant improved over the first postnatal week with conservative management, but she suffered multifocal subcortical stroke, likely related to her intracardiac shunt. The clinical pre...
Source: Neonatology - January 10, 2018 Category: Perinatology & Neonatology Authors: León RL, Zaban NB, Schamberger MS, Ho CY, Mietzsch U Tags: Neonatology Source Type: research

Cyanosis and Stroke due to Functional Cor Triatriatum Dexter in a Neonate
Small remnants of the right valve of the sinus venosus are commonly found in adults, but the incidence and risk associated with these embryonic remnants in neonates are not well studied. The following report describes a cyanotic neonate with a large Eustachian valve remnant creating a functional cor triatriatum dexter who was initially diagnosed with persistent pulmonary hypertension of the newborn. The cyanosis in this infant improved over the first postnatal week with conservative management, but she suffered multifocal subcortical stroke, likely related to her intracardiac shunt. The clinical presentation and questions ...
Source: Neonatology - January 9, 2018 Category: Perinatology & Neonatology Source Type: research

Influence of PCO2 Control on Clinical and Neurodevelopmental Outcomes of Extremely Low Birth Weight Infants.
, Rossi R, Rascher W, Böttger R, Seidenberg J, Hansen G, Bode H, Zernickel M, Muche R, Hummler HD, PHELBI Study Group Abstract BACKGROUND: Levels or fluctuations in the partial pressure of CO2 (PCO2) may affect outcomes for extremely low birth weight infants. OBJECTIVES: In an exploratory analysis of a randomized trial, we hypothesized that the PCO2 values achieved could be related to significant outcomes. METHODS: On each treatment day, infants were divided into 4 groups: relative hypocapnia, normocapnia, hypercapnia, or fluctuating PCO2. Ultimate assignment to a group for the purpose of this analy...
Source: Neonatology - January 4, 2018 Category: Perinatology & Neonatology Authors: Thome UH, Dreyhaupt J, Genzel-Boroviczeny O, Bohnhorst B, Schmid M, Fuchs H, Rohde O, Avenarius S, Topf HG, Zimmermann A, Faas D, Timme K, Kleinlein B, Buxmann H, Schenk W, Segerer H, Teig N, Ackermann B, Hentschel R, Heckmann M, Schlösser R, Peters J, R Tags: Neonatology Source Type: research

Influence of PCO < sub > 2 < /sub > Control on Clinical and Neurodevelopmental Outcomes of Extremely Low Birth Weight Infants
Background: Levels or fluctuations in the partial pressure of CO2 (PCO2) may affect outcomes for extremely low birth weight infants.Objectives: In an exploratory analysis of a randomized trial, we hypothesized that the PCO2 values achieved could be related to significant outcomes.Methods: On each treatment day, infants were divided into 4 groups: relative hypocapnia, normocapnia, hypercapnia, or fluctuating PCO2. Ultimate assignment to a group for the purpose of this analysis was made according to the group in which an infant spent the most days. Statistical analyses were performed with analysis of variance (ANOVA), the Kr...
Source: Neonatology - January 3, 2018 Category: Perinatology & Neonatology Source Type: research

Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner
Conclusion: These findings reveal sepsis-like conditions and neuroinflammation specific to the inflammatory stimulus (gram-positive vs. gram-negative) in the neonatal rat. They emphasise the importance of pre-clinical models being pathogen dependent, and should always be carefully tailored to their clinical scenario.Neonatology 2018;113:212-220 (Source: Neonatology)
Source: Neonatology - December 22, 2017 Category: Perinatology & Neonatology Source Type: research

Low- versus High-Dose and Early versus Late Parenteral Amino-Acid Administration in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis
Conclusions: Administering a high dose (>3.0 g/kg/day) or an early dose ( ≤24 h) of parenteral amino acids is safe and well tolerated but does not offer significant benefits on growth. Further large-scale randomized controlled trials in preterm infants are needed to study the effects of early and high-dose amino acids on growth and morbidity more consistently and extens ively.Neonatology 2018;113:187-205 (Source: Neonatology)
Source: Neonatology - December 21, 2017 Category: Perinatology & Neonatology Source Type: research

Gastro-Oesophageal Reflux and Apnoea: Is There a Temporal Relationship?
Background: Gastro-oesophageal reflux (GOR) and apnoea are common in infants; whether there is a causal relationship is controversial.Objectives: To determine whether there was a temporal relationship between GOR and apnoea, in particular, the frequency of obstructive apnoeas and if the frequency of GOR episodes correlated with apnoea frequency when maturity at testing was taken into account.Methods: Polysomnography and pH/multichannel intraluminal impedance (MII) studies were performed. Apnoeas were classified as central, obstructive, or mixed. MII events were classified as acidic (pH (Source: Neonatology)
Source: Neonatology - December 20, 2017 Category: Perinatology & Neonatology Source Type: research

