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Impact of restrictive platelet transfusion strategies on transfusion rates: A cohort study in very preterm infants
DISCUSSION: Implementation of restrictive platelet guidelines led to reduction of the rate and number of platelet transfusions.PMID:38660945 | DOI:10.1111/trf.17844 (Source: Transfusion)
Source: Transfusion - April 25, 2024 Category: Hematology Authors: L E Heeger N A M Houben C Caram-Deelder S F Fustolo-Gunnink J G van der Bom E Lopriore Source Type: research

The Association Between Unintended Pregnancy and Perinatal Outcomes in Low ‐Risk Pregnancies: A Retrospective Registry Study in the Netherlands
This study used data (N = 9803) from a Dutch nationally representative registry of people with low-risk pregnancies receiving primary midwife-led care in the Netherlands between 2012 and 2020. Using logistic (mediation) regression analyses adjusted for potential confounders we investigated associations between unintended pregnancy and neonatal outcomes (low Apgar score, small for gestational age, and prematurity), parental morbidity (hypertension and gestational diabetes mellitus), and obstetric interventions (induction of labor, pain medication, assisted vaginal birth, and cesarean birth) and whether delayed initiation of...
Source: Journal of Midwifery and Women's Health - April 25, 2024 Category: Midwifery Authors: Amke M.G. van Tintelen, Danielle E.M.C. Jansen, Sophie H. Bolt, J. Catja Warmelink, Corine J. Verhoeven, Jens Henrichs Tags: RESEARCH ARTICLE Source Type: research

IJERPH, Vol. 21, Pages 538: Randomized Controlled Trial Protocol on the Effects of a Sensory Motor Intervention Associated with Kangaroo Skin-to-Skin Contact in Preterm Newborns
This study protocol details a two-arm parallel clinical trial methodology, involving participants with a postmenstrual age of 34–35 weeks admitted to a Neonatal Intermediate Care Unit (NInCU) with poor repertoire GMs. Thirty-four participants will be randomly assigned to either the experimental group, receiving a 10-day sensory motor physical therapy associated with kangaroo skin-to-skin contact, or the control group, which will only receive kangaroo skin-to-skin contact. The study will measure GMs (primary outcome), and body weight, posture and muscle tone, behavioral state, length of hospital stay, and brea...
Source: International Journal of Environmental Research and Public Health - April 25, 2024 Category: Environmental Health Authors: Mariane de Oliveira Nunes Reco Daniele Almeida Soares-Marangoni Tags: Study Protocol Source Type: research

Impact factors and obstetric outcomes of preeclampsia in twin pregnancies by prepregnancy body mass index: a six-year retrospective cohort study
Volume 37, Issue 1, December 2024 . (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - April 25, 2024 Category: Perinatology & Neonatology Authors: Jia-yi MaoShuang LuoLan WangYa ChenQing ZhouChun-yan YangXue XiangDa-ping WangHong-mei ZuoTai-hang LiuLi WenSi-meng QuTing Houa Department of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, (Women and Children ’s Hospital of C Source Type: research

Rebalancing of professional identity roles in an integrated maternity and neonatal care setting designed to increase parent autonomy: a qualitative study among health professionals
J Interprof Care. 2024 Apr 24:1-9. doi: 10.1080/13561820.2024.2343843. Online ahead of print.ABSTRACTThis case-based qualitative study explored the professional identity as experienced by health professionals working in an integrated maternal-neonatal ward when their practice changed from a "paternalistic" model, in which physicians and nurses were in charge, to a shared or "consumerist" model, to increase parent autonomy. We analyzed transcripts of focus group discussions and interviews with 60 health professionals on their experiences with empowering parents and described factors associated with themes of professional id...
Source: Journal of Interprofessional Care - April 24, 2024 Category: Health Management Authors: Mireille Stelwagen Alvin Westmaas Anne Van Kempen Fedde Scheele Source Type: research

Mitochondrial-dependent oxidative phosphorylation is key for postnatal metabolic adaptation of alveolar macrophages in the lung
Int Immunopharmacol. 2024 Apr 23;133:112012. doi: 10.1016/j.intimp.2024.112012. Online ahead of print.ABSTRACTAlveolar macrophages (AMs) seed in lung during embryogenesis and become mature in perinatal period. Establishment of acclimatization to environmental challenges is important, whereas the detailed mechanisms that drive metabolic adaptation of AMs remains to be elucidated. Here, we showed that energy metabolism of AMs was transformed from glycolysis prenatally to oxidative phosphorylation (OXPHOS) postnatally accompanied by up-regulated expression of mitochondrial transcription factor A (TFAM). TFAM deficiency distur...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jun Zhang Yu Peng Haosen Song Siqi Liu Chuanwei Li Yi Zhang Xiaowei Shi Huifang Guo Yingping Xu Source Type: research

Dynamic Changes in Lymphocyte Populations Establish Zebrafish as a Thymic Involution Model
J Immunol. 2024 Apr 24:ji2300495. doi: 10.4049/jimmunol.2300495. Online ahead of print.ABSTRACTThe thymus is the site of T lymphocyte development and T cell education to recognize foreign, but not self, Ags. B cells also reside and develop in the thymus, although their functions are less clear. During "thymic involution," a process of lymphoid atrophy and adipose replacement linked to sexual maturation, thymocytes decline. However, thymic B cells decrease far less than T cells, such that B cells comprise ∼1% of human neonatal thymocytes but up to ∼10% in adults. All jawed vertebrates possess a thymus, and we and others...
Source: Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Ameera Hasan Jose J Macias Brash é Wood Megan Malone-Perez Gilseung Park Clay A Foster J Kimble Frazer Source Type: research