Effect of Prophylactic Indomethacin in Extremely Low Birth Weight Infants Based on the Predicted Risk of Severe Intraventricular Hemorrhage
Conclusions: These findings do not support selective prophylactic indomethacin treatment to improve long-term outcomes of ELBW infants at high risk for severe IVH.Neonatology 2018;113:183-186 (Source: Neonatology)
Source: Neonatology - December 19, 2017 Category: Perinatology & Neonatology Source Type: research

Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome
In this report, we describe the first case, to our knowledge, of congenital Zika syndrome with concomitant critical congenital heart disease. The mother had a confirmed ZIKV infection in the first trimester of pregnancy. Fetal ultrasonography at 31 weeks of gestation revealed cerebral cortical calcifications and hypoplastic left heart syndrome. The severity of brain involvement was assessed by postnatal magnetic resonance imaging and echocardiogram, and palliative surgery was performed. The ethical dimensions of this infant's clinical management are discussed. ZIKV is known to affect neural progenitor cells, but whether it...
Source: Neonatology - December 15, 2017 Category: Perinatology & Neonatology Source Type: research

Errata.
Authors: PMID: 29237174 [PubMed - in process] (Source: Neonatology)
Source: Neonatology - December 14, 2017 Category: Perinatology & Neonatology Tags: Neonatology Source Type: research

Diagnosis and Management of Necrotizing Enterocolitis: An International Survey of Neonatologists and Pediatric Surgeons
Conclusion: Our results indicate a wide variation in the management of NEC, with significant differences between neonatologists and pediatric surgeons. A better appreciation of the relative significance and weighting that should be applied to the clinical features and investigations should reduce the variation in interpretation that appears to exist.Neonatology 2018;113:170-176 (Source: Neonatology)
Source: Neonatology - December 14, 2017 Category: Perinatology & Neonatology Source Type: research

Cot Death: History of an Iatrogenic Disaster
Since antiquity, cot death has been explained as accidental suffocation, overlaying, or smothering. Parents were blamed for neglect or drunkenness. A cage called arcuccio was invented around 1570 to protect the sleeping infant. Up to the 19th century, accidents were registered as natural causes of death. From 1830, accidental suffocation became unacceptable for physicians and legislators, and “natural” explanations for the catastrophe were sought, with parents being consoled rather than blamed. Two assumed causes had serious consequences: thymus hyperplasia was irradiated, causing thyroid cancer, and the concep...
Source: Neonatology - December 14, 2017 Category: Perinatology & Neonatology Source Type: research

Errata
Neonatology 2018;113:92 (Source: Neonatology)
Source: Neonatology - December 13, 2017 Category: Perinatology & Neonatology Source Type: research

The Laryngeal Mask Airway and Its Use in Neonatal Resuscitation: A Critical Review of Where We Are in 2017/2018.
Abstract Studies using videotape recordings and respiratory function monitoring have shown that both face mask (FM) application and endotracheal tube (ETT) placement represent a challenge for resuscitators. Hence, there is a strong need for devices that can largely be used independently of individual operator training levels, in order to ensure more reliable support in time-critical situations, such as neonatal resuscitation. The laryngeal mask airway device (LMA) has evolved as a potentially very valuable tool. We conducted a systematic review of studies evaluating the use of the LMA in neonatal resuscitation. An...
Source: Neonatology - December 13, 2017 Category: Perinatology & Neonatology Authors: Bansal SC, Caoci S, Dempsey E, Trevisanuto D, Roehr CC Tags: Neonatology Source Type: research

The Laryngeal Mask Airway and Its Use in Neonatal Resuscitation: A Critical Review of Where We Are in 2017/2018
Studies using videotape recordings and respiratory function monitoring have shown that both face mask (FM) application and endotracheal tube (ETT) placement represent a challenge for resuscitators. Hence, there is a strong need for devices that can largely be used independently of individual operator training levels, in order to ensure more reliable support in time-critical situations, such as neonatal resuscitation. The laryngeal mask airway device (LMA) has evolved as a potentially very valuable tool. We conducted a systematic review of studies evaluating the use of the LMA in neonatal resuscitation. An electronic litera...
Source: Neonatology - December 12, 2017 Category: Perinatology & Neonatology Source Type: research

Topical Coconut Oil in Very Preterm Infants: An Open-Label Randomised Controlled Trial
Background: The immature fragile skin of preterm infants represents an inadequate protective barrier. The emollient and anti-infective properties of coconut oil make it a potentially beneficial topical agent for this population.Objectives: Our aim was to evaluate feasibility, safety, and the effects of topical coconut oil on skin condition in very preterm infants.Methods: An open-label randomised controlled trial in preterm infants (Source: Neonatology)
Source: Neonatology - December 1, 2017 Category: Perinatology & Neonatology Source Type: research

Topical Coconut Oil in Very Preterm Infants: An Open-Label Randomised Controlled Trial.
Abstract BACKGROUND: The immature fragile skin of preterm infants represents an inadequate protective barrier. The emollient and anti-infective properties of coconut oil make it a potentially beneficial topical agent for this population. OBJECTIVES: Our aim was to evaluate feasibility, safety, and the effects of topical coconut oil on skin condition in very preterm infants. METHODS: An open-label randomised controlled trial in preterm infants
Source: Neonatology - December 1, 2017 Category: Perinatology & Neonatology Authors: Strunk T, Pupala S, Hibbert J, Doherty D, Patole S Tags: Neonatology Source Type: research

Classifying Apnea of Prematurity by Transcutaneous Electromyography of the Diaphragm.
Abstract BACKGROUND: Treatment of apnea is highly dependent on the type of apnea. Chest impedance (CI) has inaccuracies in monitoring respiration, which compromises accurate apnea classification. Electrical activity of the diaphragm measured by transcutaneous electromyography (EMG) is feasible in preterm infants and might improve the accuracy of apnea classification. OBJECTIVES: To compare the accuracy of apnea classification based on diaphragmatic EMG (dEMG) and CI tracings in preterm infants. METHODS: Fifteen cases of central apnea, 5 of obstructive apnea, and 10 of mixed apnea were selected from recor...
Source: Neonatology - December 1, 2017 Category: Perinatology & Neonatology Authors: Kraaijenga JV, Hutten GJ, de Waal CG, de Jongh FH, Onland W, van Kaam AH Tags: Neonatology Source Type: research

Classifying Apnea of Prematurity by Transcutaneous Electromyography of the Diaphragm
Background: Treatment of apnea is highly dependent on the type of apnea. Chest impedance (CI) has inaccuracies in monitoring respiration, which compromises accurate apnea classification. Electrical activity of the diaphragm measured by transcutaneous electromyography (EMG) is feasible in preterm infants and might improve the accuracy of apnea classification.Objectives: To compare the accuracy of apnea classification based on diaphragmatic EMG (dEMG) and CI tracings in preterm infants.Methods: Fifteen cases of central apnea, 5 of obstructive apnea, and 10 of mixed apnea were selected from recordings containing synchronized ...
Source: Neonatology - November 30, 2017 Category: Perinatology & Neonatology Source Type: research

Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study.
This study aimed to describe the use of raw MOM in hospitalised neonates before day 7 (early use), and to investigate: (i) related factors, (ii) maternal satisfaction, and (iii) the association with breastfeeding continuation. METHODS: This prospective cohort included 516 neonates intended to be breastfed in 2 French neonatal units. Neonates receiving raw MOM before day 7 were compared to those who did not. The association between early use of MOM and breastfeeding continuation at hospital discharge, and up to 6 months later, was measured by logistic regression. RESULTS: More than one-third (36.2%) of breastfed n...
Source: Neonatology - November 30, 2017 Category: Perinatology & Neonatology Authors: Fischer Fumeaux CJ, Denis A, Prudon MB, Plaisant F, Essomo Megnier-Mbo CM, Fernandes L, Touzet S, Claris O, Laborie S Tags: Neonatology Source Type: research

Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study
This study aimed to describe the use of raw MOM in hospitalised neonates before day 7 (early use), and to investigate: (i) related factors, (ii) maternal satisfaction, and (iii) the association with breastfeeding continuation.Methods: This prospective cohort included 516 neonates intended to be breastfed in 2 French neonatal units. Neonates receiving raw MOM before day 7 were compared to those who did not. The association between early use of MOM and breastfeeding continuation at hospital discharge, and up to 6 months later, was measured by logistic regression.Results: More than one-third (36.2%) of breastfed neonates did ...
Source: Neonatology - November 29, 2017 Category: Perinatology & Neonatology Source Type: research

Should All Extremely Premature Infants Be Screened for Pulmonary Hypertension
Neonatology 2018;113:89-91 (Source: Neonatology)
Source: Neonatology - November 29, 2017 Category: Perinatology & Neonatology Source Type: research

Should All Extremely Premature Infants Be Screened for Pulmonary Hypertension?
PMID: 29183024 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - November 29, 2017 Category: Perinatology & Neonatology Authors: Young KC, Bancalari E Tags: Neonatology Source Type: research

Should All Extremely Premature Infants Be Screened for Pulmonary Hypertension?
Neonatology 2018;113:89-91 (Source: Neonatology)
Source: Neonatology - November 28, 2017 Category: Perinatology & Neonatology Source Type: research