A longitudinal study on the association between trait mindfulness and maternal bonding across the perinatal period
CONCLUSION: Mindfulness-based interventions may be helpful in supporting expectant mothers who are at risk for suboptimal bonding.PMID:38655861 | DOI:10.1080/02646838.2024.2342904 (Source: Journal of Reproductive and Infant Psychology)
Source: Journal of Reproductive and Infant Psychology - April 24, 2024 Category: Psychiatry & Psychology Authors: Myrthe G B M Boekhorst Noor de Waal Lisanne Smit Lianne P Hulsbosch Marion I van den Heuvel Inga Schwabe Victor Pop Ivan Nykl íček Source Type: research

Magnitude of Thrombocytopenia and Associated Factors among Pregnant Women Attending the Antenatal Care Service Unit of Wachemo University Nigist Ellen Mohammed Comprehensive Specialized Hospital Hosanna, Southern Ethiopia
CONCLUSION: The magnitude of thrombocytopenia in this study was 14.8%. Rural residence, cigarette smoking, alcohol consumption, and anemia were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during antenatal care visits for proper diagnosis and to minimize bleeding during and/or after childbirth.PMID:38655566 | PMC:PMC11039013 | DOI:10.1155/2024/8163447 (Source: Advances in Hematology)
Source: Advances in Hematology - April 24, 2024 Category: Hematology Authors: Dembelo Tirago Tilahun Yemane Edosa Tadasa Source Type: research

GSE264293 Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPAR α and ATF4
Contributors : Andre Weber ; Max Chang ; Christopher Benner ; Robert TukeySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTriclosan (TCS) is an antimicrobial toxicant found in a myriad of consumer products and has been detected in human tissues, including breastmilk. We have evaluated the impact of lactational TCS on UDP-glucuronosyltransferase 1A1 (UGT1A1) expression and bilirubin metabolism in humanized UGT1 (hUGT1) neonatal mice. In hUGT1 mice, expression of the hepatic UGT1A1 gene is developmentally delayed resulting in elevated total serum bilirubin (TSB) levels. We found tha...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

High prevalence of multidrug-resistant Enterobacterales carrying extended-spectrum beta-lactamase and AmpC genes isolated from neonatal sepsis in Ahvaz, Iran
This study aimed ... (Source: BMC Microbiology)
Source: BMC Microbiology - April 24, 2024 Category: Microbiology Authors: Sima Mansouri, Mohammad Savari, Arash Malakian and Effat Abbasi Montazeri Tags: Research Source Type: research

Melatonin in infants —physiology, pathophysiology and intervention options
AbstractThe effectiveness of melatonin in nonorganic sleep disorders in children and adolescents has been examined in 33  randomised controlled studies [1]. This review presents the current state of knowledge on the physiology, pharmacokinetics, pathophysiology and toxicity of melatoninin infancy based on well-documented studies. Up to the third month of life, premature and full-term babies cannot produce their own melatonin, so they are dependent on exogenous supply via their own mother ’s breast milk, non-pooled breast milk or non-pooled formula. Non-pooled means that a distinction should be made between melatonin-ri...
Source: Somnologie - Schlafforschung und Schlafmedizin - April 24, 2024 Category: Sleep Medicine Source Type: research

Prophylactic indomethacin and the risk of serious pulmonary hemorrhages in preterm infants less than 28 weeks’ gestation
Journal of Perinatology, Published online: 24 April 2024; doi:10.1038/s41372-024-01971-xProphylactic indomethacin and the risk of serious pulmonary hemorrhages in preterm infants less than 28 weeks’ gestation (Source: Journal of Perinatology)
Source: Journal of Perinatology - April 24, 2024 Category: Perinatology & Neonatology Authors: Ronald I. Clyman Nancy K. Hills Source Type: research

Human milk derived fortifiers are associated with glucose, phosphorus, and calcium derangements
Journal of Perinatology, Published online: 24 April 2024; doi:10.1038/s41372-024-01977-5Human milk derived fortifiers are associated with glucose, phosphorus, and calcium derangements (Source: Journal of Perinatology)
Source: Journal of Perinatology - April 24, 2024 Category: Perinatology & Neonatology Authors: Danielle Ackley Jiamin Yin Carl D ’Angio Jeffrey Meyers Bridget Young Source Type: research

Use of Respiratory and Contact Precautions to Decrease the Spread of SARS-CoV-2 Infection Was Not Associated with a Decrease in Endometritis –Intra-Amniotic Infection
Conclusion The use of respiratory and contact precautions to limit the spread of SARS-CoV-2 was not associated with risk of endometritis/IAI. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 24, 2024 Category: Perinatology & Neonatology Authors: Roig, Jacqueline DeBolt, Chelsea A. Cabrera, Mariela Spiera, Emily Goldberger, Cody Bianco, Angela Stone, Joanne A. Factor, Stephanie H. Tags: Original Article Source Type: research